VIOLIN: Vaccine Investigation and Online Information Network

pomp90A
Gene Name	pomp90A
Sequence Strain (Species/Organism)	Chlamydophila abortus
VO ID	VO_0011058
NCBI Protein GI	187438939
Other Database IDs	CDD:273587
Taxonomy ID	83555
Gene Strand (Orientation)	?
Protein Name	polymorphic outer membrane protein 90A
Protein pI	4.63
Protein Weight	35956.31
Protein Length	446
Protein Note	Chlamydial polymorphic outer membrane protein repeat; TIGR01376
Protein Sequence	>ACD10929.1 polymorphic outer membrane protein 90A, partial [Chlamydia abortus] MSNSLSFANDAQTALTPSDSYNGNVTSEEFQVKETSSGTTYTCEGNVCISFAGKDSGLKKSCFSATDNLT FLGNGYTLCFDNITTTASNPGAINVQGQGKTLGISGFSLFSCAYCPPGTTGYGAIQTKGNTTLKDNSSLV FHKNCSTAEGGAIQCKGSSDAELKIENNQNLVFSENSSTSKGGAIYADKLTIVSGGPTLFSNNSVSNGSS PKGGAISIKDSSGECSLTADLGDITFDGNKIIKTSGGSSTVTRNSIDLGTGKFTKLRAKDGFGIFFYDPI TGGGSDELNINKKETVDYTGKIVFSGEKLSDEEKARAENLASTFNQPITLSAGSLVLKDGVSVTAKQVTQ EAGSTVVMD
Molecule Role	Protective antigen
Molecule Role Annotation	Genetic immunization was used to functionally test the genes of C. abortus as vaccines in a mouse challenge system. Protective clone CP #4 (OMP90A, pomp90A) was diluted 1/2000 in a non-protective sublibrary pool of clones. This CP #4-spiked sublibrary conferred protection. Five clones were significantly more protective than the genes encoding fewer than 50 amino acids (CP #1–5 and 7, p-value of less than 0.05 when comparing lung weights). (Stemke-Hale et al., 2005).
Related Vaccines(s)	C. abortus DNA vaccine Pomp90A
References