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Equine rotavirus

Table of Contents
  1. General Information
    1. NCBI Taxonomy ID
    2. Disease
    3. Introduction
  2. Vaccine Information
    1. Equine Rotavirus Killed Virus Vaccine (USDA: 1E15.20)
  3. References
I. General Information
1. NCBI Taxonomy ID:
10937
2. Disease:
Rotaviral Diarrhea
3. Introduction
Rotavirus, a non-enveloped RNA virus, is a major infectious cause of foal diarrhea and has been documented to cause 50% or more of foal diarrhea cases in some areas. While rotavirus diarrhea morbidity can be high (50% of susceptible foals), mortality is low (<1%) with veterinary intervention. Equine rotavirus is transmitted via the fecal-oral route and damages the small intestinal villi resulting in cellular destruction, maldigestion, malabsorption, and diarrhea. As many as 70% of all foals in the United States will have at least one diarrheal episode prior to weaning. Mare owners need to be aware that strict biosecurity and disinfection during the foaling season also mitigates the morbidity associated with most types of infectious foal diarrheas and other contagious diseases. Vaccination of mares results in a significant increase in foals’ rotavirus antibody titers. Field trials of rotavirus vaccination in pregnant mares have shown a decrease in incidence and severity of foal diarrhea on farms that historically had annual rotaviral diarrhea cases. Other studies have shown increased rotavirus antibody in vaccinated mares’ colostrum (AAEP: Rotaviral Diarrhea).
II. Vaccine Information
1. Equine Rotavirus Killed Virus Vaccine (USDA: 1E15.20)
a. Manufacturer:
Wyeth
b. Vaccine Ontology ID:
VO_0001783
c. Type:
Inactivated or "killed" vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Horse
III. References
1. AAEP: Rotaviral Diarrhea: AAEP: Rotaviral Diarrhea [http://www.aaep.org/rotaviral_diarrhea.htm]