Currently, Protegen includes 605 protective antigens for
175 pathogens or host organisms (e.g., human, mouse). These protective antigens have been proven to induce protection against infectious diseases or non-infectious diseases (e.g., cancer, allergy). The detailed curated data is shown below:
| Index |
Pathogen Name |
Disease |
No. of Protective Antigens |
| Bacteria |
| G+ Bacteria |
| 1 |
Bacillus anthracis |
Anthrax |
4
|
| 2 |
Clostridium botulinum |
Botulism |
6
|
| 3 |
Clostridium perfringens |
Food poisioning, Gas gangrene |
0 |
| 4 |
Clostridium tetani |
Tetanus |
1
|
| 5 |
Corynebacterium diphtheriae |
Diphtheria |
1
|
| 6 |
Erysipelothrix rhusiopathiae |
Erysipelas |
0 |
| 7 |
Listeria monocytogenes |
Listeriosis |
2
|
| 8 |
Mycobacterium avium |
|
0 |
| 9 |
Mycobacterium tuberculosis |
Tuberculosis |
24
|
| 10 |
Staphylococcus aureus |
Staph infections |
5
|
| 11 |
Streptococcus agalactiae |
Group B streptococcus (GBS) infection |
4
|
| 12 |
Streptococcus equi |
Strangles (also equine distemper) |
6
|
| 13 |
Streptococcus pneumoniae |
Pneumonia |
12
|
| 14 |
Streptococcus pyogenes |
Group A streptococcal infections, Strep throat, Scarlet fever |
5
|
| G- Bacteria |
| 15 |
Actinobacillus pleuropneumoniae |
porcine pleuropneumonia |
5
|
| 16 |
Aeromonas hydrophila |
|
0 |
| 17 |
Aeromonas salmonicida |
Furunculosis, Bald sea urchin disease |
2
|
| 18 |
Bordetella avium |
Bordetellosis |
0 |
| 19 |
Bordetella bronchiseptica |
Infectious bronchitis, kennel cough |
0 |
| 20 |
Bordetella pertussis |
Whooping Cough |
10
|
| 21 |
Borrelia burgdorferi |
Lyme Disease |
4
|
| 22 |
Brucella spp. |
Brucellosis |
19
|
| 23 |
Burkholderia pseudomallei |
Melioidosis |
4
|
| 24 |
Campylobacter fetus |
bovine venereal campylobacteriosis (BVC) |
0 |
| 25 |
Campylobacter jejuni |
Campylobacterosis |
10
|
| 26 |
Chlamydia muridarum |
|
10
|
| 27 |
Chlamydia trachomatis |
Chlamydia |
0 |
| 28 |
Chlamydophila abortus |
Abortion and fetal death |
10
|
| 29 |
Chlamydophila pneumoniae |
Pneumonia |
5
|
| 30 |
Chlamydophila psittaci |
Respiratory psittacosis, avian chlamydiosis |
3
|
| 31 |
Coxiella burnetii |
Q fever |
2
|
| 32 |
Edwardsiella ictaluri |
Enteric septicemia of channel catfish (ESC) |
0 |
| 33 |
Edwardsiella tarda |
|
0 |
| 34 |
Escherichia coli |
Hemorrhagic colitis |
17
|
| 35 |
Flavobacterium columnare |
Columnaris |
0 |
| 36 |
Francisella tularensis |
Tularemia |
9
|
| 37 |
Haemophilus influenzae |
Meningitis |
14
|
| 38 |
Haemophilus parasuis |
Glasser's disease |
0 |
| 39 |
Haemophilus somnus |
|
0 |
| 40 |
Helicobacter pylori |
Ulcers |
8
|
| 41 |
Lawsonia intracellularis |
Lawsonia intracellularis infection |
0 |
| 42 |
