VIOLIN: Vaccine Investigation and Online Information Network

Neisseria meningitidis

Table of Contents

Protective Antigens
1. ExbB
2. GNA1030
3. GNA1162
4. GNA1220
5. GNA1870
6. GNA1946
7. GNA2001
8. GNA2091
9. GNA2132
10. GNA33
11. GNA992 (hsf)
12. LctP
13. LpdA
14. LPS
15. NadA
16. NspA from N. meningitidis
17. NspA from N. meningitidis MC58
18. P1
19. TBP2
20. TbpA

I. Vaccine Related Protective Antigens

1. ExbB

Gene Name : ExbB
Sequence Strain (Species/Organism) : Neisseria meningitidis MC58
VO ID : VO_0011186
NCBI Gene ID : 903370
NCBI Protein GI : 15677575
Locus Tag : NMB1729
Genbank Accession : AE002098
Protein Accession : NP_274732
Taxonomy ID : 122586
Gene Starting Position : 1812128
Gene Ending Position : 1812790
Gene Strand (Orientation) : -
Protein Name : biopolymer transport protein
Protein pI : 9.81
Protein Weight : 22358.4
Protein Length : 220
Protein Note : identified by similarity to EGAD:145333; match to protein family HMM PF01618

DNA Sequence : Show Sequence

>gi|77358697:1812128-1812790 Neisseria meningitidis MC58, complete genome
ATCAGCTATCCTTTTGATTAAGCAGGCGGACGTGCAAATCGTGCGCCATCGCATCCAAATCCTGGGTCAG
TATTTTTGTGCCGCGATTGAGGAAGTTGTATGCCAACACCGCCGGAATCGCCACGAACAAACCCGCCGCC
GTCGCCACCAGTGCCTCGCCAATCGGGCCGGCAACCGCCGCAATACTCATCTGCCCGCTTTGCCCGATAT
TGATCAGGGCGTGGTAAATCCCCCAAACCGTGCCGAACAGCCCGATAAACGGCGCGGTCGCGCCGATGGA
GGCAAGCGCGGTCATCCCGTAATCAAACCGGCGCATAATCTGCGCCATACTGTTGCGGATTTGAATGACC
AAATACTCGTTCAACGGCAAAGCCTGCGCCAGTTCGGACGCTTCGTTTCGGCGGTAGTTGCGGTAAGACT
GCAATGCCTCTTGCGCCAGTTTGGACAAAGGCGCATCGACGGCGCGCACTTTTTCGACCGCGTCGTTCAG
CGACAAAGTATCGCGCATATGCCGTTTGACGGCGGCATTCCCTTTGCGCGCCCGATACAGCTTGATGCAG
CGCAAGACAACCAAACACCACGTTACGATACTCATCAACAGCATCAACACAAACACACCAATCAGGACGG
GATCGCCCGATTCAAACACTAATTTCAAATTCA

Protein Sequence : Show Sequence

>gi|15677575|ref|NP_274732.1| biopolymer transport protein [Neisseria meningitidis MC58]
MNLKLVFESGDPVLIGVFVLMLLMSIVTWCLVVLRCIKLYRARKGNAAVKRHMRDTLSLNDAVEKVRAVD
APLSKLAQEALQSYRNYRRNEASELAQALPLNEYLVIQIRNSMAQIMRRFDYGMTALASIGATAPFIGLF
GTVWGIYHALINIGQSGQMSIAAVAGPIGEALVATAAGLFVAIPAVLAYNFLNRGTKILTQDLDAMAHDL
HVRLLNQKDS

Molecule Role : Protective antigen
Molecule Role Annotation : A total of 11 meningococcal proteins that are necessary for establishing systemic infection were expressed as recombinant antigens and assessed for their ability to protect mice against live bacterial challenge against N. meningitidis; ExbB, which is required for iron acquisition, elicited protective immunity (Sun et al., 2005).
COG: COG0811U, under U: Intracellular trafficking, secretion, and vesicular transport
Related Vaccine(s): N. meningitidis ExbB Protein Vaccine

2. GNA1030

Gene Name : GNA1030
Sequence Strain (Species/Organism) : Neisseria meningitidis MC58
VO ID : VO_0010983
NCBI Gene ID : 903167
NCBI Protein GI : 15676917
Locus Tag : NMB1030
Genbank Accession : NC_003112
Protein Accession : NP_274064
Taxonomy ID : 122586
Gene Starting Position : 1045039
Gene Ending Position : 1045602
Gene Strand (Orientation) : -
Protein Name : hypothetical protein
Protein pI : 8.65
Protein Weight : 19439.53
Protein Length : 187
Protein Note : identified by similarity to EGAD:89838; match to protein family HMM PF04264

DNA Sequence : Show Sequence

>gi|903167|gb|U25577.1|HIV1U25577 Human immunodeficiency virus type 1 isolate E10587A3 envelope glycoprotein (env) gene, partial cds
GAAAATCTCACAAATAATGCCAAAACCATAATAGTACACCTTAATAGATCTGTAGAAATCAATTGTACCA
GACCCTTCAAAATTATAAGAACAAGTACACGTATAGGACCAGGACGAGTATTCCATAAAACAGGAAGCAT
ACTAGGAGATATAAGAAAAGCATATTGTGAGATTAATGGAACAAATTGGAATAAAGTTTTAAGGCAGGTA
ACTAAAAAATTAAAAGAGCACTTTAAGAATAAGACAATAACCTTTCAACCACCCTCAGGAGGAGATCTAG
AAATTACAATGCATCATTTTAATTGT

Protein Sequence : Show Sequence

>gi|15676917|ref|NP_274064.1| hypothetical protein NMB1030 [Neisseria meningitidis MC58]
MKKIIFAALAAAAISTASAATYKVDEYHANARFAIDHFNTSTNVGGFYGLTGSVEFDQAKRDGKIDITIP
IANLQSGSQHFTDHLKSADIFDAAQYPDIRFVSTKFNFNGKKLVSVDGNLTMHGKTAPVKLKAEKFNCYQ
SPMEKTEVCGGDFSTTIDRTKWGMDYLVNVGMTKSVRIDIQIEAAKQ

Molecule Role : Protective antigen
Molecule Role Annotation : Protective antigen as shown in some assays (Giuliani et al., 2006)
COG: COG2353S, under S: Function unknown

3. GNA1162

Gene Name : GNA1162
Sequence Strain (Species/Organism) : Neisseria meningitidis MC58
VO ID : VO_0010976
NCBI Gene ID : 903582
NCBI Protein GI : 15677037
Locus Tag : NMB1162
Genbank Accession : AE002098
Protein Accession : NP_274189
Taxonomy ID : 122586
Gene Starting Position : 1167697
Gene Ending Position : 1168344
Gene Strand (Orientation) : -
Protein Name : hypothetical protein
Protein pI : 6.26
Protein Weight : 20946.7
Protein Length : 215

DNA Sequence : Show Sequence

>gi|77358697:1167697-1168344 Neisseria meningitidis MC58, complete genome
CTTATTTGGGCTGCTCTTCAACGAATCTCGGACCTTTCAAGATGCCGTTGTGAGAATAGGGCGACAGCAG
GTTGTATGCGGCGGTTTTGGAAACCTGATAACCGCGGTCGGTCAGGCTGTTGGCAATCTGATTGACCACT
GCGCTGACCAAAGCCCCCAACAGGCCGCTGTTGCTGTTGTTGCTGCCTTCGCGGATGCTGGCCGAACCCG
ACCACAACTCTTTTCCGTTGCGGGAATCGACCAGCCGTGCTTTGGCGGATACGGTCGTCACGCTGTCTAA
AATTTGATATGAAGTGCCGTATTCGGTAACCGTAATGTACAAAACCGCATCATTGCCGAAAATCTGATGC
AGTTTTTCCGGCCGGACGGCGTGAATATCGGCGGCATTGGTCAAGCCGTTTTGTTTGAAGGTTTCCTCCA
CGACTGCGGCGGGGAAGACGTAATAGCCGGCTTCGGAAAGCGGCGCGGCGGTCGAAGCCAGTACACCCCA
TGTTCCGTTGACATCGGGCGATTCGTTCAGCGGCGGAACCACCAAAATTGAAGCCGGTTTGCTTTCCTTG
AATGACGTGTAGTCGAAATCGGGCGCTTTTTGAACTTGGCAGGCAGACAGCGCCAACACGGCGGCAAGCC
CTAAAATCAAAGGTTTCA

Protein Sequence : Show Sequence

>gi|15677037|ref|NP_274189.1| hypothetical protein NMB1162 [Neisseria meningitidis MC58]
MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYY
VFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSR
NGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSHNGILKGPRFV
EEQPK

Molecule Role : Protective antigen
Molecule Role Annotation : Protective antigen(Pizza et al., 2000)
COG: COG4380S, under S: Function unknown

4. GNA1220

Gene Name : GNA1220
Sequence Strain (Species/Organism) : Neisseria meningitidis MC58
VO ID : VO_0010975
NCBI Gene ID : 903642
NCBI Protein GI : 15677093
Locus Tag : NMB1220
Genbank Accession : NC_003112
Protein Accession : NP_274245
Taxonomy ID : 122586
Gene Starting Position : 1224371
Gene Ending Position : 1225318
Gene Strand (Orientation) : -
Protein Name : stomatin/Mec-2 family protein
Protein pI : 5.52
Protein Weight : 32124.16
Protein Length : 315
Protein Note : identified by similarity to GP:2984585; match to protein family HMM PF01145

