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Marek's disease virus

Table of Contents
  1. General Information
    1. NCBI Taxonomy ID
    2. Disease
    3. Introduction
  2. Vaccine Related Pathogen Genes
    1. MDV040 (Protective antigen)
    2. MDV095 (Protective antigen)
  3. Vaccine Information
    1. Bursal Disease-Marek's Disease Serotype 3, Live Marek's Disease Vector Vaccine (USDA: 1A88.R0)
    2. Bursal Disease-Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1288.42)
    3. Bursal Disease-Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1288.4A)
    4. Bursal Disease-Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1A82.50)
    5. Bursal Disease-Marek's Disease Serotypes 1 & 2 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 1281.R0)
    6. Bursal Disease-Marek's Disease Serotypes 1 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 1281.R1)
    7. Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1288.43)
    8. Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1288.44)
    9. Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1288.45)
    10. Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1B82.50)
    11. Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 1A88.R1)
    12. Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 1A88.R2)
    13. Bursal Disease-Marek's Disease Standard & Variant, Serotype 3, Live Virus Vaccine (USDA: 12C8.40)
    14. Bursal Disease-Marek's Disease Standard & Variant, Serotype 3, Live Virus Vaccine (USDA: 12C8.43)
    15. Bursal Disease-Marek's Disease Standard & Variant, Serotypes 2 & 3, Live Virus Vaccine (USDA: 12C8.42)
    16. Bursal Disease-Marek's Disease Standard & Variant, Serotypes 2 & 3, Live Virus Vaccine (USDA: 12C8.44)
    17. Bursal Disease-Marek's Disease Variant Strain, Serotypes 2 & 3, Live Virus Vaccine (USDA: 12C2.52)
    18. Bursal Disease-Marek's Disease Variant, Serotype 3, Live Virus Vaccine (USDA: 1282.50)
    19. Bursal Disease-Marek's Disease Variant, Serotypes 2 & 3, Live Virus Vaccine (USDA: )
    20. Bursal Disease-Marek's Disease Variant, Serotypes 2 & 3, Live Virus Vaccine (USDA: 12C2.50)
    21. Bursal Disease-Marek's Disease Variant, Serotypes 2 & 3, Live Virus Vaccine (USDA: 12C2.51)
    22. Fowl Laryngotracheitis-Marek's Disease Serotype 3, Live Marek's Disease Vector Vaccine (USDA: 16J1.R1)
    23. Fowl Laryngotracheitis-Marek's Disease Serotypes 2 & 3, Modified Live & Live Marek's Disease Vector Vaccine (USDA: 16J1.R2)
    24. Fowl Pox-Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 15E2.00)
    25. Marek's Disease Serotype 1, Live Virus Vaccine (USDA: 16L1.00)
    26. Marek's Disease Serotype 1, Live Virus Vaccine (USDA: 16L1.04)
    27. Marek's Disease Serotype 1, Live Virus Vaccine (USDA: 16L1.09)
    28. Marek's Disease Serotype 2, Live Virus Vaccine (USDA: 1631.00)
    29. Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1641.00)
    30. Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1641.01)
    31. Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1641.06)
    32. Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 16L1.06)
    33. Marek's Disease Serotypes 1 & 2 & 3, Live Virus Vaccine (USDA: 16L1.01)
    34. Marek's Disease Serotypes 1 & 3, Live Herpesvirus Chimera Vaccine (USDA: 1631.R0)
    35. Marek's Disease Serotypes 1 & 3, Live Virus Vaccine (USDA: 16G1.02)
    36. Marek's Disease Serotypes 1 & 3, Live Virus Vaccine (USDA: 16L1.02)
    37. Marek's Disease Serotypes 1 & 3, Live Virus Vaccine (USDA: 16L1.08)
    38. Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1651.00)
    39. Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1651.01)
    40. Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1651.02)
    41. Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1651.05)
    42. Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 16G1.00)
    43. Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 16L1.07)
    44. Marek's Disease Virus Vaccine rFPV/gB1
    45. Marek's Disease Virus Vaccine rFPV/gI
    46. Marek's Disease-Newcastle Disease Serotype 3, Live Marek's Disease Vector Vaccine (USDA: 16N1.R0)
    47. Marek's Disease-Newcastle Disease Serotypes 1 & 2 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 16N1.R2)
    48. Marek's Disease-Newcastle Disease Serotypes 1 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 16N1.R1)
    49. Marek's Disease-Newcastle Disease Serotypes 2 & 3, Live Virus & Live Marek's Disease Vector Vaccine (USDA: 17H1.R1)
    50. Marek's Disease-Newcastle Disease Serotypes 2 & 3, Live Virus & Live Marek's Disease Vector Vaccine (USDA: 17H1.R2)
    51. Marek's Disease-Tenosynovitis Serotypes 2 & 3, Live & Modified Live Virus Vaccine (USDA: 16T1.00)
    52. Marek's Disease-Tenosynovitis Serotypes 2 & 3, Live Virus Vaccine (USDA: 16T1.03)
    53. Vaxxitek HVT+IBD
  4. References
I. General Information
1. NCBI Taxonomy ID:
10390
2. Disease:
Marek's disease
3. Introduction
The causative agent of Marek’s disease. Gallid HV2 (Marek's disease virus)is highly contagious in chickens and induces T cell lymphomas in susceptible birds, causing annual losses to the worldwide poultry industry estimated at US$100 billion (Morrow and Fehler 2004). In the 100 years since Marek’s disease was first described, the disease has substantially increased in severity of symptoms. The first vaccines for gallid HV2 were developed in the late 1960’s and early 1970’s; but new, more virulent strains of the virus have emerged that are resistant to vaccine-induced immune responses (Nair 2005).

