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Selected Bacteria

Brucella spp. (16)

B. anthracis (4)

E. coli (17)

M. tuberculosis (11)

N. meningitidis (18)

Selected Viruses

Ebola virus (13)

HIV (5)

Influenza virus (36)

Selected Parasites

Plasmodium spp. (23)

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Protegen: Protective Antigens

     Vaxgen is targeted for collection and analysis of pathogen protective antigens. The data in Vaxgen comes from the manually curated VIOLIN database. Users are encouraged to submit vaccine-related genes through the VIOLIN online submission system.

Protegen Search
Search Field	Search Parameter
Pathogen Genome	Any pathogen Actinobacillus pleuropneumoniae Aeromonas salmonicida Babesia bovis Babesia canis Bacillus anthracis Bordetella avium Bordetella pertussis Bovine herpesvirus 1 bovine leukemia virus Brucella spp. Burkholderia pseudomallei Campylobacter jejuni Cancer Canine coronavirus Canine distemper virus Canine parvovirus Chlamydia muridarum Chlamydophila abortus Chlamydophila pneumoniae Chlamydophila psittaci Classical swine fever virus Clostridium botulinum Clostridium tetani Coccidioides spp. Corynebacterium diphtheriae Coxiella burnetii Dengue Virus Ebola virus Eimeria maxima Eimeria spp. Eimeria tenella Escherichia coli Feline leukemia virus Francisella tularensis Giardia duodenalis Haemophilus influenzae Hantavirus Hepatitis A virus Hepatitis B virus HERPES SIMPLEX VIRUS TYPE 1 AND 2 Human Immunodeficiency Virus Human papillomavirus Infectious Hematopoietic Necrosis Virus Influenza virus Japanese encephalitis virus Lassa Fever Virus Lawsonia intracellularis Leishmania amazonensis Leishmania donovani Leishmania infantum Leishmania major Marburg Virus Marek’s disease virus Measles virus Mumps virus Mycobacterium tuberculosis Mycoplasma gallisepticum Mycoplasma synoviae Neisseria meningitidis Neospora caninum Newcastle disease virus Plasmodium spp. Poliovirus Porcine circovirus 2 Porphyromonas gulae Pseudorabies virus Rabies virus Rickettsia spp Rotavirus Rubella virus Salmonella spp. Sarcocystis neurona SARS-CoV Shigella Streptococcus equi Streptococcus pneumoniae Theileria annulata Theileria parva Tick-borne Encephalitis Virus (TBEV) Toxoplasma gondii Trypanosoma brucei Trypanosoma cruzi Varicella-zoster virus Variola virus VEE Virus Vibrio anguillarum Vibrio cholerae West Nile virus Yellow fever virus Yersinia pestis Yersinia ruckeri
Gene Name	(e.g., sodC)
Locus Tag	(e.g., BAB2_0535)
Database ID	NCBI Gene GI NCBI Nucleotide GI NCBI Protein Accesion No NCBI Protein GI Other Database ID
COG category	Any Amino acid transport and metabolism Carbohydrate transport and metabolism Cell cycle control, cell division, chromosome partitioning Cell motility Cell wall/membrane/envelope biogenesis Chromatin structure and dynamics Coenzyme transport and metabolism Cytoskeleton Defense mechanisms Energy production and conversion Extracellular structures Function unknown General function prediction only Inorganic ion transport and metabolism Intracellular trafficking, secretion, and vesicular transport Lipid transport and metabolism Nuclear structure Nucleotide transport and metabolism Posttranslational modification, protein turnover, chaperones Replication, recombination and repair RNA processing and modification Secondary metabolites biosynthesis, transport and catabolism Signal transduction mechanisms Transcription Translation, ribosomal structure and biogenesis
Subcellular Localization	Any Localization Cellwall Cytoplasmic Cytoplasmic Membrane Extracellular Outer Membrane Periplasmic Unknown
Maximum Number of Transmembrane Helices	(Note: check box to include)
Minimum Adhesin Probability (0-1.0)
No Similarity to Human Proteins
No Similarity to Mouse Proteins
Description	(e.g., superoxide dismutase)

Protegen BLAST search for genes and proteins associated with vaccine:

     Vaccine-related genes and proteins can also be searched based on sequence similarity using BLAST. Please provide your sequence data as input, and this program will output vaccine-related genes and proteins which has sequences similar to your input sequence.

Protegen BLAST for genes and proteins associated with vaccine:

Program blastp blastn blastx tblastn tblastx Database Protective antigen Protein Sequences Protective antigen DNA Sequences

Enter here your input data as Sequence in FASTA format Accession or GI

Or load it from disk

Statistics: Vaxgen includes 585 genes for now.

Provenance: The data in Vaxgen originates from the VIOLIN database.