VIOLIN: Vaccine Investigation and Online Information Network

mspC
Gene Name	mspC
Sequence Strain (Species/Organism)	Leishmania donovani
VO ID	VO_0011158
NCBI Protein GI	21954466
Other Database IDs	CDD:302875 GOA:Q8MM48 HSSP: 1LML InterPro: IPR001577 UniProtKB/TrEMBL: Q8MM48
Taxonomy ID	5661
Gene Strand (Orientation)	?
Protein Name	GP63
Protein pI	6.49
Protein Weight	63738.41
Protein Length	691
Protein Note	Leishmanolysin; cl19482
Protein Sequence	>CAD42816.1 GP63 [Leishmania donovani] MSVDSSSTHRHRSVAARLVRLAAAGAAVIAAVGTAAAWAHAGAVQHRCIHDAMHPRVRQSVARHHTAPGA VSAVGLPYVTLDTAAAADRRPGSAPTVVRAANWGALRIAVSTEDLTDPAYHCARVGQRVNNHAGAIATCT ADDILTDEKRDILVKYLIPQALQLHTERLKVRQVQDKWKVTDMVDEICGDFKVPPAHITDGLSNTDFVMY VASVPSEEGVLAWATTCQVFSDGHPAVGVINIPAANIASRYDQLVTRVVTHEMAHALGFSGTFFTEILVV TQMMNIRGKDFNVSVINSSTAVAKAREQYGCGTLEYLEIEDQGGAGSAGSHIKMRNAKDELMAPAAAAGY YSALTMAIFQDLGFYQADFSKAEEMPWGRNAGCAFLSEKCMEQNITKWPAMFCNVSVDVVRCPTSRLMLG TCGIRGYSTPFSPYWQYFTNISLGGYSPFLDYCPFVIGYGDGSCNQDASLATGFFGAFNVFSDAARCIDG AFRPKNRTAADGYYAGLCANVRCDTATRTYSVQVCGSMDYVNCTPGLRVELSTVSSAFEEGGYITCPPYV EVCQANVKGAKDFAGDSDSSSSAGDAADRAAMQRWNDRMAGLATAAMVLLGMVLSLMALVVVWLLLLTCP WWCCKFGGLPT
Molecule Role	Protective antigen
Molecule Role Annotation	Study showed that cationic distearoyl phosphatidylcholine (DSPC) liposomes, when used as vaccine adjuvant with the immunodominant 63-kDa glycoprotein (gp63, mspC) of Leishmania donovani promastigotes, induced significant protection against progressive visceral leishmaniasis in susceptible BALB/c mice. gp63 used without adjuvant elicited partial protection but in association with liposomes exhibited marked resistance in both the livers and spleens of the mice challenged 10 days after the last vaccination (Bhowmick et al., 2008).
Related Vaccines(s)	L. donovani gp63 Protein Vaccine
References

mspC