Leptospira spp. |
Leptospirosis |
0 |
| 43 |
Mannheimia haemolytica |
Bovine Respiratory Disease |
0 |
| 44 |
Mycoplasma gallisepticum |
Chronic respiratory disease |
1
|
| 45 |
Mycoplasma hyopneumoniae |
Porcine Enzootic Pneumonia |
1
|
| 46 |
Mycoplasma synoviae |
Respiratory tract disease and synovitis |
0 |
| 47 |
Neisseria meningitidis |
Meningitis |
20
|
| 48 |
Pasteurella multocida |
Pasteurellosis, fowl cholera |
1
|
| 49 |
Piscirickettsia salmonis |
Salmon Rickettsial Disease, Piscirickettsiosis |
0 |
| 50 |
Porphyromonas gulae |
Canine periodontitis |
0 |
| 51 |
Pseudomonas aeruginosa |
Pseudomonas aeruginosa infection |
3
|
| 52 |
Rickettsia spp |
|
3
|
| 53 |
Riemerella anatipestifer |
New duck disease, Infectious serositis, Pasteurella anatipestifer infection |
0 |
| 54 |
Salmonella spp. |
Salmonellosis |
6
|
| 55 |
Shigella |
Shigellosis |
5
|
| 56 |
Treponema pallidum |
Syphilis |
3
|
| 57 |
Vibrio anguillarum (Listonella anguillarum) |
Vibrosis |
1
|
| 58 |
Vibrio cholerae |
Cholera |
3
|
| 59 |
Yersinia enterocolitica |
|
1
|
| 60 |
Yersinia pestis |
Plague |
25
|
| 61 |
Yersinia pseudotuberculosis |
Yersiniosis |
1
|
| 62 |
Yersinia ruckeri |
Enteric redmouth disease |
0 |
| Viruses |
| 63 |
Adenovirus |
Respiratory infection |
0 |
| 64 |
Avian Encephalomyelitis Virus |
Avian Encephalomyelitis |
0 |
| 65 |
Avian Paramyxovirus |
|
0 |
| 66 |
Avian pneumovirus |
Turkey rhinotracheitis, Avian rhinotracheitis, Swollen head syndrome |
0 |
| 67 |
Avian Polyomavirus |
Papovavirus, Budgerigar fledgling disease, Psittacine polyomavirus |
0 |
| 68 |
Avian Reovirus |
Viral Arthritis, Pale Bird Syndrome, Tenosynovitis |
0 |
| 69 |
Bluetongue virus |
Bluetongue disesase |
0 |
| 70 |
Bovine coronavirus |
|
0 |
| 71 |
Bovine herpesvirus 1 |
Infectious bovine rhinotracheitis |
4
|
| 72 |
Bovine Leukemia virus |
|
1
|
| 73 |
Bovine papillomavirus |
Warts |
0 |
| 74 |
Bovine Parainfluenza 3 Virus (BPIV-3) |
|
0 |
| 75 |
Bovine Respiratory Syncytial Virus |
Respiratory Disease |
0 |
| 76 |
Bovine viral diarrhea virus 1 |
Bovine viral Diarrhea (BVD) |
0 |
| 77 |
Canarypox virus |
Canary Pox |
0 |
| 78 |
Canine adenovirus type 1 |
Fox Encephalitis, Infectious Canine Hepatitis |
0 |
| 79 |
Canine Adenovirus Type 2 |
|
0 |
| 80 |
Canine coronavirus |
|
0 |
| 81 |
Canine distemper virus |
Canine distemper |
2
|
| 82 |
Canine parainfluenza virus |
|
0 |
| 83 |
Canine parvovirus |
Canine parvovirus infection |
2
|
| 84 |
Chicken Anemia Virus |
Chicken infectious anemia, Blue wing disease, Anemia dermatitis syndrome, Hemorrhagic aplastic anemi |
0 |
| 85 |
Classical swine fever virus |
Classical swine fever |
3
|
| 86 |
Dengue Virus |
Dengue Fever |
