VIOLIN: Vaccine Investigation and Online Information Network

SLC5A5
Gene Name	SLC5A5
Sequence Strain (Species/Organism)	Homo sapiens
NCBI Gene ID	6528
NCBI Protein GI	4507035
Genbank Accession	AB032811
Protein Accession	NP_000444
Taxonomy ID	9606
Chromosome No	19
Gene Starting Position	17871393
Gene Ending Position	17895174
Gene Strand (Orientation)	+
Protein Name	transcript variant X1
Protein pI	7.43
Protein Weight	63209.43
Protein Length	643
Protein Note	Also known as NIS; TDH1
DNA Sequence	>NC_000019.10:17871393-17895174 Homo sapiens chromosome 19, GRCh38.p12 Primary Assembly CCCACTCAGAACTTGAGCTCTGAATGTCTCCCACCCAGCTTAGCCCAAGAGCGGGGTTCAGTGATGCCCA CCCCCTAAGGCTCTAGAGAAAGGGGGTAGGCCCACATGCCAGTTTGGGGGTGGTAAAGCCAGGTAAGTTT TCTTTATGGGTCCCCTGAAACCCTGAAAGTGAACCCCAGTCCTGCATGAAAGTGAGCTCCCCATAGCTCA AGGTATTCAAGCACAATACGGCTTTGAGTGCTGAAGCAGGCTGTGCAGGCTTGGATAGTGACATGCCCTC TCTGAGCCTCAATTTCCCCACCTGTCAACAGCAGACAGTGACAGCTGTGATCAGGGGATCACAGTGCATG GGGATGGGTGGGTGCATGGGGATGGAGGGGCATTTGGGAGCCCTCCCCGATACCACCCCCTGCAGCCACC CAGATAGCCTGTCCTGGCCTGTCTGTCCCAGTCCAGGGCTGAAAGGGTGCGGGTCCTGCCCGCCCCTAGG TCTGGAGGCGGAGTCGCGGTGACCCGGGAGCCCAATAAATCTGCAACCCACAATCACGAGCTGCTCCCGT AAGCCCCAAGGCGACCTCCAGCTGTCAGCGCTGAGCACAGCGCCCAGGGAGAGGGACAGACAGCCGGCTG CATGGGACAGCGGAACCCAGAGTGAGAGGGGAGGTGGCAGGACAGACAGACAGCAGGGGCGGACGCAGAG ACAGACAGCGGGGACAGGGAGGCCGACACGGACATCGACAGCCCATAGATTCCTAACCCAGGGAGCCCCG GCCCCTCTCGCCGCTTCCCACCCCAGACGGAGCGGGGACAGGCTGCCGAGCATCCTCCCACCCGCCCTCC CCGTCCTGCCTCCTCGGCCCCTGCCAGCTTCCCCCGCTTGAGCACGCAGGGCGTCCGAGGACGCGCTGGG CCTCCGCACCCGCCCTCATGGAGGCCGTGGAGACCGGGGAACGGCCCACCTTCGGAGCCTGGGACTACGG GGTCTTTGCCCTCATGCTCCTGGTGTCCACTGGCATCGGGCTGTGGGTCGGGCTGGCTCGGGGCGGGCAG CGCAGCGCTGAGGACTTCTTCACCGGGGGCCGGCGCCTGGCGGCCCTGCCCGTGGGCCTGTCGCTGTCTG CCAGCTTCATGTCGGCCGTGCAGGTGCTGGGCGTGCCGTCGGAGGCCTATCGCTATGGCCTCAAGTTCCT CTGGATGTGCCTGGGCCAGCTTCTGAACTCGGTCCTCACCGCCCTGCTCTTCATGCCCGTCTTCTACCGC CTGGGCCTCACCAGCACCTACGAGGTACCGGACAGAGGCCCGGGGGTAGGACCTGCCCCACTGGCAGTGC TGGGACCCCGTGTGGGGGAGGCGCTGGGGCTTTGGGCCGCTGTACAGGAGGACGCGGATGGCACCTCGGT GCTTTAACGGAAGGGGCCCCTAGGCAGACACGTGGGGAGGGTTCTAGGAAGAGGCCCCAGGCGCCCGGCG AGGGGCAGGAAGGAGGAAGAGAGAGCCTGGCGTCCTGCTCCTTCGGTGGAAGCGCGCGCGGGGCGGGGCC CGGCTCGACCAGGTGTGTCCTCACGGGTGGACACACACCTGCCCCCCACCTGCCCGGGCGTGCAGACCCA CGTGTGCGCGCTAGAGGGGACTGCTGACGGCTCCGGGGTTCGAAACCTGGCTTCACTGCTTTCTTGTATC TTGGGCAAGGGGCGTGCCTCTCTGTTTGGGTTTCCCAGCTGTCCAATGGGCGAATTACAGGACCTCCCTC CAGGGGAGAGGGTAAAGCGATTAAAATCGTGACCGGGGCCCGGTGCGGTGGCTCACGCCTGTAATCCCAG CACTTTGGGAGGCCAAAGCATGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGCG AAACCCCGTCTCTACTAAAAATACAAAAATTAGCCGGATGTGGTGGTGGGCACCTGTAATCCCAGCTACT TGGGAGGCTAAGACAGGAGAATTGCTTGAACCCGGGAGGTTGCAGTGAGCCGATATCGCGTCACTGCACT CCAGCCTGGGCGACAGAGCGAGACTCTTGTCTCAAAGGAAAAAAAAATATTGTGGCAGGGCGCAGTGGCT CACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGC CTGGCTAACATGGTGAAACCCCGTCTTTACTAAAAATACAAAAATTAGCCGGGCATGGTCGCGCGCGCCT GTAATCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATTGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAG CCGAGATCGTGCCAGTGCACCCTAGCCTGGGCGACAGAGCGAGACTCCGTCCCCCCTCCCCCCCAAAAAA ATCGTGACAGGTATATCCTAGGCGGCCAACACCATTGGCCCGGGGCACTGTCTACACTGTGCGCTTGCGG GCCACGTCGGTGTCTGCTGAGCGGTGGCTGCTCCAGGAGCCCGCGCCCGTCAGGCGCAAGTGGGAGGGCG CGTGCACACGCATGGACCAGTCCTCCAGGTCCACGGGGTACGCACAGGCACGGGATGGCACCTGTGCACG GGTGTGTGCGTGCGGCGGGGCCCCCACGTGCAAGAATCTGGCGGGCGCGGTTGGCTTCCGGAGGGAGGGG CCCACCTAGAGAGCAGACCAGGGACCCGAGAGGCCTCGGCTCCTGGGTAAGGACTGTCCAGGTGACCTCG