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MSLN

Gene Name MSLN
Sequence Strain (Species/Organism) Homo sapiens
NCBI Gene ID 10232
NCBI Protein GI 293651530
Genbank Accession AE006464
Protein Accession NP_001170826
Taxonomy ID 9606
Chromosome No 16
Gene Starting Position 760733
Gene Ending Position 768864
Gene Strand (Orientation) +
Protein Name transcript variant 1
Protein pI 5.82
Protein Weight 64397.13
Protein Length 622
Protein Note Also known as MPF; SMRP
DNA Sequence
>NC_000016.10:760733-768864 Homo sapiens chromosome 16, GRCh38.p13 Primary Assembly
CGTCATTTGTTCCCTTTGACGGCCCGGGAGGCTGCCAGGCTCTCCACCCCCACTTCCCAATTGAGGAAAC
CGAGGCAGAGGAGGCTCAGGTGTGGCCAATCACCCTGCACATCAGAGTTACCCTGGGCAGGGCCCACTGA
GACCTGGGAGGGGCCACTCGGGACCTGGAGGGCTGGGGGCTGCCCGGGCGTTAGGGGTAAAGCTCCCTAC
CCAACTGCGCAGAAGGCCTCAGAGGCCTGGGGGCTGGGCTTCCCCTTTCACATCGCCCTTTAGAGGCCCA
CGTGTGGGCATTGGCCCGCGATCTGAAAGGGGCTGTCCTGTTCCTCATGGGCGCTGCCAGCGCCACGCAC
TCCTCTTTCTGCCTGGCCGGCCACTCCCGTCTGCTGTGACGCGCGGACAGAGAGCTACCGGTGGACCCAC
GGTGCCTCCCTCCCTGGGATCTGTAAGTAACAACCTTTGAGCTCTTCCTGTTGTGGTGTGGATGGAATCT
GCACCTTCCATCTGGAGAACTGGGGCCGCCCCAGGCCGGGCTTCCAGCACCAGAGCGATGGTCAGGCTTC
AGCTGGACGCAGATTTCACCCCGCAGGGCACACGCAGACCCATTTGTTTGGAAGCGGCAGTCCTAAGGCA
GTGCAGGTGCCTCCACGGCCCCAGCCCAGCTCTCCTGCAGGTGTAAAGGATGCAGATTCCAGGGCCCCCC
ATGGCCTGCAGAGGCCCCTCAGAGCAGGAAGGGCCGGGCTCTCGGGGAGCCCCCATCCCAGGTGCTGAGG
TCCTTGGGTCACATGGAGCTGGGGTGGGGAGTGCCCAGGTCCCCTGTGATCCGATGGCCACGTTTCCCTC
CTGGCTTCACGCACCCCAAGGGCTGGGGGTCCCACTCACTGCCCATTTTCTGGCTGTGGGGGGGGTCTGT
TTTCTTCCACCTTCTCAAGGTGTTCAGAGCCTCAGGGGCCTCCCCACTTCCTCTGGGGCCTGGGGGAGTA
GAGTCTGTCACCCGGAGGCTGTGTGCCTCCCCGCGACATTCCCCAGTGGCCGGGCCGACCAGGCAGGCTC
TGCCTGTGGATGGGGCTGCTGAGCATGAGCGTGTGACCCCCATTTCTGAGCTGTGGGTGGACCCACCGGG
CCTGGGCCAAGGTTTTCAGGAGGCAGCTCTATTCTACTCCGCCATGGTGGCCTCCCTGAAAGGGGTGAGT
GTAGAAGCCAGTTCCCTCTTCTGCGAGCCCCACCCCTACCCCAGGAGGACAATTCTTGTTCAGGGAGGGT
CTCCCCACCCACTTCCCCACCCCACAGTGGCCCACAGGCCCCACCCTAGAGAGTACAAGGGGCTCCCCAG
GCTGCTCACTGGCCCAGCCCCGCCCCACCTGGACTGCACCTGAAAATGGGCTCAGAGAGGCCAAGTGGCC