4
|
| 87 |
Duck enteritis virus |
Duck Plague |
0 |
| 88 |
Duck hepatitis virus 1 |
Duck virus hepatitis (DVH) |
0 |
| 89 |
Eastern Equine Encephalitis Virus |
Encephalitis |
0 |
| 90 |
Ebola virus |
Ebola hemorrhagic fever |
13
|
| 91 |
Equid herpesvirus |
Equine Rhinopneumonitis |
0 |
| 92 |
Equine arteritis virus |
Equine arteritis |
0 |
| 93 |
Equine rotavirus |
Rotaviral Diarrhea |
0 |
| 94 |
Feline calicivirus |
Feline Respiratory Infections |
0 |
| 95 |
Feline herpesvirus 1 |
Feline viral rhinotracheitis |
0 |
| 96 |
Feline immunodeficiency virus |
Feline AIDS |
0 |
| 97 |
Feline infectious peritonitis virus |
Feline infectious peritonitis (FIP) |
0 |
| 98 |
Feline leukemia virus |
Feline leukemia virus infection |
2
|
| 99 |
Feline panleukopenia virus |
Feline Distemper |
0 |
| 100 |
Foot-and-mouth disease virus |
Foot-and-mouth disease |
0 |
| 101 |
Fowlpox virus |
Fowlpox |
0 |
| 102 |
Gallid herpesvirus 1 |
Avian infectious laryngotracheitis, Fowl Laryngotracheitis |
0 |
| 103 |
Hantavirus |
Hantavirus Pulmonary Syndrome |
9
|
| 104 |
Hendra virus |
Hendra virus disease |
1
|
| 105 |
Hepatitis A virus |
Hepatitis A |
1
|
| 106 |
Hepatitis B virus |
Hepatitis B |
3
|
| 107 |
Herpes simplex virus type 1 and 2 |
Herpes |
9
|
| 108 |
Human Immunodeficiency Virus |
Acquired Immunodeficiency Syndrome (AIDS) |
5
|
| 109 |
Human metapneumovirus |
Respiratory tract infection |
0 |
| 110 |
Human Papillomavirus |
HPV infection |
4
|
| 111 |
Human Respiratory Syncytial Virus |
Respiratory tract disease |
0 |
| 112 |
Infectious Bronchitis Virus (IBV) |
Infectious Bronchitis |
0 |
| 113 |
Infectious Bursal Disease Virus (IBDV) |
Infectious Bursal Disease |
0 |
| 114 |
Infectious Hematopoietic Necrosis Virus |
Infectious hematopoietic necrosis |
1
|
| 115 |
Infectious salmon anemia virus |
Infectious Salmon Anemia |
0 |
| 116 |
Influenza virus |
Influenza (flu) |
37
|
| 117 |
Japanese encephalitis virus |
Japanese encephalitis |
6
|
| 118 |
Lassa Fever Virus |
Lassa fever |
2
|
| 119 |
Marburg Virus |
Hemorrhagic fever |
6
|
| 120 |
Marek's disease virus |
Marek's disease |
2
|
| 121 |
Measles virus |
Measles |
5
|
| 122 |
Mink enteritis virus |
Mink Enteritis |
0 |
| 123 |
Mumps virus |
Mumps |
1
|
| 124 |
Newcastle disease virus |
Newcastle disease |
2
|
| 125 |
Nipah virus |
Nipah virus disease |
2
|
| 126 |
Orf Virus |
Orf disease, Sore mouth (Ovine Ecthyma) |
0 |
| 127 |
Pigeonpox virus |
Pigeon Pox |
0 |
| 128 |
Poliovirus |
Polio |
1
|
| 129 |
Porcine circovirus 2 |
Postweaning multisystemic wasting syndrome |
1
|
| 130 |
Porcine parvovirus |
SMEDI, reproductive failure |
0 |
| 131 |
Porcine respiratory and reproductive syndrome virus |
