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FASLG
Gene Name	FASLG
Sequence Strain (Species/Organism)	Homo sapiens
NCBI Gene ID	356
NCBI Protein GI	4557329
Genbank Accession	AB013303
Protein Accession	NP_000630
Taxonomy ID	9606
Chromosome No	1
Gene Starting Position	172659007
Gene Ending Position	172666872
Gene Strand (Orientation)	+
Protein Name	transcript variant 1
Protein pI	9.71
Protein Weight	29599.28
Protein Length	281
Protein Note	Also known as FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1
DNA Sequence	>NC_000001.11:172659007-172666872 Homo sapiens chromosome 1, GRCh38.p12 Primary Assembly CAGAATCAGAGAGAGAGAGATAGAGAAAGAGAAAGACAGAGGTGTTTCCCTTAGCTATGGAAACTCTATA AGAGAGATCCAGCTTGCCTCCTCTTGAGCAGTCAGCAACAGGGTCCCGTCCTTGACACCTCAGCCTCTAC AGGACTGAGAAGAAGTAAAACCGTTTGCTGGGGCTGGCCTGACTCACCAGCTGCCATGCAGCAGCCCTTC AATTACCCATATCCCCAGATCTACTGGGTGGACAGCAGTGCCAGCTCTCCCTGGGCCCCTCCAGGCACAG TTCTTCCCTGTCCAACCTCTGTGCCCAGAAGGCCTGGTCAAAGGAGGCCACCACCACCACCGCCACCGCC ACCACTACCACCTCCGCCGCCGCCGCCACCACTGCCTCCACTACCGCTGCCACCCCTGAAGAAGAGAGGG AACCACAGCACAGGCCTGTGTCTCCTTGTGATGTTTTTCATGGTTCTGGTTGCCTTGGTAGGATTGGGCC TGGGGATGTTTCAGCTCTTCCACCTACAGAAGGAGCTGGCAGAACTCCGAGAGGTAAGCCTGCCGGCAGA CTGCTGTGCCCTGGAGGCACCAGGCATAAGGGGATGGAGGGCCCACTGCCTGGCTTGCAAAGTGCTTTTC AATCCTTTTTTTTTTTTTCTTAGAAATGGGTTGTTCTAGTTATTCTATTCTATAGACAGAGAAATGGAGG CTCATAGGGGTGAAGGGAATATTTTTTACTTTGTAAAGAATCAGAGCCCAACAGTTTGTCTTTCCTCAGT TGTCAACTCAGTCTGTTGAACCACTTACTGCCTCATACCTATTGATTTAAGGAGTAAAAAACAAACAAAC AAAACTTTTAAGTTTTGCTTGGAAGTAAATTTGTTCAGATGACCAAACTAAATCTTGAAAATTGGTACGA TTCCAAATCACAAAACTGAGGGACAGTGAGGCAAAATTGCTTGGCCAAAGCCCAAGTTAGCAGAACTTCT GAGGTATTTGGATTCTCTTTCCAGGGCTTGGTTTATTTGACGATTCTGCCTCTTTTGCTTAAAGAATTTT ATTTTTATTATACATCTTTTCTCTTTCTGTTTTACTAGTCTACCAGCCAGATGCACACAGCATCATCTTT GGAGAAGCAAATAGGTGAGTCTTTTTTCGCATGTACATTGAGTTCCCAAAGATGATCCTCAGCACAGAAC TATGTTAATGGAATGCCTTAAATTCTGTCCCACACTTTGGTTTCTGTACACTATAAGAGGAATTCTGGCT AATTCAGAATCTCTGGTCTATGATTCCTTGAGCTGCTTTAAAAATGTGAAGTGAATTGAATTGCTCACAA TCAATATAGCTGAGCACTGCACACAATTCAAAATCACTTCCACTTGACTTTGGAAAGAGACACACATATA CAACCCTGGACCTTTGCCCCCTGAGAAGTGGCTCCAGGCCTGTCCCCTTCCACAGACATCCTGGTCCTGG CACACACGCCAGTGGCTGTAACTCCTGGGAAGAGAAGGCGAAATGAAGGCAGAGACAGATGTTTCTGAGA AACGTCCTTTCCTCTTTTAAATGCCCTAAAGAGATTACATTGAAGCTTTATTTACAATATGTTTTATAGG ATGTAAGCTTTTAAAACATGGATAATCAATTCCCCACATTAGAATGGTTTTTCTTGAAGTCACTGAGAAG