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Bovine herpesvirus 1

Table of Contents
  1. General Information
    1. NCBI Taxonomy ID
    2. Disease
    3. Introduction
  2. Vaccine Related Pathogen Genes
    1. G from BRSV (Protective antigen)
    2. gB (Protective antigen)
    3. gIV (Protective antigen)
    4. UL44 (Protective antigen)
    5. UL49 (Protective antigen)
    6. US6 (Protective antigen)
    7. US7 (Protective antigen)
    8. UL23 (Virmugen)
    9. US8 (Virmugen, Virmugen)
  3. Vaccine Information
    1. BHV1 gD subunit vaccine
    2. Bovilis IBR Marker
    3. Bovine herpesvirus 1 DNA vaccine AdCMVgC
    4. Bovine herpesvirus 1 DNA vaccine AdCMVgD
    5. Bovine herpesvirus 1 DNA vaccine pMASIAtgB encoding a truncated, secreted form of gB
    6. Bovine herpesvirus 1 DNA vaccine pRSV-gC
    7. Bovine herpesvirus 1 DNA vaccine pRSVgIV
    8. Bovine herpesvirus 1 DNA vaccine tgD-VP22
    9. Bovine herpesvirus 1 GPI protein vaccine
    10. Bovine herpesvirus 1 recombinant vector vaccine BHVl/BRSVG
    11. Bovine herpesvirus 1 recombinant vector vaccine rLaSota/gDF encoding gD
    12. Bovine herpesvirus 1 recombinant vector vaccine rLaSota/gDFL encoding gD
    13. Bovine herpesvirus 1 UL23 mutant vaccine
    14. Bovine herpesvirus 1 US8 (gE) mutant vaccine
    15. Bovine Rhinotracheitis Killed Virus Vaccine (USDA: 1105.20)
    16. Bovine Rhinotracheitis Killed Virus Vaccine-Haemophilus Somnus-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 45H5.20)
    17. Bovine Rhinotracheitis Killed Virus Vaccine-Haemophilus Somnus-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 45H5.21)
    18. Bovine Rhinotracheitis Killed Virus Vaccine-Haemophilus Somnus-Mannheimia Haemolytica-Pasteurella Multocida-Salmonella Typhimurium Bacterin-Toxoid (USDA: 4109.20)
    19. Bovine Rhinotracheitis Modified Live Virus Vaccine (USDA: 1101.00)
    20. Bovine Rhinotracheitis Modified Live Virus Vaccine (USDA: 1101.20)
    21. Bovine Rhinotracheitis Modified Live Virus Vaccine (USDA: 1101.21)
    22. Bovine Rhinotracheitis Modified Live Virus Vaccine (USDA: 1101.22)
    23. Bovine Rhinotracheitis Modified Live Virus Vaccine (USDA: 1101.B0)
    24. Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4019.00)
    25. Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin (USDA: 4059.00)
    26. Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Hardjo-Pomona Bacterin (USDA: 4069.20)
    27. Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4089.00)
    28. Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4089.20)
    29. Bovine Rhinotracheitis-Parainfluenza 3 Killed Virus Vaccine-Mannheimia Haemolytica-Pasteurella Multocida Bacterin (USDA: 4265.00)
    30. Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1121.00)
    31. Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1121.20)
    32. Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1121.21)
    33. Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1121.24)
    34. Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1121.31)
    35. Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine-Haemophilus Somnus Bacterin (USDA: 4139.20)
    36. Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4129.00)
    37. Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin (USDA: 4179.00)
    38. Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4209.00)
    39. Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.00)
    40. Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.20)
    41. Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.21)
    42. Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.22)
    43. Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.23)
    44. Bovine Rhinotracheitis-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 11B5.20)
    45. Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine (USDA: 1155.20)
    46. Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine (USDA: 1155.30)
    47. Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4145.20)
    48. Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4145.21)
    49. Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Haemophilus Somnus-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 43S5.20)
    50. Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Haemophilus Somnus-Mannheimia Haemolytica-Pasteurella Multocida-Salmonella Typhimurium Bacterin-Toxoid (USDA: 43T5.20)
    51. Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4335.20)
    52. Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4336.30)
    53. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine (USDA: 1151.00)
    54. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine (USDA: 1151.20)
    55. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine (USDA: 1151.22)
    56. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine (USDA: 1151.23)
    57. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine (USDA: 1151.26)
    58. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4141.20)
    59. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4339.00)
    60. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin (USDA: 4359.00)
    61. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Hardjo-Pomona Bacterin (USDA: 4399.20)
    62. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4389.00)
    63. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4389.20)
    64. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4389.21)
    65. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Killed Virus Vaccine (USDA: 1175.20)
    66. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4435.20)
    67. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.00)
    68. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.20)
    69. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.22)
    70. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.24)
    71. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.25)
    72. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.26)
    73. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.27)
    74. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.30)
    75. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4560.24)
    76. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4560.25)
    77. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Haemophilus Somnus-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4489.30)
    78. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4439.00)
    79. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4439.20)
    80. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin (USDA: 4479.00)
    81. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4509.00)
    82. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Mannheimia Haemolytica Bacterin (USDA: 44A5.20)
    83. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.00)
    84. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.20)
    85. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.21)
    86. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.22)
    87. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.23)
    88. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.24)
    89. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.25)
    90. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.26)
    91. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.28)
    92. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.30)
    93. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1185.20)
    94. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1185.22)
    95. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44M5.20)
    96. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44M5.22)
    97. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B5.20)
    98. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B6.20)
    99. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B6.21)
    100. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus Somnus Bacterin (USDA: 44C5.20)
    101. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus Somnus Bacterin (USDA: 44C7.20)
    102. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus Somnus Bacterin (USDA: 44D5.20)
    103. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D7.20)
    104. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D7.22)
    105. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus Somnus-Mannheimia Haemolytica Bacterin (USDA: 4477.20)
    106. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4465.20)
    107. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4465.21)
    108. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4465.22)
    109. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4466.20)
    110. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4466.21)
    111. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona-Mannheimia Haemolytica Bacterin (USDA: 4475.20)
    112. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.20)
    113. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.21)
    114. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.22)
    115. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.25)
    116. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1189.00)
    117. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1189.21)
    118. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1189.30)
    119. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B9.21)
    120. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B9.22)
    121. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Haemophilus Somnus Bacterin (USDA: 44F9.20)
    122. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.20)
    123. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.22)
    124. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.25)
    125. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.30)
    126. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.20)
    127. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.22)
    128. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.23)
    129. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.25)
    130. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus Bacterin (USDA: 44C9.20)
    131. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus Bacterin (USDA: 44C9.21)
    132. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus Bacterin (USDA: 44C9.23)
    133. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus Bacterin (USDA: 44C9.24)
    134. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D9.20)
    135. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D9.21)
    136. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D9.23)
    137. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D9.24)
    138. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4461.20)
    139. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4461.21)
    140. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4461.22)
    141. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4461.25)
    142. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.00)
    143. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.01)
    144. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.23)
    145. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.24)
    146. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.26)
    147. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Hardjo Bacterin (USDA: 4L49.20)
    148. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Mannheimia Haemolytica Toxoid (USDA: 4X49.20)
    149. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Mannheimia Haemolytica Toxoid (USDA: 4X49.21)
    150. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 45B9.20)
    151. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 45B9.21)
    152. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus-Mannheimia Haemolytica-Pasteurella Multocida Modified Live Virus, Avirulent Live Culture Vaccine (USDA: 11A8.22)
    153. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 11A5.20)
    154. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 11A1.20)
    155. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 11A1.26)
    156. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 11A1.30)
    157. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.20)
    158. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.26)
    159. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.30)
  4. References
I. General Information
1. NCBI Taxonomy ID:
10320
2. Disease:
Infectious bovine rhinotracheitis
3. Introduction
Bovine herpesvirus 1 (BHV-1) is a virus of the family Herpesviridae that causes several diseases worldwide in cattle, including rhinotracheitis, vaginitis, balanoposthitis, abortion, conjunctivitis, and enteritis. BHV-1 is also a contributing factor in shipping fever. It is spread through sexual contact, artificial insemination, and aerosol transmission. Like other herpesviruses, BHV-1 causes a lifelong latent infection and shedding of the virus. The sciatic nerve and trigeminal nerve are the sites of latency. There is a vaccine available which reduces the severity and incidence of disease.

The respiratory disease caused by BHV-1 is commonly known as infectious bovine rhinotracheitis. Symptoms include fever, discharge from the nose, cough, difficulty breathing, and loss of appetite. Ulcers commonly occur in the mouth and nose. Mortality may reach 10%. The genital disease causes infectious pustular vulvovaginitis in cows and infectious balanoposthitis in bulls. Symptoms include fever, depressios, loss of appetite, painful urination, a swollen vulva with pustules and discharge in cows, and pain on sexual contact in bulls. In both cases lesions usually resolve within two weeks. Abortion and stillbirths can occur one to three months postinfection. BHV-1 also causes a generalized disease in newborn calves, characterized by enteritis and death (Wiki: Bovine herpesvirus 1).
1. G from BRSV
  • Gene Name : G from BRSV
  • Sequence Strain (Species/Organism) : Bovine respiratory syncytial virus
  • NCBI Gene ID : 1489813
  • NCBI Protein GI : 9631274
  • Locus Tag : BovRSVgp07
  • Genbank Accession : AF092942
  • Protein Accession : NP_048054
  • Taxonomy ID : 11246
  • Gene Starting Position : 4689
  • Gene Ending Position : 5528
  • Gene Strand (Orientation) : +
  • Protein Name : mRNA
  • Protein pI : 10.63
  • Protein Weight : 27981.73
  • Protein Length : 257
  • DNA Sequence : Show Sequence
    >gi|9631267:4689-5528 Bovine respiratory syncytial virus, complete genome
    TGGGGCAAATACAAGTATGTCCAACCATACCCACCATCTTAAATTCAAGACATTAAAGAGGGCTTGGAAA
    GCCTCAAAATACTTCATAGTAGGATTATCATGTTTATATAAGTTCAATTTAAAATCCCTTGTCCAAACGG
    CTTTGACCACCTTAGCAATGATAACCTTGACATCACTCGTCATAACAGCCATTATTTACATTAGTGTGGG
    AAATGCTAAAGCCAAGCCCACATCCAAACCAACCATCCAACAAACACAACAGCCCCAAAACCATACCTCA
    CCATTTTTCACAGAGCACAACTACAAATCAACTCACACATCAATTCAAAGCACCACACTGTCCCAACTAC
    CAAACACAGACACCACTAGAGAAACTACATACAGTCACTCAATCAACGAAACCCAAAACAGAAAAATCAA
    AAGCCAATCCACTCTACCCGCCACCAGAAAACCACCAATTAACCCATCGGGAAGCAACCCCCCTGAAAAC
    CACCAAGACCACAACAACTCCCAAACACTCCCCTATGTGCCTTGCAGTACATGTGAAGGTAATCTTGCTT
    GTTTATCACTCTGCCAAATCGGGCCGGAGAGAGCACCAAGCAGAGCCCCTACAATCACCCTCAAAAAGAC
    TCCAAAACCCAAAACCACCAAAAAGCCAACCAAGACAACAATCCACCACAGAACCAGCCCTGAAGCCAAA
    CTGCAACCCAAAAACAACACGGCAGCTCCACAACAAGGCATCCTCTCTTCACCAGAACACCACACAAATC
    AATCAACTACACAGATCTAACAACACACCTCCATATAATATCAATTATGTTCATATATAGTTATTTAAAA
  • Protein Sequence : Show Sequence
    >gi|9631274|ref|NP_048054.1| G [Bovine respiratory syncytial virus]
    MSNHTHHLKFKTLKRAWKASKYFIVGLSCLYKFNLKSLVQTALTTLAMITLTSLVITAIIYISVGNAKAK
    PTSKPTIQQTQQPQNHTSPFFTEHNYKSTHTSIQSTTLSQLPNTDTTRETTYSHSINETQNRKIKSQSTL
    PATRKPPINPSGSNPPENHQDHNNSQTLPYVPCSTCEGNLACLSLCQIGPERAPSRAPTITLKKTPKPKT
    TKKPTKTTIHHRTSPEAKLQPKNNTAAPQQGILSSPEHHTNQSTTQI
  • Molecule Role : Protective antigen
  • Related Vaccine(s): Bovine herpesvirus 1 recombinant vector vaccine BHVl/BRSVG
2. gB
  • Gene Name : gB
  • Sequence Strain (Species/Organism) : Bovine herpesvirus 1
  • NCBI Protein GI : 349734084
  • Other Database IDs : CDD:177560
  • Taxonomy ID : 10320
  • Gene Strand (Orientation) : ?