DNA Sequence : Show Sequence

>gi|903642|gb|U29414.1|HIV1U29414 Human immunodeficiency virus type 1 gag gene, clone 4-7, partial cds
ATGGGTGCGAGAGCGTCAGTATTAAGCGGGGGAGAATTAGATAGATGGGAAAAAATTCGGTTAAGGCCAG
AGGGAAAAAAAAGATATAAATTAAAACATATAGTATGGGCAAGCAGGGAGCTAGAACGATTCGCAGTTAA
CCCTGGCCTGTTAAAAACATCAGAAGGCTGTAGACAGATACTGGTACAGCTACAACCATCCCTTCAGACA
GGATCAGAAGAACTTAGATCATTATATAATACAGTAGCAACCCTCTATTGTGTGCATCAAAGAATAGAGG
TAAAAGACACCAAGGAAGCTTTAGAGAAGATAGAGGAAGAGCAAAACAAAAGTAAGAAAAAAGCACAGCA
AGCAGCAGCTGGCACAGGAAACAGCAGCCAGGTCAGCCAAAATTACCCTATAGTGCAGAACATCCAGGGG
CAAATGGTACATCAGCCCCTATCACCTAGAACTTTAAATGCATGGGTAAAAGTAGTAGGAGAGAAGGCTT
TCAGCCCAGAAGTAATACCCATGTTTTCAGCACTATCAGAAGGAGCCACCCCACAAGATTTAAACACCAT
GTTAAACACAGTGGGGGGACATCAAGCAGCCATGCAAATGTTAAAAGAGACCATCAATGAGGAAGCTGCA
GATTGGGATAGATTGCATCCAGTGCATGCAGGGCCTGTTGCACCAGGCCAGATGAGAGAACCAAGGGGAA
GTGACATAGCAGGAACTACTAGTACCCTTCAGGAACAAATAGGATGGATGACAAATAATCCACCTATCCC
AGTAGGAGAAATCTATAAAAGATGGATAATCCTGGGATTAAATAAAATAGTAAGGATGTATAGTCCTGCC
AGCATTTTGGACATAAGACAAGGACCAAAGGAACCCTTTAGAGACTATGTAGACCGGTTCTATAAAACTC
TAAGAGCCGAGCAAGCTTCACAGGAGGTAAAAAATAGGATGACAGAAACCTTGTTGGTCCAAAATGCAAA
CCCAGATTGTAAGACTATTTTAAAAGCATTAGGACCGGGAGCTACACTAGAAGAAATGATGACAGCATGT
CAGGGAGTAGGAGGACCCGGCCATAAAGCAAGAGTCTTGGCTGAAGCAATGAGCCAAGTAACAAATTCAG
CTACCATAATGATGCAGAGAGGCAATTTTAGGAACCAAAGAAAGATTGTTAAGTGTTTCAATTGTGGCAA
AGAGGGGCACATAGCCAGAAACTGCAGGGCCCCTAGGAAAAAGGGCTGTTGGAAATGTGGAAAGGAAGGA
CACCAAATGAAAGATTGTACTGAGAGACAGGCTAATTTTTTAGGGAAGATCTGGCCTTCCCACAAGGGGA
GGCCAGGGAATTTTCTTCAGAGCAGACCAGAGCCATCAGCCCCACCAGAAGAGAGCTTCAGGTTTGGGGA
AGAGGCAACAACTTCCCCTCAGAAGCAGGAGCTGATAGACAAGGAGCTATATCCTTTAACCTCCCTCAGA
TCACTCTTTGGCAACGACCCCTTGTCACAG

Protein Sequence : Show Sequence

>gi|15677093|ref|NP_274245.1| stomatin/Mec-2 family protein [Neisseria meningitidis MC58]
MEFFIILLVAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQ
VCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVA
ALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAEIQQS
EGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNN
LAKESNTLIMPANVADIGSLISAGMKIIDSSKTAK

Molecule Role : Protective antigen
Molecule Role Annotation : Protective antigen (Pizza et al., 2000)
COG: COG0330O, under O: Posttranslational modification, protein turnover, chaperones

5. GNA1870

Gene Name : GNA1870
Sequence Strain (Species/Organism) : Neisseria meningitidis MC58
VO ID : VO_0010981
NCBI Gene ID : 904318
NCBI Protein GI : 15677705
Locus Tag : NMB1870
Genbank Accession : AE002098
Protein Accession : NP_274866
3D structure: PDB ID : 1YS5
Taxonomy ID : 122586
Gene Starting Position : 1975217
Gene Ending Position : 1976179
Gene Strand (Orientation) : +
Protein Name : hypothetical protein
Protein pI : 9.11
Protein Weight : 32796.64
Protein Length : 320
Protein Note : also named factor H-binding protein (fHbp) or rLP-2086 (Pizza et al., 2008).

DNA Sequence : Show Sequence

>gi|77358697:1975217-1976179 Neisseria meningitidis MC58, complete genome
AATGCCGTCTGAACCGCCGTTCGGACGACATTTGATTTTTGCTTCTTTGACCTGCCTCATTGATGCGGTA
TGCAAAAAAAGATACCATAACCAAAATGTTTATATATTATCTATTCTGCGTATGACTAGGAGTAAACCTG
TGAATCGAACTGCCTTCTGCTGCCTTTCTCTGACCACTGCCCTGATTCTGACCGCCTGCAGCAGCGGAGG
GGGTGGTGTCGCCGCCGACATCGGTGCGGGGCTTGCCGATGCACTAACCGCACCGCTCGACCATAAAGAC
AAAGGTTTGCAGTCTTTGACGCTGGATCAGTCCGTCAGGAAAAACGAGAAACTGAAGCTGGCGGCACAAG
GTGCGGAAAAAACTTATGGAAACGGTGACAGCCTCAATACGGGCAAATTGAAGAACGACAAGGTCAGCCG
TTTCGACTTTATCCGCCAAATCGAAGTGGACGGGCAGCTCATTACCTTGGAGAGTGGAGAGTTCCAAGTA
TACAAACAAAGCCATTCCGCCTTAACCGCCTTTCAGACCGAGCAAATACAAGATTCGGAGCATTCCGGGA
AGATGGTTGCGAAACGCCAGTTCAGAATCGGCGACATAGCGGGCGAACATACATCTTTTGACAAGCTTCC
CGAAGGCGGCAGGGCGACATATCGCGGGACGGCGTTCGGTTCAGACGATGCCGGCGGAAAACTGACCTAC
ACCATAGATTTCGCCGCCAAGCAGGGAAACGGCAAAATCGAACATTTGAAATCGCCAGAACTCAATGTCG
ACCTGGCCGCCGCCGATATCAAGCCGGATGGAAAACGCCATGCCGTCATCAGCGGTTCCGTCCTTTACAA
CCAAGCCGAGAAAGGCAGTTACTCCCTCGGTATCTTTGGCGGAAAAGCCCAGGAAGTTGCCGGCAGCGCG
GAAGTGAAAACCGTAAACGGCATACGCCATATCGGCCTTGCCGCCAAGCAATA

Protein Sequence : Show Sequence

>gi|15677705|ref|NP_274866.1| hypothetical protein NMB1870 [Neisseria meningitidis MC58]
MPSEPPFGRHLIFASLTCLIDAVCKKRYHNQNVYILSILRMTRSKPVNRTAFCCLSLTTALILTACSSGG
GGVAADIGAGLADALTAPLDHKDKGLQSLTLDQSVRKNEKLKLAAQGAEKTYGNGDSLNTGKLKNDKVSR
FDFIRQIEVDGQLITLESGEFQVYKQSHSALTAFQTEQIQDSEHSGKMVAKRQFRIGDIAGEHTSFDKLP
EGGRATYRGTAFGSDDAGGKLTYTIDFAAKQGNGKIEHLKSPELNVDLAAADIKPDGKRHAVISGSVLYN
QAEKGSYSLGIFGGKAQEVAGSAEVKTVNGIRHIGLAAKQ

Molecule Role : Protective antigen
Molecule Role Annotation : Protective antigen (Giuliani et al., 2006)

6. GNA1946

Gene Name : GNA1946
Sequence Strain (Species/Organism) : Neisseria meningitidis MC58
VO ID : VO_0010974
NCBI Gene ID : 904205
NCBI Protein GI : 15677776
Locus Tag : NMB1946
Genbank Accession : AE002098
Protein Accession : NP_274940
3D structure: PDB ID : 3GXA
Taxonomy ID : 122586
Gene Starting Position : 2041081
Gene Ending Position : 2041944
Gene Strand (Orientation) : -
Protein Name : outer membrane lipoprotein
Protein pI : 4.96
Protein Weight : 29236.71
Protein Length : 287
Protein Note : identified by similarity to EGAD:30554; match to protein family HMM PF03180

