VIOLIN: Vaccine Investigation and Online Information Network

ERBB2
Gene Name	ERBB2
Sequence Strain (Species/Organism)	Homo sapiens
NCBI Gene ID	2064
NCBI Protein GI	54792098
Locus Tag	RP23-355L10.8
Genbank Accession	AB025285
Protein Accession	NP_001005862
Taxonomy ID	9606
Chromosome No	17
Gene Starting Position	39688083
Gene Ending Position	39728661
Gene Strand (Orientation)	+
Protein Name	transcript variant 3
Protein pI	5.82
Protein Weight	126717.24
Protein Length	1225
Protein Note	Also known as NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
DNA Sequence	>NC_000017.11:39688083-39728661 Homo sapiens chromosome 17, GRCh38.p12 Primary Assembly GAAGTTCCTGTGTTCTTTATTCTACTCTCCGCTGAAGTCCACACAGTTTAAATTAAAGTTCCCGGATTTT TGTGGGCGCCTGCCCCGCCCCTCGTCCCCCTGCTGTGTCCATATATCGAGGCGATAGGGTTAAGGGAAGG CGGACGCCTGATGGGTTAATGAGCAAACTGAAGTGTTTTCCATGATCTTTTTTGAGGTAGGGCTGTTTAC TGTCACCACCCCTGTCGGATTTTACTTCCTAAACGTACCTGTAACTATCCACTTCTCTCCATCTCTTCTG GCACCACCCTGGTTAAAGACACCATCATGTGTCGCCAAGACAGCCGCAGTAGCTTCTTAATGGCTCTCCC TGCCTCTACTTTTGCCTCTTCCAACCTGCGCTCCATTTTGAAAAATTAAAATTTGCCCATATCACTTTTT TTTTCTTAAAATTATTTACTGGCTCCCAATTACCTTGGGTAAAATACAGTCTCCACAAACCCTGCCTGAT TTGGCCCCTGTCCACTGGTCTCCCTCACTCCCTTGCTCCAGACCCGCTTCAGAGGGCTATGTCCCTCAAG CTTCCTGACTGCCTGGCCTGGTCTGAATCACTCACTCTTCTTTTTTCTTCTAGTCGCAATTGAAGTACCA CCTCCCGAGGGTGATTGCTTCCCCATGCGGGGTAGAACCTTTGCTGTCCTGTTCACCACTCTACCTCCAG CACAGAATTTGGCTTATGGTAGGCGCTAACTGCGTTTGTTTGTTCTTCTGTTTAATGAATGAACAGCATA CATCAACATAAGAACTTGACAAATCCAGGGCTGTAAAATCATCAGTATGGTTCTGCACTGAGATCGGAGA GAAGTAATATTTCTAGGAAAATTAGGAACCCTGGGAACAGGACGCTTGCTTTAGTATCCTCTCCCTGCTC ACCTCCCCTGCACTCCCATCAGCACCGACCCACACCCAATCTCATAGAAGCCTTGTAGCTAAGGATCACC CTTTCTCCTCCCCCACTCTCCTCACCCCTTGTCAACTTTTCTTTTTCGTCCTGGGGGTTGGAATGAGTAA GAAGTAGCCTGGGATTCCATTCACTCACTTAACAAACATTTCTGAGTCCTTAGCTCTAGCACCTTGCTAA GCAAGGCAAAATCTCCAGGAGGCACCATTCACATTGCATTTTCTGTGAATGGTGCTCTGGGGAGCAGCAT TCACATTGCCTTTTCTGTGAATGGCAAATTCTTCCAGTTAAATATAACATGAATAGTGTCCCCTGGAGTT GACCACCCAACTGATACTGACTGAGAAGCTGAAATGAACAAAACAACCCCTTAGCCCTCCAGGAGCTGAC CGGAAATCCAGTGCTAATACTACTTTGCATCTTACAGATTAGTTCTTTTACAATACTGTTTTTTTTTCTT TTTTCATTTCATTTTGTCCTTTCTGTGACTCTGGGATGAGTCTTTTTATGAGGATCCTCATATAAAGATG GACATTTAGGATTAAAGAGGATGAAATCCTGACAAAATAGGGAGTCTCCCCTTTAGAAAATTCCTAAGTA AGGCTGGGGGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGACGGATCACCTGAG GTTAGGAGTTTGAGACCAGCCTGACCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAATTAGTTG GGTGTGGTGGTGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGG GAGGCAGAGGTTGTGGTGAGCCAAGATTGCGCCATCGCACTCCAGCCTGGGCAACAAGAGCGAAACTCAA AAAAAAAAAAAAAAAGAAAAAGAAAATTCCAATTTTGAAGGCCTCATCCTATATTATGTCAAACATACTG AAATGCAGTAACGCCCCACATTAAATAAGATTTATAAATAACTATACATATATATAATTCAATCTAATTG CTGTTAATAGTTGACATATTGCTACATTTATATACATTTAGTTAAAAAAAATTTTTTTTCCCAGACAGCC TCTCACTCTTTCACCTAGACTGAAGTGCAGTGGCATGATCACGACTCACTGCAACCTCAACCTCCCAGAC TCAAGTGATCCTTCCATCTCAGCCTCCTGAGTAGCTGGGACTGCAGCATGCGCCACTATGCCCTGCTAAT TTTTTTAATTTTTTGTAGAGACACGGTCTTGCTATGTTGCCTAGACTGGTCTCCAATTCCTGGGCTCGAG TGATCCTCCCGCCTCAACCTCCCAAAGTGCTGGGATTACGGGCGTGAGCCATGCCACACGGCCATAAAAT ATTAATTTTCGCAGCTTTCTTATATTTTAGAACTAACAATGGAAATTTGTTCGGGTCTAAAGTATTTCAG AGGTCCTTGAAAACCCATGCCTACATACCTGATGGAAAAAGCAATCCTAGGTTAATGGTGGAAGTGGGAG TAGAGACTTCTGTTCTGTTGACTTCTTGGAAGATGGGGTACTGTCTCTCTGGGACAGCTCTTGAGAATTT CCCTGCCAGCACAGCCCCAGATAACAATCTCTAGATGGCGATTACCTGGCCTCTCTTCCCAACTTTCTAG CCTGGAGCCCCTAGTTCTCCCCTGAGCCTCCTTAGCTTGTCCTTCTTCCTAACTTGTATTTGGCTTCAGA TGTGATCCACAGTCTGAAAAGTCACTAATTCATTCCTTCAACTCAGGCTTATTGAGTCCTCCTGTGTATC AGCCATTGTACTCATGGGGGAAAAAAAAGACAAAGCATATGTTAATAGTAGAGTGTGCTGGACAGGCACA GTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGGCGAGGCAGGTGGATCATCTGAGGTCAGGAGTTCG AGACCAGCCTGACCTAACATGGAGAAACTCCTGAGATCGTGCCATTGCACTCCAGCCTGGGCAACAAGAG CAAAACTCCGTTTCAAAAAAAAAAAAAAAAGTATAGTGTGCTAAAGGCTCAACGGCAAGCTGACCATGTT CTTAGATCAAAATTGGTAGAGAGTCTACAATGTGGGTTCCTTATTCATCAAATGTTTATTAAGTTTACCA TGTGCAAGTCTCTGGGAACAGAGTGATGAACAAGGCACTGTACTTTTCATGGTCAGAGGAGGGAAACAGG CCATAAACAAGTGTCAAACAAAAGACTGAAGCCAGGTGCGGTGGCTCACATCTGTAATCCCAGCACTGTG GGAGGCCAAGGCAGGCGGATCATGAGATCAGGAGATCGAGACCATCCTAGCCAACATGGTGAAACCCCAT CTCTACTAAAAATACAAAAAAATTAGCTGGGCATGGTGGCACGTGCCTGTAATCCCAGCTACTCCGGAAG CTGAGGCAGGAGAATTGCTTGAACCAGGGAGTTGGAGGTTGCAGTGAGCCTGGATTATGCCACTGCACTC CAGCCTGGTGACAGAGCGAGACTCCATCTACATTAAAAAAAAAAATATATATATATATATATACACACAC ACACACACACACACACACATACCCTCTAACCCAGGAATTTCACTCCTAGGTATACCTACATAAGCTCCAG TATACCTAAACAAGTGCAAATTTGTTTAAGTACAGTTATTTGTGGTAGCATTAGTCATTGTTTTCAATAG CAAGAAGAAAAAGGAAACAACTAAATGTCCATCAATAGGGAATGAATTATATTAATGGAGGGAGAGCCAT ACAATGGAAGGCTGAACAGAAATTAATAGGAATGGGGCAGATTTGTAATGTACTAGCATGGTAAAACCTT CATGATAGATATAGATATAGATATAGATATAGATATAGATATATATACATATACATATACATATACATAT ACATATATATATATATATATATATATCTCTTGTGTCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGT GCCACCACATCCGGCTAATTTTTGTATTTTTTAGTAGAGACAGGGCTTCACCATGTTGGTAAGGCTGTCT TGAACTCCCGACCTCAGGTGATCCACCTGTCTCAGCCTCCCAAAGTGCTGGGATTATAGGCATGAGCCAT CACACCTGGCCAAATATTTTTGATAAGTATCAAGTGCACAGTGCAGAACAAAATATGTGTGTGTGTATGC ATGTGTATGTACACCTATACACTTATATACAGTACCCCATGTGAAGAAAAATAAGGGTACGTGTTATGCG CGTAGTATTATGGTTGTTATTTTTGAGAATATATCTAGAAAGATAAAAAAGAAAGTGGAAATAGTTCTTG CCTCTGGTGGGAAGTGGGACTATGTGCCTGATCAATAGGGAAGTAAGGAACACTTTTTTTTTTTTTTTTT AAACGGAGTTTTTGCTCTTGTTACCCAGGTTGGAGTGCAATGGCGCGATCTTAGCTCACTGCAACCTCTG CCTCCCAGGTTCAAGCGATTCTGCTGCCTCAGCCTCCTGAGTAGCTGGGATTATAGGCATGCGCCTCCAC GCCTGGCTAATTTTGTATTTTTAGTAAAGATGGGGTTTCTCCATGTTGGTCAGGCTGGTCTTGAACTCCC CACCTCAGGTGATCCGTCCGCCTCAGCCTCCCAAAGTGCTAGGATTACAGGCGTGAGCCACCGTGCCTGG CCAGGAACGCTTTTTATTTTTGTACCTTTAAAAGTGTGTACCGTCTGTGTATATAATCAGTTAAAAACAA AGAAAAGCTGAGTGTGGTGGCTCATGCCTGTAATCCCAGCCCTTAAGGAGGCCGAGGCCGGCGGCAGATC ACCTGAGGTCAGGAGTTCAAGACCGGCCTGACCAAAACGGTGAAAACTCATCTCTACAAAAACATAAAAA TTAGCCAGGCATGATGGCAAGTGCCTGTAATCCCAGCTGGTTGGGAGGCTGAGGTGGGAGACTTGCTTGA