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P97
Gene Name	P97
Sequence Strain (Species/Organism)	Mycoplasma hyopneumoniae 232
NCBI Gene ID	3105444
NCBI Protein GI	54020389
Locus Tag	mhp183
Genbank Accession	AE017332
Protein Accession	YP_115696
Taxonomy ID	295358
Gene Starting Position	224079
Gene Ending Position	227405
Gene Strand (Orientation)	-
Protein Name	protein p97; cilium adhesin
Protein pI	9.5
Protein Weight	120335.63
Protein Length	1108
DNA Sequence	>NC_006360.1:224079-227405 Mycoplasma hyopneumoniae 232, complete genome TTTATTTAGATTCTGGTTCCTGATTATTATTACTTTGTTTTACTGTTATTTTAACTTTTAGACTTGATTT TTTAGGATCACCGGATTTTGAATCATCCCTTAGGATAAAGTATAGCAATTTAGCATCTCCAGCGATATTA TCCTCGATTAGTTCAACCTCTGTTTTTCAATTTTTACCTTGTTTTTTAATGATTTCGTCAATTTTTTTAC CTAAGTCAGGAAGGTAATTAGTTAATTCGGTAGTTGGGCTTTGTTGACTAGGTGCTCCCTCTGCTTTTTT CCCTTGGTTAGGAGTTCCTTCGGCTTTTTTACCTTGGTTAGGCGCGCCTTCTGCTTTTTTACCTTGGTTA GGAGTTCCTTCGCTTTTTTTACCTTGATTTGAAGATCCTTCGGTCATCATTGGGTGGCTAAGTTTCTGAT ATTGGTCACTAGTTACCTTGACTTCCTGGAATTGATATTGAAGATTTAAAACAGTTTTATCTAGTTCCTT TATTATTTCTTGTTCTTCATACTCGCTTTGATGAACTAGTTCTAAAAATACATTAATTTCCGGTGTTTTT AGGCTTAATTTATTTTCGTCAGTATATTCTAATTTATAACTAAAAGCCATTGGGAAATAGTCTTCTTTTG GTTTATTTGTAAGTGAAAAGCCAGTATTAGTAGCAACTGGTTTTGCTGCTTCTGGTTTAGCCGCTACTGG TTTTGCTGCTTCTGGTTTAGCCGCTACTGGTTTTGCTGCTTCTGGTTTAGCCGCTACTGGTTTTGCTGCT TCTGGTTTAGCCGCTACTGGTTTTGCTGCTTCAGGTTTAGCTGCTTCAGGTTTAGCTGCTACTGGTTTTG TTGTTTCTGGTTTAGCCGCTACTGGTTTTGCTGCTTCTGGTTTTGCTGCTGGGGGCTGAGGCAATATACC TTTTATTTTATTATCCAATTCCTTAACTTTTTTATCTACTTCTTCTCTTTTACCTTCTTTTGTAGTTTCC CCTTTTTTGATAGCTTCAAATGAATACTGAAGATTATCGTCTAATTTTGCTCAAGGAGCAAAATTATTAA ATTGGGCTGCTTTAAGGAAAAATGCTTTTAAAAAATCACCGAAGGTTTTAAAATCAGTCCCTTCAAGTAA ATTTTTATCTAAAATAGTAGTTTTAAAAGCCGAGTTCTCAATTAAAGAATACTTTTTAAGCGCTTCAAAA ATTTGCGCCTCATTTTTGCCTTCTAATTCAGTTTTTACACTTTGGGGCAATAATAAAACTCCGTAAAATC CATCAGATTTTATTACATCGTTACGGGCTAAAATATTAAAGGAAAGTTGGTGAATTTCTTTTATCTGATT GTAAGGATCCTTTTTCTTCAATTCCAAAAATTTTAATTTATCTGCTTCTGCAAAAATATCTTTTGTATAT