CAAAAAGACGCTGCTGGGTGGGAAGGGGCGGTGGCCTCTGTGCCCGCAGTGCCCCTCCTGCCTCAAGGGT
GTTGTCTGCCTGGCAGAGCCTGGGGTGTTCACAAAGCCCAGGCACCTGCAGCTGAGGGCAGGGGAGAGGG
AAGGGAGCCACATCCAGGCGACGGGGCTGCTCGTCCTCCTGTGCGAGAGTGGGGAGACTCAGGCCAGCCC
AAGTGGGCGGCGGCCCCGGTTGCTTGATCTAAGCTCTGCTCACACTGCCCTGCCCTTCTGGGAGAGGGGT
GGGCGCCAACTGACTCCTGGGCTGTCTGGGCTGGGGACCGGGATCTCAGACCCAGCCCCTCCCCTGGACA
GGAGGAGCCAGTCCAGGGGACAGAGGGCTCAGTGGCTGGAGGGCAGGGCCAGGGTGCGGACACAAGCTGC
AGGTACCACAGAAGTTTGCTCTGGGAGCCCCTCCTGGGCCCATGTGGCCCCAGGCTGGCCCAGGACAGAG
GCGTGGGGTGGGAGCAGGGGGTCCCATCCTGAGTCACTGCCCTCCACAGACACAGACCATGGCCTTGCCA
ACGGCTCGACCCCTGTTGGGGTCCTGTGGGACCCCCGCCCTCGGCAGCCTCCTGTTCCTGCTCTTCAGCC
TCGGTGCGTACTTGATGGGGCTGCTGGTGAGGTGGGGACGGCCCAGGGGCCTTGGGGGCCAGGCCCCCAG
CAAGGCTTTGCCTGCCCCTGCCTTCTCCCTGGAGTGCCTGTGGTGGCCACGTCTCAGCAGCAGTCTCTGC
CCCCAGAGGTGACTGGAGCTGGAGATCCAGCCAGGGAGTGATGGGGCTCAGGACACAGTGGGGATGTCTG
TGGGATGGGTGGTCTGACCGGCCAAGCAGCCGGGTCTCAGGGAAAGATGTGGAAGGCCGGGCTCCCTGGT
GGAGTCCCGACCCCTGTGCCTGGGGGACTGTGATGTCACGGGGTACATGGGCCTGAGCCACTGGCTTCTC
TTTGGGGTGTGCACAGGGCTGGCTGTGGGGGCGGCCAGGCTCTGCCTCCTTCCTCCCCTGGGTCAGGGCA
CAGCCCAGAGGCCCGCCCCCTCCCCCAAGCTGTCCCCTCTGCCCCTTTAGGATGGGTGCAGCCCTCGAGG
ACCCTGGCTGGAGAGACAGGGCAGGTAAGGTCCCCTCTGGGGAAACAGGGGAGGGTCTTCAGGTCCCAGG
TGGGGGTGCCATGCTGTGTTCTCTCTGTCACGTATCCACGGTGCTTGCCAGTTTCCACGGTCCTTGCTTG
CAAAGGGGCACCTGGACCTGCATGTGACTGGCCTGGGAGCAGCCAGGTCCAGGGAGCGGCAGAGCTGAAA
TTGCAGCTGGGTCTGGGAAGTAGATGGATGAGAAGCAGCCAAGCCCATGGGTCTGAGACACAGCCAGGCC
TGGGAAGTAGCTGAACTCGGGGAGTACCTGGCCCAGGGGTAGCGGGACCTGGGAACTCCTGCTCCAGAGA
GCTGGTCTGAGCCATGTTCAGCAGGCCCTGTGTCCCCAGGAGGCTGCGCCCCTGGACGGAGTCCTGGCCA
ACCCACCTAACATTTCCAGGTGGGTCTGGGGTCCTCACAGTCCTCAAGGGTGAGGCTCGAGGGGCCCTCG
GGACTGAGGGTGGGCAGGGCACCCCATCCCCCAGCATCCCCTCCCCCTTCCTCCTCTGCTCCACCTCAGA
TCTGACTGGGCTCAGGACTGCGGGAGGGACTGACACCCCTCAGGTGATGGCAACTCCCGGCCCTTGAGGG
CGTCACCTGGTCTTGGGGGGAGGTCTGCAGGGAGCACCAGGGTCCTTTGGGGAGAGGTGGGGCTGTGGGG
CTTGGGGAGCACTGGGTGGACATTGCAGGGGAGGGGCGATCGTGGGTGCCCAGCCCGACCCTTCCTGCAG