  • Protein Name : glycoprotein B
  • Protein Length : 148
  • Protein Note : glycoprotein BALF4; Provisional
  • Protein Sequence : Show Sequence
    >gi|349734084|gb|AEQ16470.1| glycoprotein B [Bovine herpesvirus 1]
    SKAEYLRSGRKVVAFDRDDDPWEAPLKPARLSAPGVRGWHTTDDVYTALGSAGLYRTGTSVNCIVEEVEA
    RSVYPYDSFALSTGDIIYMSPFYGLREGAHREHTSYSPERFQQIEGYYKRDMATGRRLKEPVSRNFLRTQ
    HVTVAWDW
  • Molecule Role : Protective antigen
  • Related Vaccine(s): Bovine herpesvirus 1 DNA vaccine pMASIAtgB encoding a truncated, secreted form of gB
3. gIV
  • Gene Name : gIV
  • Sequence Strain (Species/Organism) : Bovine herpesvirus 1
  • NCBI Protein GI : 330746
  • Other Database IDs : CDD:177571
    CDD:195706
  • Taxonomy ID : 10320
  • Gene Strand (Orientation) : ?
  • Protein Name : glycoprotein gIV
  • Protein Length : 417
  • Protein Note : envelope glycoprotein D; Provisional
  • Protein Sequence : Show Sequence
    >gi|330746|gb|AAA46050.1| glycoprotein gIV [Bovine herpesvirus 1]
    MQGPTLAVLGALLAVAVSLPTPAPRVTVYVDPPAYPMPRYNYTERWHTTGPIPSPFADGREQPVEVRYAT
    SAAACDMLALIADPQVGRTLWEAVRRHARAYNATVIWYKIESGCARPLYYMEYTECEPRKHFGYCRYRTP
    PFWDSFLAGFAYPTDDELGLIMAAPARLVEGQYRRALYIDGTVAYTDFMVSLPAGDCWFSKLGAARGYTF
    GACFPARDYEQKKVLRLTYLTQYYPQEAHKAIVDYWFMRHGGVVPPYFEESKGYEPPPAADGGSPAPPGD
    DEAREDEGETEDGAAGREGNGGPPGPEGDGESQTPEANGGAEGEPKPGPSPDADRPEGWPSLEAITHPPP
    APATPAAPDAVPVSVGIGIAAAAIACVAAAAAGAYFVYTRRRGAGPLPRKPKKLPAFGNVNYSALPG
  • Molecule Role : Protective antigen
  • Related Vaccine(s): Bovine herpesvirus 1 DNA vaccine pRSVgIV
4. UL23
  • Gene Name : UL23
  • Sequence Strain (Species/Organism) : Bovine herpesvirus 1
  • NCBI Gene ID : 1487380
  • NCBI Protein GI : 9629852
  • Locus Tag : BoHV1_gp21
  • Genbank Accession : Z78205
  • Protein Accession : NP_045336
  • Taxonomy ID : 10320
  • Gene Starting Position : 63259
  • Gene Ending Position : 67035
  • Gene Strand (Orientation) : +
  • Protein Name : thymidine kinase
  • Protein pI : 6.75
  • Protein Weight : 35103.27
  • Protein Length : 359
  • Protein Note : 2.7.1.21
  • DNA Sequence : Show Sequence
    >gi|9629818:63259-67035 Bovine herpesvirus 1, complete genome
    CATGGCCGAGCCCGCGCGCGCTCTCCGCGTCGTGCGTATCTACCTGGACGGCGCGCACGGGCTGGGAAAG
    ACAACAACGGGCCGCGCGCTCGCGGCCGCTTCCACCGCTGGGGAGGGCGTGCTCTTTTTCCCGGAGCCGA
    TGGCGTACTGGCGCACGATGTTTGGTACGGACGCCTTAAGTGGGATCCTCGCGGCGTCTGCGCGATGCGC
    CGCAGCCTCGCACGGGAGCGCACGCGGCGCCGGCGGGCCGGCGCACCGCGCAGACGCGGACGCGGCGGGC
    CTGGTTGCGTACTACCAGGCCAGGTTCGCGGCCCCGTACTTAATTTTGCACGCGCGCGTGTCCGCGCTGC
    TGGCGCCGCCTGGGCCGGCGCCGGGCGGCACTGTGACCCTCGTGTTCGACCGCCACCCCGTGGCCGCGTG
    CCTCTGCTACCCCTTCGCCCGCTACTGCCTCCGCGAGATCAACGCGGAAGATCTGCTCATGCTCGCGGCC
    GCCATGCCCCCGGAAGCGCCCGGGGCCAACCTCGTCGTGTGCACCCTCCCCCCGGCCGAGCAACAGCGCC
    GCCTGGCGGCGCGGGCCAGGCCCGGAGACCGCGCGGACGCGGGCTTTCTGGTCGCTGTGCGCAATGCTTA
    CGCGCTCCTGGTGAACACGTGCGCTTTCCTGCGCGCGGGGGGCGCATGGCGCGACGGCTGGGACGCGCTG
    GAGTGGGCGGACGCAAATGCATTGGCCGCGCTCGCAGACCCCAGTTGTGATGAATGCAAAATGGCGCCGG
    CGCCGGCGCTGCGCGACACCCTGTTCGCGGCGCTCAAGTGCCGCGAGCTCTACCCGGGCGGCGGGACGGG
    CTTGCCCGCGGTTCACGCCTGGGCGCTGGACGCCCTGGCCGGCCGCCTCGCCGCCCTCGAGGTGTTCGTG
    CTGGACGTGTCCGCGGCGCCAGACGCGTGCGCGGCCGCCGTACTGGACATGCGGCCCGCCATGCAGGCCG
    CTTGCGCGGACGGGGCGGCGGGCGCGACGCTGGCGACCCTGGCGCGTCAGTTCGCGCTAGAGATGGCGGG
    GGAGGCCACGGCGGGCCCTAGGGGACTATAAAGCTGCCCCTGCGCTCGCTCGCTCGCTGCATTTGCGCCC
    CGATCGCCTTACGGGGACTCGGCGCTCGGCGGATCCCCTCCCGGCCCCGCCGCGAAGCGAGCCGCCAGAC
    AAAAAAATGCGGCGCCCGCTCTGCGCGGCGCTATTGGCAGCGGCTGTCCTCGCGCTCGCCGCGGGCGCCC
    CCGCCGCCGCCCGCGGCGGCGCGGGGGGCCGAAGCAGGGAGCACAGAGACGCCCGATACGAAATCGAAGA
    GTGGGAAATGGTGGTCGGAGCCGGGCCGGCCGTGCACACGTTCACCATCCGCTGCCTCGGGCCGCGGGGC
    ATTGAGCGCGTGGCCCACATTGCAAACCTCAGCCGGCTGCTGGACGGGTACATAGCGGTCCACGTTGACG
    TTGCGCGCACCTCTGGCCTGCGGGACACCATGTTTTTCCTGCCGCGCGCGGCCGTCGACAACGCTTCGGC
    CGCTGACATTCCGGACACCCCGGCCGTACAGTCGCACCCGGGGCTCTTCGGGGCGGCCTTTTCCTGGAGC
    TACTTGCAAACGCGCCACCTCGTAGACTACGACCTGGTGCCGAGCCGCCCCCTGCAGGACTGGTACTTTT
    CGCAGGCGCGCGCCGAGAGCAACGCCGCGCGCCCGCCGCCCGCCCCGCGCGTCACACCAACGCCGGCGGG
    GCGGGTGGCCGCTTTTGACATCAACGACGTGCTGGCCAGCGGCCCGGAGCACTTCTTTGTGCCTGTGCGA
    GCGGACCGCAAGCGGCGCGAGCGCCACGTGGCGGATTTTGCCGCGGTGTGGCCCGTGTCCTACATCCCCG
    CAGGACGGGCAGTGCTAAGCTGCGAGCGAGCCGCGGCTCGGCTGGCGGTGGGGCTCGGCTTCCTGAGCGT
    CTCGGTGACGTCGCGGGACCTCCTGCCTCTGGAGTTTATGGTCGCGCCCGCGGACGCCAACGTGCGCATG
    ATTACCGCCTTTAACGGGGGCGGCGCTTTTCCGCCACCCGGGCCCGCGGCCGGTCCGCAGCGGCGGGCCT
    ACGTAATCGGCTACGGGAACTCGCGGCTGGACAGCCATATGTATCTGACCATGCGCGAGGTGGCGTCGTA
    CGCGAACGAGCCCGCTGACTTTCGCGCGCACTTGACCGCCGCGCACCGGGAGGCTTTTTTGATGCTCCGG
    GAGGCGGCAGCCGCGCGCCGCGGACCGAGCGCCGGCCCCGCGCCCAACGCTGCCTACCACGCGTACCGGG
    TCGCGGCGCGGCTGGGACTCGCGCTCTCCGCGCTCACCGAGGGGGCGCTCGCGGACGGCTACGTGCTCGC
    GGAGGAGCTAGTCGACCTTGACTACCACCTCAAGCTGCTGTCGCGCGTGCTGCTCGGCGCAGGGCTTGGC
    TGCGCCGCCAACGGCCGCGTGCGCGCCCGCACCATCGCGCAGCTGGCCGTGCCCCGCGAGCTACGCCCGG
    ACGCGTTCATCCCAGAGCCCGCCGGGGCGGCGCTCGAGAGCGTGGTGGCCCGCGGGCGCAAGCTGCGCGC
    CGTGTACGCTTTTTCGGGTCCGGACGCTCCGCTAGCTGCGCGGCTGCTGGCCCACGGCGTGGTGTCGGAC
    CTCTACGACGCCTTCCTGCGCGGCGAGCTGACGTGGGGGCCGCCCATGCGCCACGCGCTTTTTTTCGCCG
    TCGCGGCGTCGGCGTTCCCCGCGGACGCCCAGGCGCTGGAGCTCGCGCGGGACGTGACGCGCAAGTGCAC
    GGCTATGTGCACCGCCGGGCACGCCACGGCGGCCGCGCTGGACCTGGAGGAGGTATACGCGCACGTCGGC
    GGCGGCGCCGGGGGCGACGCGGGCTTTGAGCTGCTGGATGCCTTCTCGCCGTGCATGGCCTCTTTCCGCC
    TGGACTTGCTCGAGGAGGCGCACGTGCTGGACGTGCTCTCGGCCGTGCCCGCGCGGGCCGCGCTGGACGC
    CTGGCTGGAGGCGCAGCCCGCGGCCGCCGCGCCGAACCTCAGCGCGGCGGCGCTCGGCATGCTGGGCCGG
    GGAGGCCTCTTCGGCCCGGCGCACGCCGCCGCGCTCGCGCCCGAGCTCTTCGCGGCGCCCTGCGGCGGGT
    GGGGCGCGGGCGCCGCCGTGGCGATCGTCCCCGTGGCGCCGAACGCTAGCTATGTCATCACGCGCGCACA
    TCCGCGGCGCGGGCTGACGTACACCCTCCAGGGAATTGACGTCGCTAACCCCCTGCTGGTGACTTTTGTG
    CGCGGCACGTCGTGCGTGTCGGCCAGCGGCGCGGTGGAGGCGCGCCGCCTTGCGGTCCCCGGCCCGCTGG
    ACGCGTGCGCCTACTGCGGCAGCGTGTTCGTGCGATACTTGCCCTCGGGCGCGGTTATGGACATCGTGCT
    CATTGCGGACAAGCGCACCGAGGTTGAGTTCTCGCGCGGCGCCAACTCTAGCATGCCCGTCTTCAACCCT
    CGCCTCCACAGCGGGCGCTCCCGCGCCATGCTGCTGTTCCCCAACGGGACGGTCGTAAGCGTCCTGGCCT
    TCGCCGGGCACGAAGCGCCGACGTTTTCGCCGGCGTACGTCTGGGCGTCGGTAGGCGGGGCGCTGGTCGC
    GGGTACCACGATATACGCCATCGCGAAGATGCTGTGCAGCTCGGTCCCGCTCGCGCGCGGGTACTCGTCG
    GTCCCGGTGTTTTAGCGCGCGCGTTGCCCTCCCCCCCTTCCCCCTTTTCACGTCTCCCCGCCAATAA
  • Protein Sequence : Show Sequence
    >gi|9629852|ref|NP_045336.1| thymidine kinase [Bovine herpesvirus 1]
    MAEPARALRVVRIYLDGAHGLGKTTTGRALAAASTAGEGVLFFPEPMAYWRTMFGTDALSGILAASARCA
    AASHGSARGAGGPAHRADADAAGLVAYYQARFAAPYLILHARVSALLAPPGPAPGGTVTLVFDRHPVAAC
    LCYPFARYCLREINAEDLLMLAAAMPPEAPGANLVVCTLPPAEQQRRLAARARPGDRADAGFLVAVRNAY
    ALLVNTCAFLRAGGAWRDGWDALEWADANALAALADPSCDECKMAPAPALRDTLFAALKCRELYPGGGTG
    LPAVHAWALDALAGRLAALEVFVLDVSAAPDACAAAVLDMRPAMQAACADGAAGATLATLARQFALEMAG
    EATAGPRGL
  • Molecule Role : Virmugen
  • Molecule Role Annotation : A thymidine kinase-deficient mutant (B8-D53) showed no detectable thymidine kinase-inducing activity and was attenuated in calves. B8-D53 also induced protection from challenge with wild type BHV-1 (Kit et al., 1985).