DNA Sequence : Show Sequence

>gi|77358697:2041081-2041944 Neisseria meningitidis MC58, complete genome
CTTATTTGGCTGCGCCTTCATTCCATGCGGCAGGGGATTTGTAGCCCTCGAAGCGTTTGTGCGCGTAGGC
TTTGAACGCGTCGGAGTTATAGGCCTCGGTTACGTCTTTAAGCCATTGGCTGTCTTTGTCGGCGGTTTTG
ACGGCAGACCAGTTGACATAGGCAAAGCTCGGTTCTTGGAACAGGGCTTCGGTCAGCTTCATGCCGCTGC
TTATGGCGTAGTTGCCGTTGACGACGGCAAAATCCACGTCGGCGCGGCTACGCGGCAGTTGCGCGGCTTC
AAGCTCGACGATTTTGATGTTTTTCAGGTTCTCGGCGATGTCCGCTTTGGATGCGGTCAACGGATTGATG
CCGTCTTTGAGTTTGATCCAACCCAGTTCGTCGAGCATCACCAAGACGCGGGCGAAGTTGGACGGGTCGT
TGGGCGCGGATACGGTGCTGCCGTCTTTGACTTCTTCCAGCGATTTCAGCTTGCCCGGGTACAGTCCCAA
AGGCGCGGTCGGCACTTGGAAGACTTCGGTGATGTCCAGATTGTGTTCTTTTTTGAAGTCGTCAAGATAG
GGTTTGTGTTGGAAGACGTTGATGTCCAACTCGCCCTCAGCCAATGCCAGATTCGGGCGTACATAGTCGG
TAAACTCGACCAGTTTGACGGTGTAGCCTTTTTTCTCCAGCTCGGCTTGGATTTGTTCTTTGACCATATC
GCCGAAGTCGCCGACGGTCGTGCCGAAGACGATTTCTTTTTTCGCCGCGCCGTTGTCGGCGGCGGCAGAA
GCGGATGCGGCGGGCGCGCTGTCTTTTTGACCGCCGCAGGCGGCGAGGATGAGCGCGAGTGCGGCGGCGG
AAAGGGTTTTGAAGAAGGTTTTCA

Protein Sequence : Show Sequence

>gi|15677776|ref|NP_274940.1| outer membrane lipoprotein [Neisseria meningitidis MC58]
MKTFFKTLSAAALALILAACGGQKDSAPAASASAAADNGAAKKEIVFGTTVGDFGDMVKEQIQAELEKKG
YTVKLVEFTDYVRPNLALAEGELDINVFQHKPYLDDFKKEHNLDITEVFQVPTAPLGLYPGKLKSLEEVK
DGSTVSAPNDPSNFARVLVMLDELGWIKLKDGINPLTASKADIAENLKNIKIVELEAAQLPRSRADVDFA
VVNGNYAISSGMKLTEALFQEPSFAYVNWSAVKTADKDSQWLKDVTEAYNSDAFKAYAHKRFEGYKSPAA
WNEGAAK

Molecule Role : Protective antigen
Molecule Role Annotation : Protective antigen (Pizza et al., 2000)
COG: COG1464P, under P: Inorganic ion transport and metabolism

7. GNA2001

Gene Name : GNA2001
Sequence Strain (Species/Organism) : Neisseria meningitidis MC58
VO ID : VO_0010947
NCBI Gene ID : 904124
NCBI Protein GI : 15677829
Locus Tag : NMB2001
Genbank Accession : NC_003112
Protein Accession : NP_274993
Taxonomy ID : 122586
Gene Starting Position : 2114380
Gene Ending Position : 2115135
Gene Strand (Orientation) : +
Protein Name : hypothetical protein
Protein pI : 10.78
Protein Weight : 26229.95
Protein Length : 251
Protein Note : identified by similarity to EGAD:91561; match to protein family HMM PF00877

DNA Sequence : Show Sequence

>gi|904124|gb|L37919.1|LRZRBCL Lardizabala biternata ribulose-1,5-bisphosphate carboxylase large subunit gene, 3' end of cds
NTGTCACCACAAACAGAGACTAAAGCAAGTGTTGGATTCAAAGCTGGTGTTAAAGATTACAAATTGACTT
ATTATACTCCTGACTATATCACCAAAGATACTGATATCTTGGCAGCATTCCGAGTAACTCCTCAACCTGG
AGTTCCACCTGAAGAAGCAGGGGCCGCGGTAGCTGCCGAATCTTCTACAGGTACATGGACAACTGTGTGG
ACCGATGGACTTACCAGCCTTGATCGTTACAAAGGACGATGCTACGATATCGAGCCTGTTGCTGGAGAGG
AGAACCAATATATTTGTTATGTAGCTTACCCTTTAGACCTTTTTGAAGAAGGTTCGGTTACTAACATGTT
TACTTCCATTGTGGGTAATGTATTTGGGTTCAAAGCGCTACGCGCTCTACGTCTGGAAGATCTGCGAATC
CCTCCTGCTTATGTTAAAACTTTCCAAGGCCCGCCTCATGGCATCCAAGTTGAGAGAGATAAATTGAACA
AGTATGGTCGTCCCCTATTGGGCTGTACTATTAAACCAAAATTGGGATTATCTGCTAAGAACTACGGTAG
AGCGGTTTATGAATGTCTCCGTGGTGGACTGGATTTTACCAAGGATGATGAAAACGTGAACTCCCAGCCA
TTTATGCGTTGGAGAGACCGTTTCCTATTTTGTGCCGAAGCAATTTATAAAGCACAGGCCGAAACAGGTG
AAATCAAAGGACATTACTTGAATGCTACTGCAGGTACATGCGAAGAAATGATCAAAAGAGCTGTATTTGC
CAGAGAATTGGGAGTTCCTATCGTAATGCATGACTACTTAACGGGGGGATTCACTGCAAATACTAGCTTG
GCTCATTATTGCCGAGATAATGGTCTACTTCTTCACATCCACCGTGCAATGCATGCAGTTATTGATAGAC
AGAAGAATCATGGTATCCATTTCCGTGTACTAGCTAAAGCGTTACGTATGTCTGGGGGAGATCATATTCA
CTCTGGTACCGTAGTAGGTAAACTGGAAGGGGAAAGAGAAATCACCTTGGGCTTTGTTGATTTACTACGT
GATGATTTTATTGAAAAAGACCGAAGTCGCGGTATTTATTTCCTGCAAGATTGGGTCTCTCTACCAGGTG
TTTTGCCCGTGGCTTCAGGGGGTATTCACGTTTGGCATATGCCTGCTCTGACCGAGATCTTTGGGGATGA
CTCCGTACTACAGTTCGGTGGAGGAACTTTAGGACACCCTTGGGGAAATGCACCGGGTGCCGTAGCTAAT
CGAGTAGCCCTAGAAGCGTGTGTACAAGCTCGTAATGAGGGACGTGATCTTGCTCGTGAAGGTAATGAAA
TTATCCGTGAGGCTAGCAAATGGAGCCCTGAACTAGCTGCTGCTTGTGAAGTATGGAAGGAGATCAAATT
CGAATTTGAAGCAATGGATACTTTGTAA

Protein Sequence : Show Sequence

>gi|15677829|ref|NP_274993.1| hypothetical protein NMB2001 [Neisseria meningitidis MC58]
MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAM
GLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGT
SVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNR
FIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFLN

Molecule Role : Protective antigen
Molecule Role Annotation : Protective antigen (Pizza et al., 2000)
COG: COG0791M, under M: Cell wall/membrane/envelope biogenesis

8. GNA2091

Gene Name : GNA2091
Sequence Strain (Species/Organism) : Neisseria meningitidis MC58
VO ID : VO_0010982
NCBI Gene ID : 903958
NCBI Protein GI : 15677911
Locus Tag : NMB2091
Genbank Accession : AE002098
Protein Accession : NP_275079
Taxonomy ID : 122586
Gene Starting Position : 2211862
Gene Ending Position : 2212470
Gene Strand (Orientation) : +
Protein Name : putative hemolysin
Protein pI : 10.22
Protein Weight : 19563.68
Protein Length : 202
Protein Note : identified by similarity to EGAD:28637; match to protein family HMM PF04972

DNA Sequence : Show Sequence

>gi|77358697:2211862-2212470 Neisseria meningitidis MC58, complete genome
GATGAAACCCAAACCGCACACCGTCCGCACCCTGATTGCCGCCATTTTCAGCCTTGCCCTTAGCGGCTGC
GTCAGCGCAGTAATCGGAAGCGCCGCCGTCGGCGCGAAATCCGCCGTCGACCGCCGAACCACCGGCGCGC
AAACCGACGACAACGTTATGGCGTTGCGTATCGAAACCACCGCCCGTTCCTATCTGCGCCAAAACAACCA
AACCAAAGGCTACACGCCCCAAATCTCCGTCGTCGGCTACAACCGCCACCTGCTGCTGCTCGGACAAGTC
GCCACCGAAGGCGAAAAACAGTTCGTCGGTCAGATTGCACGTTCCGAACAGGCCGCCGAAGGCGTGTACA
ACTATATTACCGTCGCCTCCCTGCCGCGCACTGCCGGCGACATCGCCGGCGACACTTGGAACACATCCAA
AGTCCGCGCCACGCTGTTGGGCATCAGCCCCGCCACACAGGCGCGCGTCAAAATCGTTACCTACGGCAAC
GTAACCTACGTTATGGGCATCCTCACCCCCGAAGAACAGGCGCAGATTACCCAAAAAGTCAGCACCACCG
TCGGCGTACAAAAAGTCATCACCCTCTACCAAAACTACGTCCAACGCTG

