VIOLIN: Vaccine Investigation and Online Information Network

SAG1
Gene Name	SAG1
Sequence Strain (Species/Organism)	Neospora caninum
VO ID	VO_0011196
NCBI Gene ID	13442867
NCBI Protein GI	4583447
Other Database IDs	CDD:282012
Taxonomy ID	29176
Gene Strand (Orientation)	?
Protein Name	surface antigen SAG1
Protein pI	7.44
Protein Weight	30194.36
Protein Length	377
Protein Note	SRS domain; pfam04092
Protein Sequence	>AAD25091.1 surface antigen SAG1 [Neospora caninum] MFPRAVRRAVSVGVFAAPALVAFFDCGTMASEKSPLLVNQVVTCDNEEKSSVAVLLSPKLNHITLKCPDN STAVPAALGYPTNRTVCPAESGGQTCTGKEIPLESLLPGANDSWWSGVDIKTGVKLTIPEASFPTTSKSF DVGCVSSDASKSCMVTVTVPPRASSLVNGVAMCSYGANETLGPITLSEGGSSTMTLVCGTDGKPVPPDPK QVCSGTTVKDCKAKPFTDVFPKFSADWWQGKPDTKDGAKLTIKKGAFPPKEEKFTLGCKSVSSPEVYCTV QVEAERASAGIKSSAENVGRVSLFAVTIGLVGSIAAGVA
Molecule Role	Protective antigen
Molecule Role Annotation	NcSAG1 and NcSRS2, the two major immunodominant tachyzoite surface antigens of the apicomplexan parasite Neospora caninum, were investigated for their potential as vaccine candidates in mice. Results suggest that a combined DNA/recombinant antigen-vaccine, based on NcSAG1 and NcSRS2, respectively, exhibited a highly significant protective effect against experimentally induced cerebral neosporosis in mice (Cannas et al., 2003).
Related Vaccines(s)	N. caninum DNA vaccine encoding NcSAG1 and NcSRS2, combined with recombinant NcSAG1 and NcSRS2 Proteins
References