The virulence of gallid HV2 is expected to be a polygenic trait, with allelic variants at a number of loci playing a role (Shamblin et al. 2004). Thus, homologous recombination is expected to play an important role in the evolution of virulence, because it can bring together new mutations that originally evolved against different genetic backgrounds. DNA replication in alphaherpesviruses is recombination-dependent, providing a mechanism for homologous recombination between genetically distinct viruses infecting the same cell (Thiry et al. 2004). Sequence analysis has provided evidence of past homologous recombination events in several herpesviruses, including alphaherpesviruses (Bowden et al. 2004; Norberg et al. 2004; Peters et al. 2006) (Hughes and Rivailler, 2007).
1. MDV040
  • Gene Name : MDV040
  • Sequence Strain (Species/Organism) : Gallid herpesvirus 2
  • VO ID : VO_0011164
  • NCBI Gene ID : 4811501
  • NCBI Protein GI : 125745079
  • Locus Tag : MD5V_040
  • Genbank Accession : AY129968
  • Protein Accession : YP_001033956
  • Taxonomy ID : 10390
  • Gene Starting Position : 61024
  • Gene Ending Position : 63651
  • Gene Strand (Orientation) : -
  • Protein Name : glycoprotein BALF4
  • Protein pI : 8.4
  • Protein Weight : 92434.87
  • Protein Length : 865
  • Protein Note : glycoprotein BALF4; the Herpesviridae are non-segmented dsDNA viruses with genomes ranging from 120-230kbp; although herpes viruses vary greatly in sequence identity and homology, they all share four common elements: an envelope, a tegument which is composed of viral enzymes, a capsid of 162 capsomers, and a core composed of genomic DNA; BALF4 is a transmembrane glycoprotein found in the lipid envelope of several herpesviruses
  • DNA Sequence : Show Sequence
    >gi|125745044:61024-63651 Gallid herpesvirus 2, complete genome
    TTTTATTCAGTTCAAATATAATAGTGCCCACTTACACAGCATCATCTTCTGAGTCTGAATATGTAGTAGG
    TAACTTATCATATTTAGGGTTACTATTTTTAATCCTCATTTTTGCCAGGTGGTCCGATAGAACGGCGGTA
    GTGCCTCGCCTCTTTCTCCGCAGTTTTTTCTCGTGGCGTTCTTCCGCGGAGACTAACGCCATATATTTTA
    TCATTTCTCTAGCTTCTTCTAATTTTCTTTCATCAATAGATGTTCGTTCCAAATCATCTGATTCCTCGCC
    ATGCAACTCACGCGTTGCCTGTGCCTTAAGCACTTCTGTTGTCATAGGATAAAGGGCTTTCATTGGATTG
    CTTTTAAGCTTGTTTACATAACGATATGCTAAAAATGCAGCCACGAGTCCTGCTATAATGATTAAACCGA
    TTGCCAAAGCCCCAAAGGGATTTGACATGAAAGCAGAGACACCAGATATGGTAGATACGATTGCACCGGC
    AGCCCCTACTACAACTTTGCCTATAGCTTGCCCTACCTGACCCATACCGTTAAACAATTCGGCCAAACCG
    TTCATAAACGCGTAATTTGTATCCACTTCTATTACTTTGTTTATGTCATAAAATTTAAGTTCATGTAGTT
    GATTGCGGCGAGCTACTTCTGCATAATCCAATACACCAACATCACGCAACTCTTCTTTTGTGTAAACGGA
    TAAAGGCAAAATTTCCCGATCTTCTAGCAGGGTTAGATTAAGCTCGACAAATGTGCTAGCAATCTGTATA
    TCGGCAGCGTCTACCATCTTAACAAAATTATAGTTTTCAAATAAAGCATAACCGGATCCAAACAGAAAAT
    ATCTACGATGATTAGCCGAGCATGGCTCTACAGCCTCTAGCGTTGGAAGCAACTCGTTGTTTTCACCGAG
    TTGTCCCTGTATGTTTCCTTGGTTTTCTCCATATGAAAATAGAACCAATGGTCGGCTATAACATGTATTA
    GTGGATGTGATAACTCGCATAGAATTTTGCAAAGTGACGGATTCCGCATCTATAGCAGTGCAGCTCGATA
    CAGCAGCGACATCCCCCAACATCTTTGCAGCCACTCTCCTTCCTAATGTTGCACTCGCTGTAGCGCTAGG