AGTCCCTCCTTGCAGTACCTGGAGATGCGCTTCAGCCGCGCAGTGCGGCTCTGCGGGACTTTGCAGTACA TTGTAGCCACGGTGAGTGGCCTCGGCCCCGCCCTCCGCTCAGGGCCCCGAGAGCGTCAGCCTTCACTAGC CCGGCCCCCACCATTCAAGACCCCGCCCAGACCCCGCCCCCCATGCTCCCGTTCTGACCCCGCCCCCATC AGTCCCCTCCCACACCACAGCCGGCCTGACCCCGCCTGCACTCTGGAAGACCCGGCCTATCTGCCCCGCC CATATTCTGGGACCACCCTTCTGCCTCCTCTCCCCATCCCCAACTCGCCCAGACGCCCTCCCTGCTCACC CGCCCCACACTCTGTCTACAGATGCTGTACACCGGCATCGTAATCTACGCACCGGCCCTCATCCTGAACC AAGGTGTGACTCTGGGAGATTAGGGAAGCATGTCTGGGAAGAGAAAGGGAGGGAGAGGAGAACCCAAGAC TAAGTTTGCGCCCCGCCCAGGGGCCTAACAGGGGGACCTCTTTTTGCATAGTGACCGGGCTGGACATCTG GGCGTCGCTCCTGTCCACCGGAATTATCTGCACCTTCTACACGGCTGTGGTGAGTGGCCCTGGGAACTCA CTCCATACGGGGGATCGGGCCCACTGTGTCTCTTGTGGGGAGACTCTGGGCTTGCCCCTTTCTCCTGAGG AAGCCTCTGTCCCAGCTGGGACCCAGTGTCCTCATCTTTATAGTGAAAAATGATCTGAAAAGCTTATTGC TGAGAATCTAGAGGTATGGTAGCTTCAGGCATGGCTGGATCCAGGCTTCCACCTCTTCTGGCTTCCAGTC CAGCAGGAAGTGAGCTCCTGCTTCATCCTGGGGCTGGCTGAGGTCCCAGGGAGGGCTACCTTTGGCTGGC TCAGGTCTGACCTTGATGGCGATATTATCATCGTAGTGATAATAATAGTAATGGCGGCCGGGCGCGGTGG CTCACGTCTGTAATCCCAGCACTTTGGGAAGCAGAGGCAGGCGGATCACCTAAGGTCAGGAGTTCGAGAC CAGCCTGGCCAACATGATGAAACCCCGTCTCTACTAAGAATACAAAAATTACCTGGGCGCAGTGGCACGC GCCTGTAATCCTAGCCTCTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGTGGAGGTTGCGG TGCGTGGAGATTGCGCCATTGCACTCCAGCCTGGGCGACAGAGCAAGACTCCATCTCAAAAAAATATAAT AATAATAATAATAATAGTAATGGCAGCAATCACTCACTGACACTCGTATATGTCAAGTCATATTCCAAAT CTTTTTCACTTATTAACTTGTTTAATTCTACTGGGCACAGTGGCTCATACCTGTAATCCCAGCACTTTGA GAGGCCAAGGTAGGAGGATCACTTGAGGCCAGGGGTTCGAGACCAGCCTAGGCAACATAGTGAGACCCCC CCCCGCCCCCATCTCTACAAAAAAAATTTTTTTTAAATTAGTCGGGCATGGTGGCACCTGCTGTAGCTCC AGCTACTCCGGAGGCTGAGGCAGGAGGATCACTTGAGCCTAAGAGTTCCAGTCTGCAGTGAGCTGTGATC ACACCACTGCACTCCAGCCTGGGCAAAAGACAGAAACCTTTTCTTTAAAAATAAAATAACTAACTTAATT CTTACAACAACACAGTAAGAAGGTATTATTATTAATCCCACTTTAGAGAGGAGGAGACTGAGGCATAGAA GGGCATCAGTCCTAGGCACCACTGAAGGCCAGGTCCCCCATCTAACCGCCCCTCTCCCTCTCTCTGTCCC ATGCTGCAGGGCGGCATGAAGGCTGTGGTCTGGACTGATGTGTTCCAGGTCGTGGTGATGCTAAGTGGCT TCTGGGTTGTCCTGGCACGCGGTGTCATGCTTGTGGGCGGGCCCCGCCAGGTGCTCACGCTGGCCCAGAA CCACTCCCGGATCAACCTCATGGAGTGAGTGAAAATGCAGAGGATACTCCAGCAGGATGGGGCTGGGACC AGTGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACTTGAGCTCAGG AGTTCAAGACCAGCCTGGGCAACATGGTGAAAACCCATCTCTACAAAAATACAAAAATTAGCTGGGCGTG GTGGTGCACCTGTGGTCCCAGGTAGTTGAGAGGCTGAGGCTGGAGGATTGCTTGAGCCCGGTAGGTGGAG GCTGCAGCAAGCTGAGATCACACTACTGCACTCCAGCCTGGATGACAGAGCTAGACCCTGTCTCAAAAAA AAAAAAAAAAAGAGGCTGGGTGCAGTGGTTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGG GGATCACCTGAGGTCAGGAATTTGAGACCAGCATGACCGACATCGAGAAACCCCATCTCTACTAAAAAAT ACAAAATTAGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGATGGCAGAT CATGAGGTCAAGAGATTGAGACCATCCTGGCCAACTTGATGAAAGTCCGTCTTTACTAAAAATACAAAAA TTAGCTGGGCATGCTGGCAGGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGA ACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATGGCATCACTGCACTCCCGCCTGGTGACAGAGAGAGAC TCCGTCCCCCCCCTAAAAAAAAAAAAAATTAGCAGGGCGTGGTGGCGCATGCCTGTAATTCCAGCTACTC GGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCGGTGAGCCGAGATCACACCAT TGCACTCCAGCCTGGGCAACAAGAGCGAAACTCCATCTTTAAAAAAAAAAAAAGAGGATGGGGCTGGGCT CCCTTTGTGCCGTGGGATGGTAGAAATCAGCCAATGCCTCCTGCTCCAGGAGGCCCTCGCTGCTCTCTTC TCCTCCCCTCAGACCAGATTGGGGGCTAAAGCCTCTCTGAACTCTCAGCTGGGCAAAGAAAGGTTTTTAA GTGCGTGGATAGATGATTCAGTAAACAAATACGTGAATTTTCAATCTGGCAAATGCCTATGCATATGTCA AACCCACTCCATTTATTATTTATTTATTTTTAATTTAATTAATTTTTTTTTTTTTGAGATGGAGTCTCGC TCTGTCACCCAGGCTGGAGTGCAATGGCACGATCTCAGCTCACTGCAACCTCCGCCTCCTGGGTTGAAGT GATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTAGAGGCACCCGCCATTATTCCCAGCTAATTTTTG TATTTTTATAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGCCTTGAACTGTGACCTCAGGTGATCCAT CCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCTGGCCAACAAAACCCACTCC AAATGTCCCCTATAAGGTCCAGAAGCGCTGTCTGGGGCCCTTGGGAGGGTGAAGTCAGCGTGACATCTCC ACGTGGCTAACTTGCCCTGTCCCCACCCAGCTTTAACCCTGACCCGAGGAGCCGCTATACATTCTGGACT TTTGTGGTGGGTGGCACGTTGGTGTGGCTCTCCATGTATGGCGTGAACCAGGCGCAGGTGCAGCGCTACG TGGCTTGCCGCACAGAGAAGCAGGCCAAGCTGTGAGTGTTTCGGGGAGCAAGGTCGGGGTTTCTGGGACA TGCTGCCCCCCTCCACCAGCCTGAGGCTATCCCCTAAGCCTGAGGCTGCCTCTTCCCCCAGGGCCCTGCT CATCAACCAGGTCGGCCTGTTCCTGATCGTGTCCAGCGCTGCCTGCTGTGGCATCGTCATGTTTGTGTTC TACACTGACTGCGACCCTCTCCTCCTGGGGCGCATCTCTGCCCCAGACCAGGTGAGTCCCACCCAGGCTC CTGGTTGGCTCTGCACTCCCTCACTAGCTTGGTGGGATTGAGGTCGAAGAGCATTCCTAGCAGAGGGAAT GGCCTGTGCAAAGGCCAAGAAGTAGGAAAGAGCTGAGAGGAGGCCAGGTGCGGCGGCTCATGCCTGTATC CCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGTCTGGCTAACAT GGTGAAACCCTGTCTCTACTAAAAATATAAAAATTAGCTGGACGTGGTGGCACGCACCTGTAGTCCCGGC TACTCAGGAGGCTGAGGCAGGAGAATCTCTTGAACCCGGGAGGCGGAGGTTGCGATGAAGGGAGATCGCA CCACTACACTCCACCTTGGATGACAGAGTGAGACTCTGTCTCAAAAAAATAAAATAAAATAAAATAAAGA GTTCAGAGGAGGATCTGCAAGGAATGGGAAAGGTGAGTCTGGGAGGCAATGGACCGCCCTCAGTAGGTGT GAGCAGACAAGGGCCACATTCAGATCTAGAGTTCCAGAGAGTTCCAAAGATCCCCTGGGAGATGCTCAGG AGGAGATGAAACCATGACCCAGGCCGGGCATGTTGGCTCACGCCTGTAATCCCAGCACTTTTGGAGGCCG AGACAGGCAGATCACTTGAGGTTAGAAGTTCGAAACCAACCTGGCCAACATGGTGAAACCCCCCTCCACT AAAAATACAAAAATTACCTAGGCCTGGTGATGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAG GAGAATAGCTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCAGAGATCGCGCCATTGCACTCCAGCCTGGG TGACAGAGAGAGACTCCATCTCAAAAAAAAAAAAAACAAAAAAAAAAAACCAAAACAAGGCTGGGCGCGG TGGCTTACGCCTATAATCTCAGCACTTTTGGAGGCTGAGGCAGGGGTATCACCTGAGGTCATGAGTTGAA GACCATCCTGACCAACATGGAAAAACCCCGTCCCTACTGAAAAATACAAAATTAGCCGGGTGTGGTGGTG CATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATAGCTTAAACCTGGGAGGCGGAGGTTG CGGTGAGCTGAGATGGCGCCATTGCACTCCAGCCTGGGCAACAAGAGAGAAACTCCGTCTCAAACAAAAA TAAAAACAAAACAAAACAAACCCACAAAAACAAAAACAAAAACTGTAATCCAGCGGGAACTAATCATGTT GGTGATAATAATAATGACAGCTCTGGTCTCCCATGTCCCAAGCGTCCACTCTGTGCCTCATGCTGTTCCC TTCACCAGCAGTTAGTTCTCCATCTAATCTTTCTTCTGAGAAAGGCAGGGCAGTCACGGCTCCAACTTTA CAGATGAGGAAATTGAGGCTCGGGGGGAAGTCACTGCCTGAGGTCAATGGGCAAGTCGGGGGGCGGTGCC AGGACCCATGCCTAGGTCACACCCCAAGTAGAGTTCTGACCATGGGGTTCAGAGTTAGCAGAGGGTACGG GGGACCACCCCATCTGCAGTCCTCCCTGGAGGTCAGATCCGGGACTGCTGGACTGTGTAACTTCAGGGAG GGACTGTACTCTCTGCCTCACAGTCTTCATCAATAAAATGAGGATGACACGGGTCCCTGCTTCACAGGGA TCCCAGGGCTCAGAACACAGTGGGGCTCAGGGACAATTCTCAGGTTCATGCAGTTGATCAACAAATGCAC ATTATAGCCTGAGGAACATAGGGAGACCCCATCTTTACACAATTTTTTTTTTTTTGAGCCAGAGTCTCAC TCTGTTGCCCAGGCTGGAGTGCAGTGGCGCAACCTCAGCTCACTGCAACCTCTGGCTCCCAGGATCAAGC CATTCTCTTGCCTCAGCCCCCGAGTAGCTGGGATGACAGGCATGCGCCACCATGCCCAGCTAATTTTTTT GTATTTTTTGTAGGGGTGGGGTTTTGCCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATC CACCTGCCTCAGCCTCTGAATGTGCTGGGATTACAGGCATGAGCCACTGTGCCCGGCCTTTCTTTCTTTT CTTTCTTTTTTTTTTTTTTTGAGACAGAGTTTGGCTCTGTTGTGCAGGCTGGAGTGCAACGGCGCGATCT CCGCTCGCTGCAACCTCTACCTCTCAGATTCAGGCAATTCCTCTGCCTCAGCCTCCCAAGTAGCTGGGAC TCCAGGTGCCAACCACCACACCCAGCTAATTTATGTATTTTGGGTAGAGATGAGGTTTCACCATGTTGGC CAGGCTGGTCTTGAACTTCTGAGCTCAAGTGATCCACCCGCCTCGGCCTCCCGAAGTGTTGGGATTACAC GCGTGAGTCACCCTGCCCGGCCAGACCCCTATCTTTACACAAAAATTTAAAAAAATTAGCCAGGCATGGT GGCGCACACCTGTGGTCTCAGCTACTGGGGGACTGAAGCAGGAAGATCGCTTGAGCCCAGGAGTTCTAGG