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Mycoplasma synoviae

Table of Contents
  1. General Information
    1. NCBI Taxonomy ID
    2. Disease
    3. Introduction
  2. Vaccine Information
    1. Vaxsafe MS
  3. References
I. General Information
1. NCBI Taxonomy ID:
2109
2. Disease:
Respiratory tract disease and synovitis
3. Introduction
Mycoplasma synoviae is a Gram-negative parasitic bacteria responsible for causing respiratory tract disease and synovitis (inflammation in the lining of the joints) in turkeys and chickens, although other types of birds are susceptible as well. Naturally, this causes significant economic problems in the poultry industry. The primary habitat is the mucous membranes of the respiratory tract of the birds that are infected, although the joints are also affected. Infection occurs primarily through attachment of the bacteria to the host cell by means of specialized surface proteins and adhesins that results in prolonged intracellular persistence that may cause lethality if combined with a secondary virus (MicrobeWiki: Mycoplasma synoviae).
II. Vaccine Information
1. Vaxsafe MS
a. Tradename:
Vaxsafe MS
b. Manufacturer:
Bioproperties
c. Vaccine Ontology ID:
VO_0001049
d. Type:
Live, attenuated vaccine
e. Status:
Licensed
f. Host Species for Licensed Use:
Chicken
g. Immunization Route
Eye drop administration
h. Description
Live temperature-sensitive mutant strain; eye drop administration(Morrow et al., 1998)
III. References
1. Morrow et al., 1998: Morrow CJ, Markham JF, Whithear KG. Production of temperature-sensitive clones of Mycoplasma synoviae for evaluation as live vaccines. Avian diseases. 1998; 42(4); 667-670. [PubMed: 9876833].