VIOLIN: Vaccine Investigation and Online Information Network

ha
Gene Name	ha
Sequence Strain (Species/Organism)	Influenza A virus (A/chicken/Italy/13474/99(H7N1))
VO ID	VO_0011116
NCBI Protein GI	32261025
Other Database IDs	CDD:278910 GOA:Q7TDW9 HSSP: 1IBN InterPro: IPR000149 InterPro: IPR001364 InterPro: IPR008980 InterPro: IPR013827 InterPro: IPR013828 InterPro: IPR013829 UniProtKB/TrEMBL: Q7TDW9
Taxonomy ID	199442
Gene Strand (Orientation)	?
Protein Name	hemagglutinin
Protein pI	6.57
Protein Weight	60465.11
Protein Length	653
Protein Note	Haemagglutinin; pfam00509
Protein Sequence	>CAD37074.1 hemagglutinin [Influenza A virus (A/chicken/Italy/13474/99(H7N1))] MNTQILVFALVAIIPTNADKICLGHHAVSNGTKVNTLTERGVEVVNATETVERTNVPRICSKGKRTVDLG QCGLLGTITGPPQCDQFLEFSADLIIERREGSDVCYPGKFVNEEALRQILRESGGIDKEAMGFTYSGIRT NGTTSTCRRSGSSFYAEMKWLLSNTDNAAFPQMTKSYKNTRKDPALIIWGIHHSGSTTEQTKLYGSGNKL ITVGSSNYQQSFVPSPGERPQVNGQSGRIDFHWLMLNPNDTVTFSFNGAFIAPDRASFLRGKSMGIQSGV QVDANCEGDCYHSGGTIISNLPFQNINSRAVGKCPRYVKQESLLLATGMKNVPEIPKGSRVRRGLFGAIA GFIENGWEGLIDGWYGFRHQNAQGEGTAADYKSTQSAIDQVTGKLNRLIEKTNQQFELIDNEFTEVEKQI GNVINWTRDSMTEVWSYNAELLVAMENQHTIDLTDSEMNKLYERVKRLLRENAEEDGTGCFEIFHKCDDD CMASIRNNTYDHSKYREEAMQNRIQIDPVKLSSGYKDVILWFSFGASCFILLAIAMGLVFICVRNGNMRC TICI
Molecule Role	Protective antigen
Molecule Role Annotation	Mice and ferrets were immunised with two doses of the split virus vaccine (12-24 microg haemagglutinin derived from Influenza A virus (A/chicken/Italy/13474/99(H7N1))) with or without aluminium hydroxide adjuvant and challenged 3 weeks after second dose with the highly pathogenic A/chicken/Italy/13474/99 (H7N1) virus. The vaccine induced significant protection from disease after challenge with the wild-type virus. In the murine lethal challenge model, vaccination effectively prevented death and, furthermore, formulation with adjuvant reduced excessive weight loss and viral shedding (Cox et al., 2009).
Related Vaccines(s)	Avian influenza virus DNA vaccine pCMV-HA
References

ha