VIOLIN: Vaccine Investigation and Online Information Network

Protegen: Protective Antigens

Currently, Protegen includes 587 protective antigens for 109 pathogens or host organisms (e.g., human, mouse). These protective antigens have been proven to induce protection against infectious diseases or non-infectious diseases (e.g., cancer, allergy). The detailed curated data is shown below:

Index	Pathogen Name	Disease	No. of Protective Antigens
Bacteria
1	Treponema pallidum	Syphilis	3
G+ Bacteria
2	Bacillus anthracis	Anthrax	4
3	Clostridium botulinum	Botulism	6
4	Clostridium tetani	Tetanus	1
5	Corynebacterium diphtheriae	Diphtheria	1
6	Listeria monocytogenes	Listeriosis	2
7	Mycobacterium tuberculosis	Tuberculosis	20
8	Staphylococcus aureus		4
9	Streptococcus agalactiae	Group B streptococcus (GBS) infection	3
10	Streptococcus equi	Strangles (also equine distemper)	5
11	Streptococcus pneumoniae	Pneumonia	12
12	Streptococcus pyogenes	Group A streptococcal infections	5
G- Bacteria
13	Actinobacillus pleuropneumoniae		5
14	Aeromonas salmonicida	Furunculosis, Bald sea urchin disease	2
15	Bordetella avium	Bordetellosis	0
16	Bordetella pertussis	Whooping Cough	10
17	Borrelia burgdorferi	Lyme Disease	4
18	Brucella spp.	Brucellosis	19
19	Burkholderia pseudomallei	Melioidosis	3
20	Campylobacter jejuni	Campylobacterosis	9
21	Chlamydia muridarum		9
22	Chlamydophila abortus		10
23	Chlamydophila pneumoniae	Pneumonia	5
24	Chlamydophila psittaci	Respiratory psittacosis, avian chlamydiosis	3
25	Coxiella burnetii	Q fever	2
26	Escherichia coli	Hemorrhagic colitis	17
27	Francisella tularensis	Tularemia	10
28	Haemophilus influenzae	Meningitis	14
29	Helicobacter pylori		8
30	Lawsonia intracellularis	Lawsonia intracellularis infection	0
31	Mycoplasma gallisepticum	Chronic respiratory disease	1
32	Mycoplasma synoviae	Respiratory tract disease and synovitis	0
33	Neisseria meningitidis	Meningitis	19
34	Porphyromonas gulae	Canine periodontitis	0
35	Pseudomonas aeruginosa		3
36	Rickettsia spp		3
37	Salmonella spp.	Salmonellosis	6
38	Shigella	Shigellosis	4
39	Vibrio anguillarum (Listonella anguillarum)	Vibrosis	1
40	Vibrio cholerae	Cholera	3
41	Yersinia enterocolitica		1
42	Yersinia pestis	Plague	24
43	Yersinia pseudotuberculosis		1
44	Yersinia ruckeri	Enteric redmouth disease	0
Viruses
45	Bovine herpesvirus 1	Infectious bovine rhinotracheitis	4
46	Bovine Leukemia virus		2
47	Canine coronavirus		0
48	Canine distemper virus	Canine distemper	2
49	Canine parvovirus	Canine parvovirus infection	2
50	Classical swine fever virus	Classical swine fever	3
51	Dengue Virus	Dengue Fever	4
52	Ebola virus	Ebola hemorrhagic fever	13
53	Feline leukemia virus	Feline leukemia virus infection	2
54	Hantavirus	Hantavirus Pulmonary Syndrome	9
55	Hendra virus		1
56	Hepatitis A virus	Hepatitis A	1
57	Hepatitis B virus	Hepatitis B	3
58	Herpes simplex virus type 1 and 2		9
59	Human Immunodeficiency Virus	Acquired Immunodeficiency Syndrome (AIDS)	5
60	Human papillomavirus	HPV infection	4
61	Infectious Hematopoietic Necrosis Virus	Infectious hematopoietic necrosis	1
62	Influenza virus	Influenza (flu)	37
63	Japanese encephalitis virus	Japanese encephalitis	6
64	Lassa Fever Virus	Lassa fever	2
65	Marburg Virus	Hemorrhagic fever	6
66	Marek’s disease virus	Marek's disease	2
67	Measles virus	Measles	5
68	Mumps virus	Mumps	1
69	Newcastle disease virus	Newcastle disease	2
70	Nipah virus		2
71	Poliovirus	Polio	1
72	Porcine circovirus 2	Postweaning multisystemic wasting syndrome	1
73	Pseudorabies virus	Aujeszky's disease	8
74	Rabies virus	Rabies	2
75	Rift Valley Fever virus	Rift valley fever	2
76	Rotavirus	Gastroenteritis	8
77	Rubella virus	Rubella	0
78	SARS-CoV	Severe Acute Respiratory Syndrome (SARS)	1
79	Tick-borne Encephalitis Virus (TBEV)	Tick-borne Encephalitis	1
80	Varicella-zoster virus	chickenpox / shingles	2
81	Variola virus	Smallpox	3
82	VEE Virus	Venezuelan equine encephalitis	2
83	West Nile virus	West Nile fever	2
84	Western equine encephalomyelitis virus	Western equine encephalomyelitis (WEE)	3
85	Yellow fever virus	Yellow fever	2
Parasites
86	Babesia bovis		3
87	Babesia canis	Piroplasmosis	0
88	Cryptosporidium parvum	Cryptosporidiosis	2
89	Eimeria maxima	Coccidiosis	1
90	Eimeria spp.	Coccidiosis	0
91	Eimeria tenella	Hemorrhagic cecal coccidiosis	5
92	Entamoeba histolytica		4
93	Giardia duodenalis	Giardiasis (Beaver fever)	1
94	Leishmania amazonensis	Leishmaniasis	5
95	Leishmania donovani	Visceral leishmaniasis	11
96	Leishmania infantum	Infantile visceral leishmaniasis	5
97	Leishmania major	Cutaneous leishmaniasis	10
98	Neospora caninum	Neosporosis	8
99	Plasmodium spp.	Malaria	26
100	Sarcocystis neurona	Equine protozoal myeloencephalitis	1
101	Theileria annulata	Theileriosis	2
102	Theileria parva	East Coast Fever	1
103	Toxoplasma gondii	Toxoplasmosis	3
104	Trypanosoma brucei	African trypanosomiasis (African Sleeping Sickness)	2
105	Trypanosoma cruzi	Chagas disease	9
Fungi
106	Coccidioides spp.	Coccidioidomycosis (California disease, Desert rheumatism, San Joaquin valley fever, and Valley fev	9
Other diseases
107	Allergy		14
108	Cancer	Cancer	36
109	Ricin toxin of Ricinus communis	Ricin poisoning	1
Total	109		587