CTGCAGTGAGCCACATTCATGGGACTGCACTCCCGCCTGGGCAACAGAGCAAGATCTTTTCTCAAAACAA AACAAAACAAAACAAAACCACAGACAAAAACTAAATGCATATTAAATGCCGACTCTGAGCCCTGTCCGTC TTGGGTGCTGGGGACGTGCAGCATCAGGACAGATAGATGCCCCGGTCCTCGGGGTGCAGCTGTCTGGGAG GCTGACCCCCAGTTCTCCCCAGTACATGCCTCTGCTGGTGCTGGACATCTTCGAAGATCTGCCTGGAGTC CCCGGGCTTTTCCTGGCCTGTGCTTACAGTGGCACCCTCAGGTGAGCACCCCTGCTTGTTCATGGAGCAT TATTTCAGCCCCTGGGAGCCTCCTTATCCTGGCCTGCCATCCCTCTGGGGCATGGAATGTTCTGGACCTG TCCATCAGTCCCAGTTCCTGCTTGATCCCTAGAAGACAGCTCAGGTAGGCGCTGGCAGAGAGCATGCCCT GGGCACAGGGACCCCAACTGCAAGGGTTTACCTTCTTATCACCTGTCAGGGCCACGCCTGACTCTCCTCT CTTCTTCTTCCTTCTTTCCTTCCTTCCTCCCCAGACAAATATTTGTTGAACATCTACTATGTGGCAGGTA CTGTTTTTTTTTGTTTTTTTTCCGGATGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCCAT CTCGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGG ATTACAGGTCCACGCCACCACAGCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCGCCATGTTG GCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCATGCTTTGGCCTCGCAAAGTGCTGAGATTGC AGGCATGAGCCAACGTGCTCAGCCCAGGTACTGTTGTTCTAAACCCTGGGGCACAGCCATGACCAAGCAG TCCCCTGCTTCTGCCTTCCAAGGCCACACACTCAGGTGGTTTCCACTCTTCCGGGACTTCTGGTCACATG CCCTCACTGTCCCTTTTGCAAATCTCCCACATGTGACTGCAGTCCCTCTGGAACCAGAACCCACCTGTCT GTCCCACCTGCCCTTGGTCACAGGTGTCCTTGCTCCTGTAGGGATGTCTCAGGTCTTCGGGGAGGGGAGG GGCAAATATCTCCTTCACCTTTGCAGGACTGGGTTACCCCCACCGTTGCCCTCAGGCTGGGTGAGGTCTG GCAGGCCAGATGGTGTGGACGGTCTCTCCATATGGCCTGAGGACCCCCCGCTGCCTTCCTCACACAGCAC AGCATCCACCAGCATCAATGCTATGGCTGCAGTCACTGTAGAAGACCTCATCAAACCTCGGCTGCGGAGC CTGGCACCCAGGAAACTCGTGATTATCTCCAAGGGGCTCTGTGAGTTTCAGGGAGACCTGGGTGGGAGGC CAGGGCAGTCCCTCCCCGTTGACCGTGCCATCCTCATCCACTACAGCACTCATCTACGGATCGGCCTGTC TCACCGTGGCAGCCCTGTCCTCACTGCTCGGAGGAGGTGTCCTTCAGGTGAGACCCCACCTGCCCCCTGC CCTGGTCTCCTGAGAGGTGGGGGCACCTTTCCCTCTTTCCCATTAAACTGAGGCTCAGAGAGGTCACATG TGTCAGTGGCAGAACTCACTTCTATGTTTTTTTTTTTTTTGAGATGGGGTCTCACTGTGTTGTCCCAGGT TGGTGAGCAGAGGCCCGATCATAGCTCACTGCAACCTCCAGCTCCTGGGTTCAAGCCATCCTTCCACCTC AATCTCCCAAGTAGCTGGAGTTACAGGTGTGTGCCACCATGCCTGGCTAATTTTTTTCTTTTTTCTTTTT TTTTTTTTTTTGAGGTGGAGTGTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCGCT GCAACCTCCACCCCCTGGGTTCAAGGAATTCTGCCTCAGCCTCCAGAGTAGCTGGGATTACAGGTGCATG CCACCATGCCCGTCTAATATTTTTGTATTTTTTTTTCTTGAGACGGAGTCTCGCTCTGTTGCCCAGGCTG GAGTGCAGTGGCACCATCTTGGCTCACTGCAAGCTCAGCCTCCTGGGTTCACGCCATTCTCCTGCCTCAG CCTCCCGAGTAGCTGGGACTACAAGCGCCCGCCACCACGCCTGACTAATTTTTTGTATTTTTAGTAGAGA TGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCTCCTCGGCCTCCC AAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGCTTATATTTTTGTATTTTTATTAGAGATGGGA CTTCACCATGTTGGCCAGTCTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTCTGCCTCCCAAA GTGTTGGGATTACAGGTGTGAGCCACCACGCCTGGCCTGGCTAATTTTAAAACTTGTTTTTAGAGACAGG GTCTCGCTTCGTGCCTAGGCTTGTCTTGAACTCCTGGCCTCAAGCAACCACCCGCCTCAGCCTTCCAAGT CGCTGAGATTAAGAACTAAGTTCTATTTGATGCCAGAGGCCATCAGGGGACTTTTTTGCAGCTGGCTGGC TTGGGGTGGGGGAATTGGGAAGGGGGAGGTGGCGACAGAAAGGGCCTCCCTATGGAGGTTGCAGTGAGCC AAGATCGCGCCACTGCACTCCAACCTGGACAGCAAAGTGAGACTCTGTCTAAAAAAAAAAAAGAAGAAGA AAGGGTCTCCCTGGCTTGAGGGTGGGACTGCCACCCCCAAGAGATAATCAGTGTCTTTGCCTCCAACCCA AGGGAGATAGGCAGGAACAAGGGGGGGGGGTCCTCTCCCCTTTAGGGAAACTGAGACACAGAGGAGTCCT TGAGACCCACATTGGAGTTCCTGAGGTCTCGCTTTCCCAGCGGGTAAACTGAGGCCCAGAGCGGTGGGAG GGCTCCGCCCTCAGCCCCACTTCCACCTACTCTCCCAGGGCTCCTTCACCGTCATGGGAGTCATCAGCGG CCCCCTGCTGGGAGCCTTCATCTTGGGAATGTTCCTGCCGGCCTGCAACACACCGGTGAGTGGGGGCGGG GCAAGGGGCGGGGAGGGGCGGGGCCGGACAGGCCCCTCCCCTTCCCTGACGCCGGCTCTGCCCCCAGGGC GTCCTCGCGGGACTAGGCGCGGGCTTGGCGCTGTCGCTGTGGGTGGCCTTGGGCGCCACGCTGTACCCAC