TGGAAAACCCCTTTTGGGAATTGTGCTCTGTTAGTTTCTAGTCCCCATTTTTTTGCTAGATCATAAAGAG TCTCTAAAATTGTTAATTTGTCCTTGGTGAGTAAATCCTGGAAATAACTTGCAACTTGATGTCCATTTTT AAAAAAGTTATTACTTTTAAGACTTGAAATTACTTGTTCTTTTGTTGTTTGTGGTTGATTTAAAACTGAA TTAGAACCAATTTTAACTTGTTCTAAATGTCTTGTAAATCTTTGGATATCAGCTTTTTCAGGATGCTGAA TTTTTCCTGTTCAGGAATTAAGCACGGATTTAAAGGCCCCGAATTCATAGGCATAATTTCCATCAAGTGC TTGATAGATTTCTTGGTTTTTATTCCCTTTAAAAAGAGCTTCAACTTCAACTTTGGCAAGTTGAGTATTA TATGGATTTAAGATATTACCATAGTCTAATTTTGCTTGTTCTTCTTTACCTTTTTCAAAAAATGGTAAAT ATTCGGTTTTAAAAATTTGCTGATTGATATTAGGGAGATCAATTTTTGAGCCTTTTTTAAATCCAGTTAA TTTAAGAATCCCTTCTTTTACGAGAATATTATCTTTTGTATCTGGATATAAATCATCGGCAAAAAATTTA TCTTTAATTTCAAGGCGGTAGGGAATTAAAACTATTGATTTATCTTTTTTATCAAGACTTGCGCTTGCTG CATCTAGGCTATATTCTAAATTTGGCGAGTTAAGACGGTCGTTGAATTTTCCATTGTATTTACCAAAGTC ATAAATATTTTCTTTTTTATTTAAAAGATTACTAATTTCTGCCTTGGTATGACTGGATCTCTTGTCTCCA GGGAAAAATCCAGATTTAATATCTGCTAGAAATTCATAGGCAGAAAGATTTTGACCCTTTGCATTTAAAT CTTCTTTTTGCATATTTTTCAGTGTTAAATTATTAACAAAATCCTCAAAATTTAGAAAATAAGAAGAATT ATCTTTTTTCATTAATCTTAAAATGTTAATAACTGGCTGAACTTCATCTGGGCTAGCTAAAATTTCACGG GCACTTTGACTAAGATCTGCTTTTAAAAACAGCGAAGGAATTTGGTTCTGGATACTTACATATTGATTAG TTGAACTATCTTTTGCAAAGCTAAATTCAAAAATATTACCCAAATTATTAGGTAATTTATTCTCAGGAGC ATTATTTAGTCTGTTTATTAAATTTTTAAGTACTGGAAAATAATTAGCAAGCTTTATATCTAAATCCTCA GGATTTCGCGCTGTATTTAAATCGTATTGGAAGTCAATAGCTCTTAGAGTTGAGGGATCTTTTTGGCTGC TTGTTTTTTCATCAGCAAAATTTGTAATTTTTGTTGATAAATTTTCAATTTGTTGATTTAATTTTTCGGT AATTTTTTTAAGCGAAAAATTAAATTCGGCAACTAAAAGATTTGACTGTTTGGCAAAAGCAACTGTTTGC TCATAAATATCAGATTTGGCAATATCACCATTATGAAGTTTTTGTAATGCCTGAAATTTTACCTTAAAAT TTTGATTGACATCATCAGGGATAATTTCAAGAATCTCAAAAGTTATCTTCGCCTTGGTATATTCAGGATC TTGAAAATTAATTTTTTCTAACTGATCACCGTTTTTAGTAAAAAAGGAAAAGGAATCAATAACTTTTTCT TTATTTCTAATATTGTTATTAGAATCAACTAGTCACCTTTTGACTATTTTATAATCAGAATCAGTCTCAA AAGCATAAGGACTAAAAGCTAATGTTGAAACTTTTGCGGCAAAATCATTTGCAATCTTTCGTGGACTTTC TGATCTGTATTTTGCCAAGCTGCTAAGTCCGACAGTTAGACCAAAAACTCCAAGACCAACAATTCCGGCA GTCAAACCAATTTTAAATGTTTTTGATTTTTTACTCA