ACCTAGGAGGCAGAGATTGCAGTGAGCCAAGACTGTACCACTGCACTCCAGCCTGGGCAACAGAGCAAGT CTCTGTCTCAAAACAAAAACAAAAACACAAAGAAAAAATGTAAAACAATTTCATGCAGTAGCAAGCATCG AGTTAAATACAGTTGACCCTTGAACAACACAGGTTTGAATTGCACGGGTCCATTTATACTCACATTTCTT CCACCTCTGCCACCCCCAAAATAGCAAGACCAACCCCATCTCTTTTCCTTTCTCTTCCCCCTCCTCAGCC TACTCAATGTGAAGATGATGAGGATGAAAACCTTTGTGATGATCCACTTCCACTTAATGAATGGTAAATA TGTTTTTTCTTACTTATGATTTTCTTAGTAGCATTTTCTTTTCTCTAGCTTCCTTTATTGTAAAAATACA GTATATAACACATATCACATACAAAATGTGTGTAAATGGACTGTTTGCTATTGATAAGTATTCTGGTAAA CAGTAGACTATTAGTTTTTTTTGTTTTGTGACAAGGTCTCCCTCTGTCGCCCAGCCTGGAATGCCGTGGT GTGATCATGGCTCACTGCAGCCAAAAACTTCTGGGCTAAAGCAATCCTCTACTAAAAATACAAAAATTAG CCAGGCATGGTGGTGCGCTTCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCC GGGAGGCAGAGGTTGCAGTGAGCTGAGATTGCACCGTTGCATTCCAGCCTGGACAACAGAGCGAGACTCC ATCTCGAAAATAAAATAATAATAATAATAATAATAATAATAATAATAATAATAGGGCTGGGTGTGGTGGC TCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGACAGATCACCTGAGGTCAGGAGTCTCAATTA AAAAATAAATAGGCCGGGCACAGTGGCTCATGCCCATAATCCCAGCACTTTGGGAGGCCGAGGTGGGCAG ATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACACGGAGAAACGCTGCCTCTATCAAAAATACA AAAATTAGCTGGATGTGGTGGTGCATGCTATAATCCCAGTAATACCAGCTACTCGGAAGGCTGAGGCAGG AGAATCACTCGAATCCGGGACACGGAGGTTGCAGTGAGCCGACATCATGCCACTGCGCTCCAGCCTGGGT GACAGTGAGACTCTGTCTCAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATATATATATATATAT ATATATATATATATATATATATATATGTGTGTATATATATATATATACACATATATATGTGTATATATAT ATACACACACACATATATATGTGTATATATAAAATAAAATAAATAATAATAAAACATTTACTTTGGCTGC TGTTGCTGCGGGGAGAATTGCAGGGTGTCAAAAGTAGCACTGGTGGAGGGGTAGTGATCAAAGTCTGGTG CTTTAGCCCAAAGGAGAAATGATAGAGACTCAGACTAGCTGGTGATGGAGGTAGAATAAGCATAAATGTA TCAAAAAGAGGAGTTGATAGATCTTAAAGAATGATTGGATTTGAAGGGCAAAGGAAGAGAAGAATCAACC AGGTGGGTTCAGTGAATGAAACCATCAGAAACGAATTGTCCCCTGAAATCAAGACTTTGTGATTGCCATA GTTGTATGCTTCTCAAAGGTTCCTCGTCTCCTCTTCCTTGGACCAAAAGTCAGAGGCAAGAATGCCCTCA TTCATACCCCAGTGGTCTATACCTCCAGCAGCAAGTCGAGTGAGCAAGTGATGTCCTGAAAGGCCCAGTG GATCAGTGGAATGAAGCGGGCAGGAAGACTTAGTGCTCCTGAAACAAGGAATCCAGAATCCAGGAGAAGG ATGGCTCAGTGGGGCTTTCAAGGGACAAGTATGGGGGTTGAAGGGGTCACTGTCCCTATACCAAATCCGA AAATATTGTGACCAGGAACCATTCTGTCCAACTCTTCTATTTCAGGTGGCAAAGCAAAGCTATATTCAAG ACCACATGCAAAGCTACTCCCTGAGCAAAGAGTCACAGATAAAACGGGGGCACCAGTAGAATGGCCAGGA CAAACGCAGTGCAGCACAGAGACTCAGACCCTGGCAGCCATGCCTGCGCAGGCAGTGATGAGAGTGACAT GTACTGTTGTGGACATGCACAAAAGTGAGGTGAGTCGCAGGACAGAAGAGTGCTTTTTGTTTCAGCAGAG CAGCCTGGGGAGAGATAAAAGCTACTCCTGGGGCCTGGGCCTGCATTCCTGAGATGTGGGTAAGAGGGGC CCAGGGTCAGAGTGTCTGGCAAGCTTGGCTCTGCCCCTTTGCTGTCCTGGAGACTAGGGCTAATCCTGGG CTCAGGGAGTGGCCTCCCCATGGTTAGGATACAAGTGCTCATCAAGGGCCACCCCTAGGAAGGACCAATT TTCCTATCAGAAGCTTCTAAGTTATCCTCCTTTGGCCCAAAGGGACACCTCAAGCCTACTCTGAGGAACT CTTTCCAATGAACTAATTCCTACAGTCACTTCCCCAGCAACCTGTGCCTCAGCCTCAAGGCACTGTGGGG TAGGCCTCAGTTTGTGGCCTGGACATCGGACTGTGGACCAGACGACTCCTCCCGATTTCTGTTTGTTTTC AGTCCTCTGACCCCAAGCTGGCTGGTGAAGTAGGTAGAGGGAGGAGACTTTGGTGCATGCATACACACAC ACACACACACACACACACACACACACACACACACACACACACACACGTCTCCTGTGCCCCCCAGTCTCCA TGGCTGGTCAATGATTGACTGGCATTTCACAGGCCGCTGGTTGCAGCCCCAGCCTGTTGACTTAGAGGTC ACCCTCGGAAGCTAGAGCCCTGTCCTGCCTCTTCAGTGTCAGTGGTCACTCCACTGCCCACAGGCTGGGG TCTTGGGCAAAACACACGCATCTGCCCTGATCTGAGTTTGCTGCCCTCTGTCCCGCAGTCAGCCCCACTC TGTTCCCACTCCCTCTCCCCAGCCCCCTAGCTAGACCCCTCTCACCAGCACCCCTTTCCCTTCCCTGAGG GTCCCCCTCGCTGTCTTTGTCCCTCAGACATCCTCTTTCCTGGGCTCTCCTGCCAGGCCCTGCTGGAGGG ACAGTTAAGGAGGAAATCGAATCAGCAGCGCCCACCCCTGCCCCCCTTCCTCTCCTCTTGTCAGACACCA GACGAGGTTTTTTCCTCTGGCTTCCCAGCTCTGAATGGGCTCATTCTTTTTCAGAGGCTCGGCCCCTCTC GAGCCTCCTCCCCAGGGCGTGAGTTCTGACCCCAGCTCCTCCCCCCATCCCCACTCCAGCCCCCTCTCCA GCTTGCTCCACCCTCTCTACCGCCCACCGGGACTGGGCATTGTCTGCCAGTCCGGGTTTCTTCCTGGGAT TTGGGATGCAGAGAGGATGGGTTTGCTTGGGCGGGGGGGTGGAGAGTGAAGGGGGGAAGCAGGATCTTTG TAGAGGGAGGGACCTACAGTTACCTGGACTTCTTTCCTCTGTCTCCCCTCTTGGTACCCTTGACTGGGGC TCTTGAGGGTAATGGGTGAAGCCAAATCTGCCATGGCTCAGTTCCCAGCTCAGCTCTGTGACCTTGGGAA AGTTCCTTTAGCTCGTGGAATCTCAAGGCTCAAGGTTCCTCTTCTGCAAAATGGGGAATGATAACACCTG CCTCCTCTGGAGTCTTGGGGACTCAGTGTTCTGAGGAACGTGGCTGTAGGTCAGAGTGGCACAGAGTAGG GTCCAATGAAGCATGGCGTCCACAGTAGCTTTCCTGACTGGACTAACCTTTCCGGACACAACAGCAGGGC AGGGGTGGGGCCTGGGGAGAAAGGACACCTCTAACCCTGATCCTAACATCCCGATGGCCTCTAAGGCTGC CTGCACACTCATCCAGGTGCAAGCCCTCCAAGGTGTGGTGTGATGAACCAGTGACTCCTGGAGCCAGGTC AGCGCATCCTCTTCCCGCAGGGCTGTAAGCTGCAGGACTGAGAGGCAGGTTGACCAGGTCCTGGGCTGGA TGATGGGGTGAGAGTAAGGGGTCAGTTTTGATACATGCCCAACTTTTCTCTCTAGCCCTAAGACATCCTG GGCAAATTGCTTACCTCAGTTCCCCTGATCCTCACCCTAACCCTAACACCAGCTCAAGAGAAAATAGGGA TATTGATGGCCATCCAGAAGGGCTGCTGTGTTCCATACACAGCAATATTTCTCGAATGTTTGTGACAGCG GTCCAAGGAATAAGTTAATTTTACATTATCACTCTGGATACCTGTACAAAACTCCACCTTATCCTTACTA TATGAATGTGCTAGGGTTGTTTTTTTGTTTTGTTTTTTTTTTTTTTTTTTGAGACAGAGTTTCGCTCTTG TTGCCCAGGCTGGAGTACAATGGCGCGATCTTGGCTCACCGCAACCTCCGCTTCCCAGGTTCAAGCGATT CACCTGCCTCAGCCTTCCCGAGTAGCTGGGATTACAGGCATGCGCCACCATGCCCGGCTAATTTTGTGTT TTTAGTAGAGACAGGGTTTCTCCATGTTGGTCAGGCTGGTACCAAACTCCCGACCTCAGGTGATCCACCT GCCTTGGCCTCCCAAAGTGCTGCAATTACAGGCATGAGCCACCGCACCCAGCCGTGCTAGGGTCTTTTTC TGTTCAATTCCTTTCTCTCTCTTGCTCTCTTTCTTTCTTTCAATGGAGTCTTACTCTGTCACCCAGGCTG GAGTGCAGTGGCAAGATCTCAGCTCACTGCAACCTCTGCCCTCTGAGTTCAAGCAATTCTCCTGCCTCAG CCTCCCGAGTAGCTGGGATTACAGGTGCCTGCCACCACACCTAGTTAATTTTTGTACTTTTAGTAGAGAT GGGGTTTTGTCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCGTGATCTGCCTGTCTTGGCCTCCCA AAGTGCTGGGATTACAGGCATGAGCCGCCATACTCGGCCAACTTTGTATTACTTTCTTAAAGAGAGTTTC CCAAATTATATAAGCTTCAGGCCCCACAAAACCTAGATCTGCCCCAGTATAACTAAATCTGGGACCATTT ATTGAGCAATTATTATGTGCCAAGTATTGCGCTGAGTGCTTCCAGAGCATTATCTCCTTTAACCCCAGCA TAGTATGTCAGATGCTGTTTTACAGATGAGCCAACTGAGACCAGAGATGCTCAGTCACTTGCCCAAGGTG ACATGACTGATATGGAATAGAGTCAAGATTTTTTTTTTTTTTTTTGACACGGAGTCTCACTCTGTCTCCC AGGCTGGAGTGCAGAGGCGCAATCTCAGCTCACTGCAAGCTCTGCCTCCCAGGTTCACGCCATTCTCCTG CCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCCGCCACCACACCTGGCTAATTTTTTGTATTTTTAG CAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCTGCCTCGG CCTCCCAAAGTGCTGGAATTACAGGTGTGAGCCACCGCGACTGGCCAGATTCAAGATTTGAACCCAGGTC CTCTTGGTCCCAGAGGCCCCTGTTTCTCAACTCCCTAGGATGGCATAGCAACCTGTCCCACAAGAGGTGC CTGCTTTAAGTGTGCTCAGCACATGGAAGCAAGTTTAGAAATGCAAGTGTATACCTGTAAAGAGGTGTGG GAGATGGGGGGGAGGGAAGAGAGAAAGAGATGCTGGTGTCCTTCATTCTCCAGTCCCTGATAGGTGCCTT TGATCCCTTCTTGACCAGTATAGCTGCATTCTTGGCTGGGGCATTCCAACTAGAACTGCCAAATTTAGCA CATAAAAATAAGGAGGCCCAGTTAAATTTGAATTTCAGATAAACAATGAATAATTTGTTAGTATAAATAT GTCCCATGCAATATCTTGTTGAAATTAAAAAAAAAAAAAAAAGTCTTCCTTCCATCCCCACCCCTACCAC TAGGCCTAAGGAATAGGGTCAGGGGCTCCAAATAGAATGTGGTTGAGAAGTGGAATTAAGCAGGCTAATA GAAGGCAAGGGGCAAAGAAGAAACCTTGAATGCATTGGGTGCTGGGTGCCTCCTTAAATAAGCAAGAAGG GTGCATTTTGAAGAATTGAGATAGAAGTCTTTTTGGGCTGGGTGCAGTTGCTCGTGGTTGTAATTCCAGC ACTTTGGGAGGCTGAGGCGGGAGGATCACCTGAGGTTGGGAGTTCAAGACCAGCCTCACCAACGTGGAGA AACCCTGTCTTTACTAAAAATACAAAAAATTAGCTGGTCATGGTGGCACATGCCTGTAATCCCAGCTGCT CGGGAGGCTGAGGCAGGAGAATCACTTGAACCAGGGAGGCAGAGGTTGTGGTGAGCAGAGATCGCGCCAT TGCTCTCCAGCCTGGGCAACAAGAGCAAAAGTTCGTTTAAAAAAAAAAAAAAGTCCTTTCGATGTGACTG TCTCCTCCCAAATTTGTAGACCCTCTTAAGATCATGCTTTTCAGATACTTCAAAGATTCCAGAAGATATG CCCCGGGGGTCCTGGAAGCCACAAGGTAAACACAACACATCCCCCTCCTTGACTATCAATTTTACTAGAG GATGTGGTGGGAAAACCATTATTTGATATTAAAACAAATAGGCTTGGGATGGAGTAGGATGCAAGCTCCC CAGGAAAGTTTAAGATAAAACCTGAGACTTAAAAGGGTGTTAAGAGTGGCAGCCTAGGGAATTTATCCCG GACTCCGGGGGAGGGGGCAGAGTCACCAGCCTCTGCATTTAGGGATTCTCCGAGGAAAAGTGTGAGAACG GCTGCAGGCAACCCAGGCGTCCCGGCGCTAGGAGGGACGCACCCAGGCCTGCGCGAAGAGAGGGAGAAAG TGAAGCTGGGAGTTGCCACTCCCAGACTTGTTGGAATGCAGTTGGAGGGGGCGAGCTGGGAGCGCGCTTG CTCCCAATCACAGGAGAAGGAGGAGGTGGAGGAGGAGGGCTGCTTGAGGAAGTATAAGAATGAAGTTGTG AAGCTGAGATTCCCCTCCATTGGGACCGGAGAAACCAGGGGAGCCCCCCGGGCAGCCGCGCGCCCCTTCC CACGGGGCCCTTTACTGCGCCGCGCGCCCGGCCCCCACCCCTCGCAGCACCCCGCGCCCCGCGCCCTCCC AGCCGGGTCCAGCCGGAGCCATGGGGCCGGAGCCGCAGTGAGCACCATGGAGCTGGCGGCCTTGTGCCGC TGGGGGCTCCTCCTCGCCCTCTTGCCCCCCGGAGCCGCGAGCACCCAAGGTGGGTCTGGTGTGGGGAGGG GACGGAGCAGCGGCGGGACCCTGCCCTGTGGATGCCCCGCCGAGGTCCCGCGGCCGGCGGGGCCAGAGGG GCCCGGACGAGCTCTCCTATCCCGAAGTTGTGGACAGTCGAGACGCTCAGGGCAGCCGGGCCCTGGGGCC CTCGGGCGGGAGGGGGCAGTTACACGGCAGCGGCTCGAGATGGCCCATCCAAGAGACTGGCGCTTTCCAG GCTCCGAGGGGCTCCGGGAACTTGTCAAAGAAGTTCTCTGAAATTGTTCAGAAAGTTTTCCCGCAAAGGG TGTATTGCGTAGAGCGCGCGCGCGCGTTTCCCCCCTTCTTGAGCCCCCTCAAGCTTTCTCAAAGCCTTTC CAGTTGGCAGCCTCCGCCTCCGGACTGGCCTGGGCTGGATTCCTTGGGGGGGTCCTCTGCCCTGCCCCTC CTCCAGCCCCTCCCCGCTCCCCTTCAGACGATTTTGGTTTGGTTGCTCCTGCTTCTGGCGGGGTCGGGTG TGTGTGTGTGTGGTGGAGTGGAGGGTGGCATAGCAACCTGTCCCAACCAGAGCCGGGGAGGAAAGGGTGG CCCGGAGGGTGGCCTCTTGCTGGGGTCTGGGTTGGGGGCGGGGGAGACGTTTGCTTTGAACAGATTCTTG GGGCCAGCTTAGGGACTGTGCTCTGTGACTTTTGGAGCGCGTGGACCATGGAGGGGTGGGGGTGGGTTTC TTGGGGTGTAAAGTGGGAGAGTTCCCAGAGAAGGAAGCTAAGAAATAAGGCCAGATGGGAGCCTAGGGAG GGCTGCGTTGTTCTGCTGCCTTTTCCTTGGTGCTGTGCGTGGGGAAGGGTGAGTGGGGGCAGTGTGTATC CTGACCCATCTGTCCACCTGTGTGCATTAATCATAAAAGCTAACATATAGCCTGGGCCAGGTATACTCTG CCAGGAACTGTTTGTGGTGTTTTGCATGCATTCTCCTTTAATCCTAGAACACCCCTATAGTGGAAGTTCT GCCAGCATTCTGGACTGAGTAGCAGTCCAGAGGTTGAGTAGCAGCTAGTAAGTGGTGGGGTCAAGATGGG ACCCCAGGCAGTGCGACCCCCAACCATGCATTCGAAATCGCTATATGGATGAGTGCACCTGGAGCAATGA GGGACACTGCTCCCTGAGTCACTGGGCTGCAGGGGAGACAAAATGAAAGTGTTCTGGGAGTCGTGGGTGG TCTCCATAGGTCAGAGGGTCTGGGGAGGGAGTGGGTGTCATCGTGGCTGTGTGTTGCCCGAGGGGCCCTC TGTGAGTGAGTGCATGGCCGTGTTATCTCTGCAGGTCTACGCCAGGGTGTTCCTCAGTTGTGTGGTCTTT GTATTTGTGTGTCTGGGCTTTGTGTTGCCAAACAGCAGTCTCTCTGCTGACTTGGGGACACAGGCTGAAC TCTGTCCTCTGCAGGAACTCCCTTAAGGTGCTGGGCCAGATCTGCCATAAACAGAGGGAGGTAGCCTTCT ATGGCCACGCCTTCTTGCTGAGGAAGAAGGTTCCTCTCTTCCAGGGAGTACATCCTTGCCCTCCCTGTTT CCCAGACAAGCATCTTCACCTCTCATCTTCTGATGAGAAGGGTGAGGCCATACTGAGCTGTCAGGCTGAG CTGCTGCCCTTCCTCACCTTGGGCTGGGAGTTGATCAGGGAATGGCAGTTGCTGCAGAGCTGGATTTGAG GGCTGGGTTCTCTGGATGGGGCCTCCTCATGTCCTCACCCCTCAACCTGCACTATTGATTGTGTTGTGCA GGAGTTAGTTAAAAAGTCATTGCACAGCCTGGGCAACAAGGCAAAACTCTGTACAAAAAATACAAAAATT AGTTGGATGTGATTACACGTGCCTGTAGTCCCAGCTACTCCGGAGGCTGAGGCAGGAGGATCACCTGAGC CCAGGAAGTTGAGGCTTGCAGTGAGCTGTGATTGCAAATGCTCTCCAGCCTGGGTGACAGTGTGAGACTC CGTTTCAGAAAAAAAGTATACCACCCAGCTGCCTCCAGCACCCAGATTTTACCCAAGGGGTGAGGTCTGG GGCAGGAATGTGGGGGAAGGGGAGGCCTAGGGGGAGCCCCAGAGGGGTCAGGATTTTTCTGAAATCCTTT CTTAGAGGTATGGGTTTTACAAATTGCAGCAAATACATCCTTTTAATCTTGCAGAACTCCTTCATATTTT AATTCCAGTATGATTCTTCCAACAGCCTCCTCTCTTTACTATACTTGGGGAAAGTACTCATTTTATTTGT CAAGAAAAAAACAATTGAAAAGATAGGGATCAAATGTAAAAAGAAAAAATACGTGGCATTCCAAAGTCAA ACACAAAGCATGTTTAATTTTCTCGTGGTTTGGGATTACCCATATTCCTGCTGTATGAACCTGTCTTGTC TTAACTTTTAAGAAATGTACGGTGTACTTCCTATATGCTAGGTTTTTATCCATGCTTTCATTTAATCTCT GTGACAGTCCTGTGAAGTAGGTGCACAGATGAGAAAATGGAAGTTCAGAGAAATGAAGCAACTTATCCAA GGCTCCCAGCTACCCAGTAATGTCCAGGGAATTTTTGGACTCTGAAGAGGAGGCATTAAGAGGTGGTTAG AGTCTTATTCCAGCCAACAATAATGGGTTGAACAAAGCCTTAGGGGCAGGCAGGTGGCCAGATGGGAGGA GAAGCGCTCCTCTTGTTCAGGCGAATGACCTTTCCATCCACTTCTCTAGGCTGTAGAAAGTGGAGCTGAG CTGGGGGCCCTGAGGTTCCCTCTTGACTTCAGAGTCCTCTCCCTTCCTGTCCAGCCAATGCCTGTCTTCC TTTTGGGCCCTACCAGCATGACAGGGGGCTGCGGGCAGGAGGGGACAGAGGCCACGTTGACACACAGGGC TGTGGGTGAGAGAGACAGCTGAAGTGTCAGCGTGAGGGGCCAGTGTGGGGCTGCGGCTGGGAGGGCTGGG GTGGGGCCCAGGGTAGTTGTGCCTGTCCTTGGGTGATGGAATGATCTGGAAAGAGATTCCTTCCCTGCCC TCCACCTGTGAGAAGCCCCTCTAGAGTGACATCTCCATCTTATGTTTGGCCACCCATCCTCCCCCTGGGA AGAGAGCCGAGGTGGGGTAAGGGATGTGTACTCTTTCAAGGAGTGGGAGAATTATTCTAGCGAATGTTTG TGTTGTCCCAGTTCTGTTTACAAAGCCTCGTCATGTTTACAGATGGCTGCGCAATTCATTACCTCATTTA ACTCTCATGTACCTCCTCTGAGGGAGTAAGAGCTGTTACAGCCAAGTTTAGGTCAGTAAATATTCACCAA GTTGCAGGTACTGCAGGGCATAGAGATGAATCCGATTTAGCTTCTGCCCTGGAGGTCTGGGAACTTGCTC AAGATCACTCAGTGAGCAGCTGAGCTAGGGTTCTCAACTAAAGACCCTGGGCCCAGGCCCTGGTCTGATG TCAGGCCTGATACACCAGGTGTTTGTGGTCGGGGAATCCCAGTGTCACTTGAATGGGCTGTGACATTATG GGTCTGGGAGAGCTGAGCTTTGGGGACACAGGTCATTTTACTGTAGTATTCATGGAAACCAAGGGAAGTA TTGGCTTTTCTGCTGTGAGCAAGAGGAGCAGCTGGGGCTGCAAGCTGGTGGGGAGGAGAGAACCCACCTG AGAGAAACCTCAGGACTGGGGTCAAGTCCTGACCACCAGAGTCCAGAGAGACATGAAGGACTGTGACCAG CTCTGAGCAGAGAGATGGATTCCATGACCTCAACTGGTCCCTTTTGTTCGGAGACTCGTGACTGGACTTC