CCAGCGAGCAGACCATGAGGGTCCTGCCATCGTCGGCTGCCCGCTGCGTGGCTCTCTCAGTCAACGCCTC TGGCCTCCTGGACCCGGCTCTCCTCCCTGCTAACGACTCCAGCAGGGCCCCCAGGTGAGCAGACTTGAGG GTAGGGGGGTACCCGAGCCCTGGATGGTGTGATCTTGAAGGGAAACTTACTTGCCCTGCACTCTGTGTAA GAAGCCTGATTAGTAAAATGCATTCCTGGGGGAGGGAACGGTAGGTGCAAAGGCCCTGAGGCCACAATCG GGTTAGTCCCAGTCCAACTGCACTGAGGTTAGGGTGCATTTAATGGGAGGAGAGATGGGTGGGAGATATG GTGCAGCCAGAGGAAGCTAGTACTTTTTTTGTTTTGTTTTTCTGAGACAGAGCCTCGCTCTGTGGTCCAG GCTGGAATGCAGGGGTGCAATCTCAGCTTACTGCAGCTTCAACCTCTCAGGCTCAAGCAATCCTCCCAGC TTGAGGGAGGCCCAGAATTTGGTTTGGTTCTATTTTTTATTGAGATAAATTAGCCATTTAAAAGTGGCAT TTAGGCCAGGCAGGCACAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCA CCTGAGGTCAGGAGTTCAAGACCAGCTTGATCAACATGGGGAAACCCCCGTCTCTACTAAAAATACAAAA CTTAGCCAAGCGTGGTGGCAGGTGCCTGTAATCCCAGCTACTCGGGAGGCTGAGACAGGAGAATCGCTTG AACCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCGCACCACTGTATTCCAGCCTGGGCAACAAAAATGA AACTCCAACTCAAATAAATAAATTAAAGTGGCATTTAGTATATTTGTGCAACCATCACCACTATCTAAGT CAAGAACGTTTCCTCTTTTTTTTTTCTAATTTTGTATTTTTAGTACAGATGGGGTTTCACCATGTTGGCC AGGCTGATCTTGAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCCAAAATGCTGGGATTACAGG TGTGAGCCACTGTGCCTGGCCCCAAAAACATTTTCTATTTTTTTTTTTTTTTGGAGCAGGGTCTTGCTCT GTTGCCCAGGCTGGAGTCCAGTGGCACGATCATAGCTCACTGCTGCCTCAACCTCCTGGGCTCAAGGAAT CTTCCTACCTCAGCCCCCCTAGTTGCTGGGACCACAGGTGCACACCATCATGTCCTGCTTGTTTTTATTT TTATTTTTTGTAGAGACAGGGTCTGGCTATGTTGCCCAGGCTGGTCTGGAATTCCTGGGCTCAAGCGATC TGCCCACCTCAGCCTTGCAAAGTGCCAGGATGACAGGTGTGGGCACCCAGCCAACCAAGAACATTTTCTG TTTTGTTTATTTATTTATTTATTTATTTTGGTTTTTTGGGTGGGTTTTTTTGCTTTTTGTTTATTTGATT TTTTGGAGACAGGGTCTCACTCTAACACCCAGGCTGGAGTGCAATGGCACAATCACAGCTCACTGCACCA TTGACCTCCAGACTCCGATGATCCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTATAGGCATGTATCAC CATGCTGGGCTAAATTTTTTGTATTTTTTATAGAGACGAGTTTTTGCCATGTTGCCCAGGCTGGTCTCAA AGTATTGGGCTCAAGTGATCTGCCTGCCTCTGACTCCCAAAGTGCTGGGATTACAGGTGTGAGGCACTGT TCCTGGTCATAAGAACATTTTTATCACCCCAGAAAGAAGCCCTGTCCCCATCAGCAGTCACTTCCCACTT CCCCCTCTCCCCAGCTCCTGGCAAGCACGAATCCACTTTCTGTTTCTATGAATTTGCCTGTTCTGGGCAT TTCATGTAAATGGAATCATAAAATATGTGATCTTTTGTGTCTTAGCATAATACATATATATTTTTTGAGA CGGGGTTTCACTTTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCCCAGCTCACTGCAACCTCTGCCTCC CAGGTTCAAGCAATTCTCCTGTCTCGGCCTCCTGAGTAGCTGGGGTCACAGGCATATGCCACCACGCTTG GGTAATTTTTGTATTTTTAGTAAAGATGGGGTTTCACCATATTGATCAGGCTGGTCTTGAACTCCTGACC TCAGGAGATCCACACATCTTGGCCTTTCAAAGTACTGGGATTACAGCAGAGTACAGTGGAGCCACTGCAC TCCAGTCTGGGTAACAGAGTGAGACTCCACCAAAAACAAACAAAACCAAAAACATTTGTGAACAAGTTTT GGTATGGACATATGTTTTAATTTCTCTAGGTATATACCTATGAGTGGAATTGCTGGATCATATGGTAATT CTTTAACTTTTTTTTTTTTTTTTTAGATGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGA TCTCCACTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCCGCTTCAGCCTCCCGAGTAGCTGG GACTACAGGCATATGCCACCACGCCTGGCTAATTTTTATATTTTTAGTAGAGAAGGGGTTTCACCATGTT GGTCAGGGTGGTCTCAAACCCCTGACCTCAGATGATCCGCCTGCCTTGGCCTCCCAGGGTGTTAGGATTA CAGGCCTGAGCCACCACGCCCGGCCTATGTTTAACTTTTTGAGGAACTACCAGACTGTTTTCCACAGCGG CCACATCATTTTACATTCCGACCAGCAACATATGAGGATTCTAACTTCTCCACGTCCTCGCCAATACTCA TTATTCTCCATCCTAGTGGGTGTGAAGTGATACCTCACTGTGGTTTTGATTTGCATTTCCCTGATGAATA ATGATGTTGAGCATCTTTCTTTTCATTGGCCATTTGTGCATCTTCTTTGGAGAAATGTCTATTCAAACCC TTTGCCCATCCAGCCTGGGTAACATAGAAAGACCCTATCTCTATAAAAATAAAAATGAAAAAATTAGCTG GGCATGGTGGTGCACACTTGTAGTCCCAGCTCCTTGGGAGGCTGAGGCAAAGAGGATCGCTTGAGCCTGG GGGGCCAAGGCTGCAGTGAAGCATGATCCCACCACTGCACTCCATCCTAGGCAACAGAGCAAGACCCTGC CTCAAATTAAAAAACAAACAAACAAAAAAACACCCTTTGCCCATTTTTAAATTGGGTGATTTGTCTTTTT