Protein Sequence : Show Sequence

>gi|15677911|ref|NP_275079.1| putative hemolysin [Neisseria meningitidis MC58]
MKPKPHTVRTLIAAIFSLALSGCVSAVIGSAAVGAKSAVDRRTTGAQTDDNVMALRIETTARSYLRQNNQ
TKGYTPQISVVGYNRHLLLLGQVATEGEKQFVGQIARSEQAAEGVYNYITVASLPRTAGDIAGDTWNTSK
VRATLLGISPATQARVKIVTYGNVTYVMGILTPEEQAQITQKVSTTVGVQKVITLYQNYVQR

Molecule Role : Protective antigen
Molecule Role Annotation : Protective antigen as shown in some assays (Giuliani et al., 2006)
COG: COG2823R, under R: General function prediction only

9. GNA2132

Gene Name : GNA2132
Sequence Strain (Species/Organism) : Neisseria meningitidis MC58
VO ID : VO_0010946
NCBI Gene ID : 903357
NCBI Protein GI : 15677945
Locus Tag : NMB2132
Genbank Accession : AE002098
Protein Accession : NP_275117
Taxonomy ID : 122586
Gene Starting Position : 2238475
Gene Ending Position : 2239941
Gene Strand (Orientation) : -
Protein Name : transferrin-binding protein-related protein
Protein pI : 4.57
Protein Weight : 48171.55
Protein Length : 488
Protein Note : identified by similarity to EGAD:39989; match to protein family HMM PF01298

DNA Sequence : Show Sequence

>gi|77358697:2238475-2239941 Neisseria meningitidis MC58, complete genome
ATCAATCCTGCTCTTTTTTGCCGGCAAACACGCCGAATCCGCCCTTTTCCGCATCTGTCGGGCGATAGCT
GTATTTTCCCGCCACTTCCTCGCCGGCCGGGCCGTAAAACTTTCCGGAAACATCCCCGCTGCCATTTTCC
GTCCAAGTCCCCTTAAAGCCGTTTCCATCGATGGCGGCTTTGAATTTTTGCGTACCCATATGCAAATCAT
CGCCGCTGTCGATAATGCCGTCCACAGATTTGCTGCCGAAATCGACTTTTGCGGCAAACCTGCCCCTGGT
CGGGTACGGACGGCCGTTTTCCGTATGGAAATGCAGTACTTCGCCGTTGTACACGGCCGCGCCCGCAAGC
ATTTCGCCTTTTGCCGGTTCGCCTTGAACACGAAGGGCATACGATCCGCCGGGCAATTTTTCCGCCCCGT
AAGTCAGATACCGGTAATTCCCTTCGGGCGCGAAGATATTGCCGGAATGCCCCGTCAGGCTGACCGCTTC
CCCATCGACAATCAGCGTATCCGCCTGATTGACGGGAATCAGCGGCATCTCGGCCGGAAGCGACCGCCTC
GACCGTGCAGAACGCCTAAATCGCGCAAATGAAGTGGGTTTAGGTTTATAAAAGATAATATATTGATTGA
TTCCCTTCATCTGCACACTATCGGCAACCAAACCGACAAATTTATCATTCTTCCCATCTTTCTTGTAATT
ACTTATTTTGTCTGCATCACTTAATTTTTCAAATTCTGATTTTAGCTGTACTTCTTCATCCAAGAAATTA
TTGCCACTACAAGAATCGCCTTTACAGTGGGTCAACGTTATATTTTGCGACGGCCCGTCAATCAAAACGC
CATTAGCCAAATCAACCCTTCCAAAATTGCTACCGCCATTCGCAGGTGCAGGGTTTGACGCGGGGATGGG
ATCTGAAGAACCGGCGGCTTGATTGTTTCCGGCTTGATTTGCACCTTGGGCAGCCGTATTGCCGGCATTT
TGCCCGCCTGCCGACGGATCGTCCCCCTGCATTCCGTCCGCCGCATTTGCCATATCCGGTTGGTTTGCCG
GCTGAGACGATTCCCCGGCATCCGTTGCTTGATTTTCCATATTTCCGGCAAGCATATTCGGATCCGGGGT
GTGATTCGGTGTCGAACTATCTGTACCGGCGGCATTTTGCGGCATATCATTTTGTGCCACCTCGTCTTCA
TTTTTGGGATTATCCGCTGTTACCGCACCGCCATTGCCTGTATTTTCTTCCGAAACCGCCGCCATATCTT
GACTGCCTTGTGCGGATGGCGCGCCCTGTCCTTGAGAACCTGCCTGTGGCGCATCTTCCTTTGCCTCTGT
CTCTTTTTCAGAAACAACAGGGGCGGCAGGTTTTGACAGCGTGTCCGCCGACTTGACATCGGGCGATCCG
CCACCGCCGCCCCCGCAGGCTGAAAGGGCAAAAATACAAGCCATTGCGATTACGCTGCGTTTAAACA

Protein Sequence : Show Sequence

>gi|15677945|ref|NP_275117.1| transferrin-binding protein-related protein [Neisseria meningitidis MC58]
MFKRSVIAMACIFALSACGGGGGGSPDVKSADTLSKPAAPVVSEKETEAKEDAPQAGSQGQGAPSAQGSQ
DMAAVSEENTGNGGAVTADNPKNEDEVAQNDMPQNAAGTDSSTPNHTPDPNMLAGNMENQATDAGESSQP
ANQPDMANAADGMQGDDPSAGGQNAGNTAAQGANQAGNNQAAGSSDPIPASNPAPANGGSNFGRVDLANG
VLIDGPSQNITLTHCKGDSCSGNNFLDEEVQLKSEFEKLSDADKISNYKKDGKNDKFVGLVADSVQMKGI
NQYIIFYKPKPTSFARFRRSARSRRSLPAEMPLIPVNQADTLIVDGEAVSLTGHSGNIFAPEGNYRYLTY
GAEKLPGGSYALRVQGEPAKGEMLAGAAVYNGEVLHFHTENGRPYPTRGRFAAKVDFGSKSVDGIIDSGD
DLHMGTQKFKAAIDGNGFKGTWTENGSGDVSGKFYGPAGEEVAGKYSYRPTDAEKGGFGVFAGKKEQD

Molecule Role : Protective antigen
Molecule Role Annotation : Protective antigen (Pizza et al., 2000).

10. GNA33

Gene Name : GNA33
Sequence Strain (Species/Organism) : Neisseria meningitidis MC58
VO ID : VO_0010978
NCBI Gene ID : 902136
NCBI Protein GI : 15675973
Locus Tag : NMB0033
Genbank Accession : NC_003112
Protein Accession : NP_273099
Taxonomy ID : 122586
Gene Starting Position : 30910
Gene Ending Position : 32235
Gene Strand (Orientation) : -
Protein Name : putative membrane-bound lytic murein transglycosylase A
Protein pI : 10.02
Protein Weight : 45724.72
Protein Length : 441
Protein Note : identified by similarity to GP:974447; match to protein family HMM PF03562; match to protein family HMM PF06725

DNA Sequence : Show Sequence

>gi|902136|gb|H30980.1|H30980 SW3ICA229SK Brugia malayi infective larva cDNA (SAW94WL-BmL3) Brugia malayi cDNA clone SW3ICA229 5' similar to Filarial Ag Av 33 and Oncho immunodominant Ag, mRNA sequence
GTTNGAGATCGTGATTATATAATCCAGCAACAAGTCTGACTTCAAAGATAACTATGAAGACTCTTTTTTG
TTTGTTATTATTCGCGATAGCAGTGCTGGAAGCAGGTATAGTGAAAAGGTATAACAAACGCTTCGCTGGA
TTCAACGTTGCAGGAATTGGTGGAACAGCCGGATGTGTGGTCGTTGACAACAAACTGTTTGGGAATGGTT
TACCTCTTCGAGAATTGGCCGCCGAAGGACAAAAAGGAATTATCACGATATGTCCAAGAGTCAAATNAAT
ACAAAGGGGGTTTGGTGACGTCA

Protein Sequence : Show Sequence

>gi|15675973|ref|NP_273099.1| putative membrane-bound lytic murein transglycosylase A [Neisseria meningitidis MC58]
MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLP
HWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGY
YEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSRFPI
TARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYA
DKNEHPYVSIGRYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALG
TPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGK
QKTTGYVWQLLPNGMKPEYRP

Molecule Role : Protective antigen
Molecule Role Annotation : Protective antigen (Pizza et al., 2000)
COG: COG2821M, under M: Cell wall/membrane/envelope biogenesis

11. GNA992 (hsf)

Gene Name : GNA992 (hsf)
Sequence Strain (Species/Organism) : Neisseria meningitidis MC58
VO ID : VO_0010977
NCBI Gene ID : 903112
NCBI Protein GI : 15676883
Locus Tag : NMB0992
Genbank Accession : AE002098
Protein Accession : NP_274028
Taxonomy ID : 122586
Gene Starting Position : 1005588
Gene Ending Position : 1007363
Gene Strand (Orientation) : -
Protein Name : adhesin
Protein pI : 5.98
Protein Weight : 56655.27
Protein Length : 591
Protein Note : identified by similarity to EGAD:131908; match to protein family HMM PF03895; match to protein family HMM PF05662
Protein Annotation : hsf or called GNA992