    ATTAATCTTTATCCCTTCGTGCCATAAAACAAGTTCTCTATTCTGCAATTCGCACCAAGCTGTGGCAATC
    CTACTAAACATATCATTAATATGGGTTTGTATATGATCATAAAGAAATTGGAGCATGGCGAATTGAACAG
    ACGATGTCGATTTAATAGCTGTGGTGTCGTCTAATGTTATTTTTCTATTTGGTGCATTTCGAATATCTCG
    CCGCAATCGTGACAATGAGGTAGCATTTTTCTTATAAATTGCATGCTTATTGTTTACCAGGTCGAGCATC
    TCATCGGTCCTGTTGTCTCTCATCAATTCTCTGAGGTACATATGAGCCAGGGATTTGGATAGAACAGGCT
    GATATGCTACAATAAATCCCCCGAGAGCCAAGAAATATTGTACATGTCCAACCTTGACGTGACTGTCATT
    ATATTTTGTCCTAAATATCTGCTCGATTGCTGCTTCTGCCTCGCGTTTAATACATTGTCCTAATATGATG
    CGATTTGGATCAAACTCAGTCGTATTACTGATAAACGTTGCCGAAAGTTCACGGGCCATAAATCTGTATC
    TCCCATTAACTGTTGCACGCAACATTTCAGTCACCTCTTTCCACTTAGTCATTGAACATACACGAGTAGT
    TTTTGGAGCCCAGTCCCACCCAACTGTGAAGTGTGATGTGATGAGAAAGTTACGCTTGACTGGAAGGCTT
    GCTTTTCGACGCTTGTCCAAATCCATTGAAAAATAGCTATCTAGTTGTTTGAAATTATCCTGGGGATATC
    CCATGGGTTCTGCGGCAGCCTCTGGTGGGGATAGACCATAAAATGGAGATATGTTCGCGATGTCGCCATT
    GGCCATTGCAAAATATGAATACGGAAACACAGAGCGGGCATCCATTTCCTCTACTATACAATTGACGGAG
    GTTCCCGTTCGATATATCCATGGTGATCCCCACACGGTATACGTCTCATTAGTCGTGTGCCATGCCCTAG
    ATTCGGGCGTGTTGAATTTTGATGGTTTTAGAAGTACTTGTTTTTCTCCCGCATCCCTGTCAAACGCTTC
    AACATATACATTGTTTCTAAGGTATCTTGCTTTAGATGAGCATCTTCCTTTGCCGTCGATTAGATCCGTG
    ATCTCTTCAATGGAAACGGGCGTCCTATCTGTATATCGATTAGTGATCTGTCTATATGTCGTCCCCGTCC
    ATGTCGTCGTCTGAATGATATTTTTATAATAAAGCGTCACTTTAAATTTATATGGACTGATATTCTCTTT
    AAATAATATCGCGATTCCTTCACCCCATTCGGTGGCTTTTCTAGGTTCGGGACATTTTCGCGGCGGTTCT
    AGACGGATCACGGTTGAACCCACTGGTGGGGGACAAAGATAAAACGTAGACTCTTCCTCAGACAACTGGA
    CGCTCGAAACAACTTCTCTTGATGTCACATTTTGGGTACTCGGAGATGAGTTCGTACCATATAGAATAAC
    TATAAGGAAAAAAATGCAATTCCGCCTAAAATAGTGCA
  • Protein Sequence : Show Sequence
    >gi|125745079|ref|YP_001033956.1| envelope glycoprotein B [Gallid herpesvirus 2]
    MHYFRRNCIFFLIVILYGTNSSPSTQNVTSREVVSSVQLSEEESTFYLCPPPVGSTVIRLEPPRKCPEPR
    KATEWGEGIAILFKENISPYKFKVTLYYKNIIQTTTWTGTTYRQITNRYTDRTPVSIEEITDLIDGKGRC
    SSKARYLRNNVYVEAFDRDAGEKQVLLKPSKFNTPESRAWHTTNETYTVWGSPWIYRTGTSVNCIVEEMD
    ARSVFPYSYFAMANGDIANISPFYGLSPPEAAAEPMGYPQDNFKQLDSYFSMDLDKRRKASLPVKRNFLI
    TSHFTVGWDWAPKTTRVCSMTKWKEVTEMLRATVNGRYRFMARELSATFISNTTEFDPNRIILGQCIKRE
    AEAAIEQIFRTKYNDSHVKVGHVQYFLALGGFIVAYQPVLSKSLAHMYLRELMRDNRTDEMLDLVNNKHA
    IYKKNATSLSRLRRDIRNAPNRKITLDDTTAIKSTSSVQFAMLQFLYDHIQTHINDMFSRIATAWCELQN
    RELVLWHEGIKINPSATASATLGRRVAAKMLGDVAAVSSCTAIDAESVTLQNSMRVITSTNTCYSRPLVL
    FSYGENQGNIQGQLGENNELLPTLEAVEPCSANHRRYFLFGSGYALFENYNFVKMVDAADIQIASTFVEL
    NLTLLEDREILPLSVYTKEELRDVGVLDYAEVARRNQLHELKFYDINKVIEVDTNYAFMNGLAELFNGMG
    QVGQAIGKVVVGAAGAIVSTISGVSAFMSNPFGALAIGLIIIAGLVAAFLAYRYVNKLKSNPMKALYPMT
    TEVLKAQATRELHGEESDDLERTSIDERKLEEAREMIKYMALVSAEERHEKKLRRKRRGTTAVLSDHLAK
    MRIKNSNPKYDKLPTTYSDSEDDAV
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Recombinant fowl poxviruses (rFPVs) were constructed to express genes from serotype 1 Marek's disease virus (MDV, Gallid herpesvirus 2). rFPV/gB1 expressing MDV040 conferred 42% protection in maternal antibody-positive chickens when challenged with highly virulent MDV isolates (Lee et al., 2003).