Porcine Reproductive and Respiratory Syndrome (PRRS), Blue-Ear Pig Disease |
0 |
| 132 |
Porcine rotavirus |
Diarrhea |
0 |
| 133 |
Pseudorabies virus |
Aujeszky's disease |
8
|
| 134 |
Psittacid herpesvirus 1 |
Pacheco's Parrot Disease |
0 |
| 135 |
Rabies virus |
Rabies |
2
|
| 136 |
Rift Valley Fever virus |
Rift valley fever |
2
|
| 137 |
Rotavirus |
Gastroenteritis |
8
|
| 138 |
Rubella virus |
Rubella |
0 |
| 139 |
SARS-CoV |
Severe Acute Respiratory Syndrome (SARS) |
1
|
| 140 |
Simian Immunodeficiency Virus |
Simian AIDS |
0 |
| 141 |
Tick-borne Encephalitis Virus (TBEV) |
Tick-borne Encephalitis |
1
|
| 142 |
Transmissible gastroenteritis virus |
Porcine transmissible gastroenteritis |
0 |
| 143 |
Turkey hemorrhagic enteritis virus |
Hemorrhagic enteritis |
0 |
| 144 |
Varicella-zoster virus |
chickenpox / shingles |
2
|
| 145 |
Variola virus |
Smallpox |
3
|
| 146 |
VEE Virus |
Venezuelan equine encephalitis |
2
|
| 147 |
West Nile virus |
West Nile fever |
2
|
| 148 |
Western equine encephalomyelitis virus |
Western equine encephalomyelitis (WEE) |
3
|
| 149 |
Yellow fever virus |
Yellow fever |
2
|
| Parasites |
| 150 |
Babesia bovis |
Babesiosis, Texas Cattle Fever |
4
|
| 151 |
Babesia canis |
Piroplasmosis |
0 |
| 152 |
Cryptosporidium parvum |
Cryptosporidiosis |
2
|
| 153 |
Eimeria maxima |
Coccidiosis |
1
|
| 154 |
Eimeria spp. |
Coccidiosis |
0 |
| 155 |
Eimeria tenella |
Hemorrhagic cecal coccidiosis |
5
|
| 156 |
Entamoeba histolytica |
Amoebiasis |
4
|
| 157 |
Giardia duodenalis |
Giardiasis (Beaver fever) |
1
|
| 158 |
Leishmania amazonensis |
Leishmaniasis |
5
|
| 159 |
Leishmania donovani |
Visceral leishmaniasis |
12
|
| 160 |
Leishmania infantum |
Infantile visceral leishmaniasis |
5
|
| 161 |
Leishmania major |
Cutaneous leishmaniasis |
10
|
| 162 |
Neospora caninum |
Neosporosis |
8
|
| 163 |
Plasmodium spp. |
Malaria |
27
|
| 164 |
Sarcocystis neurona |
Equine protozoal myeloencephalitis |
1
|
| 165 |
Theileria annulata |
Theileriosis |
2
|
| 166 |
Theileria parva |
East Coast Fever |
1
|
| 167 |
Toxoplasma gondii |
Toxoplasmosis |
4
|
| 168 |
Trichomonas foetus |
|
0 |
| 169 |
Trypanosoma brucei |
African trypanosomiasis (African Sleeping Sickness) |
2
|
| 170 |
Trypanosoma cruzi |
Chagas disease |
9
|
| Fungi |
| 171 |
Coccidioides spp. |
Coccidioidomycosis (California disease, Desert rheumatism, San Joaquin valley fever, and Valley fev |
9
|
| Other diseases |
| 172 |
Allergy |
Allergy |
15
|
| 173 |
Atherosclerosis |
Atherosclerosis, arteriosclerotic vascular disease (ASVD) |
0 |
| 174 |
Cancer |
Cancer |
36
|
| 175 |
Ricin toxin of Ricinus communis |
Ricin poisoning |
1
|
| Total |
175 |
|
605 |