DNA Sequence : Show Sequence

>gi|77358697:1005588-1007363 Neisseria meningitidis MC58, complete genome
CTTACCACTGATAACCGACAGATGCGGAAGCACCGAAATGGCCGCGCGAATTGCCGGAAGCCGTGCCTTT
GATAATCCAATTTCCGCCGTCGGAAATACTGGAGTAGCCGATGGCGTAACCGGCTTCGCCGCGATAAGTG
CCGCCGCCGATCGCCATCATACTCTTGCCGGGCAAATACGCCTGAACCAGACCTGCGGTTGCAATCGCTT
GGGCGATGCCCGCACGCGCGTTGCCGTCCACATTGTCGATGCGGTTGTTCAAGTTTTGCGCCACGCCTTT
AAGTTGTGCGACGTTTGTAACATCCCCCTCTTTAACGCCCGGGGCGACATTGGTAATGCGGACGGGTTTG
TTGTCCTTCTTGCTGCCGACATTCAATGCGTCCCCATCCACGCTCAAAGTGGGCGCATCCGCCCCCGCGC
CGAGCGAAACGCTGGAAAACTGCGGGGTCATCGAAGTGGCGATGTCGATATTTTTACCGTTGCGGGTAAT
CTCGATGTTGTTGCCGGCATTAATGTTGACGGTTTCATCCATCTTTCCCTTGCTCGGCGAAACATTGCCG
CTGATGACTTTGCCCGAAGAACCTGCAACCGCTTTGGAATCCAAATTCCAACCGCTGTTTTGCAGCTGAT
TGACGTTTAGGGCATCGCCGACATTTACATCATACATAACAGTGATGTTGCCTTGATCATCTTTACTTAC
AGTCGCAGTTGTACCTTTACCACTAGCAAAGGTTACATTTGTGCCTGATGTAACGGTTTCAAACTTGTCA
GCTTGACCTGTTTGACCATTAGCGGTTGTTGTTTTCATTCTCCAACCAGCCTTGTTTACTGCATCAATCA
CTTCTTTTGCAGTCACTAAGCCTTCGCCTTCGTCTGTAGAAGAACCATTCTCGCCTTTGTCTTTACCAGT
AACCAACTTACCGTCTTTTTCTTTAATAACAGAAGTCTTCGCACCGATTTTAACTTCGGTTTTCTTGCCG
TTGTCTTTGCTTTCCACATTAACAGTCGTTGTTTTCGTATCTGCGCTCAAGAACTCGACTGTGTCGTAAG
TGCGGACGAAATCAACGTTATCGGAAGCTGTTGTACCGGGTTTAACGCCTTTAATGTTCCAGCCAGCGTT
TAATACGTCTTTAACGCTTGCCGCACGTTTTTTCTCGTCATCGGTAACGTTGTCGTTGGTTACGTTTGTG
GTCGCTCCGGTATTCAGCAGCGTATCGGTCAAAGTCGAACCAATACCGTTCAGATGAACCGTGGTGTCGC
CGTTCGTCCCAGCCGTTTCTTTCGCAAAATTCAAGCCTTTGGTGTCGCTTGTGATGTTGACTTTATTGCC
GTTTGCGCTAAACGATAATTTTTCAGTTCCAACACTGGTCAGATCTGTGAGGTCTTTTTTCAGCGAGTAG
GTGAAGTTTGTGCCGTTTTGTTTGATTTTCAGGTTGTCGCCGGCTTTGAGGGTGATTTCTCTGGCTGTTA
GTACTCCTTTCTCGTTGAAATATACTGCCCAATCTGAATTTTCTTCTACTTTTTCTTTTTCTCCCGTGCC
TTCTTTATCGGAATTGACTATCAACACGGCAACAGTGCGTTGTACGGGGTCTAAATATAAATCTTCTTCT
TGCTCTTCATTGTTAGCACTTGCCTGAACCGTTGCAAACAACAGTGTCGCCAATACGGCGGTCTTCACGG
TTGCGGAGGCGCGTTTGGTGTGGTTGCGTGTGAGCTCGGATACGACGACCCAGGCATTGAGGGCACTATT
CCAAATGATGCGGTATATTTTGTTCA

Protein Sequence : Show Sequence

>gi|15676883|ref|NP_274028.1| adhesin [Neisseria meningitidis MC58]
MNKIYRIIWNSALNAWVVVSELTRNHTKRASATVKTAVLATLLFATVQASANNEEQEEDLYLDPVQRTVA
VLIVNSDKEGTGEKEKVEENSDWAVYFNEKGVLTAREITLKAGDNLKIKQNGTNFTYSLKKDLTDLTSVG
TEKLSFSANGNKVNITSDTKGLNFAKETAGTNGDTTVHLNGIGSTLTDTLLNTGATTNVTNDNVTDDEKK
RAASVKDVLNAGWNIKGVKPGTTASDNVDFVRTYDTVEFLSADTKTTTVNVESKDNGKKTEVKIGAKTSV
IKEKDGKLVTGKDKGENGSSTDEGEGLVTAKEVIDAVNKAGWRMKTTTANGQTGQADKFETVTSGTNVTF
ASGKGTTATVSKDDQGNITVMYDVNVGDALNVNQLQNSGWNLDSKAVAGSSGKVISGNVSPSKGKMDETV
NINAGNNIEITRNGKNIDIATSMTPQFSSVSLGAGADAPTLSVDGDALNVGSKKDNKPVRITNVAPGVKE
GDVTNVAQLKGVAQNLNNRIDNVDGNARAGIAQAIATAGLVQAYLPGKSMMAIGGGTYRGEAGYAIGYSS
ISDGGNWIIKGTASGNSRGHFGASASVGYQW

Molecule Role : Protective antigen
Molecule Role Annotation : Protective antigen (Pizza et al., 2000)
COG: COG5295UW, under U: Intracellular trafficking, secretion, and vesicular transport; W: Extracellular structures

12. LctP

Gene Name : LctP
Sequence Strain (Species/Organism) : Neisseria meningitidis
VO ID : VO_0011185
NCBI Protein GI : 254667969
Other Database IDs : CDD:163899
CDD:170425
Taxonomy ID : 662598
Gene Strand (Orientation) : ?
Protein Name : L-lactate permease
Protein Length : 528
Protein Note : L-lactate permease; cl00701

Protein Sequence : Show Sequence

>gi|254667969|emb|CBA04244.1| L-lactate permease [Neisseria meningitidis]
MALFLSIFPIVLLIWLMVKKNSMPSYVALPITAVLIYAIKLFYFGDAGMLLNATAASGLVKTLTPITVIF
GAIMFNRMMETTGCIDVIRKWLATISPNPVAQLMIIGWAFAFMIEGASGFGTPAAIAAPILMSLGFNPLK
VAIFTLVMNSVPVSFGAVGTPTWFGFAPLNLSAEDILAIGRQTGVMHFFAGFVIPVIGLGFIVPWSEIRK
NLGFVAIAVFSCTIPYVALAMVNEEFPSLVAGAIGLMVSVFAANQGWGLSKDHAKDPNAEKVPFAQVAKA
LAPLGMLIGMLVVTRIKQLGIKGILTSKEEWFSFQLPFDLSKITVSDSLTITFGNIFGQDVSASYQTLYV
PAWIPFVLTVWICILLYKTKFKDAWTIYSVTFNQTKKPLLALMGALIMVQLMLVGGDNSMVKIIGKEFAA
MAGEHWVYFSPYLGAIGAFFSGSNTVSNLTFGPIQQQIALDTGLSVTLILALQSVGGAMGNMVCLNNIIA
VCTVLDVKNSEGAIIKKTVIPMAIYGVIAVVAAMIFFL

Molecule Role : Protective antigen
Molecule Role Annotation : A total of 11 meningococcal proteins that are necessary for establishing systemic infection were expressed as recombinant antigens and assessed for their ability to protect mice against live bacterial challenge against N. meningitidis; the lactate permease (LctP) elicited protective immunity (Sun et al., 2005).
Related Vaccine(s): N. meningitidis LctP Protein Vaccine

13. LpdA

Gene Name : LpdA
Sequence Strain (Species/Organism) : Neisseria meningitidis
VO ID : VO_0011181
NCBI Protein GI : 1017430
Other Database IDs : CDD:133458
CDD:176428
CDD:168567
CDD:145812
GOA:Q51191
HSSP: P06959
InterPro: IPR000089
InterPro: IPR000815
InterPro: IPR001100
InterPro: IPR001327
InterPro: IPR003016
InterPro: IPR004099
InterPro: IPR006258
InterPro: IPR011053
InterPro: IPR012999
InterPro: IPR013027
UniProtKB/TrEMBL: Q51191
Taxonomy ID : 487
Gene Strand (Orientation) : ?
Protein Name : outer membrane protein P64k or PM-6
Protein Length : 593
Protein Note : Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; cd06849

