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EsxB

Gene Name EsxB
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
VO ID VO_0010951
NCBI Gene ID 886194
NCBI Protein GI 15611010
Locus Tag Rv3874
Genbank Accession AF004671
Protein Accession NP_218391
3D structure: PDB ID 3FAV
Other Database IDs EMBL: AE000516
EMBL: AF004671
EMBL: AF419854
EMBL: BX842584
GenomeReviews: AE000516_GR
GenomeReviews: AL123456_GR
InterPro: IPR010310
KEGG: mtc:MT3988
KEGG: mtu:Rv3874
Pfam: PF06013
PIR: H70802
SMR: P0A566
TIGR: MT3988
TubercuList: Rv3874
UniProt: P0A566
Taxonomy ID 83332
Gene Starting Position 4352273
Gene Ending Position 4352575
Gene Strand (Orientation) +
Protein Name ESAT-6-like protein EsxB
Protein pI 4.31
Protein Weight 10396.66
Protein Length 100
Protein Note Rv3874, (MT3988, MTV027.09), len: 100 aa. esxB, 10 KDA culture filtrate antigen (see citations below, especially first), highly similar to O33084|CF10_MYCLE|ML0050|MLCB628.13c 10 KDA CULTURE FILTRATE ANTIGEN CFP10 HOMOLOG from Mycobacterium leprae (99 aa), FASTA scores: opt: 237, E(): 2.4e-08, (39.4% identity in 99 aa overlap). Also similar to O05440|ES6D_MYCTU|Rv3905c|MT4024|MTCY15F10.06 PUTATIVE ESAT-6 LIKE PROTEIN 13 from Mycobacterium tuberculosis (103 aa) FASTA scores: opt: 126, E(): 0.18, (23.1% identity in 91 aa overlap); and shows some similarity with other proteins from Mycobacterium tuberculosis. Contains probable coiled-coil from aa 49-93. BELONGS TO THE ESAT6 FAMILY. Note that previously known as lhp (alternate gene name: cfp10).; lhp, cfp10
Protein Annotation SUBCELLULAR LOCATION: Secreted protein (UniProt: P0A566)

SIMILARITY: Belongs to the ESAT-6 (esx) family (UniProt: P0A566)
DNA Sequence 
>NC_000962.3:4352273-4352575 Mycobacterium tuberculosis H37Rv, complete genome
CATGGCAGAGATGAAGACCGATGCCGCTACCCTCGCGCAGGAGGCAGGTAATTTCGAGCGGATCTCCGGC
GACCTGAAAACCCAGATCGACCAGGTGGAGTCGACGGCAGGTTCGTTGCAGGGCCAGTGGCGCGGCGCGG
CGGGGACGGCCGCCCAGGCCGCGGTGGTGCGCTTCCAAGAAGCAGCCAATAAGCAGAAGCAGGAACTCGA
CGAGATCTCGACGAATATTCGTCAGGCCGGCGTCCAATACTCGAGGGCCGACGAGGAGCAGCAGCAGGCG
CTGTCCTCGCAAATGGGCTTCTG
Protein Sequence 
>NP_218391.1 ESAT-6-like protein EsxB [Mycobacterium tuberculosis H37Rv]
MAEMKTDAATLAQEAGNFERISGDLKTQIDQVESTAGSLQGQWRGAAGTAAQAAVVRFQEAANKQKQELD
EISTNIRQAGVQYSRADEEQQQALSSQMGF
Molecule Role Protective antigen
Molecule Role Annotation The 10-kDa culture filtrate protein (CFP-10, esxB) and 6-kDa early secretory antigen of T cells (ESAT-6) are secreted in abundance by Mycobacterium tuberculosis. Study demonstrated that protective immunity is induced by CFP-10 DNA vaccination in C3H mice as measured by a CFU reduction in the lung and spleen 4 and 8 weeks after challenge with M. tuberculosis (Wu et al., 2008).
Related Vaccines(s) attenuated M. bovis strain WAg539
References