ATTCATCCACTCATTCATTCATTCACTCAGCAGACACTTATCTAGCGCTCCCTGTGGCTGGTCCTGCCTC ATACTGTCTTTGCTCTGGAGAATTGGAGGTTGGGGTTCCTGAGGGGCAGGGTCCTGGAGACAAGGACACT CCTGGGTAGAATTAGGACCTACCCCCCAGGAAATCAACGGGGACCAGGTGCCGTGGCTCACACCTGTAAT CCCAGCACTTTGGGAGGCCGAGACGGGCGGATCACAAGGTCAGCAGTTCAGGACCAGCCTGGCCAACATG GTGAAACCCGCCTCAACTAAAAATACAAAAATTAGCCAGGTGTGGTGTCAGGCACCCGTAATCCCAGCTA CTGAGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCGCC ACTGCACTCCAGCCTGGCGACAGGGCGAGACTCCATCTCAAAAAAAGAAAACCAATGGGACAGGGCAGAT ATGGGGACAATGGTAAGGAGATGGGAGAGTGGGAGGGAGGTGTCAGGAAGACCTTCTTGACTTCATGTAG GCTGGTGGGGGTGTTAGCCAGCAAGCCTCCAGTTCCCTGGGAACCGTTCTCAGGGTACCAATTTTACCAC CTGTCTGCAAACACTTTAAGATTCTTAATCAGACTCAAATTGGCCACAAATCAGGTAAACAAACTCACTA GTGGGGTGGGGCTACCACCCGTTCTGACCCTCCAGCCCAACCCAGCCCAGCCACCCTGCCCTCCGTAGAG CCTGTGGTGTTTATCGGTGGCATTGGGAGAATTAGTGTGTATTTATGTTGGCGTGGGGTGTGGGGTGGAT TTGTGTGTGTGCAGTTAGGCCTAGTGGAAGGAATGTGGGATCTGAAGGCAGGCCAGCCTGAGTTCCAGTC CTGCCTGTTGCTCACAAGCTTTATGAGGCGAGAGCTAACCCCTGCCAGCCTCAGTTGTCTTCTTTGCAAG ATGGAGGTTGCAGCCCCAGTCTCTGGAGCATGTTATGCAGATCCACCGAGAGTGCCTGCCAGGCACACAG TAGGTGCTCAGCTCAGTTACTGTGGCGGCCCCCACTCCCCATTGTTGTTGTTTTCCTATTGCCTGGCGGC CACAGCTGGTATCCCTTGAAAAGGGCTACAGGGGGTGGAGTCGGACCCTGCCCCAGCCCTGTGGAGACCC TGGGCTTGGGCCAGGGCCTGGGGTCTGGGCCTGCAGACAGCTGTGTCTATAAAGCAGCTGAAGGGCTGAG GCCGGGGGAGGTCCTGGCAGCAGGGCGTTATTTTGGGCCTGGCCTGCCACCCCCAGCTCCTGTTTCTCTT GGGAGTCTGTTGGGGGAGGAAGTGTGGGGAAGAGGAGGGGGTGCAAGTGGGTGAGGCATGGAGTGGGGAG GCCTCCCTCAGGGACATGGACCCTTGAGTTCTATTTCTGTTCCTCCCTCCTGTTCCTCCCTCTTTGTCCT TATCTGCCTAGAGAGGTGGGAATAGAGGCCATTCTGAGTATCACTAGGAGACCACCAGTTTGTGGCCACT GGCCACTGGCCCAGGCAGGGAACCTGGGGGCTTGCCCTACCAGCCTCTCCCAGCAATCTGAAGGCAGGGG GTACCTCGTATTACCCCCTAGGATTTGACCTTAGGCTCCAACTTGCTGGGAGAGCAGTGCCTCTGGTGTC AGACCCCAAGCCAGCCCTTGTGCTGTCCCTGAATCTGCATGTAGCCTGTGGGAGGCGGAGCAGTGACCGG CAGGAATTCTGGGCAGCTCAGGCACCTGTGGGCCTGAGGGTGCCCTCTGCCCCCACCCTTCCGATCTCCT GGGCAAGACACGCCAGGTGATTCATCTCACCAGAGCAGAAAAACAAGTTCAACTGGGCACTTTAATCTCC CCTCACTGGCAGGCCTGGTGTGAGCTGCTACCCCGGCGCCCCTCACCAGGGGTGCTTTACCTCCTCTAGT ATTCCTGACCTTAGTGGGCATTTCTGGTCTCAGGGATACCAGGCTGGGGTCCAAGTGGGCCAGGTGTGGC AGTTCAGCCCTATGCCCCATGGCTGATGGCTCGCGCTGGGCAGGTATGCAGGGCTGACGTAGTGCCTTTG TGGCAGCAGTTTCGTGGCACACATTCTGCCAGCTGGTTCTGGAGTCTTGCCCTGAGGAGGTGGCCAGGGT GAGGGTGCCAGCGCAGGAACCTTTGGCGCATGCTTCACCCTGGCCTGGGATCTGCAGCCTGGGTCCAGAT GCCCACAACTGGAATCTGACGCTCCTTTTCTCTTCATGGGGGACTCCCAGAGGTCTCTGCAATGACCAGA GCCCCGGTTGTCCCATGCCTCAGCTGCAACTCCAGCTGACCCTCCTTCCCCACTCTCTGGGTGGCATTAC GGGGGTGTGGATCCCTTGCCAAGAGGTTGGCATGTGGGTGTGCTGGAATGGCATAGGGAGAATGCACCGA GTTTGTTTGCTTGGGAGAGGGGCAGGGGGTATCCAGAAGATTCATGATTCGTCATCGCCTCTCTTGGGGG ATTTTTACCCCTTTGCCCTGAGTTGTGCCTTTGGGACAAAGGAAGCCTTTCTTTGCCAGCCAACACCCTG TACTGGCGGGCGAGCTCCCCAGGGCTGGCACGCTGGGGCAGCCTCTGAATGCACAGGGTGGGCCTAGTCA GAAGAAGCCTTTCCCCTGAAATCCCTCTACTTCCCAAGCACGCAAGCTTTCTCCTGCTGTTAAACCTGCA GTGTGCAAGGGACATGGGCGGAGGGGTCCTTCAGTCAGGCTTCTCCCTGTCTGAGGTGGCATGACTTGGA GTGAGTTTGGATGGGGTGGCCAGGTCTGAGAAGGTCCCCCGCCAGTGTCCTCTGACCCATCTGCTCTCTC CTGCCAGTGTGCACCGGCACAGACATGAAGCTGCGGCTCCCTGCCAGTCCCGAGACCCACCTGGACATGC TCCGCCACCTCTACCAGGGCTGCCAGGTGGTGCAGGGAAACCTGGAACTCACCTACCTGCCCACCAATGC CAGCCTGTCCTTCCTGCAGGTGAGGCCCGTGGGCAACCCAGCCAGGCCCTGCCTCCAGCTGGGCTGAGCC CTCTGTTTACAGGTGGGTGGCAGAAGAAGGTGCCCTGCCCTTCTGTTTCCTCTCTTGTTGTGGTTTCTCA ACCAGGAAGTCCTTTCTAACATCTAACCCCCATTCATTTTACTGCAGAATCAGTTGACTCTCTCTATAAC GTGGCTGGCCGAGGTCATGTCTGGATGGGATGCGTCTGTGTTTCCGCTAAATCTTGTGCTCTCTTGCCAG CATGATCATGTCCCCTGTCCACCTGCTCCAGCCACTATCCCTCTCCCACTTACAGCAGAAGAAAGGGCTG GTGAGAAAGGTGGATTACAGGCCCACTTCTGCCACTGACGAGCCCTATGAATGTGGCCTACACCCCCTTA GCTTCACTGGGTCTCAGTTTCCCTATCTGTATATTGGGAGCAGTTGTGAAGCTCAGAAGAGAAATGTCTG TGAAAAGGTTATGAACAGGAGGGAGAGTGGAAACCAACCTGCTGGATCGTGTCCACAGACCCTGGAATGG GGCCACATGCTTGGTTTGTCAAATTGCAGACGCCGGCCGGGTGCGATGGCTCATGCCTGTAATCCCAGCA CTTTGGGAGGCCGAGGCGGACAGATCACTTGAGGTCGGGAGTTCGAGACCAGCCTGACCAACATGGAGAA ACCCCGTCTCTACTGAAAATACAAAATTAGCCAGGCATGGTGGCACATGCCTATAATCCCAGCTACTTGG GAAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGACGGAGGTTGTGGTGAGCCTAGATCGTGCCATTG TACTCCAGCCTGGGCAACAAGAGTGAAACTCCGTCTCAAAAAAAAAAAATTTGCAGACGCCATCCCATCC AGGCCTTTGCTTTCACTGATGAAGAAACTGAGATACAGAGAGGGCAGGGCACCTGTTCGGAGTTTATGAA ATGCCCCCCCACCATTATCTTTCTTGATCATATAAGAATCTGGTGAGGCAAGGTAGGGCGTGATCTTTAT CTCTATTTTATCGTTTTATTTAAGCGGGAACAGGACTGCTCAGTGGCTGGGGGCCTTGCCCAAGATCTCC AAGTACTGGGGAACCCCAGGGAGGCCCTGGGGGGTGGCAGTGTTCCTATTTCAGCCCCACTCTGCTTCCC CCTCCCAGGATATCCAGGAGGTGCAGGGCTACGTGCTCATCGCTCACAACCAAGTGAGGCAGGTCCCACT GCAGAGGCTGCGGATTGTGCGAGGCACCCAGCTCTTTGAGGACAACTATGCCCTGGCCGTGCTAGACAAT GGAGACCCGCTGAACAATACCACCCCTGTCACAGGGGCCTCCCCAGGAGGCCTGCGGGAGCTGCAGCTTC GAAGCCTCACAGGTGGCCTTCACCGTCATTGAAACCTTCTCTTGGTTATTCAGAGCTGACCAGGGCCACT GCTAACCAGGGGGAGGCTTTGTGTGCATTAGAAATGGTGTCCCTTCTGGGCAGACGCAGGCAGAGCCCGG GAAGACGCCCTCAGAAGATTGGAAAAAGATTCCCCTTCTTCCTGGGAAGTTGTAGCTTGCGTCAGCACAT ATAATTCAATCGTGAGAATGCAGGCTGGGTTTTTGCCCCCACTTGGCTGAGTGAAGTGTACAGTGAACAA CCTATGTAACTATTTGCTGGCCCTGGAGCCGACTCTGCCCCAGAGTCTGGGTGCCAGGTGCTTTGCCCGC ATGGCCCATTTCAGTCACGCTGCAGTCCTGTCAGGAAAAAATCAGTGTTATTCTCATTCTACATATGAGA AAACTGAGGCTTGCAGATATAAGGGCCAAAAGTTACACAGCTAGTGAGTGATGGGGCTGAGTTTCAGACT CCACAGTCTCTTAACCACCAAGCAGCATGCCCAGAGTAGAGGTGAGAAGGAAGGAGAGAGCTGCGGTCCA CATGAGCATCTGGACCTAGCATGGACAACTCACTCCTCCCTGGCTCTCGCTTTGTTCTTGTTGCGGGTGT GGTGGTGGTGGGACTCAAAGACGGTAAAGATAGCTTTCTCTCCTCCCTGGGGAATCTGGGGGTTGTTTAA AAGGCCTGCTCCTCTTTTAGAAGGCAGGAGGGCCCCAAGGGAAGCAGAAGGTGACAGAAGGGGAAAGGGT CCTCTGATCATTGCTCACCCCACAGAGATCTTGAAAGGAGGGGTCTTGATCCAGCGGAACCCCCAGCTCT GCTACCAGGACACGATTTTGTGGAAGGACATCTTCCACAAGAACAACCAGCTGGCTCTCACACTGATAGA CACCAACCGCTCTCGGGCCTGTAAGCCATGCCCCTCCCTGCTGCCTCTTCTCTCAGACAGCCTGACCCCA GCCGCAAACTCCCAACTTACAACCCAGTGCCTGCCCGCCACTGCCCCAGCCGCCTACACCACCCATTTCC TCCCTCTCTGTCCCTCCTGCCATCTCCCTGTGCCTCTTCATCTCTGGGGTTCTCTGTCTTGTCTCCCTCT GCTTATAGGTTGTGCCTCTGGTTTGGGGGCCTCTCAGCCTGTCTGGGTCCCTCCCTTGCTGTGCAGTTGG