ATTGTTGAGTTATAATTTACATATTTTTATATCTTTATGTATTCTGGGTACAAGCCCCTGATCAGATGTA TAATTTGCATGTGATATTTTCTCCCATTCTGTAGGTTGTCTTCATTCTCTCGATAGAATCCTTTGATGCA CAGAAGTTTTTAATTCTTTTTTTTGGTGGGCGGATGGAGTCTAACTCTGTCACCCAGGCTGGAGTGCAGT GGTGCGATTTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGGGATTCTCCCACCTCAGCCTCGTGAG TAGCTGTGACTACAGGTGCACACCACTATGCCAGGCTAATTTTTATATTTTTAGTAGAGATGGGGTTTCA CCATGTTAGCCAGCCTGGTTTCAACTCCTGACCTCAGCCTGCCTCAGCCTCCCAAAGTGCTAGGATTACA GGCATGAGCCAACATGCCTGGCCAGAAGTTTTTAATTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTC TGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACTGCAAGCTCCACCTCCCGGGTTCATGCCA TTCTCCTGCCTCAGCCTCTCGAGTAGCTGGGACTACTGGCACCCGCCATCAGGCCTGGCTAATTTTTTAT TATTTTTTTATTTTTAGTAGAGACAGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCG TGATCCACCCGCCTTGGCCTCCCAAAGTGCTAGGATTACAGGTGTGAGCCACCACGCCCAGCCAGTTTTT AATTTTTGATGAAGTCCAATTGATTTATTTTTTTCTTTGGTGGCTTTTGCTTTTGGCGTCATATCTAAGA AACAATTGCAGTCACGAAGATTCCCACCTATGTTTTCTTCTGAGAGTTTAATTTGGTTTGATTTTGAGGG TGACAGGGAGCCACAGAGGGTGACGGGCAGCAGCAGGTGATCTGAGTTACATTTTAGTAATGTGCCCTTT GGCTGTGTGTGGAGGACGTCTAGGGTGGGGATGGGATACCTGGAGGGAAGGAACATTGGCTACTGCACAG ATCTGGGCAGACAGTAATGGAGGTCTGTGCTAGGCCATGGCAGTTGGGGGAAGGAAGCAGGGGGTGAGGT TGGAACAGCTTTTGAGTGCAGGCAGGGGATAAAAGAGGAGGTTCAAGTCTGTCTCTCCCAACCTGCAGCT CAGGAATGGACGCCAGCCGACCCGCCTTAGCTGACAGCTTCTATGCCATCTCCTATCTCTATTACGGTGC CCTGGGCACGCTGACCACTGTGCTGTGCGGAGCCCTCATCAGCTGCCTGACAGGTAGGTAAACAGAGCAT GTGGCCTCAGAGGTCATCCCATTCATCTCTCTGCCTCAAGGCTCCACCCAGCAGGGAGGGGAGAAAGGAC GCTCCCATTGGCCAAACTGCCACTGTGTGCTGTACACATTTGTACCTTATTATTATTATTATTATTATTA TTATTATCATCATCATCATCATCATCATCATCATTTTTGAGATAGAGTCTCACTCTGTCACCCAGGCTGG AGTGCAGTGGTGTGATCTCAGTTCATTGCAACCTCCACCTCCCAGATTCAAGCGATTCTCATGTCACAGC CTCCCGAGTAGCTGGGATTACAAGTGTGTGCCGCCATGCTTGGCTAATTTTGCATTTTTAGTAGAGACGG AGTTTCGCCATGTGTCTCGAACTCCTGGGCTCAAGTGATCCGCCCACCTCGGCCTCGCAAAGTTCTGGGA TTATAGGTGTGAGCCACTGCACCTGGGCTGTACCTATTTTTTTAAAAGGAAAAAAAAAGTTTGTGAGGAA AAAAGAAGTGTGTGTGTATATATACACATACATACACACTTTTATGTGTATATATACATAAAAGAAATTA TGAATATATATAAAAATTATGACTATATATATACATAAAAGAAAGTGTATATATATATAGTTTCTTTTAA AGGGACGGGGTCGACTGGGCGTAGTGGCTCATGCCTGTTATCCCAGCACTTTGGGAGGCCGAGGCGGGTG GATCACCTGAGGTCAGGAGTTCAAGACCAGCCCGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATAC AAAAAAATTAGCTGGGCATGGTGGCAGGCGCCTGTAATGCCAGCTACTTGGGAGGCTGAGGTAAGGGAAT CGCTTGATCCTGGGAGATGGAGGTTGCAGTGAGCCAAGATTGCGTCACTGCACTCCAGCCTGGGCAAGAG AGTGAGACTCCATCTAAAAGAAAGAAAGAAAGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAAGAGAAAG AGAGAGAGAGAGAAGGAGAGAAAGAGAGAGAGAAAGAAAAGAGACAGGTCTCACTGTTACCCAGACTGGA GTGCAGTGGCACAATCATGGCTCACTGCAACCTTGAACTCCTGAGCTGAAAGCAATCCTCCCACCTCATC CTCCCGAGTAGCTGAGACTACAGGTGCGCGCCAACGTGCCCGGCTCACATTTACACCCTTTAAAGCTATG TTGCTTTCTTGACAACCCTGCACCTCTCAGAGCTTGCCCTATTTTGCAGAGGCAGAAACGGAGGCATTGC CTGCAACTCCTCTCCCCAACAAGATTAAGTCCTCAGTAGAGGATATGGGTTGGGGCGGGCGGCGCTATCC CTGGTGCTGAAATATCTTCTAAAGCTGCCGGTGACTCCGCACTTGTTAGGGAATTCTAAATTCCACGGAA AAGTAGAAGGAGACAAAGAGGGGAAAGTCAGTAGTGATAACAGTACCTGCTCACACTTCTTGAGTCTCAG ACTTCACAGTCATCAGGCCTTTATCGAGTCCTCCTCTGTGCTGGACGCTATTTTAGGCACTGGGGATGCA GCAGTGAATGGAACCGTGTGCTGGACCCTCCCAGCCATCCATTAATGTCTTTGTTTTGTTTTGTTTTGTT TTTTTGAGATGGAGTTTCACTCTGGTCGCCCAGGCTGGAGTGCAATGGTGCGATGTTGGCTCACTGCAAC CTCTGACTCCCGGGTTCAAGCAATTCTCTTACCTCAGCCTCCCGAGTAGCTGGGATTACAAGCGCCCACC CCCACGCCTGGCTAATTTTTGTATTTTTAGTAGAAATGGGGTTTCGCCATGTTGGCCAGACTAGTCTCGA ACTCCTGACGTCAAGTGATCCCCTGCCTTGGTCTTCCAAAGTGCTGGGACTACAGGCGTGAGCCACCGTG CCCAACCTCCAATGATGTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTAGAAACAGGGTCTCACTCTGTCA CCAAGCTGGAGTGCAGTGGCACAATGACGGCTCACTGCAGCCTCGACCTCTTGGGCTCAAGCAATCCTCC TGCCTCAGCCTCCCAAGTAGCTGAGACTAGAGGCACACACCACCATGCCTGGCTAATTTTTTAATATTTT GTAGAGATGGGTTCTTGCTATGTTGCCTAGGCTGGTCTCCAACTACTGGGCAACTCTAAGCAATCCTATT GCCTTAGACTCCCAAAGTGCAATTATGAGCCACCATACCTGGCCTCACTGATGTTTTATTACAACTTCAC TGTGTAGATGAGGAAACTGAGGCTCAGAGGCTTGCCAGGGTCCCTTAGTGGGACTGGAGCCTGTTAGACT TCATAGACCAGGGATCTCCTTTCTCCTTCCCAGGACCTGGTCTCCAACCCCCATGACCCCTTCACTGAAT GCCTGGATTTCTCCATTTCTCCCCGCCTCTCAGGCCCCACCAAGCGCAGCACCCTGGCCCCGGGATTGTT GTGGTGGGACCTCGCACGGCAGACAGCATCAGTGGCCCCCAAGGAAGAAGTGGCCATCCTGGATGACAAC TTGGTCAAGGTCAGTCTTAGGCTGGGTTCCCAGATCTAGAGGCAGCCAAGTGACTTTAGGACGTGACCAC AGCTCAGGGGAGGGACATGGTATATCAGCACCTTTCTCCATCGCTCATTATCTCCAGTCAAAAGACTCTA TTGGGAGCTGATTCATCCTCAACAGTTTTTATCTCCCTTCACAAGGACTGAACAGAGTTTAATACTATTC CTTTTTGTTTGTTTGTTTTTTGAGACAGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCAATC TCGGCTCACTGCAACCTCCACATCCCGAGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGCTA CTACAGGCGCATGCCACCGCACCCAGCTAATTTTTATGTTTTTAGTAGAGATGGGGTTTCACCATGTTGC CCAGGCTGGTCTCGAACTCCTGACCTCAAATGATCCACCCACCTTAGACCCCCAAAGTGCTGGGATGACA GGCATGAGCCACCGAGCCCAGCCTCATCTTCAAGTTTTTGTTATCTCCCTTCATAAGGACTGAACAAAGT TGAATACTATTCCTTTTTGTCGTTATCTGTTTTTACAGTGACTTCCAATCTTTGGCAGGTGAAACTGGTG TGCTGTTAGGGTATTGATGTAAAGTCTCTTCTTAAAATAAAATTACTTAATTCAAAAGTGAGTCAACTTG GGGAAAAAATCTTACATAAGAAACACAACAGATGGTAAACCGATTTTGGCTAAAACCGCGTGGTTGCTTT GTGAATTCCCAGAGTTTGGAAAATGCTGTCCCTGGGGGACCTGATCCCATGCCTACCCCTGTTTTGGAAT CCCTGTTCCATTCTCTCATTTATTGAGCACCTGCTGTGTACCCAGTCCTGCTCTGGGCTATGGTCTAAGA CCCCCACCCCACCCTCATCTAGCAGGGGCAGGTGAAAACTAAAAAGAGAAACATGTAGGGTCTGTCTCAG TATGTGATAAGCATTCAAAAGATAATACAACCAGATGCTGTCAGGCCGGGCACGGTAGCTCACGCCTGTA ATCCCAGCACTTTGGGAGGTTGAGGTGGATCGCTTGAGGCCAGGAGTTCAAGACCAGCCTGTCGAACATG GCAAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCGGGCATGGTGGCGTGTGCCTGTAATCCCAGCT ACTCAGTGGAATGAGGCAGAAGAATTGAACAATTGAACCCGGGAGGTAGAGGTTGTAGTGAGCTGAGATC GCGCCACTGCATTCCAGCCTGGGTGACAGAGCAAGACTTCGTCAAAAAGATAGGAAAGCAGGAAGGGAGG GAGGGAGGGAAAAGAAGGAAGGAAAGGAAAGAGCCAGGCGTGATGGCTCACCCCTGTAATCCCAGCACTT TGGGAGACTTAGGCAGGTGCATCACCTGAGGTCAGGAGTTCGAGACCACCCTGGCCAACATGGTGAAACC CCATCTCTACTAAAAATACAAAAAATTAGCCGGGTGTGGTGGTGCATGCCTATAATTCCAGCTATTCGGA AGGCTGAGGCAGGAGAATCGATTGAACTCAGGAGGTGGAGGTTGCAGAGAGCAGAGATTGTGCCATTGCA CTCCAGCCTGGGCAACAACAGCCAGACACTGTCAGAAAGAAAGAAAAGACAGAGAGAGAGAGAGAGAGAG AGAGAGAGAGAGAGAGAGAGAGAGAGCAAGCTAAAAAGAAAAACGTGTAGGGTCTCAGCATGATAAATAT TCAAAGGATAATAAAACCGGATGCTGTGATGGGGAGCAACTTTAGCCAGGGAAGTCAGGGGTGGCCTCTT GGGAGAGGTGACATTGATTGACCCTGAGTTAGGAGAAGAGGAACCAGCCACAGACAGGAACAGCTTTGAC TGAGAAGGGGATTGGGAGGGGAGGGGTTTGCCTGAAGGTGTTTAAAGCTCCCTCCAGCTGCCCTAGAGAA GTGTTTATCTTTTCTTTCTTTCCTCTTTTCTTTTCCTTTCTCTTCTTTTCTTTTTTTTCTTTCTCTCTCT TTTTTTGTTCTTTATTATTTTATTTTTCTTTTTTGTTGTCTTTGTTTTATTTGTGTGTTTTTTTTCTTTT TTGTCTTTTTTTTTTTTCCTTTTTTTGAGATAGGGACTCACTCTATTGCCCAGGCTGGAGTGTAGTGGCA TGACCATGGCTCACTGCAGCCCCAACCTCCATGGTCCGAGAAATTCTCCCATCTTTCAACCTCCTGAGTA GCTGGGATTATAGGCATGCACCACCGAGTCTGGTTAATTTTTTTATTTTTGGTAGAGATGGGGTTTTGCC ATATTGGCCAGGCTGGTCTTAAACTCCTGGGCTCAAGTGATCTGCCCACCTTGGCCTCCCAAAGTGCTAG GATTACAGGGGTGAGCCACCGTGCCCGGCCAGAAATATTTATTTTCTTGAAGGTGAACAGGCAGAGAAGC AGAGAAAGGAGGGAGGAACTATAGCAGGCATCTGAGAAAGCGTTGATGGCCTGGGCTGTAGGTGACATGT GAGTGGGGAAGAGAAGCGCATGGAAATTTTGGAGGCAGAGCGGGCAGGACTGGCCCGTGCACTGAGCAAG GGGATAGTATGCAATTCTGTGCACGCCCCGTCCCGCCAGGTCATCAGTAGCCCATCTGGGAGATGAGCTG