CCTCTCCCCTCGCCAACTCCTTGGCTTCCCGTGTGCGGAGGTGTCCGGCCTGAGCACGGAGCGTGTCCGG
GAGCTGGCTGTGGCCTTGGCACAGAAGAATGTCAAGCTCTCAACAGAGCAGGTCAGTCTCAGTTGGGCTG
AGGCAGGTGGGCACAGCTGGGGCTGAGGAATTCACAGGCAGCTCTGCAGTGCCCACCTTGCCACCACGGT
CCCCTCTGTCCCTGCTGCCATCTCTCCCCGGCCAGTTCTTCCCAGAGTTCCTCTGGCCACCCAAGCTGAC
CACTGGGGTGCCTGTCCACGTCAGGGGCTGGCTCCCCAGGAGCAAGTCTGATATGACGCTGTGTGCTGGG
CCCCCTCCTGGAGCGCCGTGGGCAGCCCTCCAGGCTCTGCCCCAAGGGTGAATCTTTTTCGGGGGAGTGG
GTGAGATCTGGGGAAGGGGAGCGGAGCCAGGCACGGGAGCCCCCATCCCCCAGGGCAGCGCTGCAGGCGG
CCAGAGATCCACTTCCACAGATTCTCGTGGCCAGGGCAGGGGTGTGTTGTGGTGGGCAGACTGGCCAGGC
GACCCTGGCCCACCATGTGAGTGGCGGCTCGAAACGCTCTGTGCTGGACTCCCTGCCCCTGCAGCTGCGC
TGTCTGGCTCACCGGCTCTCTGAGCCCCCCGAGGACCTGGACGCCCTCCCATTGGACCTGCTGCTATTCC
TCAAGTAGGCCCTGCCCCCTGAACCCACCCCCCCGGCTTTTGCCGCCAGCCCTCAGCCCCCAACCCCCTG
CCCCTTGCCTCGGATCCCAGGCCACAGCAGAGATGTGGAGGCCGGCCGGGCTGCCTCTCAGGGTGGGGAC
GGGTGTGATCAGTGCGGCCTGTCCCCAGCACCCTCTCTTCACAGCCCAGATGCGTTCTCGGGGCCCCAGG
CCTGCACCCGTTTCTTCTCCCGCATCACGAAGGCCAATGTGGACCTGCTCCCGAGGGGGGCTCCCGAGCG
ACAGCGGCTGCTGCCTGCGGCTCTGGCCTGCTGGGTAGGGGCTGGGGCCAGCGCGGGGCGGAGAGGGCTC
GGCAGTTCCAAAAGCGCTGAGGCCAGCCTCTCTGCAGGGTGTGCGGGGGTCTCTGCTGAGCGAGGCTGAT
GTGCGGGCTCTGGGAGGCCTGGCTTGCGACCTGCCTGGGCGCTTTGTGGCCGAGTCGGCCGAAGTGCTGC
TACCCCGGCTGGTGAGCTGCCCGGGACCCCTGGACCAGGACCAGCAGGAGGCAGCCAGGGCGGCTCTGCA
GGGCGGGGGACCCCCCTACGGGTAAGTGAAGGTGTCTGGAACCTCGAAGGCTCACCTGGCGGCGTGGTAT
CAGCAGCGTGAGGACACTTGCGGCCATGCCTCAAGGCCCAGGGTCAGTCACCCCCGCCACCACCCCTGCC
AATGCCCCCAGCGTCCCCTCCACAGCCAGGGGGTACGGCCTGGCCTCTTCCCTCTCTGGGGCTGCACGTG
GGGGGTCCCTGAGCTGTGTCCCGTGTCTGCACAGCCCCCCGTCGACATGGTCTGTCTCCACGATGGACGC
TCTGCGGGGCCTGCTGCCCGTGCTGGGCCAGCCCATCATCCGCAGCATCCCGCAGGTGAGACCCCAATCC
CCAGCCCGTGGGGATGCCCGGCCACCCGAGGCTCAGCCCAGGTCCTGCTCGTCCTCAGGGCATCGTGGCC
GCGTGGCGGCAACGCTCCTCTCGGGACCCATCCTGGCGGCAGCCTGAACGGACCATCCTCCGGCCGCGGT
TCCGGCGGGAAGTGGAGAGTGAGTGCCGTGCCCTGCGCAGTCTGGCACCAGGCTGGGCAGCACCCCTGGG
GGTGGGCATCACTTTAGGGTCTCACCTGCCCCTCCCTGGCTCTGCAGCACATCCCATTATAATCACAGAG
AGTGGACAGAATCCCTGTTTGCCAGTGGGTAAACTGAGGCACAGGGAGGGTCACAAATGGCCCGAGGTCT
