VIOLIN: Vaccine Investigation and Online Information Network

NP from Influenza B virus
Gene Name	NP from Influenza B virus
Sequence Strain (Species/Organism)	Influenza B virus
VO ID	VO_0011110
NCBI Gene ID	956539
NCBI Protein GI	8486155
Locus Tag	FLUBVsRNA-5gp1
Genbank Accession	K01395
Protein Accession	NP_056661
Taxonomy ID	11520
Segment No	RNA 5
Gene Starting Position	57
Gene Ending Position	1739
Gene Strand (Orientation)	+
Protein Name	nucleoprotein
Protein pI	9.94
Protein Weight	58594.17
Protein Length	560
DNA Sequence	>NC_002208.1:57-1739 Influenza B virus (B/Lee/1940) segment 5, complete sequence AATGTCCAACATGGATATTGACAGTATAAATACCGGAACAATCGATAAAACACCAGAAGAACTGACTCCC GGAACCAGTGGGGCAACCAGACCAATCATCAAGCCAGCAACCCTTGCTCCGCCAAGCAACAAACGAACCC GAAATCCATCTCCAGAAAGGACAACCACAAGCAGTGAAACCGATATCGGAAGGAAAATCCAAAAGAAACA AACCCCAACAGAGATAAAGAAGAGCGTCTACAAAATGGTGGTAAAACTGGGTGAATTCTACAACCAGATG ATGGTCAAAGCTGGACTTAATGATGACATGGAAAGGAATCTAATTCAAAATGCACAAGCTGTGGAGAGAA TCCTATTGGCTGCAACTGATGACAAGAAAACTGAATACCAAAAGAAAAGGAATGCCAGAGATGTCAAAGA AGGGAAGGAAGAAATAGACCACAACAAGACAGGAGGCACCTTTTATAAGATGGTAAGAGATGATAAAACC ATCTACTTCAGCCCTATAAAAATTACCTTTTTAAAAGAAGAGGTGAAAACAATGTACAAGACCACCATGG GGAGTGATGGTTTCAGTGGACTAAATCACATTATGATTGGACATTCACAGATGAACGATGTCTGTTTCCA AAGATCAAAGGGACTGAAAAGGGTTGGACTTGACCCTTCATTAATCAGTACTTTTGCCGGAAGCACACTA CCCAGAAGATCAGGTACAACTGGTGTTGCAATCAAAGGAGGTGGAACTTTAGTGGATGAAGCCATCCGAT TTATAGGAAGAGCAATGGCAGACAGAGGGCTACTGAGAGACATCAAGGCCAAGACGGCCTATGAAAAGAT TCTTCTGAATCTGAAAAACAAGTGCTCTGCGCCGCAACAAAAGGCTCTAGTTGATCAAGTGATCGGAAGT AGGAACCCAGGGATTGCAGACATAGAAGACCTAACTCTGCTTGCCAGAAGCATGGTAGTTGTCAGACCCT CTGTAGCGAGCAAAGTGGTGCTTCCCATAAGCATTTATGCTAAAATACCTCAACTAGGATTCAATACCGA AGAATACTCTATGGTTGGGTATGAAGCCATGGCTCTTTATAATATGGCAACACCTGTTTCCATATTAAGA ATGGGAGATGACGCAAAAGATAAATCTCAACTATTCTTCATGTCGTGCTTCGGAGCTGCCTATGAAGATC TAAGAGTGTTATCTGCACTAACGGGCACCGAATTTAAGCCTAGATCAGCACTAAAATGCAAGGGTTTCCA TGTCCCGGCTAAGGAGCAAGTAGAAGGAATGGGGGCAGCTCTGATGTCCATCAAGCTTCAGTTCTGGGCC CCAATGACCAGATCTGGAGGGAATGAAGTAAGTGGAGAAGGAGGGTCTGGTCAAATAAGTTGCAGCCCTG TGTTTGCAGTAGAAAGACCTATTGCTCTAAGCAAGCAAGCTGTAAGAAGAATGCTGTCAATGAACGTTGA AGGACGTGATGCAGATGTCAAAGGAAATCTACTCAAAATGATGAATGATTCAATGGCAAAGAAAACCAGT GGAAATGCTTTCATTGGGAAGAAAATGTTTCAAATATCAGACAAAAACAAAGTCAATCCCATTGAGATTC CAATTAAGCAGACCATCCCCAATTTCTTCTTTGGGAGGGACACAGCAGAGGATTATGATGACCTCGATTA TTA
Protein Sequence	>NP_056661.1 nucleoprotein [Influenza B virus (B/Lee/1940)] MSNMDIDSINTGTIDKTPEELTPGTSGATRPIIKPATLAPPSNKRTRNPSPERTTTSSETDIGRKIQKKQ TPTEIKKSVYKMVVKLGEFYNQMMVKAGLNDDMERNLIQNAQAVERILLAATDDKKTEYQKKRNARDVKE GKEEIDHNKTGGTFYKMVRDDKTIYFSPIKITFLKEEVKTMYKTTMGSDGFSGLNHIMIGHSQMNDVCFQ RSKGLKRVGLDPSLISTFAGSTLPRRSGTTGVAIKGGGTLVDEAIRFIGRAMADRGLLRDIKAKTAYEKI LLNLKNKCSAPQQKALVDQVIGSRNPGIADIEDLTLLARSMVVVRPSVASKVVLPISIYAKIPQLGFNTE EYSMVGYEAMALYNMATPVSILRMGDDAKDKSQLFFMSCFGAAYEDLRVLSALTGTEFKPRSALKCKGFH VPAKEQVEGMGAALMSIKLQFWAPMTRSGGNEVSGEGGSGQISCSPVFAVERPIALSKQAVRRMLSMNVE GRDADVKGNLLKMMNDSMAKKTSGNAFIGKKMFQISDKNKVNPIEIPIKQTIPNFFFGRDTAEDYDDLDY
Molecule Role	Protective antigen
Molecule Role Annotation	BALB/c mice were immunized intranasally with an adjuvant (cholera toxin B subunit containing 0.2% of the whole toxin)-combined with A or B virus recombinant NP. The NP-immune mice, when challenged intranasally with a sublethal dose of the virus 3 wk after immunization, had accelerated virus clearance from the nasal site in both an influenza type-specific and a nonspecific manner, as shown by the protection from high morbidity from the second day after challenge (Tamura et al., 1996).
References

NP from Influenza B virus