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TPBG
Gene Name	TPBG
Sequence Strain (Species/Organism)	Homo sapiens
NCBI Gene ID	7162
NCBI Protein GI	262205665
Genbank Accession	AJ012159
Protein Accession	NP_001159864
Taxonomy ID	9606
Chromosome No	6
Gene Starting Position	82363205
Gene Ending Position	82367416
Gene Strand (Orientation)	+
Protein Name	transcript variant 1
Protein pI	6.83
Protein Weight	43252.68
Protein Length	420
DNA Sequence	>NC_000006.12:82363205-82367416 Homo sapiens chromosome 6, GRCh38.p12 Primary Assembly CTTTCTCTCTCTCTCTCTCTTAAAGTTGGCGCGCTCTCTTCACAAGTTCCATCACTACCCAAGAAGTGAG GGGGCGGGGGGGACAGGCGGGAAGGCATTAATTACACCTAAATCTGAAGTTTGCGGCCTCAAGTACCACT TTGATGGGGAGAGCTTCTGAAGCTTCCATACAACCTGCCGTGCCTTTGCTGCTGCCGCAGTAGATTTTCA GCTCATTTCTTTCTGCTGCTGCTTCGCGCTGCTCTGTCATGCCTAAATCTATCTCGTCACTGCCAAAGGT GCCTGAATCAGGGTGAATTCCACGAGATTCACCAGCGGTTTTGCTCCAGTCCAAGGTAAATACAGTATGC AAAATGAGGAACCACCCAAGGATGTCGGGGAGGGGGGAGAGAAAGGGATTCCCTCACCTTTTCCGGCACA TTCCTCGTTAATTTCCACCAGGAGGAGGCGCGCAGCCCAGCTCCCCTAGTCTCTCTTCTTAAATCCCCCT ACCTACGGCTGCCGAGGTTGGCCGCGCGTCGGGAATCTCCCCGACAGTCCTGGCCCTCCCCCGCCCCCCG GGTTGGTTTTTCCCAGCTGCGGAGGTTGGGAGGTTGGGCCAGGGGCTGGGGTGCGAAGAGAGTCGGCGCC CGCAACGCGGAGCCGGGAAGTCGTCGCTACTCTGGTGGAACTCAGAGTTGGTTCTGGAGGCGGCGGACGC GGAGGTGAGCAGTGGGAGCCCGCGGCCTGGGAGAGACCCGGGAGGCGTCGTTGGGGCCCCTCCCCATCCT CGGGTGGAGAGTAGGGTTGGTTCGGGTTGCCACTGTACCCCGAGTCCCACTGCTGCTTTGTTCCCAGACT CTCCCCTCCTCTTTGGAGATGACTTGAACCCCTTTGAGATCCGAGGGGCTGGCGGGGCGCGGGCTGGGGG GCGACAGTTGTAGCTCCACTTCCTGCTAATGCGAGAAGGTACAAAAAGAGATCAAAAAGTCCTGTAACCT GAAACTTCCCTCGCATCCTAACCGGGACCTGGTGGAGAGGTCTGGGCGGGGGCGGAGACACCCGGAGGCC GACCTTCCGCCGAGGCGGTGCAGGAAGGAACGGGAGAGGGAGAAGTTTGGTAGGGAAGGAATTGGGGATT AAGCGGTAAGTTAGACGCGGGAGACGAGTCTCCTCGGGAAAGGCGGAGGGCGGGAGGCCGGTCGGGTTTA TTTAGTGTGGGCCAGGGAAGAAGGAAGACTTTGCGGTCTGGGTGTCGGATGCGCGTCCCCCTCCGGAGTA AAAGTGACCGGAGGGGTTGGGGAGGCGAGGCCGGGGCGGGCTTTTGGAAGGAGGTCTCTGGGACAGACTG GAGACGACTAGACTCGAAAAGGCCGGTTTTTGCACTCCGGAAGCCGCGGCAGCCACCGCTGTTCACGCCT CTCTCCTGCTTGTCCCAGGTCCCTCAGAGGATCCAGCGAGGGGCGCCAACAAGAGGCGAAGAGGTGGCAC CAGGGCGGCGGCAGGAAGAGGAGCGGGAGCAGGAGCGCGGAGCGGAGCGTCCCGACCCGCCGTGCGTACT TTCTGGAGGGAAGGGGCGGGGGAATCGGCCCCTGAGGGAAGCGCCCGGTGGCGAGGGGGTTAGCCAAGTT CCGGCTGCGGCGCCACTCCCTCGGTTCCACGAGAGGAAAGTTTTTTTTTTCCAGACGCTTCCGCCGGCTC GCGCCCTCCGGGCCCAGCCTCCCGAGCCTTCGGAGCGGGCGCCGTCCCAGCCCAGCTCCGGGGAAACGCG AGCCGCGATGCCTGGGGGGTGCTCCCGGGGCCCCGCCGCCGGGGACGGGCGTCTGCGGCTGGCGCGACTA GCGCTGGTACTCCTGGGCTGGGTCTCCTCGTCTTCTCCCACCTCCTCGGCATCCTCCTTCTCCTCCTCGG CGCCGTTCCTGGCTTCCGCCGTGTCCGCCCAGCCCCCGCTGCCGGACCAGTGCCCCGCGCTGTGCGAGTG CTCCGAGGCAGCGCGCACAGTCAAGTGCGTTAACCGCAATCTGACCGAGGTGCCCACGGACCTGCCCGCC TACGTGCGCAACCTCTTCCTTACCGGCAACCAGCTGGCCGTGCTCCCTGCCGGCGCCTTCGCCCGCCGGC CGCCGCTGGCGGAGCTGGCCGCGCTCAACCTCAGCGGCAGCCGCCTGGACGAGGTGCGCGCGGGCGCCTT CGAGCATCTGCCCAGCCTGCGCCAGCTCGACCTCAGCCACAACCCACTGGCCGACCTCAGTCCCTTCGCT TTCTCGGGCAGCAATGCCAGCGTCTCGGCCCCCAGTCCCCTTGTGGAACTGATCCTGAACCACATCGTGC CCCCTGAAGATGAGCGGCAGAACCGGAGCTTCGAGGGCATGGTGGTGGCGGCCCTGCTGGCGGGCCGTGC