CCTCGTGGCCTCTGCTGCTGTTTGTGCCTCTCTCTGTTACTAACCCGTCCTCTCGCTGTTAGACATCTCT CTCACTGCCTGTCTCTGGTTCTGTCCTCAGGCCACCCCTGTTCTCCGATGTGTAAGGGCTCCCGCTGCTG GGGAGAGAGTTCTGAGGATTGTCAGAGCCGTGAGTCTCAGGGAGGCCTGGAGTCAGGGAAGGGGAGGGCT GGGGCCGGGTGGAATGCAGGTGTCATACAGGTGACATGGGAGGGGTGGGATAACAGGCTTGGGATGTCTC CCCTGGGCCAGGTAGTCTCCCTAGAAGGTGATGCTGATGAGGGTCTGGTGCCCAGGGCGCCACTCAGCCC TCATCCTGCCCTTTGCCCAACAGTGACGCGCACTGTCTGTGCCGGTGGCTGTGCCCGCTGCAAGGGGCCA CTGCCCACTGACTGCTGCCATGAGCAGTGTGCTGCCGGCTGCACGGGCCCCAAGCACTCTGACTGCCTGG TATGTGCCTCTGCTTTGTGCCCAATGTGCTCTACCCCCCAGGATGCAAGGGGTGGGCACCCTGCCTGGTA CTGCCCTATTGCCCCTGGCACACCAGGGCAAAACAGCACAGTGAAAGCCAGCCACCTGTCCCCCCAGGCC TGCCTCCACTTCAACCACAGTGGCATCTGTGAGCTGCACTGCCCAGCCCTGGTCACCTACAACACAGACA CGTTTGAGTCCATGCCCAATCCCGAGGGCCGGTATACATTCGGCGCCAGCTGTGTGACTGCCTGTCCCTG TGAGTGCCAGGGAGAAACACAGTTTTCTCATTTTGGTGGGGAGGTTTGTTTCTGTAAATGGGAGCATATG GGGAGCACTGTCTGCATCTTGCTTTGAGAGCTGGTCATGACAGTTCCTGCCGAGCTGCCTTGTTCTTTCA ACAGCTGTGGAGCAGGTGGCAGTAAGGAGAGGCAGCTAAGAGCCCAGACTTGGGAGCCAGACTGCCTGGG TTTGAAACCCAGCTCTATCAATTAGTAGGCACGTGACCCTCTTGCTGTGCCTCAGTTTCCTCATCAGTAA AATGGGGGCAAGAATAGTCCCAACTGCATAAGATGGTTATAACATTTGAAAGAGTTAATATTTGTAAAGC TCTTAGAACGGTGCCTGGTATGTACTAAGTGCTCCTAAATGTTAGCTTTTATTCTATAGCCTGGTGAGGT CAGTTTTACCTTTCGTTTTGTTTTTGAGACCGAATTTAGTTAGCTCTATCGCAGTGGCGCGATCTCGGCT CACTGCAACCTCCGCCTCCCAGGTTCGTGCTATTCTCGTGTCTCAGCCTCCTGAGTAGCTGGGATTACAG GCGCCCACCACCATGCCTCGCTAAATTTTGTATTTTTAGTAGAGACAGGGTTTCACCACGTTGGCCAGAC TGGTCTCGAACTCCTGACTTCAGGCGATCCACCTGCCTCGGCCTCTGAAAGTGCTGGGATTACAGGCGTG AGCCACTGCACCCGGACTTTTTTTTTTTTGGCAGAGTCTCGCTCCATTGCCCAGGCTGGAGTGCAGTGGT GCAATTTTGGCTCACTGCAACCTCTGCCTTCCGCATTCAAGCAATTCTTGTGCCTCAGACTCTTGAGTAG GTGGAACTACAGGCATGCACCACCATGGCTGGGTAATTTTTGTATTTTTAGTAGAGACGGAGTTTCACTA TGTTGGCCAAGCTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTTGGTCTCCCAAAGTGCTGGG ATTACAGGCATGAGCCATCGTGCCTGGCCTAGCTCAGTTTTATTTAACAGATCACCTATTTACTGATGGG CGTTTATGGACTGGGCTCAGACCTGGGGAACCTCTTTCCTCCTCTCACAGGAACAGGAGTGGGCCTTCAG ATCCTGGCTGACTGTGTTAGGGAGAGGACAAAATGTAGAGCCAGACCATTTGGGTTCAAATCCTCGCTCC TCCACTCACTAGCACAATGACCTTGAATAATTTACAGAACTCTCTGCTTTGGTCTCCCTTTTTGCAAAAT GGGAATCTCACAGTGCTGATCCCGTCTGGTTGTTGTGAGGGGTAAATGGATGTCAGGTGCTGATGCGTGG TAGGGCATTTAAGTATTGGTTGATATTATTCTTCTTGTGCCTGGGCACGGTAATGCTGCTCATGGTGGTG CACGAAGGGCCAGGGTATGTGGCTACATGTTCCTGATCTCCTTAGACAACTACCTTTCTACGGACGTGGG ATCCTGCACCCTCGTCTGCCCCCTGCACAACCAAGAGGTGACAGCAGAGGATGGAACACAGCGGTGTGAG AAGTGCAGCAAGCCCTGTGCCCGAGGTACCCACTCACTGCCCCCGAGGCCAGCTGCAGTTCCTGTCCCTC TGCGCATGCAGCCTGGCCCAGCCCACCCTGTCCTATCCTTCCTCAGACCCTCTTGGGACCTAGTCTCTGC CTTCTACTCTCTACCCCTGGCCCCCCTCAGCCCTACAAGTGTCCCTATATCCCCTGTCAGTGTGGGGAGG GGCCCGGACCCTGATGCTCATGTGGCTGTTGACCTGTCCCGGTATGAAGGCTGAGACGGCCCCTTCCCCA CCCACCCCCACCTCCTCAGTGTGCTATGGTCTGGGCATGGAGCACTTGCGAGAGGTGAGGGCAGTTACCA GTGCCAATATCCAGGAGTTTGCTGGCTGCAAGAAGATCTTTGGGAGCCTGGCATTTCTGCCGGAGAGCTT TGATGGGTAAGAGTGGGCACGATGACCTGAGACAGTGTCAGGGCAGACAGAGTCCTGAGGATCCAGATGT GGCAGCATCTCTTGGGGATGGCAGGAGACAGAAGTGGGGGGATCAAGAATGCAAAGAAAGCAGATGGGAG ACCAGAGGAGCAGGGCCTTTGGTGGGTGGGGGTGATTATTTTTGTAAATGACATGCTATCCGTGAACAAG GACTTGTATGGAGGTCAGACCATCTAGATAAAGTAAAATTCCCTTTGAGTTCATAGCAGCTTTATTCAAA ATATCCCCAAATTGGAAATAACTCAAATGTGCATCACTAGGTGAAGGAATAAACAAGTGGCAGTGTATCC ATTTGGTGAAGTTCTACTTAGCAACCAAAGGAAATGAACTACCGATACAACATAAATGAATCTCAGAAAC ATTACATTGAGCAAAAGAAGCCAGAGACAAGATTCCATACTGTCTGATCCCCTTTATGTGAGGCTCTGAA CCGAAAAAACCACTCTGTGGTGGGAGAGATCAGAACGGTGGTTGCCCCAGGGTGGGGGGCTTCAAAAGGG AGGCACACAAGGACATTTCTGGGGTAATAGAAATGCTCTGTATAGTGATTGGGGTAGTGGATACATGAGC GAATCCATTTGTCAAAACTCATCAAACTGTGTGATAAGAGTCTGTGCATTTTATTTATTTCATTTTATTT TTTGAGATAGAGTCTCACTCTGTCAGCAGGCTGGAGTGCAGTGGTACGATCTTGGCTCACTGCAACCTCT GCCTCCTGGATTCAAGCAATTCTCCTGCCTCAGTCTCCTGAGTAGCTGGGACTACAGGTGTGTGCCACCA TGCCCAGCTAATTTTTGTATTTTTAATAGAGATGGGGTTTCACCATGTTGGCAAGGATGGTCTCGATCTC TTGACGTCGTGATCCGCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACACCCGG TGCATTTTATTGTATATAAGTTATACTTCAATAAGAAATGAATTGGGGCCAGGCACGGTGGCTCACGCCT GTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCAGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGC CAACATGGTGAAACCCCATCTCTACTAAAAAATATAAAAAATTAGCCAGGCTTCCTGGCATGCGCCTATC ATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCATGAACTCGGGAGGTGGAGGTTGTAGTGAGCTG AGATTTCGCTATTGCACTCCAGCCTGGGCGACAGAGTGAGACCCTGTCTCAAAAAGAAAAAAAAAAAAAA GGGTCAGGCGCCGTGGTGCACACCTGTAATCCCAGCACTTTGGGAGGCTGAAGCAGGAAGATTGCTTGAG CCCAGGAATTCAAGAACAGCGTGGGCAACATAGTGAGATCCCATCTCTACAAAAAAACACAAAAAATTAG CCGGGCATGGTGGTACGCACCTGTAGTCTCAGCTACTAGGGAGACTGAGGTGGGAGAATCACCTGAGCCT GGGAGGTGGAGGTTGCAGTGGGTTGAAATCATGTCACTGTACTCCAGCCTGGGTGACAGAATGAGACCCT GTCTCAAAAAAAAAAAAAAAAAAAAAATTCCCTTTCACACTTCCTTTACCTCCACTCCCCTTTCCAGAGG GGGCCATGGTTAACAGTGTGTGTGTTCACCTAGACCGTTTATGCATCTGTAGACACACACACAGTGAAGT GTGGTTTTCGTCGTTTTGGTGGGGAGGTTGGTTTCTGTAAATGGGAACATATAGGGAGCACTGTCTGCAC CTTGCTTTGAGAGCCGGTCATGACAGTTCCCATTGAACTGCCTTGTTCTTTCAATAGCTGCAGAGCAGGT GGCGGCAAGGAGAGGCAGCTAAGAGCCCAGACTTGGGAGCCAGACTGCCTGGGTTTGAAACCCGGCTCTA CCACTTACTAGGCATGTGACCCTTGTGCTGTGCCTCAGTTTCTTCATCTGTAAAGTGGGGGCAAGAACAG TCCCAACTTCATAAGATGGTTATACCACCATGCCTGGCCAGATGATTATAAAGTTTGAATGAGTTAATAT TTGTAAAGCTCTTAGAACAGTGCCTGGCAGATACTAGGTGCTCCTAAATGTTGGTTTTTATTATGTGGCT GGGTGGCTCGGGGTTTTATTTAACAGCTCCCCTATTTACTAATAGACATTTAGATCATGTTCCATTTTCA CTCTTACAAACAGTTCCACTTTGTGTGTGGCTCTGGGAACATGGGCCAGTGTCTCCCTAGGCCACATTCC TAGAAATAAGATTTCTTTTCTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTTTATCGCCAGGCTGGTGT GCAGTAGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTC TCGAGTAACTGGGACTATAGGCGCGCGGCACCACACCCAGCTAATTTTTGTATTTGTAGTAGAGATGGGG TTTCACCATGTTGGCCAGGATGGTCTCCATCTCTTGACTTCGTGATCCGCCCGCCTCGGCCTCCCAAAGT GCTGGGATTACAGGCGTGAGCCACTGAGCCCAGGCAGAAATAAGATTTCTAGATCAAAGGATATAAATAC TGTTTTGATAGATGTTGCCGAACTAAGGCCTGGGCTTTGAAGCCCAGGATGGGAACAGCTGGGCTCGATG GGCAAAGGGTTTGAGTGAAGGCATTCATGGTGGGGAGTGGCTGGCATGGCCAGTGCTGGGAGTGATGTCC