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gam82
Gene Name	gam82
Sequence Strain (Species/Organism)	Eimeria maxima
VO ID	VO_0011062
NCBI Gene ID	25336658
NCBI Protein GI	38565038
Taxonomy ID	5804
Gene Strand (Orientation)	?
Protein Name	82 kDa gametocyte antigen
Protein pI	4.8
Protein Weight	63301.57
Protein Length	661
Protein Note	tyrosine and serine rich gametocyte precursor protein; involved in oocyst wall formation
Protein Sequence	>AAO47083.2 82 kDa gametocyte antigen [Eimeria maxima] MTRAAALAGVLALAAAGSSLALPTVLDTTTGTQVEWTETPLDTTEVTMGEMGSTTSGTTPTSTGVRMMEA ETTTPSTPEAPQQQQQMPQPQPQPQQTTPVPEAVLEAIMQEMQNIFRSSLVPGWDTVGTAADAVRQIVTR VRERLTGPLMMTEMDTGLGRTGPLSTTGATGATTGPVAALRGVTNDFLREIMIQEAVLETLWAVVRDAQE RPWLVNEQEALHAATADAVQGFLGRMHDRLRATGFSEEEVMRLLPRSRNGGCTRTGGLFDQCNDAPPSRL LGKRMYSTGYYGYGYPSYYSYGYSYPAYSHYPVSYPYYGYSWGPSYYYGSGYYGKHGYKYGHYYRRLAEQ EPRPVMPPAAATAAANLRAAAAAAAEVPPPPPPAAVPPPPPAAAAGTPAMMPPPMMGVEEPVPFRSLYPS YSWSYPAYTRVSPSYSYYTPSYSSSYYYPRYNYAYNYPLYSDYSWYDYSYPLAYSSYSSYPLSYSSYSYP LSYTYPSAFYRRLEVPDLTTTTTTHHEQQQQQQQESTTTAVPTETITTPSTRNTHSSSLRRVGERYEPIT PTQRTFYNNTEGTNNPVYTPENLTEDEPQTVWETYN
Molecule Role	Protective antigen
Molecule Role Annotation	Animals vaccinated with Gam82 and challenged with E. maxima showed lower oocyst shedding and reduced intestinal pathology compared with non-vaccinated and parasite-challenged animals. Gam82 vaccination also stimulated the production of antigen-specific serum antibodies and induced greater levels of IL-2 and IL-15 mRNAs compared with non-vaccinated controls. These results demonstrate that the Gam82 recombinant protein protects against E. maxima and augments humoral and cell-mediated immunity (Jang et al., 2010).
Additional Molecule Role	Protective antigen
Additional Molecule Role Annotation	(Jang et al., 2010)
Related Vaccines(s)	E. maxima Gam82 protein vaccine
References

gam82