  • Related Vaccine(s): Marek's Disease Virus Vaccine rFPV/gB1
2. MDV095
  • Gene Name : MDV095
  • Sequence Strain (Species/Organism) : Gallid herpesvirus 2
  • VO ID : VO_0011165
  • NCBI Gene ID : 4811454
  • NCBI Protein GI : 125745128
  • Locus Tag : MD5V_095
  • Genbank Accession : AF243438
  • Protein Accession : YP_001034012
  • Taxonomy ID : 10390
  • Gene Starting Position : 161182
  • Gene Ending Position : 164094
  • Gene Strand (Orientation) : +
  • Protein Name : envelope glycoprotein I
  • Protein pI : 6.7
  • Protein Weight : 37988.3
  • Protein Length : 355
  • Protein Note : envelope glycoprotein I; the Herpesviridae are non-segmented dsDNA viruses with genomes ranging from 120-230kbp; although herpes viruses vary greatly in sequence identity and homology, they all share four common elements: an envelope, a tegument which is composed of viral enzymes, a capsid of 162 capsomers, and a core composed of genomic DNA;virion envelope glycoproteins bind to cellular receptors; envelope glycoprotein E and glycoprotein I form a heterodimer that play important roles in virus cell-to-cell spread
  • DNA Sequence : Show Sequence
    >gi|125745044:161182-164094 Gallid herpesvirus 2, complete genome
    GATGTATCTACTACAATTATTATTTTGGATCCGCCTCTTTCGAGGCATCTGGTCTATAGTTTATACTGGA
    ACATCTGTTACGTTATCAACGGACCAATCTGCTCTTGTTGCGTTCTGCGGATTAGATAAAATGGTGAATG
    TACGCGGCCAACTTTTATTCCTGGGCGACCAGACTCGGACCAGTTCTTATACAGGAACGACGGAAATCTT
    GAAATGGGATGAAGAATATAAATGCTATTCCGTTCTACATGCGACATCATATATGGATTGTCCTGCTATA
    GACGCCACGGTATTCAGAGGCTGTAGAGACGCTGTGGTATATGCTCAACCTCATGATAGAGTACAACCTT
    TTCCCGAAAAGGGAACATTGTTGAGAATTGTCGAACCCAGAGTATCAGATACAGGCAGCTATTACATACG
    TGTAGCTCTCGCTGGAAGAAATATGAGCGATATATTTAGAATGGCTGTTATTATAAGGAGTAGCAAATCT
    TGGGCCTGTAATCACTCTGCTAGTTCATTTCAGGCCCATAAATGTATTCGCTATGTCGACCGTATGGCCT
    TTGAAAATTATCTGATTGGACATGTAGGCAATTTGCTGGACAGTGACTCGGAATTGCATGCAATTTATAA
    TATTACTCCCCAATCCATTTCCACAGATATTAATATTATAACGACTCCATTTTACGATAATTCGGGAACA
    ATTTATTCACCTACGGTTTTTAATTTGTTTAATAACAATTCCCATGTCGATGCAATGAATTCGACTGGTA
    TGTGGAATACCGTTTTAAAATATACCCTTCCAAGGCTTATTTACTTTTCTACGATGATTGTACTATGTAT
    AATAGCATTGGCAATTTATTTGGTCTGTGAAAGGTGCCGCTCTCCCCATCGTAGGATATACATCGGTGAA
    CCAAGATCTGATGAGGCCCCACTCATCACTTCTGCAGTTAACGAATCATTTCAATATGATTATAATGTAA
    AGGAAACTCCTTCAGATGTTATTGAAAAGGAGTTGATGGAAAAACTGAAGAAGAAAGTCGAATTGTTGGA
    AAGAGAAGAATGTGTATAGGTTTGAGAAACTATTATAGGTAGGTGGTACCTGTTAGCTTAGTATAAGGGG
    AGGAGCCGTTTCTTGTTTTAAAGACACGAACACAAGGCAGTAAGTTTTATATGTGAATTTTGTGCATGTC
    TGCGAGTCAGCGTCATAATGTGTGTTTTCCAAATCCTGATAATAGTGACGACGATCAAAGTAGCTGGAAC
