VIOLIN: Vaccine Investigation and Online Information Network

ICP27
Gene Name	ICP27
Sequence Strain (Species/Organism)	Herpes simplex virus type 1
VO ID	VO_0011101
NCBI Protein GI	75812153
Other Database IDs	CDD:293457 CDD:283185
Taxonomy ID	10298
Gene Strand (Orientation)	?
Protein Name	ICP27
Protein pI	6.82
Protein Weight	53658
Protein Length	566
Protein Note	Identical sequence is also seen in starin: BBY-C-1802; laboratory host: Vero cell, human embryonic lung cell
Protein Sequence	>BAE44982.1 ICP27 [Human alphaherpesvirus 1] MATDIDMLIDLGLDLSDSDLDEDPPEPAESRRDDLASDSSGECSSSDEDMEDPHGEDGPEPILDAARPAV RPSRPEDPGVPSTQTPRPTERQGPNDPQPAPHSVWSRLGARRPSCSPEQHGGKVARLQPPPTKAQPARGG RRGRRRGRGRGGPGAADGLSDPRRRAPRTNRNPGGPRPGAGWTDGPGAPHGEAWRGSEQPDPPGGPRTRG VRQAPPPLMTLAIAPPPADPRAPAPERKAPAADTIDATTRLVLRSISERAAVDRISESFGRSAQVMHDPF GGQPFPAANSPWAPVLADQGGPFDAETRRVSWETLVAHGPSLYRTFAGNPRAASTAKAMRDCVLRQENFI EALASADETLAWCKMCIHHNLPLRPQDPIIGTAAAVLDNLATRLRPFLQCYLKARGLCGLDELCSRRRLA DIKDIASFVFVILARLANRVERGVAEIDYATLGVGVGEKMHFYLPGACMAGLIEILDTHRQECSSRVCEL TASHIVAPPYVHGKYFYCNSLF
Molecule Role	Protective antigen
Molecule Role Annotation	Epitopes from the ICP27 (H1, H2), glycoprotein B (gB) and glycoprotein D (gD) proteins of HSV-1 were attached to either the J TCBL/ICBL or the G TCBL/ICBL. The JH1, JH2, JgB and JgD vaccines elicited DTH responses without antibody but conferred protection upon lethal challenge with HSV (Goel et al., 2005).
Related Vaccines(s)	Herpes simplex virus DNA vaccine ICP-27 DNA encoding ICP-27
References