ACCCTGTTCCTGGCCCTGCTGACTCCTCTCCTGACCCCTCCAGGGACCCAGCCTCCAACACTGCCCCGCT CCAGCCAGAGCAGCTCCAAGTGTTTGAGACTCTGGAAGAGATCACAGGTGGGCTCTGTCTCTGCATCCTG TTCTGCAGGGGCTGGGAGTCCTTGTCCTGTCCCCACTCCTTTAATCTCACCCTCTGCCTGCAGGTTACCT ATACATCTCAGCATGGCCGGACAGCCTGCCTGACCTCAGCGTCTTCCAGAACCTGCAAGTAATCCGGGGA CGAATTCTGCACAAGTGAGCACTGAGAAAGAGGGGGCCTGATGGGGAGGAGTCCCAGGGAGGAGTCCCTG TGGGAAGCTTTGGGCCTGAGGGAGTACTCCTGTAGCAGTAACCTTTCCATGAAAGTCTGCAGAGTGTGCT GGGGATGGAGGAAGATGAGAATAGCCTTTGCTGACCGGGAAGGGGTCCGTGGTAAGGTGCCCACCTTTCT CCCATAGTGGCGCCTACTCGCTGACCCTGCAAGGGCTGGGCATCAGCTGGCTGGGGCTGCGCTCACTGAG GGAACTGGGCAGTGGACTGGCCCTCATCCACCATAACACCCACCTCTGCTTCGTGCACACGGTGCCCTGG GACCAGCTCTTTCGGAACCCGCACCAAGCTCTGCTCCACACTGCCAACCGGCCAGAGGACGAGTGTGGTA AGACAGGGAGCCCAGTGTGCGCACTCCCCATCTGCCAGCACACAGCAGTGCCCAGGGGGCCCTGGCAGCA GCGTTCTTGGACTTGTGCAGACTGCCCGTCTCTGTGCACCCTTCTTGACTCAGCACAGCTCTGGCTGGCT TGGCCTCTTGGCATGGCTTCTCTAGCTGGGTCCTACCTGCCTTGGCATCCTTCCCTCCCCCTCTGTTTCT GAAATCTCAGAACTCTTCCTCTCCCTACATCGGCCCCACCTGTCCCCACCCCTCCAGCCCACAGCCATGC CCACAGCCAGTTCCCTGGTTCACTTGGACCTGGGGCCTCCCCTAAAAGTCCCCTGCGGTCCCTTCCTCCT CACTGCAGTGGGCGAGGGCCTGGCCTGCCACCAGCTGTGCGCCCGAGGGCACTGCTGGGGTCCAGGGCCC ACCCAGTGTGTCAACTGCAGCCAGTTCCTTCGGGGCCAGGAGTGCGTGGAGGAATGCCGAGTACTGCAGG GGTATGAGGGGCGGAGGAGAGGGTGGCTGGAGGGGTGCATGGGGCTCCTCTCAGACCCCCTCACCACTGT CCCTTCTCTCAGGCTCCCCAGGGAGTATGTGAATGCCAGGCACTGTTTGCCGTGCCACCCTGAGTGTCAG CCCCAGAATGGCTCAGTGACCTGTTTTGGACCGGTGAGCTGCTGGCGGGCTCAGAGCTGGGTGGAGGGGG GCAGCGAGGGGGATTGCCAGGGACTTGGCAGGATGGCGAGATGCAGTAGGGTGTGCTATCTGGTAAAATA TCCCTGGAGAGGGCTCAGCGCTCAGACCTGAACAGCAACAGAGTGGCAGAAAAGGGGCCTGGGGGACACT GGGGCCCTTCAGACTATGAAAAGGTTCTAAGGAGGTCTGTGTTGGTGGCTGTGACTGTGGCTGTGCTAGG GTGGTGAGCCCTGTGGGCTCAGGCGTCAGACTACCTGGATTCAGACCCAGCTCCTGCTTCCAACCTTGGT TTTTTATTCCTAAAATGGGTATTGTAATAATACCTACCTTGCTGGGGTGTGGCAAGAATGAAATTAAACA GGGCTTGGCACAGTGAAGCACGGGAAAGGCTTTCTACAGAGCAGTGACTGTTGTTACTCGCTGTTACACC TTAGGTAATGCGTTTTCCTCTCTGGGTGCCTCCCATTTTCTGGCTCAAGTCCCTGCCCAGGATCAAGCTT GGAGGAGGGCCCCGAGGGAGGGGCCACAGAGACTGGGTGAAGAGCAAGGGTGTTTGTCCCAGGAGCATGG CGAAAATTGCTGCTGGGTGGCCTTGGGAAGCACAAAGGGGACCCAACTAAGGGCCTGATCCTACTGCCCT GGGGGTGTCAGTGCCAGCCCCCCACAAATCTTTTCTGCCCCCCCCAGGAGGCTGACCAGTGTGTGGCCTG TGCCCACTATAAGGACCCTCCCTTCTGCGTGGCCCGCTGCCCCAGCGGTGTGAAACCTGACCTCTCCTAC ATGCCCATCTGGAAGTTTCCAGATGAGGAGGGCGCATGCCAGCCTTGCCCCATCAACTGCACCCACTCGT GAGTCCAACGGTCTTTTCTGCAGAAAGGAGGACTTTCCTTTCAGGGGTCTTTCTGGGGCTCTTACTATAA AAGGGGACCAACTCTCCCTTTGTCATATCTTGTTTCTGATGACAAAAATAACACATTGTTAAAATTGTAA AATTAAAACATGAAATATAAATTAATGCCCTAGCAGTTCTATCCCCACTGTTAATAATTTGAAATATTTT TCCTCTAGTTATTTTTGTCTGTGCACATTCTAATATGTATATATAAGTTAACATATATTAATATTATTCT CCAGTTATTTTTATCTGTGCACATTTTAACACACACACACACACACACACACACACACATATGTATTTTT AGACGGAGTTTCACTCTGTCGCCCAGGCTGGAGTGCAGTAGTACAATCTTGGCTCACTGCAGCCTCCACC TCCTGGGTTTAAGCAATTCTCCTGCTTCCGCCTCCTGAGTAGCTGGGATTACGGGAACGTGCTACCTTGC CTGGCTAATTTTTGTATTTTTAGTACATAGGATTTCACCATGTTGGCCAGGCTGGTCTCGAACCCCTGAC CTCAGGTGATCTGCCAGCCTCGGTCCCCCAAAGTGTTGGGATTACAGCGGTGAGCCACCATGCCCAGTCA TATATTTCTTTTTAACAAATAGAATCATAGATCATACATATTGTTTGCAAATTGCTTTTTCTCACTTTCC AGAACCTTGAAATGTTTTTCCATGTTCTAACATGGTGATCTACCTTATTCTTTTAATTTTTCTTATTTAG TTGTCTTTACACATGAAACACATGAATACATCCTTGTGATAAACATTTTCAGTAACATAAAAGTATAAAT GTTACAAAGCCAACGTGCCCTTTCACTCAACTCCCTGTCCACCCAGTCTCTCCTGTCTGCTGGGAGAACC ACCGCATTGACTTGTGTGTTCACCCTTCCAGGCTCTTTTCTGCACACTTATATAGACATACTACATTTAT ATTAGGTCGAGTCAAATAAGATTGCTGTTTGTGTAAACCAAAAAGTGTCAAGAGCCTGGGCGCAGTGACT CACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCACTTGAGATCAGGAGTTCGAGACCA ATCTGGCCAACATAGCGAGACCCCGTCTCTACTAAAAATACAAAAACTAGCCAGGTGTGGTGATGCTGTT CTGCACTTTGCTTTCCCCCCGACTTGAGGTATCCTTTCTTGTGAGTACAGACGGATCTACCACCTTTATT TTTTTTTTAATTACTCAACCTGTAACATGGATGTAATTTCACTTTGTTTTTGAGGGATATTGAGCTTGTT TCCCTGTTTTTGCAGTTTATTGCAATTGAGCTCCACACACAAGTGAGCCCTCTTTTGTATGCCCCCTAGT GGGAATACAGTGCTGGCAATGTTTATCACAAGGATATATTCATGCATTTCAATTTAAAGACAACTAAATG AGAAAAATTAAAAGAATATGGATCCAGGCTGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGA GGCCGAGGCAGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGCAAAACCCCGTC TCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTATTTGAGAGGTTG AGACAGGAGAATTGCTTGAACCTGGGCAGCGGAGGTTGCAGTGAGACGAGATTGCACCAGTGCACTCCAA CCTGGGCAACACAGTGCAACTCCTTCTCAAGAAAAAAAAGAAAAAAAAAAAGAATATGGGTCCAGATCCA TATGGATCCTAGATCCAGATCACGGTGTTAGAACATGGAAAAACATTGCAAGATTCTGCTAAGTGAAAAA AGCATTTGCAAACAGTATGTACAGTCTATATTCAGAGGAGGAACTGCTGGGTCATAGATGATATTTCATA GGTATTGCCAAACCGTTCTCTGGAGAAGTGGTATGGGTTTACCCTGGGATTCTTCTATGGAGGGAATAGT TGAGCTCCCGGGCTTGCTCTTCTGGGTGCCCCTCCCCGCTTCCTATCCACCACAAGGAGCTGCAGGGGAG CGGGGCATGCCGGTTCCTTGGCTGGAGAAGGAGTCTCCTTGTGAGGTGGTAGAAGGAGCACTGACGGCCT TGAGCCCAGTTTCTGCCTTTGTCAAATGGGGATAATGACCCAGCCACACCCCTCCCAGGGTTGTTGTGAG GCTGGAAAGGTGGTTCCCAAGAGGGTGGTTCCCAGAATTGTTGATGAGACTGTTTCTCCTGCAGCTGTGT GGACCTGGATGACAAGGGCTGCCCCGCCGAGCAGAGAGCCAGGTTGGCCTGGACCCCAGGATGTACCCTT CATTGCCCTTCACTCCCCCACTGGATGCTGGGTGGTCACTGCTGTAGGGAGGGGACCCCCTGACATATGT CCCTTCCCACCCACTCTTCCACTGTGGAACCTCCTGTCATTTTCCACTTCACCAAGTGACAGAGGACCTG CTCAGATGCTGAGGGGAGGGGACTGCAAGGAAAGATGGCTAGGAAACCCAGTCCCTCCACACCCTAGAGT AACTTGATGCCTTGTGAGGGACACAGGCAAAGTTCAATTCCTTGGAAGTCAAGGGAGACTGAGAAGAGTA CAGCTGCAGCACTGAGGGAGTGATGAATTCTTAACTGGGGATGGTGGGAGGCTTCGAGTGGGAGGTGGCA TTTGAGCTAGGCTTTGAGAGAGGAGCAGGTATTGCACTTGCATTTAGGTAGAAAGCATTGGGGTGCAAGG TGACACTGGAGGGGGAGGCATCAGGAAATCCAGGATGTCTTCAAAGTTCTGGTGTCGGGGGCTGTTGAGT AAGCACAGGAATAAGGGGGTCAAGTTAGAGTCAGGGTGGGGTCTGACCTGGATGCCATAGGACCTGATCC CCAAGCCACAGGGTGGGACTTGACTGGGCAGTGGGGACCTTTGGAAAGGACTTTGGGGAGAAAAACAGAC TGGAGTCTGTCTTAGGCGATCATCGGTCCGTGAAATGAGCATGTGTTACAGGCTTGGTATGTACCAGACC CTGTGCTAAGCAAGGGGGTATGGAGAGGAGAGGGTGACAAGAATATTGGATCAACACCCGGGAGCTCCAT CTATCCCAGGATGCACTATCTTTTTTTTATTTTTTTGAGACGGAGTCTCACTCTGCCTGCAGGCTGGAGT GCAGTGGCTCCATCTCGGTTCACTGCAACCTCTGCCTCCTGGGTTCAAGCGCTTCTTGTGCCTCAGCCTC CCAAGTAGCTGGGATTACAGGCACATGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGG TTTCACCATGTTGGCCAGGATGGTCTCGATCTCTTGACCTCAAGATCCGCCCACCTTGGCCTCCCAAAGT GCTGGGATTACAGACATGAGCCACCGTGCCCAGCCAGATACGCTATCTTTTTATTGAGTGATTGAGACAG GGTCTTGCTCTCTTGTCCAGTCTTGAATGTGGTGGTGTAATCACAGGCTCACTGCAGCCTTGACCTCCTG GGCTCAAGTTACCCTTCTGCAGTAGCTGGGACTATAGGAGCGTGCCACCACGCCTGGGTAATTTAAAAAA TTTTTTTTGTATAGACAGGGTCTCACTATGTTGCCCGAGCTGGTCTCAAACTCGTGGGCTCAAGTGATCC TCCAGTTTTGGCCTCCCAAAATGTTGGGATCACAGGAGTGAGCCACCACTCCTGGCGATGAGCCAAGTCT TTTTTTTTTTTTTTTTTTTTTGATATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAATGACACGATC TTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCAGTTCAAGCAATCCTCCTGTCTCAGCCCCCCAGT AGCTGGGATTACAGGCATGCGCTACCACGTCCGGCTAATTTTTGTATTTTTAGTAGAGATGAGGTTTTGC CATGTTGGCCAGGCTGGTCTTGAACTGCTGACCTCAGGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTG GGATTACAGGTGTGAGCCATCGTGCCTGGCGGAGCCGAGTCTTAAAAGATGACCCTGTGGAGAAATGGTG GTCCAGGCTGAAGGGACAGCCTATGCAAACACTGGGAGGTGTGGAAAATCATGACCTGTGGGTGGAAATT TTGGCTAGAACATCAAAATCATCAGGTGTACATTCCTGTACCCATGCAGCAGTCAGAATCTCTGGGGGTG GGGCCCCAAAATTGTATGCATACAGACTGTGTGCTGATTTGTGATATTACTTAGGATTTTTTGACTTTAC AATGGTGGAAAAGCAATAATATACATTCAGTATAAACCGTACTTTGAATACCCATACAGCCATTCTGTTT TTCACTTTTATTTTTATTTATTTATTTATTTATTATTTATTTTGAGATGTCATTTTGCTGTTGTTACCCA GGCTGGAGTGCAATGGCGCAGTCTTGGCTCACCGCAACCTCCACCTCTCAGGTTCAAACGATTCTCCTGC TTCAGCCTCCAGAGTGGCTGGGATTACAGGCAGGCACCACCACACCCGGCTAATTTTGTATTTTTAGTAG AGACGGGGTTTCTCCATGTTAGTCAGGCTGGTCTCGAACTCGAGAGCTCAGGTGATCTGCCCATCTCAGC CTCAAGCCACCATGCCCAGCCCTACTTTCAGTATTCAATAAATTACATAGCCAGGCACCGTGGCTCACAC CTGTAATCCCAGCACTTTAGGAGGCCAAGGTGGGAGGATCCTTTGAGGCCAGAAGCTCGAGACCAGCCTG GGCAACATAGTGAGACCCCATTTCTACAAAAAATAAAAAAACTAGCTGAGTGTGGTGGCGTGTGTCTGTA GTCCCAGCTACTTGGGCAGCTGAGGTGGAAAGACTGCTTGAGCCCAGAGGTCAGGGCTGCAGTGGGCCAT GATCTCACCACTGCACTCAGCCTGGGCAACACAGCAAGGCCCTGTCTCAAAAATAAATAAATAAATAACA CAAACTTATTTAACAGTTTACTATAAAATAGGCTTTGTGTCAGATGATTCTGCCCAACTGTAAGCTGCTG GCAGTGTAAATGTTCTGAGCACGTGTAAGCCAGGCTAGGTGTCTTAAATGCATTTTCAGTTTCAACTTAG AATTGGTTTATCAGGACGTAGCCCCTTGGTGTTGAGGGGCATGTGTATTAACAGTCTCCTTAGTGACTTT TTTTTTTTTGAGATGGAGTCTTGCACTGGCCGTAGTGCAGTGGCACAATCTCAGCTCACTGCAACCTCTT GTCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGTCTCCCAAGTAGCTGGGATTACAGGCACCCACACCAC GCCCAGCTAATTTTTGTGTGTGTGTATTTTTAGTAGAGACGGGGGTTTCACTATGTTGGCCAGGCTGGTC TCGAACTCCTGACCTTGTGATCTGCCCACCTCAGACTCTCAAAGTGCTAGGATTCCAGGCATGAGCCACC GCGCCCAGAGTCCTTAGTGATTTTTACACCATGAATTGTTGAAGCCCTAAGCCAGAGCCAAGGGCAAGAG TATAGAGAATCTGGAGATGCGGAGAGGGTTCTGATTGCCTACAAGGAGTTTGGACTTTATTGTGGAGGCA GCGGGGAGCCAAGGCAGGTTTTAGAGTAGGAGAGGGTCCAAGCCTGTGGGTCACCCTTCCGACTTCCCTT TCCGAATGCCAAACACCTTCATGTCCCCCGTGGGCCCCCTTTGTCCCTCCCACCCCAAACTAGCCCTCAA TCCCTGACCCTGGCTTCCGCCCCCAGCCCTCTGACGTCCATCATCTCTGCGGTGGTTGGCATTCTGCTGG TCGTGGTCTTGGGGGTGGTCTTTGGGATCCTCATCAAGCGACGGCAGCAGAAGATCCGGAAGTACACGAT GCGGAGACTGCTGCAGGAAACGGAGGTGAGGCGGGGTGAAGTCCTCCCAGCCCGCGTGGGGTCTGCACCG GCCCCCGGCACTGACCCACCACCCCCTCACCCCAGCTGGTGGAGCCGCTGACACCTAGCGGAGCGATGCC CAACCAGGCGCAGATGCGGATCCTGAAAGAGACGGAGCTGAGGAAGGTGAAGGTGCTTGGATCTGGCGCT TTTGGCACAGTCTACAAGGTCAGGGCCAGGTCCTGGGGTGGGCGGCCCCAGAGGATGGGGGCGGTGCCTG GAGGGGTGTGGTCGGCAGTTCTGATGGGAGGGGCAAGAGCTGGAGGCAGTGTTTGGGGGAGGGCAGTTAC AGCGGAGAAGGGAGCGGGGCCAAGCCCTAGGGTGGTGAAGGATGTTTGGAGGACAAGTAATGATCTCCTG GAAGGCAGGTAGGATCCAGCCCACGCTCTTCTCACTCATATCCTCCTCTTTCTGCCCAGGGCATCTGGAT CCCTGATGGGGAGAATGTGAAAATTCCAGTGGCCATCAAAGTGTTGAGGGAAAACACATCCCCCAAAGCC AACAAAGAAATCTTAGACGTAAGCCCCTCCACCCTCTCCTGCTAGGAGGACAGGAAGGACCCCATGGCTG CAGGTCTGGGCTCTGGTCTCTCTTCATTGGGGTTTGGGGAGATATGACTCCCGCAAACCTAGACTATTTT TTTGGAGACGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGTTATCTCGGCTCACTGCAACCT CCACCTCCTGGACTCAAGCGATTTTCATGCCTCAGGCTCCTGAGTAGCTGGGATTACAAGCGCCCGCTAA TTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCACCCAGGCTAGAGTGAAATGGTGCGGTCTCAGC TCAGCCTCCCAGGTTAAAGCGATTCTTCTCCCTCAGTCTCCTGAGTAGCTGGGATTACAGGCGCGAGCCA CCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGATTTCACCATGTTGGCCAGGTTGGTGTCAAA CTCCTGACCTCATGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCC CGGCCTAATCTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGTCCAGGCTGGTACTTTGAGCCTT CACAGGCTGTGGGCCATGGCTGTGGTTTGTGATGGTTGGGAGGCTGTGTGGTGTTTGGGGGTGTGTGGTC TCCCATACCCTCTCAGCGTACCCTTGTCCCCAGGAAGCATACGTGATGGCTGGTGTGGGCTCCCCATATG TCTCCCGCCTTCTGGGCATCTGCCTGACATCCACGGTGCAGCTGGTGACACAGCTTATGCCCTATGGCTG CCTCTTAGACCATGTCCGGGAAAACCGCGGACGCCTGGGCTCCCAGGACCTGCTGAACTGGTGTATGCAG ATTGCCAAGGTATGCACCTGGGCTCTTTGCAGGTCTCTCCGGAGCAAACCCCTATGTCCACAAGGGGCTA GGATGGGGACTCTTGCTGGGCATGTGGCCAGGCCCAGGCCCTCCCAGAAGGTCTACATGGGTGCTTCCCA TTCCAGGGGATGAGCTACCTGGAGGATGTGCGGCTCGTACACAGGGACTTGGCCGCTCGGAACGTGCTGG TCAAGAGTCCCAACCATGTCAAAATTACAGACTTCGGGCTGGCTCGGCTGCTGGACATTGACGAGACAGA GTACCATGCAGATGGGGGCAAGGTTAGGTGAAGGACCAAGGAGCAGAGGAGGCTGGGTGGAGTGGTGTCT AGCCCATGGGAGAACTCTGAGTGGCCACCTCCCCACAACACACAGTTGGAGGACTTCCTCTTCTGCCCTC CCAGGTGCCCATCAAGTGGATGGCGCTGGAGTCCATTCTCCGCCGGCGGTTCACCCACCAGAGTGATGTG TGGAGTTATGGTGTGTGATGGGGGGTGTTGGGAGGGGTGGGTGAGGAGCCATGGCTGGAGGGAGGATGAG AGCTGGGATGGGGAGAATTACGGGGCCACCTCAGCATGTGAAGGGAGGGAAGGGGCTGCCTGTGCCCCAC CTTGCAGGGTCTGTGCACTTCCCAGGATTAGGGAAAGACCGGGTAGGGTCTGTCTCCTGGCATCACATCT CCCCCTGCTACCTGCCATGATGCTAGACTCCTGAGCAGAACCTCTGGCTCAGTACACTAAAGCTCCCTCT GGCCCTCCCACTCCTGACCCTGTCTCTGCCTTAGGTGTGACTGTGTGGGAGCTGATGACTTTTGGGGCCA AACCTTACGATGGGATCCCAGCCCGGGAGATCCCTGACCTGCTGGAAAAGGGGGAGCGGCTGCCCCAGCC CCCCATCTGCACCATTGATGTCTACATGATCATGGTCAAATGTGCGTGGCTGAGCTGTGCTGGCTGCCTG GAGGAGGGTGGGAGGTCCTGGGTGGAGGAGCCCACAAGGGGCATGAAAGGGGACCAGGATGTATGTAGAC CCAGGAGCCCTAGTATGTTAGGAGCCTCAAAACCTTCTTGTATCCCTTTTACAGTCAAAGTCCAAAGCCA CTCTTGAGGAACACTCTTGTACAAAATTAAGCTGGGCACAGTGGCTCATGCCTGTAATCCCAGTACTTTT GGAGGCTGAGGTGGGAGGATCCCTTGAAGCCAGGAGTTCAAGACCAGCCTGGGCAACATAGTGAGATCCT ATCTCTACAAAAAATAAAAAAATTATCTGGGTGTGGTGGTGTGTGCCAGTAGTCCCAGCTACTCAGGAGA GGCTGAGGCAGGAAGATCACTTGAGCCTAGTTTAAGGTTGCAGTAAGCTATGATTGCACCACTGAAATCC