CTTAAGGGAAGACTTCAGCCATCATTCAAAGGATGTTCAGCTTCACCCACAGAGGCAGTCATGAGGTACC CTTGATCACAAAGGAAAATCCTTTGTATGGGAGCTAGGGCAAGAAGATGATAGGTTGAACACTGATCTCA TGAAATTTCAGGGCATAGTTGTGCAAGCTCTGTACAGATAGATTTTACAGTGTGCTTCACTAGTCTAAGA TTCATTGAAATTTTAGATTTAGATTTACAATGAGATTCATTGAATTTTTAGAGGTGGAAGGAAGCTTAGA ATATATCTAGTCCAGCCATTTCATTTTTTGGAAGAGAAACAAAATACCAGATGGATTAGGTGAATATGCC CAAGACCACTGGTATGCCATTGGGGCTAGAAGGAACACAGGCTCTTGATGCCTTGTCACCTACAGGGCTT TCCAGTACTGGACTGGTGCCTCATGAAGGAGGGAAACTCCTGTCTCTCTGTAGTGAGCATGGAATAAGAA ATAGATGAAAAGCAGGATACCTCTGCAAAGACTATAGGTAGATCTCATCCTTAGAAACTCAGAATAAAGA AGAAGGCAGCACTGGCCATCTATTAAGTGAAGCAAGTTCCAGTTTCTCCGGATGTGGCTACTGCACATGA CCCAGTCGCCTGTCTACTATCCTAGACTGTTAAGTTCTTATATGAGCCACTGTTGGGATGCTCTGGCCCC TGCTTCTGTGTCCTAATCCTTAAATGTTAGAAAGTCCATATGTACACAAGCAGAGTGGAAATATTTGATA GAAAAGTAAAGCCTCTGGAGGACGTCTGAAATAAGATCATTTTGAAAATCTGTGGAATGTGCCTGGTCTG ATAGGTATCTAATTATTCATCTTTCACCCACTCTCTGGAGTCAATTTAGTGATTAAAAGTCAAATGATCA GGTGAGTCAGATCCATCTACCCCAGTAAGCAATTATGTTCTCTAGATCAACCCAAATAAACCAGAAATTG GTAAATCATCACATGGAAATCAAATCAGTAACTTTACTAATAAGAAAAGAGATGCAAATTAAAAATAGGG AATACCAATTTTCATCAAATTAATAAAGATTAAAAAAAAACCCAGACTGACAAAGATTTGAGAGAAAAGT GCCTGTGCAAACATTAGTTTCAGCCAGTATACATGTAAATTGCTATAACTTTTTTTGAAGAGCGCTTTAG AAATACATAGCAAAAGCTTGTAACTAGTAGTTTACGTTGTAATCCTATCGCTAAGAATTTATCTTAAGAA AATAATCAGAGATGTGCCCGAAGATTTATATATAAGGATGTTCATTACTTCCTTATGAGCCTATTTATAA TAAATAATTCAGAAGAAACTTGAATGCCTCATACGAGATTAGTTATATACATTATGGTGTATTCAGACAA GCACATAATAAGCAGCAACTAAAAGTGATGTATCAGAAGGACATTTAATGCTTTGGGGATTGTGCACTCT GTATTGTTAGATAAAAAGACAAGTTACAAAAGGGTATGTTTAGTTTCATACTGACTATGTAACCATGTAT GCACATTTTTATATTCTTAGGAACTGGAAAGTTTTACACACTGACATACTAACAGTGATTTTCTCTGGGA GATACTATTATAGATTATTTATACTTTCTAATTTGCTCCTTTTTACATTTTCCATTTTTTTCCGGTTAAC TAATTAAATCTTTTATTCATTCACATGTGTGAGGCTAGATGTTGGGTGTTGGATGCTGATTGAGGATGAG CCAGCCCAGGGGGCCTGTCCTTATGGAGCTTTTAGCAGGGGGAAGAAGCTAAACAAAAGCAAGCAAACAG ACCATGCAATTCCAAAGTTGTACTAAGTACAACCTGAGAATCTTCTTTAAGGAGGTGTTGTTTACGCTAA CACCTTGGGGGTCAGAAGCCCGATGAGTGAACGGCTGTGTGCATGTGCTGTGGAGTGGGGTGGGGCTGGG GGCGGGCATTTCAGCGCTGGGAACGGCACATGCAAAAACCCTGGGGCAGGAAGCACTCATAACCAGTGTC TAGGATATCCTTGCAATTTATTTATTCCAGTATAGGTACAGCAGATATTCTTAGTGAGCATGTTCTGTAA GAATAACGTTGTACTAGGCTCTGTGAGGGATATAAAGACATGCAACATGTGGTTCTCTGTTCCGTTTCCT GCCGGTGCGTGGCTGAGTGCCAGATTAGTTGCTCGGGTGGTTTGCGGTGTAGGAATGCAGAGGAGACTCA GTTTTGCCTTTCCTGTTCGCTAACACCTCCTACATGGTGGGTTGTCTTGGATGACTAGAGAGGTCATGAT