  • Related Vaccine(s): Bovine herpesvirus 1 UL23 mutant vaccine
5. UL44
  • Gene Name : UL44
  • Sequence Strain (Species/Organism) : Bovine herpesvirus 1
  • VO ID : VO_0011043
  • NCBI Gene ID : 4783424
  • NCBI Protein GI : 9629830
  • Locus Tag : BoHV1_gp105
  • Genbank Accession : Z54206
  • Protein Accession : NP_045314
  • Taxonomy ID : 10320
  • Gene Starting Position : 16612
  • Gene Ending Position : 18208
  • Gene Strand (Orientation) : -
  • Protein Name : envelope glycoprotein C
  • Protein pI : 8.25
  • Protein Weight : 50150.91
  • Protein Length : 508
  • Protein Note : envelope glycoprotein C; the Herpesviridae are non-segmented dsDNA viruses with genomes ranging from 120-230kbp; although herpes viruses vary greatly in sequence identity and homology, they all share four common elements: an envelope, a tegument which is composed of viral enzymes, a capsid of 162 capsomers, and a core composed of genomic DNA;virion envelope glycoproteins bind to cellular receptors; the nonessential glycoprotein gC interacts with cell surface proteoglycans, whereas the essential glycoprotein gD is involved in stable secondary attachment
  • DNA Sequence : Show Sequence
    >gi|9629818:16612-18208 Bovine herpesvirus 1, complete genome
    GTTTATTATGAAATTGTACATGCGTGGTCTTTGGGGGGGGGCGCGGCGGCTTTGCCGTCGGGGCCCCGCG
    CCTACAGGCGCGCCCGGGCCTTGCGCCGCAGGCACGAGGCCGCCACCAGCAGGAGCCCCACGGCGCCGAG
    ACCGCAGGCGACGGCCACGACGCTGACGAGGACGGGGCTTCCGATTAGGCCGGGCGAGGCGTCGTACGTG
    GCGGTCGCGGAGAACTCGGGCAGCGGTGCCGGGTAGCCAGTGGCGGTGCAGGTGTAGTCGACGGGCCCGT
    CGGTTGTAGAAAGCAGGCGCACGCCGCGCAGGTTTACCAGCCCGGGCCGCTCGGCGCAGACGCCGGTCTG
    CTCAGTGCGCGACGGGGCGATGCCGTCGCGCACCGTCCAGCGCAGGGAGACGCGCCCCTCGGGGACGCAG
    CGCGCCTCGCAGACGGCCTCGCCGCCCTCGAAGTACACGCGCAGCTCGGGCGGGCGGTAAACGGCCGGCG
    TGCCAGCCGCGTAAAAGCGGCGCTCCATGTTAGCGCTCTGGAACCAGGAGACGTCGCAGCGCAGGTTGGG
    CGGGTGGGCGGTTGGCGTCGCGTCCTCGAGCGTAAGGACGGACGTGCGCGAAAAGAGCCCGGAGTCGTCG
    ACCGTAAAGACGTCGCGCGCGTGCCGAGCCTCCACGGGGTAGCCGTTGCGGAACCAGTGCAGGCGCGTGG
    AGCGCGGCGGGTAGTACTCGGCGGCGCGGCACACGGCCGCGTAGCCGGCGCCTTCTAGCGCTGGCTGGGG
    TTCGACGGAAACAGCGGGCGCGCGGTGCGTCGTGACGGTCACGACCTTGCGCTGTGACTTGGTGCCCATG
    TCGCGGCGCCAAGTGTACACGCCCTCGGTGGCGGCCGTCAGGGAGCGCACGGTCAGGGGCAAGTTGCGGG
    GGTCGGCGGGCGAAGGGAAAATATAGTTGTCGCCCAGCTCCGCGCTACGGTACGCGATCGAGCCGTTCTG
    GGCTACGAACAGCAGCACGGGCGGGGCCCGCGGAAAGGGGTTGCGCACGGCCTCGTCGTCGCCGCGCGTG
    GAGCGGAACCTGCCCACGCGCTGAAACCAGAGCTCCAGGCGCGCACCGCCAGTGGCGTTGTCGGCCACGC
    CGCAGTGCACGTACAGCGGCTCGGCGTACGAGGCGGCCACGGCCTCGCGCTCGCAGAGCATCCACTTGCG
    CTCCTTCGGCGGGGCTTTGCTCGGCCGCGGGGGGCGAGGCCGCCCCCCGCCGCTAGGTCGCCCATCGCGG
    CTCGCGTTGCCAGCGCCGCCGGGTCGCCCGTCCTCGGGCGGGGCGGGCGGCGGCGTGCTGTTGGTAACGG
    GCGGGTCGTGCTCGGACACGGACGGCGGCTCCGGCGTCCCCACGGGCGTAGTAGCACCGGGCGTGCTGTC
    CTCTGGCGTAGCGTCGGGGCTGTTGGGCGTGGGGGGCGTTGCGCCGGTGGTCCCAGCGGAGCTTTCCGTC
    TCGGTTGGGGACGGGGAGGGCGGAGGCGAGGGCGAGGCTTCCGCCTCCTCGGCGAGCCCCCGCCGGGCAG
    ACAGGAGCGCCCAGGCGAAAATAGCTGCGATCAGCCACGCTCGCCCCAGCGGGCCCA
  • Protein Sequence : Show Sequence
    >gi|9629830|ref|NP_045314.1| envelope glycoprotein C [Bovine herpesvirus 1]
    MGPLGRAWLIAAIFAWALLSARRGLAEEAEASPSPPPSPSPTETESSAGTTGATPPTPNSPDATPEDSTP
    GATTPVGTPEPPSVSEHDPPVTNSTPPPAPPEDGRPGGAGNASRDGRPSGGGRPRPPRPSKAPPKERKWM
    LCEREAVAASYAEPLYVHCGVADNATGGARLELWFQRVGRFRSTRGDDEAVRNPFPRAPPVLLFVAQNGS
    IAYRSAELGDNYIFPSPADPRNLPLTVRSLTAATEGVYTWRRDMGTKSQRKVVTVTTHRAPAVSVEPQPA
    LEGAGYAAVCRAAEYYPPRSTRLHWFRNGYPVEARHARDVFTVDDSGLFSRTSVLTLEDATPTAHPPNLR
    CDVSWFQSANMERRFYAAGTPAVYRPPELRVYFEGGEAVCEARCVPEGRVSLRWTVRDGIAPSRTEQTGV
    CAERPGLVNLRGVRLLSTTDGPVDYTCTATGYPAPLPEFSATATYDASPGLIGSPVLVSVVAVACGLGAV
    GLLLVAASCLRRKARARL
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : A DNA vaccine expressing glycoprotein C (gC, UL44) of bovine herpesvirus-1 (BHV-1) was evaluated for inducing immunity in bovines. Results indicate that DNA immunization with gC could induce neutralizing antibody and lymphoproliferative responses with BHV-1 responsive memory B cells in bovines. However, the immunity developed sufficient for only partial protection against BHV-1 challenge (Gupta et al., 2001).
  • Related Vaccine(s): Bovine herpesvirus 1 DNA vaccine AdCMVgC , Bovine herpesvirus 1 DNA vaccine pRSV-gC
6. UL49
  • Gene Name : UL49
  • Sequence Strain (Species/Organism) : Bovine herpesvirus 1
  • VO ID : VO_0011040
  • NCBI Gene ID : 1487397
  • NCBI Protein GI : 9629826
  • Locus Tag : BoHV1_gp05
  • Genbank Accession : Z54206
  • Protein Accession : NP_045310
  • Taxonomy ID : 10320
  • Gene Starting Position : 9383
  • Gene Ending Position : 10228
  • Gene Strand (Orientation) : +
  • Protein Name : tegument protein VP22
  • Protein pI : 10.07
  • Protein Weight : 25574.19
  • Protein Length : 258
  • DNA Sequence : Show Sequence
    >gi|9629818:9383-10228 Bovine herpesvirus 1, complete genome
    CATGGCCCGGTTCCACAGGCCCTCCGAAGACGAGGACGATTACGAGTACAGCGACCTTTGGGTGCGAGAA
    AACAGCCTCTATGACTACGAGTCCGGCTCGGATGACCACGTATACGAAGAGCTGCGCGCCGCGACGAGCG
    GACCCGAGCCGAGCGGGCGGCGCGCTAGCGTCCGTGCGTGCGCCAGCGCTGCAGCCGTCCAGCCCGCCGC
    CCGCGGCCGCGATCGAGCCGCAGCCGCGGGGACGACCGTAGCTGCGCCCGCCGCCGCGCCGGCCCGCCGC
    TCGAGCAGCCGGGCGTCCTCGCGCCCGCCGCGAGCTGCCGCCGACCCGCCCGTCCTCCGGCCAGCCACGC
    GCGGGTCCTCCGGCGGCGCCGGGGCAGTCGCCGTCGGTCCACCTCGACCTCGCGCGCCCCCCGGTGCTAA
    TGCTGTTGCGTCTGGCCGGCCGCTGGCGTTCAGCGCGGCTCCGAAAACGCCCAAGGCGCCCTGGTGTGGA
    CCGACGCACGCCTACAACCGAACGATCTTTTGCGAGGCCGTCGCGCTCGTGGCCGCCGAGTACGCCCGGC
    AGGCGGCTGCCAGCGTCTGGGACTCGGACCCCCCAAAGAGCAACGAGCGATTGGATCGCATGTTGAAGTC
    GGCGGCAATTCGCATCCTCGTGTGCGAGGGCTCCGGGCTTCTCGCCGCCGCGAACGACATCTTGGCCGCG
    CGGGCCCAGCGCCCCGCCGCGCGCGGGAGCACAAGCGGCGGGGAAAGCCGCCTTCGCGGCGAGCGGGCCC
    GGCCGTAGCGCGAGCGGGAGGGCTTTTTCGACGCGCGCGGCTTAAGCAGCGCGCTGCTGTGCTAGTATGA
    AAATAA
  • Protein Sequence : Show Sequence
    >gi|9629826|ref|NP_045310.1| tegument protein VP22 [Bovine herpesvirus 1]
    MARFHRPSEDEDDYEYSDLWVRENSLYDYESGSDDHVYEELRAATSGPEPSGRRASVRACASAAAVQPAA
    RGRDRAAAAGTTVAAPAAAPARRSSSRASSRPPRAAADPPVLRPATRGSSGGAGAVAVGPPRPRAPPGAN
    AVASGRPLAFSAAPKTPKAPWCGPTHAYNRTIFCEAVALVAAEYARQAAASVWDSDPPKSNERLDRMLKS
    AAIRILVCEGSGLLAAANDILAARAQRPAARGSTSGGESRLRGERARP
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Protection against a BHV-1 challenge was obtained in calves immunized with the plasmid encoding tgD-VP22 (UL49), as shown by significant reductions in viral excretion (Zheng et al., 2005).
