VIOLIN: Vaccine Investigation and Online Information Network

NP
Gene Name	NP
Sequence Strain (Species/Organism)	Influenza A virus H3N2
VO ID	VO_0011111
NCBI Protein GI	3722159
Other Database IDs	CDD:278907
Taxonomy ID	41857
Gene Strand (Orientation)	?
Protein Name	nucleoprotein
Protein pI	9.57
Protein Weight	54706.76
Protein Length	558
Protein Note	Influenza virus nucleoprotein; pfam00506
Protein Sequence	>AAC63462.1 nucleoprotein [Influenza A virus H3N2] MASQGTKRSYEQMETDGERQNATEIRASVGKMIDGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSA FDERRNRYLEEHPSAGKDPKKTGGPIYKRVDGRWMRELVLYDKEEIRRIWRQANNGDDATAGLTHMMIWH SNLNDTTYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGIGTMVMELIRMIKRGINDRNFWRGE NGRKTRSAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFSARSALILRGSVAHKSCLPACV YGPAVSSGYNFEKEGYSLVGIDPFKLLQNSQVYSLIRPNENPAHKSQLVWMACHSAAFEDLRLLSFIRGT KVSPRGKLSTRGVQIASNENMDNMESSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPF EKSTVMAAFTGNTEGRTSDMRAEIIRMMEGAKPEEVSFRGRGVFELSDEKATNPIVPSFDMSNEGSYFFG DNAEEYDN
Molecule Role	Protective antigen
Molecule Role Annotation	BALB/c mice were immunized intranasally with an adjuvant (cholera toxin B subunit containing 0.2% of the whole toxin)-combined with A or B virus recombinant NP. The NP-immune mice, when challenged intranasally with a sublethal dose of the virus 3 wk after immunization, had accelerated virus clearance from the nasal site in both an influenza type-specific and a nonspecific manner, as shown by the protection from high morbidity from the second day after challenge (Tamura et al., 1996).
Related Vaccines(s)	Influenza virus DNA vaccine d1TTFC-NP encoding NP
References

NP