CATCTCACAGGAGGTGTGGGAGGAAGAAGGGGTCAAACGAACTCCGGCCCTGACCCCTGACCCCTGTGCC
CTGCAGAGACAGCCTGTCCTTCAGGCAAGAAGGCCCGCGAGATAGACGAGAGCCTCATCTTCTACAAGAA
GTGGGAGCTGGAAGCCTGCGTGGATGCGGCCCTGCTGGCCACCCAGATGGACCGCGTGAACGCCATCCCC
TTCACCTACGAGCAGCTGGACGTCCTAAAGCATAAACTGGATGAGGTAGTTCATGACTCAAGTTCCCACC
GGCCTGCTGTGTCCAAGCCATCCCCAGCCCCTCTGGGAGTGACATGGGCCCTCCTGGTCTCTTGGCCTGC
AGCTCTACCCACAAGGTTACCCCGAGTCTGTGATCCAGCACCTGGGCTACCTCTTCCTCAAGATGAGCCC
TGAGGACATTCGCAAGTGGAATGTGACGTCCCTGGAGACCCTGAAGGCTTTGCTTGAAGTCAACAAAGGG
CACGAAATGAGTCCTCAGGTGACCGTCCGGCTCGGGGGTCATGTGGCATGAGATTGGGAAGGGCTGAGGG
GCAGAGTGGGGGACAAAGCCTGAGGTTGGGCGGGCCTGGGGTCAGGGGCACGGCCTGAGGTTATGCTGGT
GGTGGAGGGATACATCTCTCCTTGCCACAAGGCTCCTCGGCGGCCCCTCCCACAGGTGGCCACCCTGATC
GACCGCTTTGTGAAGGGAAGGGGCCAGCTAGACAAAGACACCCTAGACACCCTGACCGCCTTCTACCCTG
GGTACCTGTGCTCCCTCAGCCCCGAGGAGCTGAGCTCCGTGCCCCCCAGCAGCATCTGGTGAGTCCCCAG
AACTCTGCCCGGCAAGGTGGGTCCGTGTGCTGGCGCTCACTGTCCACCCACCGTGTCCCCAGGGCGGTCA
GGCCCCAGGACCTGGACACGTGTGACCCAAGGCAGCTGGACGTCCTCTATCCCAAGGCCCGCCTTGCTTT
CCAGAACATGAACGGGTCCGAATACTTCGTGAAGATCCAGTCCTTCCTGGGTGAGCCAGGGAGTCCCTGG
CCAGGGTGGGCAACACAACGGGGGAAGCACAGACTCCACTCGGGGGTGCCAGGCCTTTGCCTCGCCGGGC
CGTCTGCTGCCAGGGTAACTGGGTGGTCACCCGCCCTCTGCCCCCCGGGGTGTGTATGGCCTTAGGGGCT
GTGGGTTCTGACCCCAGCTCGGGGCGCCAGCCACCTCCAGGGTCTCCCACGCCTGGGGGTCAGGCGGCTA
GGCAAACCCAGGCCCTGGAATCCCTAAGGAAAAAGGGAAGCCCTGTAAGGCAAGTGGGCTTCCTGCAGCC
TGTGGTCAAGGGCCTGGGGGTGTGAGGTGAGGCCTCAGCTCGGGCCCCTCTCCCGGCGGGCAGGTGGGGC
CCCCACGGAGGATTTGAAGGCGCTCAGTCAGCAGAATGTGAGCATGGACTTGGCCACGTTCATGAAGCTG
CGGACGGATGCGGTGCTGGTATGGCGAGCGGGAGGAGGGGCGTGTGGAGGAGGGGCCCGTGGAGGAGGGG
CGAGTGGGAGGAGGGGCGCGTGGAGGGGGGGCGTGTGGGGGGGTGCGTGGAGGAGGGGCGCGTGGAGGAG
GGGCGCGTGGAGGGGGGAGCGTGGGGGGCGTGGAGGAGGGGCGCGTGGAGGAGGGGCGCGTGGAGGGGGG
AGCGTGGGGGGCGTGGAGGAGGGGCGCGTGGAGGGGGGAGTGTGGGGGGGCGTGGAGGAGGAGGGGCGCA
TGGGGGGGTGTGGAGGGGGGCGCGTGGAGGAGGGGCGCGTGGAGGGGGGAGCGTGGGGGGCGTGGAGGAG
GGGCGCGTGGAGGGGGGCGCGTGGGGGGGGCGCATGGGGGGGCGTGGAGGGGGGTGCGTGGAGGAGGGGC
GCGTGGAGGAGGAGGGGCGCATGGGGGGGTGTGGAGGGGGGCGCGTGGAGGGGGCACGTGGAGGGGTCGC