Protein Sequence : Show Sequence

>gi|1017430|emb|CAA57206.1| outer membrane protein P64k or PM-6 [Neisseria meningitidis]
MALVELKVPDIGGHENVDIIAVEVNVGDTIAVDDTLITLETDKATMDIPAEVAGVVKEVKVKVGDKISEG
GLIVVVEAEGAATAPKAEAPATPAQEAPKAAAPAPQAAQFGGSADAEYDVVLGGGPGGYSAAFAAADEGL
KVAIVERYKTLGGVCLNVGCIPSKALLHNAAVIDEVRHLAANGIKYPEPELDIDMLRAYKNGVVSRLTGG
LAGMAKRRKVDVIQGDGQFLDPHHLEVSLTAGDAYEQAAPTGEKKIVAFKNCIIAAGSRVTKLPFIPEDP
RIIDSSGALALKEVPGKLLIIGAGIIGLEMGTVYSTLGSRLDVVEMMDGLMQGADRDLVKVWQKQNEYRF
DNIMVNTKTVAVEPKEDGVYVTFEGANAPKEPQRYDAVLVAAGRAPNGKLISAEKAGVAVTDRGFIEVDK
QMRTNVPHIYAIVDIVGQPMLAHKAVHEGHVAAENCAGHKAYFDARVIPGVAYTSPEVAWVGETELSAKA
SGRKITKANFPWAASGRAIANGCDNGFTKLIFDAETGRIIGGGIVGPNGGDMIGEVCLAIEMGCDAADIG
KTIHPHPTLGESIGMAAEVALGTCTDLPPQKKK

Molecule Role : Protective antigen
Molecule Role Annotation : Sera of the challenge group immunized with CCPS-P64kR showed a three-fold higher bactericidal response than the sera of the group immunized with the plain CCPS and they were able to protect against challenge with Neisseria meningococci in the infant rat protection model (Carmenate et al., 2004).
Related Vaccine(s): CCPS-P64kR

14. LPS

Gene Name : LPS
Sequence Strain (Species/Organism) : Neisseria meningitidis
Gene Strand (Orientation) : ?
Protein Name : lipopolysaccharide
Molecule Role : Protective antigen
Molecule Role Annotation : Seventeen monoclonal antibodies to one of three main cell surface antigens of Neisseria meningitidis group B were tested for protective efficacy in the infant rat using as challenge seven strains of different class 2/3 protein serotypes. Survival of the animals was regularly obtained with antibodies to the P1 protein and to LPS (Saukkonen et al., 1989).

15. NadA

Gene Name : NadA
Sequence Strain (Species/Organism) : Neisseria meningitidis MC58
VO ID : VO_0010980
NCBI Gene ID : 904134
NCBI Protein GI : 15677822
Locus Tag : NMB1994
Genbank Accession : AE002098
Protein Accession : NP_274986
Taxonomy ID : 122586
Gene Starting Position : 2100382
Gene Ending Position : 2101476
Gene Strand (Orientation) : +
Protein Name : putative adhesin/invasin
Protein pI : 4.54
Protein Weight : 35292.78
Protein Length : 364
Protein Note : identified by similarity to GP:2735093; match to protein family HMM PF03895

DNA Sequence : Show Sequence

>gi|77358697:2100382-2101476 Neisseria meningitidis MC58, complete genome
AATGAGCATGAAACACTTTCCATCCAAAGTACTGACCACAGCCATCCTTGCCACTTTCTGTAGCGGCGCA
CTGGCAGCCACAAGCGACGACGATGTTAAAAAAGCTGCCACTGTGGCCATTGTTGCTGCCTACAACAATG
GCCAAGAAATCAACGGTTTCAAAGCTGGAGAGACCATCTACGACATTGGTGAAGACGGCACAATTACCCA
AAAAGACGCAACTGCAGCCGATGTTGAAGCCGACGACTTTAAAGGTCTGGGTCTGAAAAAAGTCGTGACT
AACCTGACCAAAACCGTCAATGAAAACAAACAAAACGTCGATGCCAAAGTAAAAGCTGCAGAATCTGAAA
TAGAAAAGTTAACAACCAAGTTAGCAGACACTGATGCCGCTTTAGCAGATACTGATGCCGCTCTGGATGA
AACCACCAACGCCTTGAATAAATTGGGAGAAAATATAACGACATTTGCTGAAGAGACTAAGACAAATATC
GTAAAAATTGATGAAAAATTAGAAGCCGTGGCTGATACCGTCGACAAGCATGCCGAAGCATTCAACGATA
TCGCCGATTCATTGGATGAAACCAACACTAAGGCAGACGAAGCCGTCAAAACCGCCAATGAAGCCAAACA
GACGGCCGAAGAAACCAAACAAAACGTCGATGCCAAAGTAAAAGCTGCAGAAACTGCAGCAGGCAAAGCC
GAAGCTGCCGCTGGCACAGCTAATACTGCAGCCGACAAGGCCGAAGCTGTCGCTGCAAAAGTTACCGACA
TCAAAGCTGATATCGCTACGAACAAAGCTGATATTGCTAAAAACTCAGCACGCATCGACAGCTTGGACAA
AAACGTAGCTAATCTGCGCAAAGAAACCCGCCAAGGCCTTGCAGAACAAGCCGCGCTCTCCGGCCTGTTC
CAACCTTACAACGTGGGTCGGTTCAATGTAACGGCTGCAGTCGGCGGCTACAAATCCGAATCGGCAGTCG
CCATCGGTACCGGCTTCCGCTTTACCGAAAACTTTGCCGCCAAAGCAGGCGTGGCAGTCGGCACTTCGTC
CGGTTCTTCCGCAGCCTACCATGTCGGCGTCAATTACGAGTGGTA

Protein Sequence : Show Sequence

>gi|15677822|ref|NP_274986.1| putative adhesin/invasin [Neisseria meningitidis MC58]
MSMKHFPSKVLTTAILATFCSGALAATSDDDVKKAATVAIVAAYNNGQEINGFKAGETIYDIGEDGTITQ
KDATAADVEADDFKGLGLKKVVTNLTKTVNENKQNVDAKVKAAESEIEKLTTKLADTDAALADTDAALDE
TTNALNKLGENITTFAEETKTNIVKIDEKLEAVADTVDKHAEAFNDIADSLDETNTKADEAVKTANEAKQ
TAEETKQNVDAKVKAAETAAGKAEAAAGTANTAADKAEAVAAKVTDIKADIATNKADIAKNSARIDSLDK
NVANLRKETRQGLAEQAALSGLFQPYNVGRFNVTAAVGGYKSESAVAIGTGFRFTENFAAKAGVAVGTSS
GSSAAYHVGVNYEW

Molecule Role : Protective antigen
Molecule Role Annotation : Protective antigen (Giuliani et al., 2006; Comanducci et al., 2002). There is another nadA (quinolinate synthetase) [ Neisseria meningitidis MC58 ] with GeneID: 902509. However, according to sequence analysis, this nadA is not the same NadA that was found to be protective antigen (Giuliani et al., 2006; Comanducci et al., 2002).

16. NspA from N. meningitidis

Gene Name : NspA from N. meningitidis
Sequence Strain (Species/Organism) : Neisseria meningitidis
VO ID : VO_0011184
NCBI Protein GI : 5825543
3D structure: PDB ID : 1P4T
Other Database IDs : CDD:174558
Taxonomy ID : 487
Gene Strand (Orientation) : ?
Protein Name : surface protein A
Protein Length : 174
Protein Note : Surface antigen; cl01155

Protein Sequence : Show Sequence

>gi|5825543|gb|AAD53286.1|AF175683_1 surface protein A [Neisseria meningitidis]
MKKALATLIALALPAAALAEGASGFYVQADAAHAKASSSLGSAKGFSPRISAGYRINDLRFAVDYTRYKN
YKAPSTDFKLYSIGASAIYDFDTQSPVKPYLGARLSLNRASVDLGGSDSFSQTSIGLGVLTGVSYAVTPN
VDLDAGYRYNYIGKVNTVKNVRSGELSVGVRVKF

Molecule Role : Protective antigen
Molecule Role Annotation : NspA-containing outer membrane vesicles conferred protection against otherwise lethal intraperitoneal challenge of mice with N. meningitidis serogroup B, and sera raised against them mediated opsonophagocytosis of meningococcal strains expressing this antigen (O'dwyer et al., 2004).

17. NspA from N. meningitidis MC58

Gene Name : NspA from N. meningitidis MC58
Sequence Strain (Species/Organism) : Neisseria meningitidis MC58
VO ID : VO_0010979
NCBI Gene ID : 902774
NCBI Protein GI : 15676561
Locus Tag : NMB0663
Genbank Accession : NC_003112
Protein Accession : NP_273705
3D structure: PDB ID : 1P4T
Taxonomy ID : 122586
Gene Starting Position : 690297
Gene Ending Position : 690821
Gene Strand (Orientation) : -
Protein Name : outer membrane protein
Protein pI : 10.02
Protein Weight : 17106.9
Protein Length : 174
Protein Note : identified by similarity to EGAD:137514; match to protein family HMM PF02462