  • Related Vaccine(s): Bovine herpesvirus 1 DNA vaccine tgD-VP22
7. US6
  • Gene Name : US6
  • Sequence Strain (Species/Organism) : Bovine herpesvirus 1
  • VO ID : VO_0011041
  • NCBI Gene ID : 1487406
  • NCBI Protein GI : 9629886
  • Locus Tag : BoHV1_gp41
  • Genbank Accession : Z98199
  • Protein Accession : NP_045370
  • Taxonomy ID : 10320
  • Gene Starting Position : 118895
  • Gene Ending Position : 121435
  • Gene Strand (Orientation) : +
  • Protein Name : envelope glycoprotein D
  • Protein pI : 4.96
  • Protein Weight : 42542.47
  • Protein Length : 417
  • Protein Note : envelope glycoprotein D; the Herpesviridae are non-segmented dsDNA viruses with genomes ranging from 120-230kbp; although herpes viruses vary greatly in sequence identity and homology, they all share four common elements: an envelope, a tegument which is composed of viral enzymes, a capsid of 162 capsomers, and a core composed of genomic DNA;virion envelope glycoproteins bind to cellular receptors; the nonessential glycoprotein gC interacts with cell surface proteoglycans, whereas the essential glycoprotein gD is involved in stable secondary attachment
  • DNA Sequence : Show Sequence
    >gi|9629818:118895-121435 Bovine herpesvirus 1, complete genome
    CATGCAAGGGCCGACATTGGCCGTGCTGGGCGCGCTGCTCGCCGTTGCGGTGAGCTTGCCTACACCCGCG
    CCGCGGGTGACGGTATACGTCGACCCGCCGGCGTACCCGATGCCGCGATACAACTACACTGAACGCTGGC
    ACACTACCGGGCCCATACCGTCGCCCTTCGCAGACGGCCGCGAGCAGCCCGTCGAGGTGCGCTACGCGAC
    GAGCGCGGCGGCGTGCGACATGCTGGCGCTGATCGCAGACCCGCAGGTGGGGCGCACGCTGTGGGAAGCG
    GTACGCCGGCACGCGCGCGCGTACAACGCCACGGTCATATGGTACAAGATCGAGAGCGGGTGCGCCCGGC
    CGCTGTACTACATGGAGTACACCGAGTGCGAGCCCAGGAAGCACTTTGGGTACTGCCGCTACCGCACACC
    CCCGTTTTGGGACAGCTTCCTGGCGGGCTTCGCCTACCCCACGGACGACGAGCTGGGACTGATTATGGCG
    GCGCCCGCGCGGCTCGTCGAGGGCCAGTACCGACGCGCGCTGTACATCGACGGCACGGTCGCCTATACAG
    ATTTCATGGTTTCGCTGCCGGCCGGGGACTGCTGGTTCTCGAAACTCGGCGCGGCTCGCGGGTACACCTT
    TGGCGCGTGCTTCCCGGCCCGGGATTACGAGCAAAAGAAGGTTCTGCGCCTGACGTATCTCACGCAGTAC
    TACCCGCAGGAGGCACACAAGGCCATAGTCGACTACTGGTTCATGCGCCACGGGGGCGTCGTTCCGCCGT
    ATTTTGAGGAGTCGAAGGGCTACGAGCCGCCGCCTGCCGCCGATGGGGGTTCCCCCGCGCCACCCGGCGA
    CGACGAGGCCCGCGAGGATGAAGGGGAGACCGAGGACGGGGCAGCCGGGCGGGAGGGCAACGGCGGCCCC
    CCAGGACCCGAAGGCGACGGCGAGAGTCAGACCCCCGAAGCCAACGGAGGCGCCGAGGGCGAGCCGAAAC
    CCGGCCCCAGCCCCGACGCCGACCGCCCCGAAGGCTGGCCGAGCCTCGAAGCCATCACGCACCCCCCGCC
    CGCCCCCGCTACGCCCGCGGCCCCCGACGCCGTGCCGGTCAGCGTCGGGATCGGCATTGCGGCTGCGGCG
    ATCGCGTGCGTGGCCGCCGCCGCCGCCGGCGCGTACTTCGTCTATACGCGCCGGCGCGGTGCGGGTCCGC
    TGCCCAGAAAGCCAAAAAAGCTGCCGGCCTTTGGCAACGTCAACTACAGCGCGCTGCCCGGGTGAGCGGC
    CTAGGCCCTCCCCCGACCGCCCCCTTTGCTCCTAGCCCCGGCTCCTGCCGAGCCGCGCGGGGCGGGAGAT
    AAAGCGCCCGCGCGTCGGCGACTCAAGCCATTGCCGCGACCTTGTCCTCCGGCGCGCTCGCGATGCGGTG
    CCTGTTGCTCTGGATGGTGGTGCTGGCCGCGCGAGCGGCGCCCGCTCGCAGCCTTGTGTATCGCGGCGAG
    GCAGTCGGCCTGCGCGCGGACGGCCCCGTAGCGTTCGCTGTCCACCCGACCGACGCAACGCTCGCGCTGC
    GGGGCCGGCTGATTTTCCTGGAACACCAGCTCCCGGCCGGGCGGCGCTACAACGGGACCGTCGAGCTGCT
    GCGCTACCACGCCGCGGGCGACTGCTTCGTTATGCTGCAGACGACCGCGTTCGCCTCCTGCCCGCGCGTC
    GCGAACGACGCCTTTCGCTCCTGCCTGCACGCCGACACGCGCCCCGCTCGCAGCGAGCGGCGCGCGAGCG
    CCGCGGTCGAAAACCACGTGCTCTTCTCCATCGCCCATCCGCGCCCAATAGACTCAGGGCTCTACTTTCT
    GCGCGTCGGCATCTACGGCGGCACCGCGGGCAGCGAGCGCCGCCGAGACGTCTTTCCCTTGGCCGCGTTT
    GTACACAGCTTCGGTGAGCCCGGAGACCCAGAGGCCGCGGCCGCGCACCCCGGCGCCGTCGAGGCAGTCG
    CGACCCGCTGCGAGCGGGGCCTCGACGCCAGCTCGGCGAGCCTCTACGACCGCGCGCTGGCGGCGTTCCC
    CGCAGGCGCCGCCACCACGCCCGGCCCCACCGCGAGCAGCGGGAGCGGGGCCGCGACGCCGGAGAGGGTC
    GACGAGACGACGGAAGTCAAGGCCGCGACGAGAGCGGGCTCGGCGTTTGCCCTCACCACGCCCCCGGCCG
    GCCTGACCGCCAGCCCCGCCGCCAGCCCCTCCCGTGCCTTTAGCGCGGCCGCCCCGGCCGCCGCTGCGCA
    GCCGGCCGGAGACACGCCCGCTCGCTTCCGGCGCCAACTGGCGTCGATCCTAGTGCCTCTGTGCGTGCTG
    GTGCTGCTGCTGCTTGCGCTCTGCGCCGCGACGGTAAACTGCGCGCTGCGCCGCCGCCTGCTGCCGTGCT
    CTCGGCGCGTTTACAAGCCGCGGACGTGCGCGACATGCGGGAGCGGCACTTGCGCGGGGCGGCCCCCCTG
    CCGCGGCGCGGCACCGAGCGCCCCAGCCACCGTCGTGGCACTGGGCTCCCGGCCAAAGGCGCCCCCCCTC
    GCCACCATCAGCGAAGAATAA
  • Protein Sequence : Show Sequence
    >gi|9629886|ref|NP_045370.1| envelope glycoprotein D [Bovine herpesvirus 1]
    MQGPTLAVLGALLAVAVSLPTPAPRVTVYVDPPAYPMPRYNYTERWHTTGPIPSPFADGREQPVEVRYAT
    SAAACDMLALIADPQVGRTLWEAVRRHARAYNATVIWYKIESGCARPLYYMEYTECEPRKHFGYCRYRTP
    PFWDSFLAGFAYPTDDELGLIMAAPARLVEGQYRRALYIDGTVAYTDFMVSLPAGDCWFSKLGAARGYTF
    GACFPARDYEQKKVLRLTYLTQYYPQEAHKAIVDYWFMRHGGVVPPYFEESKGYEPPPAADGGSPAPPGD
    DEAREDEGETEDGAAGREGNGGPPGPEGDGESQTPEANGGAEGEPKPGPSPDADRPEGWPSLEAITHPPP
    APATPAAPDAVPVSVGIGIAAAAIACVAAAAAGAYFVYTRRRGAGPLPRKPKKLPAFGNVNYSALPG
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Calves were injected intranasally with either AdCMVgC or AdCMVgD (US6) or a combination of these two recombinants or a commercially available live vaccine for comparison. The highest BHV-1 neutralizing antibody titres were obtained with AdCMVgD (US6) followed by the live vaccine and to a lower extent with the combination of the two recombinants. Calves were protected against intranasal BHV-1 challenge performed 3 weeks after the second immunization (Gogev et al., 2002).
  • Related Vaccine(s): Bovine herpesvirus 1 DNA vaccine AdCMVgD , Bovine herpesvirus 1 DNA vaccine tgD-VP22 , Bovine herpesvirus 1 recombinant vector vaccine rLaSota/gDF encoding gD , Bovine herpesvirus 1 recombinant vector vaccine rLaSota/gDFL encoding gD
8. US7
  • Gene Name : US7
  • Sequence Strain (Species/Organism) : Bovine herpesvirus 1
  • VO ID : VO_0011042
  • NCBI Gene ID : 4783432
  • NCBI Protein GI : 9629887
  • Locus Tag : BoHV1_gp127
  • Genbank Accession : Z98199
  • Protein Accession : NP_045371
  • Taxonomy ID : 10320
  • Gene Starting Position : 120286
  • Gene Ending Position : 121435
  • Gene Strand (Orientation) : +
  • Protein Name : envelope glycoprotein I
  • Protein pI : 9.63
  • Protein Weight : 37115.17
  • Protein Length : 382
  • Protein Note : gD family
  • DNA Sequence : Show Sequence
    >gi|9629818:120286-121435 Bovine herpesvirus 1, complete genome
    GATGCGGTGCCTGTTGCTCTGGATGGTGGTGCTGGCCGCGCGAGCGGCGCCCGCTCGCAGCCTTGTGTAT
    CGCGGCGAGGCAGTCGGCCTGCGCGCGGACGGCCCCGTAGCGTTCGCTGTCCACCCGACCGACGCAACGC
    TCGCGCTGCGGGGCCGGCTGATTTTCCTGGAACACCAGCTCCCGGCCGGGCGGCGCTACAACGGGACCGT
    CGAGCTGCTGCGCTACCACGCCGCGGGCGACTGCTTCGTTATGCTGCAGACGACCGCGTTCGCCTCCTGC
    CCGCGCGTCGCGAACGACGCCTTTCGCTCCTGCCTGCACGCCGACACGCGCCCCGCTCGCAGCGAGCGGC
    GCGCGAGCGCCGCGGTCGAAAACCACGTGCTCTTCTCCATCGCCCATCCGCGCCCAATAGACTCAGGGCT
    CTACTTTCTGCGCGTCGGCATCTACGGCGGCACCGCGGGCAGCGAGCGCCGCCGAGACGTCTTTCCCTTG
    GCCGCGTTTGTACACAGCTTCGGTGAGCCCGGAGACCCAGAGGCCGCGGCCGCGCACCCCGGCGCCGTCG
    AGGCAGTCGCGACCCGCTGCGAGCGGGGCCTCGACGCCAGCTCGGCGAGCCTCTACGACCGCGCGCTGGC
    GGCGTTCCCCGCAGGCGCCGCCACCACGCCCGGCCCCACCGCGAGCAGCGGGAGCGGGGCCGCGACGCCG
    GAGAGGGTCGACGAGACGACGGAAGTCAAGGCCGCGACGAGAGCGGGCTCGGCGTTTGCCCTCACCACGC
    CCCCGGCCGGCCTGACCGCCAGCCCCGCCGCCAGCCCCTCCCGTGCCTTTAGCGCGGCCGCCCCGGCCGC
    CGCTGCGCAGCCGGCCGGAGACACGCCCGCTCGCTTCCGGCGCCAACTGGCGTCGATCCTAGTGCCTCTG
    TGCGTGCTGGTGCTGCTGCTGCTTGCGCTCTGCGCCGCGACGGTAAACTGCGCGCTGCGCCGCCGCCTGC
    TGCCGTGCTCTCGGCGCGTTTACAAGCCGCGGACGTGCGCGACATGCGGGAGCGGCACTTGCGCGGGGCG
    GCCCCCCTGCCGCGGCGCGGCACCGAGCGCCCCAGCCACCGTCGTGGCACTGGGCTCCCGGCCAAAGGCG
    CCCCCCCTCGCCACCATCAGCGAAGAATAA
  • Protein Sequence : Show Sequence
    >gi|9629887|ref|NP_045371.1| envelope glycoprotein I [Bovine herpesvirus 1]
    MRCLLLWMVVLAARAAPARSLVYRGEAVGLRADGPVAFAVHPTDATLALRGRLIFLEHQLPAGRRYNGTV
    ELLRYHAAGDCFVMLQTTAFASCPRVANDAFRSCLHADTRPARSERRASAAVENHVLFSIAHPRPIDSGL
    YFLRVGIYGGTAGSERRRDVFPLAAFVHSFGEPGDPEAAAAHPGAVEAVATRCERGLDASSASLYDRALA
    AFPAGAATTPGPTASSGSGAATPERVDETTEVKAATRAGSAFALTTPPAGLTASPAASPSRAFSAAAPAA
    AAQPAGDTPARFRRQLASILVPLCVLVLLLLALCAATVNCALRRRLLPCSRRVYKPRTCATCGSGTCAGR
    PPCRGAAPSAPATVVALGSRPKAPPLATISEE
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : Immunization of calves with truncated gpI (US7) protein induced gpI-specific nasal IgA, IgG1, serum neutralizing antibodies and gpI-specific peripheral lymphocyte proliferation. All immunized calves were protected from clinical disease after BHV-1 challenge. Further, nine of ten immunized calves had no intranasal viral shedding (Gao et al., 1994).
