VIOLIN: Vaccine Investigation and Online Information Network

Gc
Gene Name	Gc
Sequence Strain (Species/Organism)	Seoul virus
VO ID	VO_0011085
NCBI Protein GI	284157806
Other Database IDs	CDD:144961
Taxonomy ID	1980490
Gene Strand (Orientation)	?
Protein Name	Gc glycoprotein
Protein pI	6.5
Protein Weight	11999.31
Protein Length	170
Protein Note	Hantavirus glycoprotein G2; pfam01561
Protein Sequence	>ADB80030.1 Gc glycoprotein, partial [Seoul orthohantavirus] VPLWTDNAHGVGSVPMHTDLELDFSLPSSSKYTYKRHLTNPVNDQQSVSLHIEIESQGIGADVHHLGHWY DARLNLKTSFHCYGACTKYQYPWHTAKCHFEKDYEY
Molecule Role	Protective antigen
Molecule Role Annotation	Seoul virus (SEOV) is one of the four known hantaviruses causing hemorrhagic fever with renal syndrome (HFRS). A replication-competent recombinant canine adenovirus type 2 expressing the Gc protein of SEOV (rCAV-2-Gc) in BALB/c mice induced complete protection against a intensive infectious challenge with ~1,000 50% infective doses (ID50) for SEOV strain CC-2 (Yuan et al., 2010).
Related Vaccines(s)	Seoul virus vaccine rCAV-2-Gc
References