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hsp70
Gene Name	hsp70
Sequence Strain (Species/Organism)	Leishmania donovani
VO ID	VO_0011156
NCBI Protein GI	281426606
Other Database IDs	CDD:302596 GOA:D2EAU9 InterPro: IPR001023 InterPro: IPR013126 InterPro: IPR018181 UniProtKB/TrEMBL: D2EAU9
Taxonomy ID	5661
Gene Strand (Orientation)	?
Protein Name	heat shock protein 70
Protein pI	5.03
Protein Weight	47979.15
Protein Length	532
Protein Note	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cl17037
Protein Sequence	>CAZ04896.1 heat shock protein 70, partial [Leishmania donovani] DSQRQATKDAGTIAGLEVLRIINEPTAAAIAYGLDKGDDGKERNVLIFDLGGGTFDVTLLTIDGGIFEVK ATNGDTHLGGEDFDNRLVTFFTEEFKRKNKGKNLASSHRALRRLRTACERAKRTLSSATQATIEIDALFE NVDFQATITRARFEELCGDLFRSTIQPVERVLQDAKMDKRSVHDVVLVGGSTRIPKVQSLVSDFFGGKEL NKSINPDEAVAYGAAVQAFILTGGKSKQTEGLLLLDVTPLTLGIETAGGVMTALIKRNTTIPTKKSQIFS TYADNQPGVHIQVFEGERAMTKDCHLLGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAEEKGTGKRN QITITNDKGRLSKDEIERMVNDAMKYEADDRAQRDRVEAKNGLENYAYSMKNTLGDSNVSGKLDDSDKAT LNKEIDVTLEWLSSNQEATKEEYEHKQKELESVCNPIMT
Molecule Role	Protective antigen
Molecule Role Annotation	Study compared the vaccine efficacy of various L. donovani antigens encapsulated in cationic liposomes in BALB/c mice against challenge infection with L. donovani. Results demonstrated that liposomal LD72 (Hsp70) reduced parasite burden by 65%-67% (Bhowmick and Ali, 2009).
Related Vaccines(s)	L. donovani Hsp70 Protein Vaccine
References