  • Related Vaccine(s): Bovine herpesvirus 1 GPI protein vaccine
9. US8
  • Gene Name : US8
  • Sequence Strain (Species/Organism) : Bovine herpesvirus 1
  • NCBI Gene ID : 1487407
  • NCBI Protein GI : 9629888
  • Locus Tag : BoHV1_gp42
  • Genbank Accession : AJ004801
  • Protein Accession : NP_045372
  • Taxonomy ID : 10320
  • Gene Starting Position : 121713
  • Gene Ending Position : 123505
  • Gene Strand (Orientation) : +
  • Protein Name : envelope glycoprotein E
  • Protein pI : 4.53
  • Protein Weight : 56945.75
  • Protein Length : 575
  • Protein Note : envelope glycoprotein E; the Herpesviridae are non-segmented dsDNA viruses with genomes ranging from 120-230kbp; although herpes viruses vary greatly in sequence identity and homology, they all share four common elements: an envelope, a tegument which is composed of viral enzymes, a capsid of 162 capsomers, and a core composed of genomic DNA;virion envelope glycoproteins bind to cellular receptors; envelope glycoprotein E and glycoprotein I form a heterodimer that play important roles in virus cell-to-cell spread
  • DNA Sequence : Show Sequence
    >gi|9629818:121713-123505 Bovine herpesvirus 1, complete genome
    AATGCAACCCACCGCGCCGCCCCGGCGGCGGTTGCTGCCGCTGCTGCTGCCGCAGTTATTGCTTTTCGGG
    CTGATGGCCGAGGCCAAGCCCGCGACCGAAACCCCGGGCTCGGCTTCGGTCGACACGGTCTTCACGGCGC
    GCGCTGGCGCGCCCGTCTTTCTCCCAGGGCCCGCGGCGCGCCCGGACGTGCGCGCCGTTCGCGGCTGGAG
    CGTCCTCGCGGGCGCCTGCTCGCCGCCCGTGCCGGAGCCCGTCTGCCTCGACGACCGCGAGTGCTTCACC
    GACGTGGCCCTGGACGCGGCCTGCCTGCGAACCGCCCGCGTGGCCCCGCTGGCCATCGCGGAGCTCGCCG
    AGCGGCCCGACTCAACGGGCGACAAAGAGTTTGTTCTCGCCGACCCGCACGTCTCGGCGCAGCTGGGTCG
    CAACGCGACCGGGGTGCTGATCGCGGCCGCAGCCGAGGAGGACGGCGGCGTGTACTTCCTGTACGACCGG
    CTCATCGGCGACGCCGGCGACGAGGAGACGCAGTTGGCGCTGACGCTGCAGGTCGCGACGGCCGGCGCGC
    AGGGCGCCGCGCGGGACGAGGAGAGGGAACCAGCGACCGGGCCCACCCCCGGCCCGCCGCCCCACCGCAC
    GACGACACGCGCGCCCCCGCGGCGGCACGGCGCGCGCTTCCGCGTGCTGCCGTACCACTCCCACGTATAC
    ACCCCGGGCGATTCCTTTCTGCTATCGGTGCGTCTGCAGTCTGAGTTTTTCGACGAGGCTCCCTTCTCGG
    CCAGCATCGACTGGTACTTCCTGCGGACGGCCGGCGACTGCGCGCTCATCCGCATATACGAGACGTGCAT
    CTTCCACCCCGAGGCACCGGCCTGCCTGCACCCCGCCGACGCGCAGTGCAGCTTCGCGTCGCCGTACCGC
    TCCGAGACCGTGTACAGCCGGCTGTACGAGCAGTGCCGCCCGGACCCTGCCGGTCGCTGGCCGCACGAGT
    GCGAGGGCGCCGCGTACGCGGCGCCCGTTGCGCACCTGCGTCCCGCCAATAACAGCGTAGACCTGGTCTT
    TGACGACGCGCCGGCTGCGGCCTCCGGGCTTTACGTCTTTGTGCTGCAGTACAACGGCCACGTGGAAGCT
    TGGGACTACAGCCTAGTCGTTACTTCGGACCGTTTGGTGCGCGCGGTCACCGACCACACGCGCCCCGAGG
    CCGCAGCCGCCGACGCTCCCGAGCCAGGCCCACCGCTCACCAGCGAGCCGGCGGGCGCGCCCACCGGGCC
    CGCGCCCTGGCTTGTGGTGCTGGTGGGCGCGCTTGGACTCGCGGGACTGGTGGGCATCGCAGCCCTCGCC
    GTTCGGGTGTGCGCGCGCCGCGCAAGCCAGAAGCGCACCTACGACATCCTCAACCCCTTCGGGCCCGTAT
    ACACCAGCTTGCCGACCAACGAGCCGCTCGACGTGGTGGTGCCAGTTAGCGACGACGAATTTTCCCTCGA
    CGAAGACTCTTTTGCGGATGACGACAGCGACGATGACGGGCCCGCTAGCAACCCCCCTGCGGATGCCTAC
    GACCTCGCCGGCGCCCCAGAGCCAACTAGCGGGTTTGCGCGAGCCCCCGCCAACGGCACGCGCTCGAGTC
    GCTCTGGGTTCAAAGTTTGGTTTAGGGACCCGCTTGAAGACGATGCCGCGCCAGCGCGGACCCCGGCCGC
    ACCAGATTACACCGTGGTAGCAGCGCGACTCAAGTCCATCCTCCGCTAGGCGCCCCCCCCCCCGCGCGCT
    GTGCCGTCTGACGGAAAGCACCCGCGTGTAGGGCTGCATATAA
  • Protein Sequence : Show Sequence
    >gi|9629888|ref|NP_045372.1| envelope glycoprotein E [Bovine herpesvirus 1]
    MQPTAPPRRRLLPLLLPQLLLFGLMAEAKPATETPGSASVDTVFTARAGAPVFLPGPAARPDVRAVRGWS
    VLAGACSPPVPEPVCLDDRECFTDVALDAACLRTARVAPLAIAELAERPDSTGDKEFVLADPHVSAQLGR
    NATGVLIAAAAEEDGGVYFLYDRLIGDAGDEETQLALTLQVATAGAQGAARDEEREPATGPTPGPPPHRT
    TTRAPPRRHGARFRVLPYHSHVYTPGDSFLLSVRLQSEFFDEAPFSASIDWYFLRTAGDCALIRIYETCI
    FHPEAPACLHPADAQCSFASPYRSETVYSRLYEQCRPDPAGRWPHECEGAAYAAPVAHLRPANNSVDLVF
    DDAPAAASGLYVFVLQYNGHVEAWDYSLVVTSDRLVRAVTDHTRPEAAAADAPEPGPPLTSEPAGAPTGP
    APWLVVLVGALGLAGLVGIAALAVRVCARRASQKRTYDILNPFGPVYTSLPTNEPLDVVVPVSDDEFSLD
    EDSFADDDSDDDGPASNPPADAYDLAGAPEPTSGFARAPANGTRSSRSGFKVWFRDPLEDDAAPARTPAA
    PDYTVVAARLKSILR
  • Molecule Role : Virmugen
  • Molecule Role Annotation : A gE-negative (US8-negative) strain was used as whole-virus antigen in an inactivated virus vaccine. Calves given the vaccine with the highest antigen concentration were adequately protected against challenge; clinical symptoms were virtually absent and challenge virus shedding was significantly reduced as compared with unvaccinated calves (Kaashoek et al., 1995).
  • Additional Molecule Role : Virmugen
  • Additional Molecule Role Annotation : A deletion of BHV-1 gE gene in strain A is considered as a live attenuated vaccine. After challenge, vaccinated calves were protected against disease and virus shedding was reduced (Kaashoek et al., 1994).
  • Related Vaccine(s): Bovine herpesvirus 1 US8 (gE) mutant vaccine
III. Vaccine Information
1. BHV1 gD subunit vaccine
a. Vaccine Ontology ID:
VO_0004225
b. Type:
Subunit vaccine
c. Status:
Research
d. Antigen
25 μg of vaccinia recombinant gD (van et al., 1997).
e. Adjuvant: Avridine
f. Immunization Route
Intramuscular injection (i.m.)
g. Cattle Response
  • Vaccination Protocol: Calves were randomly allocated to one of five vaccine groups and immunized with either 25 μg of gD in avridine, 25 μg tgD in avridine, commercial KV, commercial MLV or avridine. All vaccines were administered intramuscularly. 3 weeks after primary immunization the calves were re-immunized (van et al., 1997).
  • Immune Response: All vaccinated calves had significantly (P<0.05) higher serum neutralizing antibody titers prechallenge than the control animals. Calves immunized with the experimental gD or tgD vaccines had significantly (P<0.05) higher antibody titers than animals immunized with KV or MLV vaccines (van et al., 1997).
  • Challenge Protocol: Calves were challenged 4 weeks after secondary immunization with BHV1. Each calf was exposed for 4 minutes to an aerosol of 107 p.f.u. ml- ’ of BHVl strain 108 (van et al., 1997).
  • Efficacy: All vaccinated calves had a significantly lower (P<0.05) rectal temperature and sick score than the placebo group. In contrast to the placebo-, KV- and MLV-immunized groups, the gD- and tgD-immunized groups experienced minimal weight loss during the period following challenge. The gD- and tgD-vaccinated calves shed significantly (P<0.05) lower amounts of virus than the placebo or KV-immunized groups throughout the follow-up period. In the gD and tgD subunit vaccine vaccinated groups only one out of eight animals shed virus (van et al., 1997).
2. Bovilis IBR Marker
a. Tradename:
Bovilis IBR Marker
b. Manufacturer:
Intervet
c. Vaccine Ontology ID:
VO_0000979
d. Type:
Live, attenuated vaccine
e. Status:
Licensed
f. Host Species for Licensed Use:
Cattle
g. Immunization Route
Intramuscular injection (i.m.)
h. Description
Live or inactivated gE-deleted marker vaccine(van et al., 1996)
3. Bovine herpesvirus 1 DNA vaccine AdCMVgC
a. Vaccine Ontology ID:
VO_0011382
b. Type:
DNA vaccine
c. Status:
Research
d. Antigen
Bovine herpesvirus 1 glycoprotein C
e. Gene Engineering of UL44
  • Type: DNA vaccine construction
  • Description: For the gC gene, a SpeI–NotI fragment (containing the gC gene) was extracted from pSKgC and cloned into pCi to yield plasmid pCigC. The expression cassettes containing the CMV promoter, splicing signals, glycoprotein gene, and SV40 polyadenylation signal, were extracted as BamHI–BglII fragments that were cloned into the BamHI site of plasmid pAd-link, resulting in plasmid pAdCMVgC (Gogev et al., 2002).
  • Detailed Gene Information: Click here.
f. Vector:
pCi (Promega)
g. Immunization Route
Intranasal
h. Cattle Response
  • Vaccination Protocol: Twenty-eight calves, 6–8 months old, were randomly allocated into five groups of five calves and one group of three calves. Three groups were inoculated twice 3 weeks apart by the intranasal route with 2 ml per nostril with a semi-purified preparation at a dose of 1010 CCID50 (Cell Culture Infectious Dose) of either AdCMVgC, or AdCMVgD or a combination of these two recombinants (5×109 CCID50 of AdCMVgC+5×109 CCID50 of AdCMVgD). At days 0 and 21, one group was inoculated twice by the intranasal route with a commercially available live vaccine whereas the group of three animals was inoculated intranasally twice 3 weeks apart with inactivated AdCMVgD, inactivated AdCMVgC, and a combination of them. One group was not inoculated and served as control (Gogev et al., 2002).
  • Challenge Protocol: On day 42, calves were challenged by the intranasal route with 5×106 plaque forming units (PFU) of BHV-1 IOWA strain. Calves were clinically examined and rectal temperatures were measured for 2 weeks after each immunization and for 3 weeks following the challenge performed on day 42 (Gogev et al., 2002).
  • Efficacy: The administration of either Ad5CMVgD or Ad5CMVgC, or a combination of them in calves by intranasal route 3 weeks apart, induced BHV-1 neutralizing antibody responses and conferred protection against challenge with BHV-1 Iowa strain (Gogev et al., 2002).
4. Bovine herpesvirus 1 DNA vaccine AdCMVgD
a. Vaccine Ontology ID:
VO_0011381
b. Type:
DNA vaccine
c. Status:
Research
d. Antigen
Bovine herpesvirus 1 glycoprotein D
e. Gene Engineering of US6
  • Type: DNA vaccine construction
  • Description: For the gD gene, a NheI–NotI fragment (containing the gD gene) was extracted from pGEMgD and cloned into pCi to yield plasmid pCigD. The expression cassettes containing the CMV promoter, splicing signals, glycoprotein gene, and SV40 polyadenylation signal, were extracted as BamHI–BglII fragments that were cloned into the BamHI site of plasmid pAd-link, resulting in plasmid pAdCMVgD (Gogev et al., 2002).
  • Detailed Gene Information: Click here.
f. Vector:
pCi (Promega)
g. Immunization Route
Intranasal
h. Cattle Response
  • Vaccination Protocol: Twenty-eight calves, 6–8 months old, were randomly allocated into five groups of five calves and one group of three calves. Three groups were inoculated twice 3 weeks apart by the intranasal route with 2 ml per nostril with a semi-purified preparation at a dose of 1010 CCID50 (Cell Culture Infectious Dose) of either AdCMVgC, or AdCMVgD or a combination of these two recombinants (5×109 CCID50 of AdCMVgC+5×109 CCID50 of AdCMVgD). At days 0 and 21, one group was inoculated twice by the intranasal route with a commercially available live vaccine whereas the group of three animals was inoculated intranasally twice 3 weeks apart with inactivated AdCMVgD, inactivated AdCMVgC, and a combination of them. One group was not inoculated and served as control (Gogev et al., 2002).