DNA Sequence : Show Sequence

>gi|902774|gb|U20470.1|IAU20470 Influenza A virus (A/tern/Potsdam/342/6/79(H7N7)) hemagglutinin precursor (HA) mRNA, partial cds
AGCAAAAGCAGGGGATACAAAATGAACACTCAAATCCTGATATTCGCTCTTGTGGCGATCATCCCAACAA
ATGCAGACAAAATTTGCCTTGGGCATCATGCCGTGTCAAACGGAACTAAAGTAAACACACTAACTGAGAG
AGGAATAGAAGTTGTCAATGCAACTGAAACAGTGGAGAGAGCAAACATCCCCAGGATCTGCTCAAAAGGG
AAAAGGACAATCGACCTTGGCCAATGTGGACTGCTGGGAACAATCACTGGACCACCTCAATGTGACCAAT
TCCTAGAATTCTCAGCTGATTTGATCATTGAAAGGCGGGAAGGAAATGATGTTTGTTATCCTGGAAAATT
TGTAAACGAAGAAGCTCTGAGACAGATTCTCAGGGAATCAGGCGGAATTGATAAGGAAACAATGGGATTC
ACATATAGCGGAATAAGAACCAATGGAGAAACCGGTGCATGTAGAAGATCAGGATCTTCATTCTATGCAG
AGATGAAATGGCTTCTGTCAAATACAGACAATGCTGCTTTCCCACAGACAACGAAGTCGTACAAGAACAC
AAGGAAAGATCCAGCTCTGATAATCTGGGGAATCCATCATTCTGGATCAACCACAGAACAGACCAAATTA
TATGGAAGTGGGAGCAAACTAATAACAGTTGGGAGTTCCAATTACCAACAGTCTTTTGTACCGAGTCCAG
GAGCGAGGCCACAAGTGAATGGCCAATCTGGACGGATCGATTTCCATTGGTTGATGCTGAATCCCAATGA
CACAGTCACTTTCAGCTTCAATGGTGCTTTTATAGCTCCAGATCGTGCAAGTTTTCTGAGAGGGAAGTCT
ATGGGAATTCAGAGCGATGTACAAGTTGATGCCAATTGTGAGGGGGATTGCTATCATAGTGGAGGAACAA
TAATAAGTAATTTGCCTTTTCAGAATATCAATAGCAGAGCAGTAGGGAAATGTCCGAGGTATGTGAAACA
AGAGAGCCTGCTACTGGCAACAGGGATGAAGAACGTTCCTGAAATTCCAAAAGGGAGAGGACTATTTGGT
GCCATAGCGGGTTTTATTGAAAATGGGTGGGAAGGTCTGGTTGATGGATGGTATGGCTTCACACATCAAA
ATGCACAGGGGGAGGGAACT

Protein Sequence : Show Sequence

>gi|15676561|ref|NP_273705.1| outer membrane protein [Neisseria meningitidis MC58]
MKKALATLIALALPAAALAEGASGFYVQADAAHAKASSSLGSAKGFSPRISAGYRINDLRFAVDYTRYKN
YKAPSTDFKLYSIGASAIYDFDTQSPVKPYLGARLSLNRASVDLGGSDSFSQTSIGLGVLTGVSYAVTPN
VDLDAGYRYNYIGKVNTVKNVRSGELSAGVRVKF

Molecule Role : Protective antigen
Molecule Role Annotation : Protective antigen (Martin et al., 1997)
COG: COG3637M, under M: Cell wall/membrane/envelope biogenesis
Related Vaccine(s): N. meningitidis NspA Protein Vaccine

18. P1

Gene Name : P1
Sequence Strain (Species/Organism) : Neisseria meningitidis MC58
VO ID : VO_0011180
NCBI Gene ID : 902192
NCBI Protein GI : 15676020
Locus Tag : NMB0088
Genbank Accession : AE002098
Protein Accession : NP_273150
Taxonomy ID : 122586
Gene Starting Position : 99776
Gene Ending Position : 101176
Gene Strand (Orientation) : -
Protein Name : putative outer membrane protein P1
Protein pI : 9.85
Protein Weight : 47342.37
Protein Length : 466
Protein Note : identified by similarity to EGAD:16317; match to protein family HMM PF03349

DNA Sequence : Show Sequence

>gi|77358697:99776-101176 Neisseria meningitidis MC58, complete genome
TTTATTTGAATTTGTAGGTGTATTGCAGACCGATGATGTCGGCGTGGTTTTTGAAACGTGCGGAAGACGC
GCCTTTGCTGTCCACATCGTTGCCGCTTGCCTTCGCCGTGCGGTAGCTGGTGTCGTTGATGTGGATGTGG
GTGTAGGCGGCATCGACGACGTGGTTTTTACCGATATGGTATTTCATACCGGCGGAGAACCAGATGCGGT
TGCCGTCGGGTAGGCTGTTCATGCGGTAGTCGGCGTTGCGGACGGGCGATTTGTCAAAAGCGATGCCGGC
GCGCAGTTGCAGCGGTTCGCTGATTTGATAAGAACCGCCGAAGCCGACTTTGTAGGTGTTGCGCCAGTTG
GGGGTGATGGTGGTGCGGTCGGATTTGCCTTTGACGACGGTTTTTTCTTTTTCAAAAACCAGTTCCGCCT
TATCGAAGCGGCTGTGGCGCGTCCAAGTTACGTCGCCGAACAGGTCGGCTTTATCGGACACTTTGTACAT
ACCGTGTACGGACAAAGACTCAGGCGTAACGATTTTAACGCGGGCTTTTTCATTCGCCGTGTAGCCGTTT
GCTGCAAGCATCGTACTCCACATTGCTTTCGCCGCCGCGCCGTCTGCCGCCCATTCGGCATCGCCTTTGA
GCGTGTGCGAGACTTTGGAACGGTAGTTCACGCCCACGCGCGCACGGTCGTTGATGTCCCACATCCACGC
CAGTTGGTAGCCGAAGCCCCAATCGCTGCCTTTGACATCGGCGTGTCCGTCGGCCTGAATTTTTGCAGCT
TCGGCTACACCGTTAGGTTTGGGCGGTTTTGCCGTCAATATCTCTGCTTTACTCTTAATCCCCCAGTCGG
CATATTTGCGCAGTTCGGCGGAAGTATGTTGGGCGATGATGCCTGCGCCGAAGGAATGGCGGTCGTTGAG
TTTCCACGCGGCGACAGGTTCGACGGCGATGCTGGTCAGACCGAGTTTGTTGATGTTGTGGCGCAACACG
GAATCTTTTTCGTATTCGGTGGCAGAGCCGAAGGGGACGTACACGCCCAAGCCCACGGTCAGATTGTCGT
TGACTTTGTATGCGCCGTAGATGTGGGGCGCGACCGTGGTTTTGGTGATTTTGCCGCTTTTCGAACCTTG
GACGGGAAGCCCGGTAAAGTCGGTGGCGGAATCCGCCTCATAATGAATGCTGGGCAGCACGATGTTGGCG
TTGACGGAAATCTGGCTGCTGTCGAGTTTGGTCAGGCCGGCAGGGTTGTAGAAGATGGTCGATGCGTCGG
CGGCTTCTGCGGCGGCGGCATTTGCCGTGCTTTGCGCGTTGACCGACTGTGTGCCGAAGTGGTAGCCGGA
TGCGTGGACGGATGCGGCGGCAAAGGCAGTGCCGAGCAGCAGGACGGTTTTTTTCAGTGCGGAAGGGGTC
A

Protein Sequence : Show Sequence

>gi|15676020|ref|NP_273150.1| putative outer membrane protein P1 [Neisseria meningitidis MC58]
MTPSALKKTVLLLGTAFAAASVHASGYHFGTQSVNAQSTANAAAAEAADASTIFYNPAGLTKLDSSQISV
NANIVLPSIHYEADSATDFTGLPVQGSKSGKITKTTVAPHIYGAYKVNDNLTVGLGVYVPFGSATEYEKD
SVLRHNINKLGLTSIAVEPVAAWKLNDRHSFGAGIIAQHTSAELRKYADWGIKSKAEILTAKPPKPNGVA
EAAKIQADGHADVKGSDWGFGYQLAWMWDINDRARVGVNYRSKVSHTLKGDAEWAADGAAAKAMWSTMLA
ANGYTANEKARVKIVTPESLSVHGMYKVSDKADLFGDVTWTRHSRFDKAELVFEKEKTVVKGKSDRTTIT
PNWRNTYKVGFGGSYQISEPLQLRAGIAFDKSPVRNADYRMNSLPDGNRIWFSAGMKYHIGKNHVVDAAY
THIHINDTSYRTAKASGNDVDSKGASSARFKNHADIIGLQYTYKFK

Molecule Role : Protective antigen
Molecule Role Annotation : Seventeen monoclonal antibodies to one of three main cell surface antigens of Neisseria meningitidis group B were tested for protective efficacy in the infant rat using as challenge seven strains of different class 2/3 protein serotypes. Survival of the animals was regularly obtained with antibodies to the P1 protein and to LPS (Saukkonen et al., 1989).
COG: COG2067I, under I: Lipid transport and metabolism

19. TBP2

Gene Name : TBP2
Sequence Strain (Species/Organism) : Neisseria meningitidis
VO ID : VO_0011182
NCBI Protein GI : 1017433
Other Database IDs : CDD:144774
GOA:Q51287
InterPro: IPR001677
UniProtKB/TrEMBL: Q51287
Taxonomy ID : 487
Gene Strand (Orientation) : ?
Protein Name : transferrin-binding protein 2
Protein Length : 699
Protein Note : Transferrin binding protein-like solute binding protein; pfam01298