TGCTCAGCTAATGTTCTCTGTGGATTGGGCCATTCTCATACCATATGTGAGTTTTACAGGCTAATCACGA ACCTGACATAGACAAGCATCTCCTGTGAATATTTATTGAAGTCTCAGTTAGCTGAATTCATTAGCTAAGT GGCAGCTGTCTATCTTGTCTGAAACAGTTGAAGTCAGAGAAATAGTGTCTGTTTTGAGAACTATTGTCTA TCCTTCCATTTAATTTGTCCAACATTTGCTAGTAACATGCCCTGTGTTAGAAACTGGGCTTCTCTGGTGA ACTCAACGTATCGTAAGGAACTTGTCGTTATTTGAGGGGAATAAGATAATTTATGTAGTTACCCCAGAGA CAAGAGGAGTCAGAAATGACAAGAGAGGGGAAGACAGAGGGATCCTAGATTTCAAAAGAGGGGCAGATCA TATTTGATCAAAAAAGGCTTGAGAGGGTTTCCCAAAGAAAGCGGTAATAGGTAGTCCTTATGGGATGTTT AGGAATTTGACACAGAAATCTGCTTGAAAGAACATTACGGGCAGAAGACATGGCATGAACAAAGGCACAG AGGAAGGAAAGTGGGGGTATGTGTAGGCCACAGAACTCCCGTTGTGTGGCAATGCTCAGTGGGAGTAAGG AGATAAGGCTGGACAGATGGGCTGGGATTGTGTGATGGGGATACTTGTATACGACGGCATCTTCGGGGAG GAGCAATTAAAGGTGTTTGAGGACTCAGTGATATGAGGTGATTGTCAGAGGTCTTAAGATAATTAATTTG GGGCAGATTGTAAAATGTCACTGGGGGAAGATCTGGTGACACGCAGACAGATCAGTAGTCTTCTTCAGCC TCTGTCCTGTAAGTCTTTGGAACAAGAGAATCAGAGTGGACAGAGCCCTGGAATTGGCGTCAGGAGAGCA GGGTGTGGTCCCATCTGTGATGCTGACTAGCTGGGTCTTCTTGGATTAGTCACCCAACTTCTAAGCTCAT TTTGCAATCGATAAGGTGGGACAATAATACCTACCTCAAAGGGTTGTGGTGAGTTCTAAATGCAATAACT GACATGACAGCTCTTTATGAATAAATGTTTATATTAATTATGTTTTATTGTAACATTATAATTTATACAT ATGTCAATCTTAATTTGGTTTATTTTTTTACCTCTTTGTTTCTGAAATATAGACTACTATGAATCCTGCA GTTCAGACCTACATGATTAGTATATGTTAGACTGTTGCCATTTACGGTTTTAAAATCTTTTTTTTAAAAT GATTGGATTTAAATTCCCACCAAAATAATAGTTGCTATTTCATTTTAACATATATTTTTCCTCTCTCTAT GATACAGGCCACCCCAGTCCACCCCCTGAAAAAAAGGAGCTGAGGAAAGTGGCCCATTTAACAGGTCTGT ATCTGGAAGGTACAGGTGAGATTTGGGAAAGCTTTTGGCAAAAGGCAAAATGGCTGCCTGGTTTCCATTA CCAGGCTCTAGAGAGTTGTTACTTCCTGGAGACAGTATTTGAACCCAATAATACTAACACTTTTCTTGTC GAGTCAGTCTTATGAACACACTTTGATCCCCTATTCTCTGGGCAAGGCCCTCTTCTAAATTGGAGACCTG GAGCTGATTATGACATGACCCCTGCCCATAAGAAGCTCATTCTTTTCAGTCATTCCAAAGTCCCTTGGGG GATTGGGGGCACAGATCCAAGAGGTGAGAGATGAGAAGGTGAGGAATGAGGACTTATTTTAGTCAGTGCT TTCTTGGTTTTCTGGAAGAGCTTCACTCTGCTTTGTCCAAGAGTATAAATAGGAGTGAGAAGGGAGACTC AATCCTGGCACTTGTAGAGTTTCAATATGTGCCTGTAAAGTGGAGTGAAATGATATGGTATGGGCACTCC CATTATAAACTACATAAATAATGGAATAAATATCACAGAAAGTGGTAGGCTATTGTCCCTGGAATTATTT AGGCAGAAATTATAGAATGATCCGGTCACATCAGCAGACACTTACTGAATACCTGCTGTGTGCCAATTTG GGGATGTGAAGATGAGTAGCACATGGCTCTTGCCCCCAGGGAGCTTGACATCTAATAGGGAAAGACAGGC ACTTATGATAATTTCAGTACTTCAGAGATTTAGGTTATGTTCATGATGTTGTGGGGATACAAAGAAAAGG GAACTGTACCCCAAATTGAGGGGCTGAATAATTCTTACTGCAGGTGAGAAGATGGACCAGATGGTCCCTA AGATCCTTCCCAACTTTAGAACTTTAGAGTTCCTTGGATTTGGCTTTTTCCTTCAGGAAAGGACTTCAAA GCCTAGCAGATTTGGTGCTAGTTCTGAAGATAGTAAAATCTTTGTTCCAGAGAGCAAATATTTTCTCAAT