  • Challenge Protocol: On day 42, calves were challenged by the intranasal route with 5×106 plaque forming units (PFU) of BHV-1 IOWA strain. Calves were clinically examined and rectal temperatures were measured for 2 weeks after each immunization and for 3 weeks following the challenge performed on day 42 (Gogev et al., 2002).
  • Efficacy: The administration of either Ad5CMVgD or Ad5CMVgC, or a combination of them in calves by intranasal route 3 weeks apart, induced BHV-1 neutralizing antibody responses and conferred protection against challenge with BHV-1 Iowa strain (Gogev et al., 2002).
5. Bovine herpesvirus 1 DNA vaccine pMASIAtgB encoding a truncated, secreted form of gB
a. Vaccine Ontology ID:
VO_0004317
b. Type:
DNA vaccine
c. Status:
Research
d. Host Species as Laboratory Animal Model:
Mice, calves
e. Gene Engineering of gB
  • Type: DNA vaccine construction
  • Description: Vector pMASIA expressed truncated, secreted form of BHV-1 gB (Huang et al., 2005).
  • Detailed Gene Information: Click here.
f. Vector:
pMASIA (Huang et al., 2005)
g. Immunization Route
Intraperitoneal injection (i.p.)
h. Cattle Response
  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: pMASIAtgB elicited both humoral responses and activated gamma interferon-secreting CD8+ CTLs, suggesting that a DNA vaccine expressing tgB induces a CTL response in the natural host of BHV-1 (Huang et al., 2005).
6. Bovine herpesvirus 1 DNA vaccine pRSV-gC
a. Vaccine Ontology ID:
VO_0011557
b. Type:
DNA vaccine
c. Status:
Research
d. Antigen
Bovine herpesvirus 1 glycoprotein C
e. Gene Engineering of UL44
  • Type: DNA vaccine construction
  • Description: The complete coding sequence of the gene for gC was excised from a recombinant plasmid containing HindIII ‘I’ fragment of BHV-1 DNA (Gupta et al., 1995). The 2.4 kb BamHI and EcoRI double digested DNA fragment containing gC gene of BHV-1 was subcloned into a pRSV vector. The recombinant plasmid (pRSV-gC) encoding gC under the control of a RSV promoter/enhancer yielded high levels of BHV-1 gC expression in transfected cell (Gupta et al., 1998). Plasmid DNA was prepared from Escherichia coli bacterial cultures by the alkali lysis method and passed over Qiagen plasmid purification columns (Qiagen, CA). The isolated plasmid was ethanol-precipitated and dissolved in 0.85% saline at a concentration of 0.5 mg/ml (Gupta et al., 2001).
  • Detailed Gene Information: Click here.
f. Vector:
pRSV containing a RSV promoter/enhancer
g. Immunization Route
Intramuscular injection (i.m.)
h. Cattle Response
  • Vaccination Protocol: Three calves were inoculated intramuscular (i.m.) six times with 500 μg of pRSV-gC and two calves were inoculated i.d. six times with 250 μg of pRSV-gC at each immunization. One calf received saline at each immunization and served as unvaccinated control. All inoculations were done at monthly intervals (Gupta et al., 2001).
  • Challenge Protocol: All calves were exposed to BHV-1 (108.5 TCID50) by intranasal aerosol installation 1 month after last injection. All calves were examined daily for clinical symptoms of the disease. Nasal swabs were collected before challenge and 1, 3, 5, 7, 9 and 11 days post-challenge for isolation of shedding virus (Gupta et al., 2001).
  • Efficacy: Results indicate that DNA immunization with gC could induce neutralizing antibody and lymphoproliferative responses with BHV-1 responsive memory B cells in bovines. However, the immunity developed sufficient for only partial protection against BHV-1 challenge (Gupta et al., 2001).
7. Bovine herpesvirus 1 DNA vaccine pRSVgIV
a. Vaccine Ontology ID:
VO_0004315
b. Type:
DNA vaccine
c. Status:
Research
d. Host Species as Laboratory Animal Model:
Mouse, calf
e. Gene Engineering of gIV
  • Type: DNA vaccine construction
  • Description: Vector pRSV expressed BHV-1 glycoprotein I (gIV) (Cox et al., 1993).
  • Detailed Gene Information: Click here.
f. Vector:
pRSV (Cox et al., 1993)
g. Immunization Route
Intramuscular injection (i.m.)
h. Cattle Response
  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Clinical symptoms including fever, nasal mucosal lesions, and inappetence were reduced in all pRSVgIV-injected calves compared with the pRSVO-injected calf (control). Increases in gIV-specific antibody titers were observed at day 6 post challenge and continued to the end of the experiment. By comparison with the titer achieved by the control calf after challenge, it is clear that all three pRSVgIV-injected calves were primed to respond to BHV-1 (Cox et al., 1993).
8. Bovine herpesvirus 1 DNA vaccine tgD-VP22
a. Vaccine Ontology ID:
VO_0011554
b. Type:
DNA vaccine
c. Status:
Research
d. Antigen
Bovine herpesvirus 1 tegument protein VP22 and glycoprotein D
e. Gene Engineering of UL49
  • Type: DNA vaccine construction
  • Description: Researchers constructed the plasmids pVP22-YFP, pMASIA-tgD-YFP, and pMASIA-tgD-VP22-YFP. For the construction of pVP22-YFP, the UL49 (VP22 gene) open reading frame was amplified from BHV-1 genomic DNA by PCR and then inserted into pEYFP-N1 (Clontech, BD Biosciences, Palo Alto, Calif.). Subsequently, pMASIA-tgD-YFP and pMASIA-tgD-VP22-YFP were generated by PCR cloning of the YFP and VP22-YFP genes from pEYFP-N1 and pVP22-YFP, respectively, into pMASIA-tgD, which encodes BHV-1 tgD (26). COS-7 cells were transfected with pMASIA-tgD-VP22-YFP, pMASIA-tgD-YFP, and pVP22-YFP and monitored every 4 h by fluorescence microscopy (Zheng et al., 2005).
  • Detailed Gene Information: Click here.
f. Gene Engineering of US6
  • Type: DNA vaccine construction
  • Description: Researchers constructed the plasmids pVP22-YFP, pMASIA-tgD-YFP, and pMASIA-tgD-VP22-YFP. For the construction of pVP22-YFP, the UL49 (VP22 gene) open reading frame was amplified from BHV-1 genomic DNA by PCR and then inserted into pEYFP-N1 (Clontech, BD Biosciences, Palo Alto, Calif.). Subsequently, pMASIA-tgD-YFP and pMASIA-tgD-VP22-YFP were generated by PCR cloning of the YFP and VP22-YFP genes from pEYFP-N1 and pVP22-YFP, respectively, into pMASIA-tgD, which encodes BHV-1 tgD (26). COS-7 cells were transfected with pMASIA-tgD-VP22-YFP, pMASIA-tgD-YFP, and pVP22-YFP and monitored every 4 h by fluorescence microscopy (Zheng et al., 2005).
  • Detailed Gene Information: Click here.
g. Vector:
pMASIA-tgD (Zheng et al., 2005)
h. Immunization Route
Intradermal injection (i.d.)
i. Cattle Response
  • Vaccination Protocol: Calves were immunized intradermally with 500 μg of pMASIA-tgD-VP22, 500 μg of pMASIA-tgD, or saline in a 500-μl volume by use of the Biojector 2000 needle-free injection system (Bioject, Bedminster, N.J.) (Zheng et al., 2005).
  • Challenge Protocol: All animals were reimmunized after 28 days and were challenged with BHV-1 strain 108 on day 54. All data from this study were analyzed with the aid of Graphpad Prism 3.0 (Zheng et al., 2005).
  • Efficacy: Protection against a BHV-1 challenge was obtained in calves immunized with the plasmid encoding tgD-VP22 (UL49), as shown by significant reductions in viral excretion (Zheng et al., 2005).
9. Bovine herpesvirus 1 GPI protein vaccine
a. Vaccine Ontology ID:
VO_0011383
b. Type:
Subunit vaccine
c. Status:
Research
d. Antigen
Bovine herpesvirus 1 envelope glycoprotein I
e. Gene Engineering of US7
  • Type: Recombinant protein preparation
  • Description: A truncated BHV-1 envelope gpI protein was secreted into the culture supernatant of D17 cells transfected with the gpI gene lacking the coding sequence for the transmembrane region (TMR). The transmembrane domain is essential for gpI stability in the envelope, virus infectivity and, most probably, natural killer cell recognition (Gao et al., 1994).
  • Detailed Gene Information: Click here.
f. Cattle Response
  • Vaccination Protocol: The 20 calves were divided into two groups (ten animals in each group) and immunized as follows:group 1 was primed intramusculary (i.m.) with concentrated gpI (17 ug/animal) emulsified in complete Freund's adjuvant, and boosted by intranasal (i.n.) aerosolization (Laboratory spray unit, Gelman Sciences Inc., Ann Arbor, MI) with 100yg gpI plus 20 ug cholera toxin subunit B (CTB) per animal at the 3rd and 9th weeks. Then, 30 yg of gpI emulsified in incomplete Freund's adjuvant was administered subcutaneously at the base of the ear at the 15th week. Alternatively, group 2 was treated as above with the same amount of non-transfected D17 cell culture supernatant concentrated from a volume equal to that of the gpI supernatant. The antibody levels in sera and nasal secretions were tested at 2-week intervals after each vaccination to assess the gpI immune response (Gao et al., 1994).
  • Challenge Protocol: All animals were challenged with 5 x 105 p.f.u, of virulent Cooper strain BHV-1 (ATCC VR864) by intranasal aerosolization. Nasal swabs were collected daily for 12 days and viral replication and shedding were detected by titration on MDBK cells. The animals were monitored for signs of disease (fever, nasal mucosal lesions, nasal discharge, conjunctivitis and depression) (Gao et al., 1994).
  • Efficacy: mmunization of calves with this truncated gpI protein induced gpI-specific nasal IgA, IgG1, serum neutralizing antibodies and gpI-specific peripheral lymphocyte proliferation. All immunized calves were protected from clinical disease after BHV-1 challenge. Further, nine of ten immunized calves had no intranasal viral shedding. One animal shed a minimal amount of virus following challenge, but produced no antibodies to other viral proteins as evidenced by immunoprecipitation of 35S-labelled viral proteins by sera from virus-challenged animals (Gao et al., 1994).
10. Bovine herpesvirus 1 recombinant vector vaccine BHVl/BRSVG
a. Vaccine Ontology ID:
VO_0004316
b. Type:
Recombinant vector vaccine
c. Status:
Research
d. Host Species as Laboratory Animal Model:
Calves
e. Gene Engineering of G from BRSV
  • Type: Recombinant vector construction
  • Description: Vector BHV1 expressed the G protein of bovine respiratory syncytial virus (Schrijver et al., 1997).
  • Detailed Gene Information: Click here.
f. Vector:
BHV1 (Schrijver et al., 1997)
g. Immunization Route
intranasal immunization
h. Cattle Response
  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: A gE-negative bovine herpesvirus 1 (BHV1) vector vaccine carrying a gene coding for the G protein of bovine respiratory syncytial virus (BRSV) (BHV1/BRSV-G) induced the same high degree of protection in calves against BRSV infection and BHV1 infection as a multivalent commercial vaccine (Schrijver et al., 1997).
11. Bovine herpesvirus 1 recombinant vector vaccine rLaSota/gDF encoding gD
a. Vaccine Ontology ID:
VO_0004319
b. Type:
Recombinant vector vaccine
c. Status:
Research
d. Host Species as Laboratory Animal Model:
Calves
e. Gene Engineering of US6
  • Type: Recombinant vector construction
  • Description: Vector pLaSota expressed a chimeric gD in which the ectodomain of gD was fused with the transmembrane domain and cytoplasmic tail of the NDV fusion F glycoprotein (Khattar et al., 2010).
  • Detailed Gene Information: Click here.
f. Vector:
recombinant Newcastle Disease Virus pLaSota carrying the full-length antigenomic cDNA of the lentogenic NDV (Newcastle disease virus ) vaccine strain LaSota (Khattar et al., 2010)
g. Immunization Route
combined IN and IT routes
h. Cattle Response
  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Following challenge with BHV-1, calves immunized with the recombinant NDVs had lower titers and earlier clearance of challenge virus compared to the empty vector control. Partial protection was observed (Khattar et al., 2010).
12. Bovine herpesvirus 1 recombinant vector vaccine rLaSota/gDFL encoding gD
a. Vaccine Ontology ID:
VO_0004318
b. Type:
Recombinant vector vaccine
c. Status:
Research
d. Host Species as Laboratory Animal Model:
Calves
e. Gene Engineering of US6
  • Type: Recombinant vector construction
  • Description: Vector pLaSota expressed gD without any modification (Khattar et al., 2010).