GTGGAGGAGGGGCGCGTGGAGGGGGCCGTGTGGGGGGGCGTGGAGGGGGGCGCGTGGAGGAGGAGGGGCG
CATGGGGGGGTGTGGAGGGGGGCGCGTGGAGGGGGCGCGTGGAGGAGGGGCACATGGAGGGGGGGGCAAG
TGGAGAAGCCCTGGTGGAGGGGCGCATGGAGGAGGGGCCAACGGGGGGTGGGAGGGCGTGTAAGGCGGGT
CTGCAGTGGGGCGAGGCCTTAGGAAGGGCAGCATCTTCCCGTGTGGTGGGGCCTAGGGAAGGGCAGCCAT
TGAGCTGAGGTCAGCTGGCCGGAGACCTCCGAAGTCTGGAGAGGCTGCGGTGGGCATCTGTGGGTGGGGC
AGTTTGGACACAGGAGAGCCTGGCAGCCCTCTGGCGGCGCTGAGGGAAGGAGACCCTCCTTGATGGCTGC
CCGGGGTCTCTGGCAGCCGTTGACTGTGGCTGAGGTGCAGAAACTTCTGGGACCCCACGTGGAGGGCCTG
AAGGCGGAGGAGCGGCACCGCCCGGTGCGGGACTGGATCCTACGGCAGCGGCAGGACGACCTGGACACGC
TGGGGCTGGGGCTACAGGGCGGCATCCCCAACGGCTACCTGGTCCTAGACCTCAGCATGCAAGGTGGGCG
GGGCGGCCAGGCCAGGGCTGGGGGCAGAGCTGGGGGCGTGGAGGTGGGCGCTCTGAGTCACCCCTCTCTC
TGTAGAGGCCCTCTCGGGGACGCCCTGCCTCCTAGGACCTGGACCTGTTCTCACCGTCCTGGCACTGCTC
CTAGCCTCCACCCTGGCCTGAGGGCCCCACTCCCTTGCTGGCCCCAGCCCTGCTGGGGATCCCCGCCTGG
CCAGGAGCAGGCACGGGTGGTCCCCGTTCCACCCCAAGAGAACTCGCGCTCAGTAAACGGGAACATGCCC
CCTGCAGACACG
Protein Sequence
>NP_001170826.1 mesothelin isoform 1 preproprotein [Homo sapiens]
MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISSLSPRQLLGFP
CAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPLDLLLFLNPDAFSGPQACTRF
FSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEADVRALGGLACDLPGRFVAESAEVLLPRLVS
CPGPLDQDQQEAARAALQGGGPPYGPPSTWSVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPS
WRQPERTILRPRFRREVEKTACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLD
VLKHKLDELYPQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQVATLIDRFVK
GRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKARLAFQNMNGS
EYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQKLLGPHVEGLKAEERHRPVR
DWILRQRQDDLDTLGLGLQGGIPNGYLVLDLSMQEALSGTPCLLGPGPVLTVLALLLASTLA
Molecule Role Protective antigen
Related Vaccines(s) Algenpantucel-L , Allogeneic Mesothelioma Tumor Lysate-pulsed Autologous Dendritic Cell Vaccine , Autologous GM-CSF-secreting Lethally Irradiated Colorectal Cancer Cell Vaccine
References