    GGCCAACATAAATCATATAGACGTTCCTGCAGGACATTCTGCTACAACGACGATCCCGCGATATCCACCA
    GTTGTCGATGGGACCCTTTACACCGAGACGTGGACATGGATTCCCAATCACTGCAACGAAACGGCAACAG
    GCTATGTATGTCTGGAAAGTGCTCACTGTTTTACCGATTTGATATTAGGAGTATCCTGCATGAGGTATGC
    GGATGAAATCGTCTTACGAACTGATAAATTTATTGTCGATGCGGGATCCATTAAACAAATAGAATCGCTA
    AGTCTGAATGGAGTTCCGAATATATTCCTATCTACGAAAGCAAGTAACAAGTTGGAGATACTAAATGCTA
    GCCTACAAAATGCGGGTATCTACATTCGGTATTCTAGAAATGGGACGAGGACTGCAAAGCTGGATGTTGT
    TGTGGTTGGCGTTTTGGGTCAAGCAAGGGATCGCCTACCCCAAATGTCCAGTCCTATGATCTCATCCCAC
    GCCGATATCAAGTTGTCATTAAAAAACTTTAAAGCATTAGTATATCACGTGGGAGATACTATCAATGTCT
    CGACGGCGGTTATACTAGGACCTTCTCCGGAGATATTCACATTGGAATTTAGGGTGTTGTTCCTCCGTTA
    TAATCCAACGTGCAAGTTCGTCACGATTTATGAACCTTGTATATTTCACCCCAAAGAACCAGAGTGTATT
    ACTACTGCAGAACAATCGGTATGTCATTTCGCATCCAACATTGACATTCTGCAGATAGCCGCCGCACGTT
    CTGAAAATTGTAGCACAGGGTATCGTAGATGTATTTATGACACGGCTATCGATGAATCTGTGCAGGCCAG
    ATTAACATTCATAGAACCAGGAATTCCTTCCTTTAAAATGAAAGATGTCCAGGTAGACGATGCTGGATTG
    TATGTGGTTGTGGCTTTATACAATGGACGTCCAAGTGCATGGACTTACATTTATTTGTCAACGGTGGAAA
    CATATCTTAATGTATATGAAAACTACCACAAGCCGGGATTTGGGTATAAATCATTTCTACAGAACAGTAG
    TATCGTCGACGAAAATGAGGCTAGCGATTGGTCCAGCTCGTCCATTAAACGGAGAAATAATGGTACTATC
    ATTTATGATATTTTACTCACATCGCTATCAATTGGGGCGATTATTATCGTCATAGTAGGGGGTGTTTGTA
    TTGCCATATTAATTAGGCGTAGGAGACGACGTCGCACGAGGGGGTTATTCGATGAATATCCCAAATATAT
    GACGCTACCAGGAAACGATCTGGGGGGCATGAATGTACCGTATGATAATACATGCTCTGGTAACCAAGTT
    GAATATTATCAAGAAAAGTCGGCTAAAATGAAAAGAATGGGTTCGGGTTATACCGCTTGGCTAAAAAATG
    ATATGCCGAAAATTAGGAAACGCTTAGATTTATACCACTGATATGTACATATTTAAACTTAATGGGATAT
    AGTATATGGACGTCTATATGACGAGAGTAAATAAACTGACACTGCAAATGAAGCTGATCTATATTGTGCT
    TTATATTGGGACAAACCACTCGCACAAGCTCATTCAACACATCCACTCTTGCTATTAAATTCCCCATTAT
    ATAACAATACTGACATAACACTCATATTAAGGGGAGAAAATAA
  • Protein Sequence : Show Sequence
    >gi|125745128|ref|YP_001034012.1| envelope glycoprotein I [Gallid herpesvirus 2]
    MYLLQLLFWIRLFRGIWSIVYTGTSVTLSTDQSALVAFCGLDKMVNVRGQLLFLGDQTRTSSYTGTTEIL
    KWDEEYKCYSVLHATSYMDCPAIDATVFRGCRDAVVYAQPHDRVQPFPEKGTLLRIVEPRVSDTGSYYIR
    VALAGRNMSDIFRMAVIIRSSKSWACNHSASSFQAHKCIRYVDRMAFENYLIGHVGNLLDSDSELHAIYN
    ITPQSISTDINIITTPFYDNSGTIYSPTVFNLFNNNSHVDAMNSTGMWNTVLKYTLPRLIYFSTMIVLCI
    IALAIYLVCERCRSPHRRIYIGEPRSDEAPLITSAVNESFQYDYNVKETPSDVIEKELMEKLKKKVELLE
    REECV
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Recombinant fowl poxviruses (rFPVs) were constructed to express genes from serotype 1 Marek's disease virus (MDV, Gallid herpesvirus 2). rFPV/gI expressing MDV095 conferred 43% protection in maternal antibody-positive chickens when challenged with highly virulent MDV isolates (Lee et al., 2003).
