VIOLIN: Vaccine Investigation and Online Information Network

RSV Prefusion F protein based
Gene Name	RSV Prefusion F protein based
NCBI Protein GI	UED36857
Other Database IDs	CDD:395418
Taxonomy ID	32630
Gene Strand (Orientation)	?
Protein Name	prefusion RSV F protein
Protein pI	9.11
Protein Weight	59319.97
Protein Length	574
Protein Note	derived from human respiratory syncytial virus A2
Protein Sequence	>UED36857.1 prefusion RSV F protein [synthetic construct] MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKKNKCN GTDAKVKLIKQELDKYKNAVTELQLLMQSTQATNNKAKKELPRFMNYTLNNAKKTNVTLSKKKKKKFLGF LLGVGSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQ SCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQI VRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVS FFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKT KCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDA SISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLYCKARSTPVTLS KDQLSGINNIAFSN
Molecule Role	Protective antigen
Molecule Role Annotation	The F protein exists in a metastable prefusion conformation (RSV Prefusion F protein) that is anchored in the viral membrane by a transmembrane domain. In this conformation the hydrophobic fusion peptide is buried within the central cavity of the protein(Gilman et al., 2019).
Related Vaccines(s)	Ad26/protein preF RSV Vaccine Coadministered With an Influenza Vaccine
References