AGCCTGGGTGACAGAGCGAAACCTCATCTCAAAAAAATAAAAAAGCAAACAAAAAGAAAAAAAAAATTAA AAGGGAAACTAGAAGAGATGCCAAAGGTTCTGGCTGAAGACCCCAGAGTCTGGTGCTACTTCTCTACCAC CTGAGGGCTTTGGGCTGTCCCTTGGGACTGTCTAGACCAGACTGGAGGGGGAGTGGGAGGGGAGAGGCAG CAAGCACACAGGGCCTGGGACTAGCATGCTGACCTCCCTCCTGCCCCAGGTTGGATGATTGACTCTGAAT GTCGGCCAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGT CATCCAGGTACTGGGCCTCTGTGCCCCATCCCTGCCTGTGGCTAAGAGCACCCTCCTGCAGAGGGTGGGA AGGAGAGATGAGTCCAGTATGCCAGGCCCCTCACGGAAGGCTGCATGCTGGGCTGGGGAGGGGCCACCAT CCTGCCTCTCCTTCCTCCACAGAATGAGGACTTGGGCCCAGCCAGTCCCTTGGACAGCACCTTCTACCGC TCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGCT TCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAG GGTCAGTGCCCTCGGTCACACTGTGTGGCTGTCTGCTTACCTCCCCCAACCCCGGTGGACTAGGGTCCCT TTCTCTGATGTTCCCTCAACTGTCACCTCTCAAGGAAACCCCATTATCCCTACAAAAAATTCTTACTGCC TTCCAACCCCTGTGACCCCATTCTCTCCACGGTGACTGTGTCATACCCCAAAGGTGACCTCTGTTTTTCT CCTGTGACCCTGTCACCTTCCATGGAGTCCCCATCCCAGATCCGTGAGTGACCCCCATCATGACTTTCTT TCTTGTCCCCAGAGTGGCGGTGGGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGT CTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGACCTGGGAATGGGGGCAGCCAA GGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCC CTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGGTATGGAGTCCAGTC TAAGCAGAGAGACTGATGGGCAGGGGAGGTGGGACCTTCAGCCCAGGGTCCACTGTGGGGGCAGAGGGAG TGGCAGAGACACCGGGGTTCCTTCCCCTAATGGGTCACCTTCTCTTGACCTTTCAGAATATGTGAACCAG CCAGATGTTCGGCCCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCA CTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGG TGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCTCCTCCTGCC TTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCA CCTTCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTCTGGACGTGCCAGTGTGAACCAGAAG GCCAAGTCCGCAGAAGCCCTGATGTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATCAAGAG GTGGGAGGGCCCTCCGACCACTTCCAGGGGAACCTGCCATGCCAGGAACCTGTCCTAAGGAACCTTCCTT CCTGCTTGAGTTCCCAGATGGCTGGAAGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGGGAGTCTT TGTGGATTCTGAGGCCCTGCCCAATGAGACTCTAGGGTCCAGTGGATGCCACAGCCCAGCTTGGCCCTTT CCTTCCAGATCCTGGGTACTGAAAGCCTTAGGGAAGCTGGCCTGAGAGGGGAAGCGGCCCTAAGGGAGTG TCTAAGAACAAAAGCGACCCATTCAGAGACTGTCCCTGAAACCTAGTACTGCCCCCCATGAGGAAGGAAC AGCAATGGTGTCAGTATCCAGGCTTTGTACAGAGTGCTTTTCTGTTTAGTTTTTACTTTTTTTGTTTTGT TTTTTTAAAGATGAAATAAAGACCCAGGGGGAGAATGGGTGTTGTATGGGGAGGCAAGTGTGGGGGGTCC TTCTCCACACCCACTTTGTCCATTTGCAAATATATTTTGGAAAACAGCT
Protein Sequence	>NP_001005862.1 receptor tyrosine-protein kinase erbB-2 isoform b [Homo sapiens] MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLR IVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWK DIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQC AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGS CTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPES FDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGI SWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHC WGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHY KDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVG ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGA FGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQL MPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLL DIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGER LPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLE DDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEG AGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPP SPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNL YYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
Molecule Role	Protective antigen
Molecule Role Annotation	Three peptides representing B-cell epitopes of the extracellular domain of Her-2/neu each of them inducing Her-2/neu specific immune responses with anti-tumor activity in vitro were identified. A study was performed to evaluate the in vivo protective capacity of a combined vaccination with these three peptides in FVB/N transgenic mice spontaneously developing c-neu overexpressing breast cancers. The three Her-2/neu peptides coupled to tetanus toxoid were administered with or without addition of recombinant IL-12. At the time all untreated mice had developed tumors about 40% of peptide-immunized mice and nearly 60% of mice immunized with the peptide vaccine co-applied with IL-12 remained tumor free (Wagner et al., 2007).
Related Vaccines(s)	Adenovirus Encoding Rat HER-2/neu , Adenovirus HER2-Transduced Autologous Dendritic Cell Vaccine , AE37 Peptide/GM-CSF Vaccine , Allogeneic Cellular Vaccine 1650-G , Allogeneic GM-CSF-Secreting Breast Cancer Vaccine , Anti-HER2/HER3 Dendritic Cell Vaccine , Autologous GM-CSF-Secreting Breast Cancer Vaccine , Autologous Ovarian Tumor Cell Lysate-Pulsed Dendritic Cell Vaccine , Cancer Her-2/neu Protein Subunit Vaccine , CD80 Breast Cancer Vaccine , EP-2101 Vaccine , HER2 ECD+TM Virus-like Replicon Particles Vaccine AVX901 , HER2-pulsed Autologous Type-1 Polarized Dendritic Cell Vaccine , HLA-A*0201-Restricted TRP2-gp100-EphA2-HER2 multipeptide Vaccine , Lapuleucel-T Vaccine , Malignant Glioma Tumor Lysate-Pulsed Autologous Dendritic Cell Vaccine , Mammaglobin-A DNA Vaccine , Melan-A/MAGE-3.DP4 Peptide Vaccine , Modified Vaccinia Ankara (Bavarian Nordic)-HER2 Vaccine , Monoclonal Antibody 4B5 Anti-Idiotype Vaccine , Multi-glioblastoma-peptide-targeting Autologous Dendritic Cell Vaccine ICT-107 , MVF-HER-2(597-626)/MVF-HER-2 (266-296) Peptide Vaccine , Nelipepimut-S Plus GM-CSF Vaccine , pNGVL3-hICD Vaccine , Poly Microsphere Encapsulated HER2/neu Oral Vaccine , pUMVC3-IGFBP2-HER2-IGF1R Plasmid DNA Vaccine , Recombinant dHER2 Vaccine , Survivin/p53/HER2 Antigen-loaded Autologous Dendritic Cell Vaccine
References

ERBB2