  • Related Vaccine(s): Marek's Disease Virus Vaccine rFPV/gI
III. Vaccine Information
1. Bursal Disease-Marek's Disease Serotype 3, Live Marek's Disease Vector Vaccine (USDA: 1A88.R0)
a. Manufacturer:
Merial, Inc., Biomune Company
b. Vaccine Ontology ID:
VO_0002197
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
2. Bursal Disease-Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1288.42)
a. Manufacturer:
Merial, Inc.
b. Vaccine Ontology ID:
VO_0002043
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
3. Bursal Disease-Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1288.4A)
a. Manufacturer:
Merial, Inc.
b. Vaccine Ontology ID:
VO_0002047
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
4. Bursal Disease-Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1A82.50)
a. Manufacturer:
Wyeth
b. Vaccine Ontology ID:
VO_0002196
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
5. Bursal Disease-Marek's Disease Serotypes 1 & 2 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 1281.R0)
a. Manufacturer:
Biomune Company
b. Vaccine Ontology ID:
VO_0002040
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
6. Bursal Disease-Marek's Disease Serotypes 1 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 1281.R1)
a. Manufacturer:
Biomune Company
b. Vaccine Ontology ID:
VO_0002041
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
7. Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1288.43)
a. Manufacturer:
Merial, Inc.
b. Vaccine Ontology ID:
VO_0002044
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
8. Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1288.44)
a. Manufacturer:
Merial, Inc.
b. Vaccine Ontology ID:
VO_0002045
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
9. Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1288.45)
a. Manufacturer:
Merial, Inc.
b. Vaccine Ontology ID:
VO_0002046
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
10. Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1B82.50)
a. Manufacturer:
Wyeth
b. Vaccine Ontology ID:
VO_0002200
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
11. Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 1A88.R1)
a. Manufacturer:
Biomune Company
b. Vaccine Ontology ID:
VO_0002198
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
12. Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 1A88.R2)
a. Manufacturer:
Merial, Inc.
b. Vaccine Ontology ID:
VO_0002199
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
13. Bursal Disease-Marek's Disease Standard & Variant, Serotype 3, Live Virus Vaccine (USDA: 12C8.40)
a. Manufacturer:
Merial, Inc.
b. Vaccine Ontology ID:
VO_0002051
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
14. Bursal Disease-Marek's Disease Standard & Variant, Serotype 3, Live Virus Vaccine (USDA: 12C8.43)
a. Manufacturer:
Merial, Inc.
b. Vaccine Ontology ID:
VO_0002053
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
15. Bursal Disease-Marek's Disease Standard & Variant, Serotypes 2 & 3, Live Virus Vaccine (USDA: 12C8.42)
a. Manufacturer:
Merial, Inc.
b. Vaccine Ontology ID:
VO_0002052
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
16. Bursal Disease-Marek's Disease Standard & Variant, Serotypes 2 & 3, Live Virus Vaccine (USDA: 12C8.44)
a. Manufacturer:
Merial, Inc.
b. Vaccine Ontology ID:
VO_0002054
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
17. Bursal Disease-Marek's Disease Variant Strain, Serotypes 2 & 3, Live Virus Vaccine (USDA: 12C2.52)
a. Manufacturer:
Intervet Inc.
b. Vaccine Ontology ID:
VO_0002050
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
18. Bursal Disease-Marek's Disease Variant, Serotype 3, Live Virus Vaccine (USDA: 1282.50)
a. Manufacturer:
Intervet Inc.
b. Vaccine Ontology ID:
VO_0002042
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
19. Bursal Disease-Marek's Disease Variant, Serotypes 2 & 3, Live Virus Vaccine (USDA: )
a. Manufacturer:
Intervet Inc.
b. Vaccine Ontology ID:
VO_0002031
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
20. Bursal Disease-Marek's Disease Variant, Serotypes 2 & 3, Live Virus Vaccine (USDA: 12C2.50)
a. Manufacturer:
Intervet Inc.
b. Vaccine Ontology ID:
VO_0002048
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
21. Bursal Disease-Marek's Disease Variant, Serotypes 2 & 3, Live Virus Vaccine (USDA: 12C2.51)
a. Manufacturer:
Intervet Inc.
b. Vaccine Ontology ID:
VO_0002049
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
22. Fowl Laryngotracheitis-Marek's Disease Serotype 3, Live Marek's Disease Vector Vaccine (USDA: 16J1.R1)
a. Manufacturer:
Intervet Inc.
b. Vaccine Ontology ID:
VO_0002141
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
23. Fowl Laryngotracheitis-Marek's Disease Serotypes 2 & 3, Modified Live & Live Marek's Disease Vector Vaccine (USDA: 16J1.R2)
a. Manufacturer:
Intervet Inc.