  • Detailed Gene Information: Click here.
f. Vector:
recombinant Newcastle Disease Virus pLaSota carrying the full-length antigenomic cDNA of the lentogenic NDV(Newcastle disease virus ) vaccine strain LaSota (Khattar et al., 2010)
g. Immunization Route
combined IN and IT routes
h. Cattle Response
  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Following challenge with BHV-1, calves immunized with the recombinant NDVs had lower titers and earlier clearance of challenge virus compared to the empty vector control, and reduced disease was observed with rLaSota/gDFL. Partial protection was observed (Khattar et al., 2010).
13. Bovine herpesvirus 1 UL23 mutant vaccine
a. Product Name:
B8-D53
b. Vaccine Ontology ID:
VO_0002949
c. Type:
Live, attenuated vaccine
d. Status:
Research
e. Host Species as Laboratory Animal Model:
Cow
f. Gene Engineering of UL23
  • Type: Gene mutation
  • Description: This UL23 mutant is from Bovine herpesvirus 1 (Kit et al., 1985).
  • Detailed Gene Information: Click here.
g. Immunization Route
intranasal immunization
h. Cattle Response
  • Persistence: A UL23 mutant is attenuated in calves (Kit et al., 1985).
  • Efficacy: A UL23 mutant induced protection in calves from challenge with wild type BHV-1 (Kit et al., 1985).
14. Bovine herpesvirus 1 US8 (gE) mutant vaccine
a. Vaccine Ontology ID:
VO_0002950
b. Type:
Live, attenuated vaccine
c. Status:
Research
d. Gene Engineering of US8
  • Type: Gene mutation
  • Description:
  • Detailed Gene Information: Click here.
e. Preparation
The bovine herpesvirus 1 (BHV1) strain Za is a conventionally attenuated strain with a 2.7 kb deletion that encompasses the complete coding region for glycoprotein E (gE) (Kaashoek et al., 1995).
f. Immunization Route
intranasal immunization
g. Cattle Response
  • Persistence: The bovine herpesvirus 1 (BHV1) strain Za is a conventionally attenuated strain with a 2.7 kb deletion that encompasses the complete coding region for glycoprotein E (gE) (Kaashoek et al., 1995).
  • Efficacy: Calves given the vaccine with the highest antigen concentration were ad.equately protected against challenge; clinical symptoms were virtually absent and challenge virus shedding was significantly reduced as compared with unvaccinated calves (Kaashoek et al., 1995)
15. Bovine Rhinotracheitis Killed Virus Vaccine (USDA: 1105.20)
a. Manufacturer:
Heska Corporation
b. Vaccine Ontology ID:
VO_0001561
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
16. Bovine Rhinotracheitis Killed Virus Vaccine-Haemophilus Somnus-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 45H5.20)
a. Manufacturer:
Texas Vet Lab, Inc.
b. Vaccine Ontology ID:
VO_0001877
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
17. Bovine Rhinotracheitis Killed Virus Vaccine-Haemophilus Somnus-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 45H5.21)
a. Manufacturer:
Texas Vet Lab, Inc.
b. Vaccine Ontology ID:
VO_0001878
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
18. Bovine Rhinotracheitis Killed Virus Vaccine-Haemophilus Somnus-Mannheimia Haemolytica-Pasteurella Multocida-Salmonella Typhimurium Bacterin-Toxoid (USDA: 4109.20)
a. Manufacturer:
Texas Vet Lab, Inc.
b. Vaccine Ontology ID:
VO_0001879
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
19. Bovine Rhinotracheitis Modified Live Virus Vaccine (USDA: 1101.00)
a. Manufacturer:
Wyeth, Colorado Serum Company, Heska Corporation
b. Vaccine Ontology ID:
VO_0001562
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
20. Bovine Rhinotracheitis Modified Live Virus Vaccine (USDA: 1101.20)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc., Heska Corporation, Texas Vet Lab, Inc., Merial, Inc., Novartis Animal Health US, Inc.
b. Vaccine Ontology ID:
VO_0001563
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
21. Bovine Rhinotracheitis Modified Live Virus Vaccine (USDA: 1101.21)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001564
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
22. Bovine Rhinotracheitis Modified Live Virus Vaccine (USDA: 1101.22)
a. Manufacturer:
Intervet Inc.
b. Vaccine Ontology ID:
VO_0001565
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
23. Bovine Rhinotracheitis Modified Live Virus Vaccine (USDA: 1101.B0)
a. Manufacturer:
SolidTech Animal Health, Inc.
b. Vaccine Ontology ID:
VO_0001566
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
24. Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4019.00)
a. Manufacturer:
Wyeth, Colorado Serum Company
b. Vaccine Ontology ID:
VO_0001880
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
25. Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin (USDA: 4059.00)
a. Manufacturer:
Colorado Serum Company
b. Vaccine Ontology ID:
VO_0001881
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
26. Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Hardjo-Pomona Bacterin (USDA: 4069.20)
a. Manufacturer:
Wyeth
b. Vaccine Ontology ID:
VO_0001882
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
27. Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4089.00)
a. Manufacturer:
Colorado Serum Company, Heska Corporation
b. Vaccine Ontology ID:
VO_0001883
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
28. Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4089.20)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc., Heska Corporation, Merial, Inc.
b. Vaccine Ontology ID:
VO_0001884
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
29. Bovine Rhinotracheitis-Parainfluenza 3 Killed Virus Vaccine-Mannheimia Haemolytica-Pasteurella Multocida Bacterin (USDA: 4265.00)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc.
b. Vaccine Ontology ID:
VO_0001885
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
30. Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1121.00)
a. Manufacturer:
Colorado Serum Company, Heska Corporation
b. Vaccine Ontology ID:
VO_0001886
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
31. Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1121.20)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc., Heska Corporation, Merial, Inc., Novartis Animal Health US, Inc.
b. Vaccine Ontology ID:
VO_0001887
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
32. Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1121.21)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001888
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
33. Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1121.24)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001889
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
34. Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1121.31)
a. Manufacturer:
Intervet Inc.
b. Vaccine Ontology ID:
VO_0001890
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
35. Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine-Haemophilus Somnus Bacterin (USDA: 4139.20)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc.
b. Vaccine Ontology ID:
VO_0001891
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
36. Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4129.00)
a. Manufacturer:
Colorado Serum Company, Heska Corporation
b. Vaccine Ontology ID:
VO_0001892
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
37. Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin (USDA: 4179.00)
a. Manufacturer:
Colorado Serum Company
b. Vaccine Ontology ID:
VO_0001893
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
38. Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4209.00)
a. Manufacturer:
Colorado Serum Company, Heska Corporation
b. Vaccine Ontology ID:
VO_0001894
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
39. Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.00)
a. Manufacturer:
Heska Corporation
b. Vaccine Ontology ID:
VO_0001895
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
40. Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.20)
a. Manufacturer:
Wyeth, Pfizer, Inc., Heska Corporation, Texas Vet Lab, Inc.
b. Vaccine Ontology ID:
VO_0001896
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
41. Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.21)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001897
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
42. Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.22)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001898
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
43. Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.23)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001899
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
44. Bovine Rhinotracheitis-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 11B5.20)
a. Manufacturer:
Merial, Inc.
b. Vaccine Ontology ID:
VO_0001900
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
45. Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine (USDA: 1155.20)
a. Manufacturer:
Heska Corporation, Novartis Animal Health US, Inc.
b. Vaccine Ontology ID:
VO_0001901
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
46. Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine (USDA: 1155.30)
a. Manufacturer:
Heska Corporation
b. Vaccine Ontology ID:
VO_0001902
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
47. Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4145.20)
a. Manufacturer:
Novartis Animal Health US, Inc.
b. Vaccine Ontology ID:
VO_0001903
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
48. Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4145.21)
a. Manufacturer:
Heska Corporation
b. Vaccine Ontology ID:
VO_0001904
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
49. Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Haemophilus Somnus-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 43S5.20)
a. Manufacturer:
Texas Vet Lab, Inc.
b. Vaccine Ontology ID:
VO_0001905
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
50. Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Haemophilus Somnus-Mannheimia Haemolytica-Pasteurella Multocida-Salmonella Typhimurium Bacterin-Toxoid (USDA: 43T5.20)
a. Manufacturer:
Texas Vet Lab, Inc.
b. Vaccine Ontology ID:
VO_0001906
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
51. Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4335.20)
a. Manufacturer:
Heska Corporation
b. Vaccine Ontology ID:
VO_0001907
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
52. Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4336.30)
a. Manufacturer:
Heska Corporation
b. Vaccine Ontology ID:
VO_0001908
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
53. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine (USDA: 1151.00)
a. Manufacturer:
Colorado Serum Company, Heska Corporation
b. Vaccine Ontology ID:
VO_0001909
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
54. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine (USDA: 1151.20)
a. Manufacturer:
Wyeth, Boehringer Ingelheim Vetmedica, Inc., Intervet Inc., Heska Corporation, Merial, Inc., Novartis Animal Health US, Inc.
b. Vaccine Ontology ID:
VO_0001910
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
55. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine (USDA: 1151.22)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc., Intervet Inc.
b. Vaccine Ontology ID:
VO_0001911
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
56. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine (USDA: 1151.23)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc.
b. Vaccine Ontology ID:
VO_0001912
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
57. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine (USDA: 1151.26)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001913
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
58. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4141.20)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc., Intervet Inc.
b. Vaccine Ontology ID:
VO_0001914
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
59. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4339.00)
a. Manufacturer:
Colorado Serum Company, Heska Corporation
b. Vaccine Ontology ID:
VO_0001915
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
60. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin (USDA: 4359.00)
a. Manufacturer:
Colorado Serum Company
b. Vaccine Ontology ID:
VO_0001916
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
61. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Hardjo-Pomona Bacterin (USDA: 4399.20)
a. Manufacturer:
Wyeth
b. Vaccine Ontology ID:
VO_0001917
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
62. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4389.00)
a. Manufacturer:
Colorado Serum Company, Heska Corporation
b. Vaccine Ontology ID:
VO_0001918
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
63. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4389.20)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc., Merial, Inc.
b. Vaccine Ontology ID:
VO_0001919
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
64. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4389.21)
a. Manufacturer:
Heska Corporation
b. Vaccine Ontology ID:
VO_0001920
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
65. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Killed Virus Vaccine (USDA: 1175.20)
a. Manufacturer:
Novartis Animal Health US, Inc.
b. Vaccine Ontology ID:
VO_0001921
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
66. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4435.20)
a. Manufacturer:
Novartis Animal Health US, Inc.
b. Vaccine Ontology ID:
VO_0001922
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
67. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.00)
a. Manufacturer:
Wyeth, Colorado Serum Company, Heska Corporation
b. Vaccine Ontology ID:
VO_0001923
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
68. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.20)
a. Manufacturer:
Heska Corporation, Merial, Inc.
b. Vaccine Ontology ID:
VO_0001924
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
69. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.22)
a. Manufacturer:
Intervet Inc., Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001925
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
70. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.24)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001926
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
71. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.25)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001927
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
72. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.26)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001928
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
73. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.27)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001929
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
74. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.30)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc.
b. Vaccine Ontology ID:
VO_0001930
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
75. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4560.24)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001931
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
76. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4560.25)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001932
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
77. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Haemophilus Somnus-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4489.30)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc.
b. Vaccine Ontology ID:
VO_0001933
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
78. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4439.00)
a. Manufacturer:
Colorado Serum Company
b. Vaccine Ontology ID:
VO_0001934
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
79. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4439.20)
a. Manufacturer:
Wyeth, Heska Corporation, Merial, Inc.
b. Vaccine Ontology ID:
VO_0001935
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
80. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin (USDA: 4479.00)
a. Manufacturer:
Colorado Serum Company
b. Vaccine Ontology ID:
VO_0001936
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
81. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4509.00)
a. Manufacturer:
Colorado Serum Company, Heska Corporation
b. Vaccine Ontology ID:
VO_0001937
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
82. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Mannheimia Haemolytica Bacterin (USDA: 44A5.20)
a. Manufacturer:
Wyeth
b. Vaccine Ontology ID:
VO_0001938
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
83. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.00)
a. Manufacturer:
Wyeth
b. Vaccine Ontology ID:
VO_0001939
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
84. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.20)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc., Intervet Inc., Heska Corporation, Novartis Animal Health US, Inc.
b. Vaccine Ontology ID:
VO_0001940
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
85. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.21)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc., Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001941
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
86. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.22)
a. Manufacturer:
Wyeth, Intervet Inc., Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001942
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
87. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.23)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc., Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001943
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
88. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.24)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc.
b. Vaccine Ontology ID:
VO_0001944
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
89. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.25)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001945
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
90. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.26)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc., Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001946
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
91. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.28)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001947
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
92. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.30)
a. Manufacturer:
Intervet Inc., Heska Corporation
b. Vaccine Ontology ID:
VO_0001948
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
93. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1185.20)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc., Merial, Inc., Novartis Animal Health US, Inc.