ACACGGAACAGGGTGGGGACAGGGTCTCTGATGGGGTCTCTTTTTCCCACTTTTCCCCAGGGTCCTGAAG AACTCCCCACTGGAAACAAGAAGCCCCCTGGCTTCCTGCCCACCAATGAGGATCGTCTGTTTTTCTTGGG GCAGAAGGAGCTGGAGGGGGCTGGCTCTTGGACCCCCTGTGTTGGACATGATGGTGGTCGAGACCAGCAG GAGACAAACCTCTGAGGACAGGGCCAGCCGCGGGACTGACACCCTGGGATGGAACCTCAGGATGGGCCAA ACCCAGACAACGGGCCCATGGCCTTGGGCTCTGATTGGCTGGATTGCCTTGTATGCAAATGAGTTCAGGA CTACAATACCCTACCCTATGGGGAGGCCCTGCCTCCGGGAGGTCATTTTTTAAATCCAGCCCCTTGCTTC AACCGTCCCCAGTATTAGACGCTGCAGCCCTGACGGCTCCCCCCAAATAAGGCTGGGTTTTTCTCTCTCT CTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTCATGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGTGA TCTCGGCTCACTGCAACCTCTGCCTCCCAGGCTCAAGTGATTCTCCTGCCTCAGCCTCTTGAGTAGCTGG GATTGTAGGTGCCCACCACCATGCCCAGCCAACTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGT TGGTCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGTTA CAGGCGTAAGCTACCATGCCCAGCCTACCGTTTTTCTCAATCTATAATAGAAAGCCACCACGCCCAGGTA ATTTTTGTAATTTTGTATTTTTGTAGAGACGGGGTTTTGCCATGTTGGCCAGGCTGGTCTCAAACTCCTG ATCTCAGGTGATCCTCCTGCCTTGGCCTCCCAAAGGGCTGGGATTACAGGGGTGAGCCACCGCGCCCCAC CTCTTTCTTATTTTCTTCCTGGGATTGGGGAGGGGATGATTCAGACCCCACATGGCCTCCAACCTTGGCC CACACACCTGCCATGGCTCCCATCATCCTGAGCATGCTAGCGTCCCCTCCTCACCTGACAATGGAGGCTC TCGAATTGGGTTGTGTCCCCCCAAAATTTATGTCTACCCAGAACCTCAGAACATGAGCTTACTTGGAAAT AGGGTCTTTGCAGGTGTAACTGGTTAAATTAAAAGAGGTATTACTGGAGGAGGATGGATGAATCCAGTGA CTGGTTCCTCATATGAAGTAGAGAAGAGATGCAGAGAAACACATGGGGAAGATGCCACGTGAAGACAGAG GCAGTGGTTGGATCAATGCATCTACGAGTCGGAGAACCCAAGGATTGCCAGCAACAACCAGAAATCAGGA GGGGGGCATGAGATGCATTATTTCTTAGAGCCTTTAGAGGGAACATGGCCCTACTGACACCTTGATGTCA GACTTCTGGCTGCTAGAACTGTCAGAGAATAAATTTCTGTTGTTTGATGCCA
Protein Sequence	>NP_000444.1 sodium/iodide cotransporter [Homo sapiens] MEAVETGERPTFGAWDYGVFALMLLVSTGIGLWVGLARGGQRSAEDFFTGGRRLAALPVGLSLSASFMSA VQVLGVPSEAYRYGLKFLWMCLGQLLNSVLTALLFMPVFYRLGLTSTYEYLEMRFSRAVRLCGTLQYIVA TMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTFYTAVGGMKAVVWTDVFQVVVMLSGFWVVLARGV MLVGGPRQVLTLAQNHSRINLMDFNPDPRSRYTFWTFVVGGTLVWLSMYGVNQAQVQRYVACRTEKQAKL ALLINQVGLFLIVSSAACCGIVMFVFYTDCDPLLLGRISAPDQYMPLLVLDIFEDLPGVPGLFLACAYSG TLSTASTSINAMAAVTVEDLIKPRLRSLAPRKLVIISKGLSLIYGSACLTVAALSSLLGGGVLQGSFTVM GVISGPLLGAFILGMFLPACNTPGVLAGLGAGLALSLWVALGATLYPPSEQTMRVLPSSAARCVALSVNA SGLLDPALLPANDSSRAPSSGMDASRPALADSFYAISYLYYGALGTLTTVLCGALISCLTGPTKRSTLAP GLLWWDLARQTASVAPKEEVAILDDNLVKGPEELPTGNKKPPGFLPTNEDRLFFLGQKELEGAGSWTPCV GHDGGRDQQETNL
Molecule Role	Protective antigen
Molecule Role Annotation	The aim of this study is to determine the feasibility of utilizing the hNIS antigenic protein in enhanced-antigen-associated immunotherapy using image analysis with a gamma counter. To accomplish this, minimalistic immunogenically defined gene expression (MIDGE), either plain or coupled to a nuclear localization signal (NLS) peptide, was used as a vector system. Vaccination with MIDGE/hNIS, MIDGE/hNIS-NLS and pcDNA3.1/hNIS produced a significant increase in the number of hNIS-associated IFN-gamma-secreting CD8(+) T cells, with MIDGE/hNIS having the strongest effect. In addition, immunization with the hNIS encoding vectors induced antigen-mediated antitumor activity against NIS-expressing CT26 tumors in vivo, with the highest tumor free rate (100%) and lowest tumor growth being observed up to 40 days after the CT26/NIS tumor challenge with MIDGE/hNIS than those resulting from other immunization groups (Choi et al., 2007).
Related Vaccines(s)	Cancer DNA Vaccine MIDGE/hNIS encoding hNIS protein
References

SLC5A5