b. Vaccine Ontology ID:
VO_0002142
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
24. Fowl Pox-Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 15E2.00)
a. Manufacturer:
Merial, Inc.
b. Vaccine Ontology ID:
VO_0002140
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
25. Marek's Disease Serotype 1, Live Virus Vaccine (USDA: 16L1.00)
a. Manufacturer:
Intervet Inc., Merial, Inc., Biomune Company
b. Vaccine Ontology ID:
VO_0001683
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
26. Marek's Disease Serotype 1, Live Virus Vaccine (USDA: 16L1.04)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001684
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
27. Marek's Disease Serotype 1, Live Virus Vaccine (USDA: 16L1.09)
a. Manufacturer:
Intervet Inc.
b. Vaccine Ontology ID:
VO_0001685
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
28. Marek's Disease Serotype 2, Live Virus Vaccine (USDA: 1631.00)
a. Manufacturer:
Intervet Inc., Merial, Inc., Biomune Company
b. Vaccine Ontology ID:
VO_0001686
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
29. Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1641.00)
a. Manufacturer:
Wyeth, Intervet Inc., Merial, Inc.
b. Vaccine Ontology ID:
VO_0001687
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
30. Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1641.01)
a. Manufacturer:
Wyeth, Merial, Inc.
b. Vaccine Ontology ID:
VO_0001688
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
31. Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1641.06)
a. Manufacturer:
Intervet Inc.
b. Vaccine Ontology ID:
VO_0001689
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
32. Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 16L1.06)
a. Manufacturer:
Biomune Company
b. Vaccine Ontology ID:
VO_0001690
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
33. Marek's Disease Serotypes 1 & 2 & 3, Live Virus Vaccine (USDA: 16L1.01)
a. Manufacturer:
Intervet Inc., Biomune Company
b. Vaccine Ontology ID:
VO_0001691
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
34. Marek's Disease Serotypes 1 & 3, Live Herpesvirus Chimera Vaccine (USDA: 1631.R0)
a. Manufacturer:
Intervet Inc.
b. Vaccine Ontology ID:
VO_0001692
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
35. Marek's Disease Serotypes 1 & 3, Live Virus Vaccine (USDA: 16G1.02)
a. Manufacturer:
Wyeth
b. Vaccine Ontology ID:
VO_0001693
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
36. Marek's Disease Serotypes 1 & 3, Live Virus Vaccine (USDA: 16L1.02)
a. Manufacturer:
Intervet Inc., Merial, Inc., Biomune Company
b. Vaccine Ontology ID:
VO_0001694
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
37. Marek's Disease Serotypes 1 & 3, Live Virus Vaccine (USDA: 16L1.08)
a. Manufacturer:
Intervet Inc.
b. Vaccine Ontology ID:
VO_0001695
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
38. Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1651.00)
a. Manufacturer:
Intervet Inc., Merial, Inc.
b. Vaccine Ontology ID:
VO_0001696
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
39. Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1651.01)
a. Manufacturer:
Intervet Inc., Merial, Inc.
b. Vaccine Ontology ID:
VO_0001697
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
40. Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1651.02)
a. Manufacturer:
Intervet Inc.
b. Vaccine Ontology ID:
VO_0001698
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
41. Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1651.05)
a. Manufacturer:
Intervet Inc.
b. Vaccine Ontology ID:
VO_0001699
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
42. Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 16G1.00)
a. Manufacturer:
Wyeth
b. Vaccine Ontology ID:
VO_0001700
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
43. Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 16L1.07)
a. Manufacturer:
Biomune Company
b. Vaccine Ontology ID:
VO_0001701
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
44. Marek's Disease Virus Vaccine rFPV/gB1
a. Vaccine Ontology ID:
VO_0011393
b. Type:
Recombinant vector vaccine
c. Status:
Research
d. Gene Engineering of MDV040
  • Type: Recombinant vector construction
  • Description:
  • Detailed Gene Information: Click here.
e. Vector:
Recombinant fowl poxviruses (rFPVs) were constructed to express genes from serotype 1 Marek's disease virus (MDV) coding for glycoprotein B1 (gB1) (Lee et al., 2003).
f. Immunization Route
wing web (ww) and intra-abdominal (i.a.) routes
g. Chicken Response
  • Vaccination Protocol: Groups of 17 chickens were vaccinated at 1 day of age with variable dosage from 101 to 106 plaque-forming units (PFU) of rFPV vaccines by both the wing web (ww) and intra-abdominal (i.a.) routes in trial 1. Monovalent vaccines of either SB-1 or HVT were administered to chickens by the i.a. route at a dose of 2000 PFU. For rFPV + MDV vaccines, each component was administered by a separate inoculation. The ab+ chickens were used in all the experiments (Lee et al., 2003).
  • Challenge Protocol: At 6 days posthatch, groups of vaccinated and unvaccinated chickens were challenged by i.a. inoculation of 500 PFU of strain Md5. Mortality during the course of the experiment was recorded, and chickens were examined for gross MD lesions (Lee et al., 2003).