b. Vaccine Ontology ID:
VO_0001949
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
94. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1185.22)
a. Manufacturer:
Wyeth
b. Vaccine Ontology ID:
VO_0001950
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
95. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44M5.20)
a. Manufacturer:
Novartis Animal Health US, Inc.
b. Vaccine Ontology ID:
VO_0001951
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
96. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44M5.22)
a. Manufacturer:
Novartis Animal Health US, Inc.
b. Vaccine Ontology ID:
VO_0001952
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
97. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B5.20)
a. Manufacturer:
Novartis Animal Health US, Inc.
b. Vaccine Ontology ID:
VO_0001953
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
98. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B6.20)
a. Manufacturer:
Novartis Animal Health US, Inc.
b. Vaccine Ontology ID:
VO_0001954
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
99. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B6.21)
a. Manufacturer:
Novartis Animal Health US, Inc.
b. Vaccine Ontology ID:
VO_0001955
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
100. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus Somnus Bacterin (USDA: 44C5.20)
a. Manufacturer:
Novartis Animal Health US, Inc.
b. Vaccine Ontology ID:
VO_0001956
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
101. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus Somnus Bacterin (USDA: 44C7.20)
a. Manufacturer:
Wyeth
b. Vaccine Ontology ID:
VO_0001957
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
102. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus Somnus Bacterin (USDA: 44D5.20)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc.
b. Vaccine Ontology ID:
VO_0001958
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
103. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D7.20)
a. Manufacturer:
Wyeth, Boehringer Ingelheim Vetmedica, Inc., Novartis Animal Health US, Inc.
b. Vaccine Ontology ID:
VO_0001959
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
104. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D7.22)
a. Manufacturer:
Novartis Animal Health US, Inc.
b. Vaccine Ontology ID:
VO_0001960
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
105. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus Somnus-Mannheimia Haemolytica Bacterin (USDA: 4477.20)
a. Manufacturer:
Wyeth
b. Vaccine Ontology ID:
VO_0001961
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
106. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4465.20)
a. Manufacturer:
Wyeth, Boehringer Ingelheim Vetmedica, Inc., Merial, Inc., Novartis Animal Health US, Inc.
b. Vaccine Ontology ID:
VO_0001962
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
107. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4465.21)
a. Manufacturer:
Wyeth
b. Vaccine Ontology ID:
VO_0001963
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
108. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4465.22)
a. Manufacturer:
Wyeth
b. Vaccine Ontology ID:
VO_0001964
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
109. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4466.20)
a. Manufacturer:
Novartis Animal Health US, Inc.
b. Vaccine Ontology ID:
VO_0001965
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
110. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4466.21)
a. Manufacturer:
Novartis Animal Health US, Inc.
b. Vaccine Ontology ID:
VO_0001966
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
111. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona-Mannheimia Haemolytica Bacterin (USDA: 4475.20)
a. Manufacturer:
Wyeth
b. Vaccine Ontology ID:
VO_0001967
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
112. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.20)
a. Manufacturer:
Heska Corporation
b. Vaccine Ontology ID:
VO_0001968
c. Type:
Live, attenuated vaccine; Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
113. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.21)
a. Manufacturer:
Wyeth, Pfizer, Inc., Merial, Inc.
b. Vaccine Ontology ID:
VO_0001969
c. Type:
Live, attenuated vaccine; Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
114. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.22)
a. Manufacturer:
Merial, Inc.
b. Vaccine Ontology ID:
VO_0001970
c. Type:
Live, attenuated vaccine; Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
115. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.25)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001971
c. Type:
Live, attenuated vaccine; Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
116. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1189.00)
a. Manufacturer:
Heska Corporation
b. Vaccine Ontology ID:
VO_0001972
c. Type:
Live, attenuated vaccine; Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
117. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1189.21)
a. Manufacturer:
Merial, Inc.
b. Vaccine Ontology ID:
VO_0001973
c. Type:
Live, attenuated vaccine; Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
118. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1189.30)
a. Manufacturer:
Heska Corporation
b. Vaccine Ontology ID:
VO_0001974
c. Type:
Live, attenuated vaccine; Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
119. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B9.21)
a. Manufacturer:
Heska Corporation
b. Vaccine Ontology ID:
VO_0001975
c. Type:
Live, attenuated vaccine; Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
120. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B9.22)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001976
c. Type:
Live, attenuated vaccine; Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
121. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Haemophilus Somnus Bacterin (USDA: 44F9.20)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc.
b. Vaccine Ontology ID:
VO_0001977
c. Type:
Live, attenuated vaccine; Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
122. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.20)
a. Manufacturer:
Heska Corporation
b. Vaccine Ontology ID:
VO_0001978
c. Type:
Live, attenuated vaccine; Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
123. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.22)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001979
c. Type:
Live, attenuated vaccine; Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
124. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.25)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001980
c. Type:
Live, attenuated vaccine; Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
125. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.30)
a. Manufacturer:
Heska Corporation
b. Vaccine Ontology ID:
VO_0001981
c. Type:
Live, attenuated vaccine; Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
126. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.20)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc., Intervet Inc.
b. Vaccine Ontology ID:
VO_0001982
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
127. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.22)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001983
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
128. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.23)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001984
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
129. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.25)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001985
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
130. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus Bacterin (USDA: 44C9.20)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc., Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001986
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
131. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus Bacterin (USDA: 44C9.21)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc.
b. Vaccine Ontology ID:
VO_0001987
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
132. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus Bacterin (USDA: 44C9.23)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc.
b. Vaccine Ontology ID:
VO_0001988
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
133. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus Bacterin (USDA: 44C9.24)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc.
b. Vaccine Ontology ID:
VO_0001989
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
134. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D9.20)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc.
b. Vaccine Ontology ID:
VO_0001990
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
135. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D9.21)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc.
b. Vaccine Ontology ID:
VO_0001991
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
136. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D9.23)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc.
b. Vaccine Ontology ID:
VO_0001992
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
137. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D9.24)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc.
b. Vaccine Ontology ID:
VO_0001993
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
138. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4461.20)
a. Manufacturer:
Wyeth, Boehringer Ingelheim Vetmedica, Inc., Intervet Inc., Heska Corporation
b. Vaccine Ontology ID:
VO_0001994
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
139. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4461.21)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001995
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
140. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4461.22)
a. Manufacturer:
Wyeth, Intervet Inc.
b. Vaccine Ontology ID:
VO_0001996
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
141. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4461.25)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0001997
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
142. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.00)
a. Manufacturer:
Heska Corporation
b. Vaccine Ontology ID:
VO_0001998
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
143. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.01)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc.
b. Vaccine Ontology ID:
VO_0001999
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
144. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.23)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc.
b. Vaccine Ontology ID:
VO_0002000
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
145. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.24)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc., Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0002001
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
146. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.26)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0002002
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
147. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Hardjo Bacterin (USDA: 4L49.20)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0002003
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
148. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Mannheimia Haemolytica Toxoid (USDA: 4X49.20)
a. Manufacturer:
Wyeth
b. Vaccine Ontology ID:
VO_0002004
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
149. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Mannheimia Haemolytica Toxoid (USDA: 4X49.21)
a. Manufacturer:
Wyeth
b. Vaccine Ontology ID:
VO_0002005
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
150. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 45B9.20)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc.
b. Vaccine Ontology ID:
VO_0002006
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
151. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 45B9.21)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc.
b. Vaccine Ontology ID:
VO_0002007
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
152. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus-Mannheimia Haemolytica-Pasteurella Multocida Modified Live Virus, Avirulent Live Culture Vaccine (USDA: 11A8.22)
a. Manufacturer:
Intervet Inc.
b. Vaccine Ontology ID:
VO_0002008
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
153. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 11A5.20)
a. Manufacturer:
Merial, Inc.
b. Vaccine Ontology ID:
VO_0002009
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
154. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 11A1.20)
a. Manufacturer:
Heska Corporation
b. Vaccine Ontology ID:
VO_0002010
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
155. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 11A1.26)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0002011
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
156. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 11A1.30)
a. Manufacturer:
Heska Corporation
b. Vaccine Ontology ID:
VO_0002012
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
157. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.20)
a. Manufacturer:
Heska Corporation
b. Vaccine Ontology ID:
VO_0002013
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
158. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.26)
a. Manufacturer:
Pfizer, Inc.
b. Vaccine Ontology ID:
VO_0002014
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
159. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.30)
a. Manufacturer:
Heska Corporation
b. Vaccine Ontology ID:
VO_0002015
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Cattle
IV. References
1. Babiuk et al., 1987: Babiuk LA, L'Italien J, van Drunen Littel-van den Hurk S, Zamb T, Lawman JP, Hughes G, Gifford GA. Protection of cattle from bovine herpesvirus type I (BHV-1) infection by immunization with individual viral glycoproteins. Virology. 1987; 159(1); 57-66. [PubMed: 3037783].
2. Caselli et al., 2005: Caselli E, Boni M, Di Luca D, Salvatori D, Vita A, Cassai E. A combined bovine herpesvirus 1 gB-gD DNA vaccine induces immune response in mice. Comparative immunology, microbiology and infectious diseases. 2005; 28(2); 155-166. [PubMed: 15582691].
3. Castrucci et al., 2004: Castrucci G, Ferrari M, Marchini C, Salvatori D, Provinciali M, Tosini A, Petrini S, Sardonini Q, Lo Dico M, Frigeri F, Amici A. Immunization against bovine herpesvirus-1 infection. Preliminary tests in calves with a DNA vaccine. Comparative immunology, microbiology and infectious diseases. 2004; 27(3); 171-179. [PubMed: 15001312].
4. Cox et al., 1993: Cox GJ, Zamb TJ, Babiuk LA. Bovine herpesvirus 1: immune responses in mice and cattle injected with plasmid DNA. Journal of virology. 1993; 67(9); 5664-5667. [PubMed: 8350420].
5. Deshpande et al., 2002: Deshpande MS, Ambagala TC, Hegde NR, Hariharan MJ, Navaratnam M, Srikumaran S. Induction of cytotoxic T-lymphocytes specific for bovine herpesvirus-1 by DNA immunization. Vaccine. 2002; 20(31-32); 3744-3751. [PubMed: 12399204].
6. Gao et al., 1994: Gao Y, Leary TP, Eskra L, Splitter GA. Truncated bovine herpesvirus-1 glycoprotein I (gpI) initiates a protective local immune response in its natural host. Vaccine. 1994; 12(2); 145-152. [PubMed: 8147097].
7. Gogev et al., 2002: Gogev S, Vanderheijden N, Lemaire M, Schynts F, D'Offay J, Deprez I, Adam M, Eloit M, Thiry E. Induction of protective immunity to bovine herpesvirus type 1 in cattle by intranasal administration of replication-defective human adenovirus type 5 expressing glycoprotein gC or gD. Vaccine. 2002; 20(9-10); 1451-1465. [PubMed: 11818166].
8. Gupta et al., 2001: Gupta PK, Saini M, Gupta LK, Rao VD, Bandyopadhyay SK, Butchaiah G, Garg GK, Garg SK. Induction of immune responses in cattle with a DNA vaccine encoding glycoprotein C of bovine herpesvirus-1. Veterinary microbiology. 2001; 78(4); 293-305. [PubMed: 11182496].
9. Huang et al., 2005: Huang Y, Babiuk LA, van Drunen Littel-van den Hurk S. Immunization with a bovine herpesvirus 1 glycoprotein B DNA vaccine induces cytotoxic T-lymphocyte responses in mice and cattle. The Journal of general virology. 2005; 86(Pt 4); 887-898. [PubMed: 15784883].
10. Kaashoek et al., 1994: Kaashoek MJ, Moerman A, Madić J, Rijsewijk FA, Quak J, Gielkens AL, van Oirschot JT. A conventionally attenuated glycoprotein E-negative strain of bovine herpesvirus type 1 is an efficacious and safe vaccine. Vaccine. 1994; 12(5); 439-444. [PubMed: 8023552].
11. Kaashoek et al., 1995: Kaashoek MJ, Moerman A, Madić J, Weerdmeester K, Maris-Veldhuis M, Rijsewijk FA, van Oirschot JT. An inactivated vaccine based on a glycoprotein E-negative strain of bovine herpesvirus 1 induces protective immunity and allows serological differentiation. Vaccine. 1995; 13(4); 342-346. [PubMed: 7793128].
12. Kaashoek et al., 1998: Kaashoek MJ, Rijsewijk FA, Ruuls RC, Keil GM, Thiry E, Pastoret PP, Van Oirschot JT. Virulence, immunogenicity and reactivation of bovine herpesvirus 1 mutants with a deletion in the gC, gG, gI, gE, or in both the gI and gE gene. Vaccine. 1998; 16(8); 802-809. [PubMed: 9627937].
13. Khattar et al., 2010: Khattar SK, Collins PL, Samal SK. Immunization of cattle with recombinant Newcastle disease virus expressing bovine herpesvirus-1 (BHV-1) glycoprotein D induces mucosal and serum antibody responses and provides partial protection against BHV-1. Vaccine. 2010; 28(18); 3159-3170. [PubMed: 20189484].
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