ACTGCAGGGGCTCCGCCGCTTGGAGCTGGCCAGCAACCACTTCCTTTACCTGCCGCGGGATGTGCTGGCC CAACTGCCCAGCCTCAGGCACCTGGACTTAAGTAATAATTCGCTGGTGAGCCTGACCTACGTGTCCTTCC GCAACCTGACACATCTAGAAAGCCTCCACCTGGAGGACAATGCCCTCAAGGTCCTTCACAATGGCACCCT GGCTGAGTTGCAAGGTCTACCCCACATTAGGGTTTTCCTGGACAACAATCCCTGGGTCTGCGACTGCCAC ATGGCAGACATGGTGACCTGGCTCAAGGAAACAGAGGTAGTGCAGGGCAAAGACCGGCTCACCTGTGCAT ATCCGGAAAAAATGAGGAATCGGGTCCTCTTGGAACTCAACAGTGCTGACCTGGACTGTGACCCGATTCT TCCCCCATCCCTGCAAACCTCTTATGTCTTCCTGGGTATTGTTTTAGCCCTGATAGGCGCTATTTTCCTC CTGGTTTTGTATTTGAACCGCAAGGGGATAAAAAAGTGGATGCATAACATCAGAGATGCCTGCAGGGATC ACATGGAAGGGTATCATTACAGATATGAAATCAATGCGGACCCCAGATTAACGAACCTCAGTTCTAACTC GGATGTCTGAGAAATATTAGAGGACAGACCAAGGACAACTCTGCATGAGATGTAGACTTAAGCTTTATCC CTACTAGGCTTGCTCCACTTTCATCCTCCACTATAGATACAACGGACTTTGACTAAAAGCAGTGAAGGGG ATTTGCTTCCTTGTTATGTAAAGTTTCTCGGTGTGTTCTGTTAATGTAAGACGATGAACAGTTGTGTATA GTGTTTTACCCTCTTCTTTTTCTTGGAACTCCTCAACACGTATGGAGGGATTTTTCAGGTTTCAGCATGA ACATGGGCTTCTTGCTGTCTGTCTCTCTCTCAGTACAGTTCAAGGTGTAGCAAGTGTACCCACACAGATA GCATTCAACAAAAGCTGCCTCAACTTTTTCGAGAAAAATACTTTATTCATAAATATCAGTTTTATTCTCA TGTACCTAAGTTGTGGAGAAAATAATTGCATCCTATAAACTGCCTGCAGACGTTAGCAGGCTCTTCAAAA TAACTCCATGGTGCACAGGAGCACCTGCATCCAAGAGCATGCTTACATTTTACTGTTCTGCATATTACAA AAAATAACTTGCAACTTCATAACTTCTTTGACAAAGTAAATTACTTTTTTGATTGCAGTTTATATGAAAA TGTACTGATTTTTTTTTAATAAACTGCATCGAGATCCAACCGACTGAATTGTTAAAAAAAAAAAAAATAA AGATTCTTAAAAGAATTACAGTGTGTGCAAGTTTGCTTTGAAAAAAGGATGAAGGGCAGGAGTATTCAAT GGTCTTGGTTCCGATGATAATTATTACTTAACATAGCTGAGAATCAAACTGTAGCAATGTCTAATATAAA TAGACTTGGGAGATCGTTTTGAAATGGTGGATCCTTTTAGTATTTAAATGGAGAGTTTGAGTATTCATGT GACTGTATGGTCCCAAAGTTAATGCTATTTATGAAACAGTTTTGTAAGAACATAATGAAGTTGGTAAAAG CTAAGCGTTCTGCACAATAAACAGTTCCCAGTTTGGGGCTTTTTCAAGGCTAATGAAGTTATTGTTGGTC TAGAAAAATAGTATTTACTTAATAAAACTCTGTTTGAAATTGTTCTGTGGATTTTTAGAGCAGAATTTGA AACAAATGTAATGCAAATAAATATAAAGATAAAGTGTCTTAAAGACAATATTCTGAAATAAAAGATATAA AATATAATTTAA
Protein Sequence	>NP_001159864.1 trophoblast glycoprotein precursor [Homo sapiens] MPGGCSRGPAAGDGRLRLARLALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPDQCPALCECSE AARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEH LPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQ GLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAE LQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPP SLQTSYVFLGIVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV
Molecule Role	Protective antigen
Molecule Role Annotation	In a pre-clinical murine model, the recombinant virus expressing the tumor associated antigen 5T4 (TPBG) induces protection against challenge with CT26–h5T4 (a syngeneic tumor line expressing h5T4). Anti-tumor activity is long lived, with protection still evident 6 months after the final vaccination. In a therapeutic setting, injection of mice with TroVax results in a reduction in tumor burden of >90% (Harrop et al., 2006).
Related Vaccines(s)	Recombinant Human Papillomavirus Nonavalent Vaccine , Recombinant Modified Vaccinia Ankara-5T4 Vaccine
References

TPBG