AATTTCTTACTGCAATGGATTACGGGTATATACTATTGTTCCAATTGTGTGGATGACAAAATAGGACAAC GTTGTTGAGGAAATTCTGTGATGGATCAAGTTCTGACCCCTCAGCCAGTTCTATACCAGCTGTCATTCTG GGTGAAACATTTGTTGAAGGAAGGGCCCACAGTTTTGCCTTAGAAACTTAGTTTGTTGGATGCATGACTA TTCCTTGTTGAAAGCTCCTTTTGGATTTATTTCAGGCAAGTCCAACTCAAGGTCCATGCCTCTGGAATGG GAAGACACCTATGGAATTGTCCTGCTTTCTGGAGTGAAGTATAAGAAGGGTGGCCTTGTGATCAATGAAA CTGGGCTGTACTTTGTATATTCCAAAGTATACTTCCGGGGTCAATCTTGCAACAACCTGCCCCTGAGCCA CAAGGTCTACATGAGGAACTCTAAGTATCCCCAGGATCTGGTGATGATGGAGGGGAAGATGATGAGCTAC TGCACTACTGGGCAGATGTGGGCCCGCAGCAGCTACCTGGGGGCAGTGTTCAATCTTACCAGTGCTGATC ATTTATATGTCAACGTATCTGAGCTCTCTCTGGTCAATTTTGAGGAATCTCAGACGTTTTTCGGCTTATA TAAGCTCTAAGAGAAGCACTTTGGGATTCTTTCCATTATGATTCTTTGTTACAGGCACCGAGAATGTTGT ATTCAGTGAGGGTCTTCTTACATGCATTTGAGGTCAAGTAAGAAGACATGAACCAAGTGGACCTTGAGAC CACAGGGTTCAAAATGTCTGTAGCTCCTCAACTCACCTAATGTTTATGAGCCAGACAAATGGAGGAATAT GACGGAAGAACATAGAACTCTGGGCTGCCATGTGAAGAGGGAGAAGCATGAAAAAGCAGCTACCAGGTGT TCTACACTCATCTTAGTGCCTGAGAGTATTTAGGCAGATTGAAAAGGACACCTTTTAACTCACCTCTCAA GGTGGGCCTTGCTACCTCAAGGGGGACTGTCTTTCAGATACATGGTTGTGACCTGAGGATTTAAGGGATG GAAAAGGAAGACTAGAGGCTTGCATAATAAGCTAAAGAGGCTGAAAGAGGCCAATGCCCCACTGGCAGCA TCTTCACTTCTAAATGCATATCCTGAGCCATCGGTGAAACTAACAGATAAGCAAGAGAGATGTTTTGGGG ACTCATTTCATTCCTAACACAGCATGTGTATTTCCAGTGCAATTGTAGGGGTGTGTGTGTGTGTGTGTGT GTGTGTGTGTGTATGACTAAAGAGAGAATGTAGATATTGTGAAGTACATATTAGGAAAATATGGGTTGCA TTTGGTCAAGATTTTGAATGCTTCCTGACAATCAACTCTAATAGTGCTTAAAAATCATTGATTGTCAGCT ACTAATGATGTTTTCCTATAATATAATAAATATTTATGTAGATGTGCATTTTTGTGAAATGAAAACATGT AATAAAAAGTATATGTTAGGATACAA
Protein Sequence	>NP_000630.1 tumor necrosis factor ligand superfamily member 6 isoform 1 [Homo sapiens] MQQPFNYPYPQIYWVDSSASSPWAPPGTVLPCPTSVPRRPGQRRPPPPPPPPPLPPPPPPPPLPPLPLPP LKKRGNHSTGLCLLVMFFMVLVALVGLGLGMFQLFHLQKELAELRESTSQMHTASSLEKQIGHPSPPPEK KELRKVAHLTGKSNSRSMPLEWEDTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNLPLSHK VYMRNSKYPQDLVMMEGKMMSYCTTGQMWARSSYLGAVFNLTSADHLYVNVSELSLVNFEESQTFFGLYK L
Molecule Role	Protective antigen
Molecule Role Annotation	Introduction of human CD95L (FASLG) cDNA into murine tumor cells did not affect growth in vitro but caused rejection in vivo. Neutrophils were primarily responsible for this rejection. A CD8 T cell-mediated protective immunity against subsequent challenge with parental tumor cells was also elicited (Seino et al., 1997).
References

FASLG