Protein Sequence : Show Sequence

>gi|1017433|emb|CAA55541.1| TBP2 [Neisseria meningitidis]
CLGGGGGSFDLDSVDTEAPRPAPKYQDVSSEKPQAQKDQGGYGFAMRLKRRNWYPSAKENEVKLNESDWE
TTGLPSNPKNLPERQKSVIDQVETDGDSNNSNIYSSPYLTQSNHQNGNTGNGVNQPKNEVTDYKNFKYVY
SGWFYKHAKREVNLAVEPKIAKNGDDGYIFYHGKDPSRQLPASGKITYKGVWHFATDTKRGQKFREIIQP
SKNQGDRYSGFSGDDDEQYSNKNESMLKDGHEGYGFASNLEVDFDNKKLTGKLIRNNANQNNNTNNDKHT
TQYYSLDATLKGNRFSGKAEATDKPKNDGETKEHPFVSDSSSLSGGFFGPQGEELGFRFLSNDQKVAVVG
SAKTKDKPANGNTAEASGGTDAAASGGAAGTSSENSKLTTVLDAVELTHGGTAIKNLDNFSNAAQLVVDG
IMIPLLPQNSTGKNNQPDQGKNGGTAFIYKTTYTPKNDDKDTKAQTVTGGTQTASNTAGDANGKTKTYEV
EVCCSNLNYLKYGLLTRKTAGNTVGSGNSSPTAAAQTDAQSMFLQGERTDENKIPSEQNVVYRGSWYGHI
ASSTSWSGNASDKEGGNRAEFTVNFGEKKITGTLTAENRQEATFTIDGKIEGNGFSGTAKTAELGFDLDQ
KNTTRTPKAYITDAKVKGGFYGPKAEELGGWFAYSDDKQTKNATDASGNGNSASSATVVFGAKRQQPVQ

Molecule Role : Protective antigen
Molecule Role Annotation : Mice immunized with purified Tbp2 survived a lethal challenge to a similar degree as animals immunized with the Tbp1-Tbp2 complex, demonstrating that Tbp2 played an important role in the protective activity observed with the complex, eliciting antibodies that are not only bactericidal but also inhibitory for meningococcal growth (Lissolo et al., 1995).
Related Vaccine(s): N. miningitidis TBP2 Protein Vaccine

20. TbpA

Gene Name : TbpA
Sequence Strain (Species/Organism) : Neisseria meningitidis K454
VO ID : VO_0012380
NCBI Protein GI : 8926211
Other Database IDs : CDD:162528
CDD:174088
CDD:73259
Taxonomy ID : 487
Gene Strand (Orientation) : ?
Protein Name : transferrin-binding protein A
Protein Length : 915
Protein Note : TbpA

Protein Sequence : Show Sequence

>gi|8926211|gb|AAF81744.1| transferrin-binding protein A [Neisseria meningitidis]
MQQQHLFRFNILCLSLMTALPAYAENVQAGQAQEKQLDTIQVKAKKQKTRRDNEVTGLGKLVKSSDTLSK
EQVLNIRDLTRYDPGIAVVEQGRGASSGYSIRGMDKNRVSLTVDGVSQIQSYTAQAALGGTRTAGSSGAI
NEIEYENVKAVEISKGSNSVEQGSGALAGSVAFQTKTADDVIGEGRQWGIQSKTAYSGKNRGLTQSIALA
GRIGGAEALLIHTGRRAGEIRAHEDAGRGVQSFNRLVPVEDSSNYAYFIVKEECKNGSYETCKANPKKDV
VGKDERQTVSTRDYTGPNRFLADPLSYESRSWLFRPGFRFENKRHYIGGILEHTQQTFDTRDMTVPAFLT
KAVFDANKKQAGSLPGNGKYAGNHKYGGLFTNGENGALVGAEYGTGVFYDETHTKSRYGLEYVYTNADKD
TWADYARLSYDRQGVGLDNHFQQTHCSADGSDKYCRPSADKPFSYYKSDRVIYGESHRLLQAAFKKSFDT
AKIRHNLSVNLGFDRFGSNLRHQDYYYQHANRAYSSNTPPQNNGKKISPNGSETSPYWVTIGRGNVVTGQ
ICRLGNNTYTDCTPRSINGKSYYAAVRDNVRLGRWADVGAGLRYDYRSTHSDDGSVSTGTHRTLSWNAGI
VLKPTDWLDLTYRTSTGFRLPSFAEMYGWRAGVQSKAVKIDPEKSFNKEAGIVFKGDFGNLEASWFNNAY
RDLIVRGYEAQIKDGKEEAKGDPAYLNAQSARITGINILGKIDWNGVWDKLPEGWYSTFAYNRVRVRDIK
KRADRTDIQSHLFDAIQPSRYVVGLGYDQPEGKWGVNGMLTYSKAKEITELLGSRALLNGNSRNTKATAR
RTRPWYIVDVSGYYTVKKHFTLRAGVYNLLNYRYVTWENVRQTAGGAVNQHKNVGVYNRYAAPGRNYTFS
LEMKF

Molecule Role : Protective antigen
Molecule Role Annotation : Recombinant TbpA protein was used in a mouse intraperitoneal-infection model to determine their ability to protect against meningococcal infection and to induce cross-reactive and bactericidal antibodies. TbpA was found to afford protection against meningococcal challenge when administered as the sole immunogen (West et al., 2001).
Related Vaccine(s): N. meningitidis TbpA Protein Vaccine

II. References

1. Carmenate et al., 2004: Carmenate T, Canaán L, Alvarez A, Delgado M, González S, Menéndez T, Rodés L, Guillén G. Effect of conjugation methodology on the immunogenicity and protective efficacy of meningococcal group C polysaccharide-P64k protein conjugates. FEMS immunology and medical microbiology. 2004; 40(3); 193-199. [PubMed: 15039094].

2. Comanducci et al., 2002: Comanducci M, Bambini S, Brunelli B, Adu-Bobie J, Aricò B, Capecchi B, Giuliani MM, Masignani V, Santini L, Savino S, Granoff DM, Caugant DA, Pizza M, Rappuoli R, Mora M. NadA, a novel vaccine candidate of Neisseria meningitidis. The Journal of experimental medicine. 2002; 195(11); 1445-1454. [PubMed: 12045242].

3. Giuliani et al., 2006: Giuliani MM, Adu-Bobie J, Comanducci M, Aricò B, Savino S, Santini L, Brunelli B, Bambini S, Biolchi A, Capecchi B, Cartocci E, Ciucchi L, Di Marcello F, Ferlicca F, Galli B, Luzzi E, Masignani V, Serruto D, Veggi D, Contorni M, Morandi M, Bartalesi A, Cinotti V, Mannucci D, Titta F, Ovidi E, Welsch JA, Granoff D, Rappuoli R, Pizza M. A universal vaccine for serogroup B meningococcus. Proceedings of the National Academy of Sciences of the United States of America. 2006; 103(29); 10834-10839. [PubMed: 16825336].

4. Lissolo et al., 1995: Lissolo L, Maitre-Wilmotte G, Dumas P, Mignon M, Danve B, Quentin-Millet MJ. Evaluation of transferrin-binding protein 2 within the transferrin-binding protein complex as a potential antigen for future meningococcal vaccines. Infection and immunity. 1995; 63(3); 884-890. [PubMed: 7868259].

5. Martin et al., 1997: Martin D, Cadieux N, Hamel J, Brodeur BR. Highly conserved Neisseria meningitidis surface protein confers protection against experimental infection. The Journal of experimental medicine. 1997; 185(7); 1173-1183. [PubMed: 9104804].

6. O'dwyer et al., 2004: O'dwyer CA, Reddin K, Martin D, Taylor SC, Gorringe AR, Hudson MJ, Brodeur BR, Langford PR, Kroll JS. Expression of heterologous antigens in commensal Neisseria spp.: preservation of conformational epitopes with vaccine potential. Infection and immunity. 2004; 72(11); 6511-6518. [PubMed: 15501782].

7. Pizza et al., 2000: Pizza M, Scarlato V, Masignani V, Giuliani MM, Aricò B, Comanducci M, Jennings GT, Baldi L, Bartolini E, Capecchi B, Galeotti CL, Luzzi E, Manetti R, Marchetti E, Mora M, Nuti S, Ratti G, Santini L, Savino S, Scarselli M, Storni E, Zuo P, Broeker M, Hundt E, Knapp B, Blair E, Mason T, Tettelin H, Hood DW, Jeffries AC, Saunders NJ, Granoff DM, Venter JC, Moxon ER, Grandi G, Rappuoli R. Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing. Science (New York, N.Y.). 2000; 287(5459); 1816-1820. [PubMed: 10710308].

8. Pizza et al., 2008: Pizza M, Donnelly J, Rappuoli R. Factor H-binding protein, a unique meningococcal vaccine antigen. Vaccine. 2008; 26 Suppl 8; I46-48. [PubMed: 19388164].

9. Saukkonen et al., 1989: Saukkonen K, Leinonen M, Abdillahi H, Poolman JT. Comparative evaluation of potential components for group B meningococcal vaccine by passive protection in the infant rat and in vitro bactericidal assay. Vaccine. 1989; 7(4); 325-328. [PubMed: 2510417].

10. Sun et al., 2005: Sun Y, Li Y, Exley RM, Winterbotham M, Ison C, Smith H, Tang CM. Identification of novel antigens that protect against systemic meningococcal infection. Vaccine. 2005; 23(32); 4136-4141. [PubMed: 15964482].

11. West et al., 2001: West D, Reddin K, Matheson M, Heath R, Funnell S, Hudson M, Robinson A, Gorringe A. Recombinant Neisseria meningitidis transferrin binding protein A protects against experimental meningococcal infection. Infection and immunity. 2001; 69(3); 1561-1567. [PubMed: 11179327].