Protein Sequence	>YP_115696.1 protein p97; cilium adhesin [Mycoplasma hyopneumoniae 232] MSKKSKTFKIGLTAGIVGLGVFGLTVGLSSLAKYRSESPRKIANDFAAKVSTLAFSPYAFETDSDYKIVK RWLVDSNNNIRNKEKVIDSFSFFTKNGDQLEKINFQDPEYTKAKITFEILEIIPDDVNQNFKVKFQALQK LHNGDIAKSDIYEQTVAFAKQSNLLVAEFNFSLKKITEKLNQQIENLSTKITNFADEKTSSQKDPSTLRA IDFQYDLNTARNPEDLDIKLANYFPVLKNLINRLNNAPENKLPNNLGNIFEFSFAKDSSTNQYVSIQNQI PSLFLKADLSQSAREILASPDEVQPVINILRLMKKDNSSYFLNFEDFVNNLTLKNMQKEDLNAKGQNLSA YEFLADIKSGFFPGDKRSSHTKAEISNLLNKKENIYDFGKYNGKFNDRLNSPNLEYSLDAASASLDKKDK SIVLIPYRLEIKDKFFADDLYPDTKDNILVKEGILKLTGFKKGSKIDLPNINQQIFKTEYLPFFEKGKEE QAKLDYGNILNPYNTQLAKVEVEALFKGNKNQEIYQALDGNYAYEFGAFKSVLNSWTGKIQHPEKADIQR FTRHLEQVKIGSNSVLNQPQTTKEQVISSLKSNNFFKNGHQVASYFQDLLTKDKLTILETLYDLAKKWGL ETNRAQFPKGVFQYTKDIFAEADKLKFLELKKKDPYNQIKEIHQLSFNILARNDVIKSDGFYGVLLLPQS VKTELEGKNEAQIFEALKKYSLIENSAFKTTILDKNLLEGTDFKTFGDFLKAFFLKAAQFNNFAPWAKLD DNLQYSFEAIKKGETTKEGKREEVDKKVKELDNKIKGILPQPPAAKPEAAKPVAAKPETTKPVAAKPEAA KPEAAKPVAAKPEAAKPVAAKPEAAKPVAAKPEAAKPVAAKPEAAKPVATNTGFSLTNKPKEDYFPMAFS YKLEYTDENKLSLKTPEINVFLELVHQSEYEEQEIIKELDKTVLNLQYQFQEVKVTSDQYQKLSHPMMTE GSSNQGKKSEGTPNQGKKAEGAPNQGKKAEGTPNQGKKAEGAPSQQSPTTELTNYLPDLGKKIDEIIKKQ GKNWKTEVELIEDNIAGDAKLLYFILRDDSKSGDPKKSSLKVKITVKQSNNNQEPESK
Molecule Role	Protective antigen
Molecule Role Annotation	a P97 recombinant replication-defective adenovirus (rAdP97c) subunit vaccine efficiency was evaluated in pigs. The rAdP97c vaccine was found to induce both strong P97 specific humoral and cellular immune responses. The rAdP97c vaccinated pigs developed a lower amount of macroscopic lung lesions (18.5 + or - 9.6%) compared to the unvaccinated and challenged animals (45.8 + or - 11.5%). rAdP97c vaccine reduced significantly the severity of inflammatory response and the amount of M. hyopneumoniae in the respiratory tract. The challenge was performed at day 28 after the first vaccination with 106 CCU of the 232 M. hyopneumoniae strain by intratracheal route (Okamba et al., 2010).
Related Vaccines(s)	rAd-P97c
References

P97