  • Efficacy: rFPV/gB1 expressing MDV040 conferred 42% protection in maternal antibody-positive chickens when challenged with highly virulent MDV isolates (Lee et al., 2003).
45. Marek's Disease Virus Vaccine rFPV/gI
a. Vaccine Ontology ID:
VO_0011392
b. Type:
Recombinant vector vaccine
c. Status:
Research
d. Gene Engineering of MDV095
  • Type: Recombinant vector construction
  • Description:
  • Detailed Gene Information: Click here.
e. Vector:
Recombinant fowl poxviruses (rFPVs) were constructed to express genes from serotype 1 Marek's disease virus (MDV) coding for glycoprotein I (gI).
f. Immunization Route
wing web (ww) and intra-abdominal (i.a.) routes
g. Chicken Response
  • Vaccination Protocol: Groups of 17 chickens were vaccinated at 1 day of age with variable dosage from 101 to 106 plaque-forming units (PFU) of rFPV vaccines by both the wing web (ww) and intra-abdominal (i.a.) routes in trial 1. Monovalent vaccines of either SB-1 or HVT were administered to chickens by the i.a. route at a dose of 2000 PFU. For rFPV + MDV vaccines, each component was administered by a separate inoculation. The ab+ chickens were used in all the experiments (Lee et al., 2003).
  • Challenge Protocol: At 6 days posthatch, groups of vaccinated and unvaccinated chickens were challenged by i.a. inoculation of 500 PFU of strain Md5. Mortality during the course of the experiment was recorded, and chickens were examined for gross MD lesions (Lee et al., 2003).
  • Efficacy: rFPV/gI expressing MDV095 conferred 43% protection in maternal antibody-positive chickens when challenged with highly virulent MDV isolates (Lee et al., 2003).
46. Marek's Disease-Newcastle Disease Serotype 3, Live Marek's Disease Vector Vaccine (USDA: 16N1.R0)
a. Manufacturer:
Intervet Inc., Biomune Company
b. Vaccine Ontology ID:
VO_0002143
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
47. Marek's Disease-Newcastle Disease Serotypes 1 & 2 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 16N1.R2)
a. Manufacturer:
Biomune Company
b. Vaccine Ontology ID:
VO_0002145
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
48. Marek's Disease-Newcastle Disease Serotypes 1 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 16N1.R1)
a. Manufacturer:
Biomune Company
b. Vaccine Ontology ID:
VO_0002144
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
49. Marek's Disease-Newcastle Disease Serotypes 2 & 3, Live Virus & Live Marek's Disease Vector Vaccine (USDA: 17H1.R1)
a. Manufacturer:
Biomune Company
b. Vaccine Ontology ID:
VO_0002182
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
50. Marek's Disease-Newcastle Disease Serotypes 2 & 3, Live Virus & Live Marek's Disease Vector Vaccine (USDA: 17H1.R2)
a. Manufacturer:
Intervet Inc.
b. Vaccine Ontology ID:
VO_0002183
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
51. Marek's Disease-Tenosynovitis Serotypes 2 & 3, Live & Modified Live Virus Vaccine (USDA: 16T1.00)
a. Manufacturer:
Merial, Inc.
b. Vaccine Ontology ID:
VO_0002146
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
52. Marek's Disease-Tenosynovitis Serotypes 2 & 3, Live Virus Vaccine (USDA: 16T1.03)
a. Manufacturer:
Intervet Inc.
b. Vaccine Ontology ID:
VO_0002147
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Chicken
53. Vaxxitek HVT+IBD
a. Tradename:
Vaxxitek HVT+IBD
b. Manufacturer:
Merial
c. Vaccine Ontology ID:
VO_0011473
d. Type:
Live, attenuated vaccine
e. Status:
Licensed
f. Host Species for Licensed Use:
Pig
g. Immunization Route
Intramuscular injection (i.m.)
h. Description
Live recombinant chimera virus expressing VP2 gene of IBD on HTV virus(Darteil et al., 1995)
IV. References
1. Darteil et al., 1995: Darteil R, Bublot M, Laplace E, Bouquet JF, Audonnet JC, Rivière M. Herpesvirus of turkey recombinant viruses expressing infectious bursal disease virus (IBDV) VP2 immunogen induce protection against an IBDV virulent challenge in chickens. Virology. 1995; 211(2); 481-490. [PubMed: 7645252].
2. Hughes and Rivailler, 2007: Hughes AL, Rivailler P. Phylogeny and recombination history of gallid herpesvirus 2 (Marek's disease virus) genomes. Virus research. 2007; 130(1-2); 28-33. [PubMed: 17566585].
3. Lee et al., 2003: Lee LE, Witter RL, Reddy SM, Wu P, Yanagida N, Yoshida S. Protection and synergism by recombinant fowl pox vaccines expressing multiple genes from Marek's disease virus. Avian diseases. 2003; 47(3); 549-558. [PubMed: 14562881].