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DnaJ

Gene Name DnaJ
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhi str. CT18
VO ID VO_0011268
NCBI Gene ID 1246524
NCBI Protein GI 16759006
Locus Tag STY0013
Genbank Accession AL513382
Protein Accession NP_454623
Taxonomy ID 220341
Gene Starting Position 13595
Gene Ending Position 14734
Gene Strand (Orientation) +
Protein Name DnaJ protein
Protein pI 8.26
Protein Weight 38831.98
Protein Length 379
Protein Note chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion
DNA Sequence 
>NC_003198.1:13595-14734 Salmonella enterica subsp. enterica serovar Typhi str. CT18, complete genome
GATGGCGAAAAGAGATTACTACGAGATTTTAGGCGTTTCCAAAACAGCGGAAGAGCGTGAAATCAAAAAG
GCGTATAAGCGCCTGGCCATGAAATATCATCCGGACCGCAATCAGGGTGATAAAGAGGCCGAAGCTAAGT
TTAAAGAGATTAAAGAAGCCTACGAAGTGCTGACCGATGCGCAAAAACGCGCAGCCTACGATCAGTATGG
TCACGCCGCGTTTGAACAAGGCGGGATGGGCGGCGGATTTGGCGGCGGCTTTAATGGCGGCGCTGATTTC
AGTGATATCTTTGGTGACGTTTTTGGCGATATCTTTGGCGGCGGGCGTGGTCGCCAACGTGCGGCGCGTG
GGGCTGATTTGCGTTATAACATGGATCTCACCCTGGAAGAAGCGGTGCGTGGCGTGACCAAAGAGATCCG
TATTCCGACGCTGGAGGAGTGCGACGTTTGCCACGGCAGCGGCGCGAAAGCTGGTACGCAACCGCAAACC
TGTCCGACCTGTCATGGTTCTGGTCAGGTACAGATGCGCCAGGGATTCTTTGCTGTACAGCAGACCTGCC
CACACTGTCAGGGCCGCGGTACGCTGATCAAAGATCCGTGCCATAAATGTCACGGTCATGGGCGTGTTGA
AAAGAGTAAAACTCTGTCCGTTAAAATCCCGGCGGGCGTGGATACCGGCGATCGTATTCGTCTGGCAGGC
GAGGGCGAAGCGGGCGAGCATGGCGCACCGGCAGGCGACTTGTACGTTCAGGTCCAGGTGAAACAACACC
CTATTTTCGAGCGTGAAGGCAATAATCTTTATTGCGAAGTGCCGATCAACTTTGCGATGGCGGCGCTCGG
CGGTGAAATTGAAGTGCCGACGTTAGATGGTCGCGTGATGCTGAAAGTACCGAGCGAAACACAAACGGGC
AAGCTGTTCCGTATGCGCGGCAAAGGCGTGAAGTCCGTACGCGGTGGCGCGCAGGGCGATTTGCTGTGCC
GTGTGGTAGTTGAAACGCCGGTCGGTCTGAGCGAAAAACAGAAGCAATTGCTAAAAGATCTTCAGGAAAG
TTTTGGCGGCCCGACGGGAGAGAAAAACAGCCCGCGTTCAAAAAGCTTCTTTGACGGCGTGAAAAAATTC
TTTGACGATTTGACTCGCTA
Protein Sequence 
>NP_454623.1 DnaJ protein [Salmonella enterica subsp. enterica serovar Typhi str. CT18]
MAKRDYYEILGVSKTAEEREIKKAYKRLAMKYHPDRNQGDKEAEAKFKEIKEAYEVLTDAQKRAAYDQYG
HAAFEQGGMGGGFGGGFNGGADFSDIFGDVFGDIFGGGRGRQRAARGADLRYNMDLTLEEAVRGVTKEIR
IPTLEECDVCHGSGAKAGTQPQTCPTCHGSGQVQMRQGFFAVQQTCPHCQGRGTLIKDPCHKCHGHGRVE
KSKTLSVKIPAGVDTGDRIRLAGEGEAGEHGAPAGDLYVQVQVKQHPIFEREGNNLYCEVPINFAMAALG
GEIEVPTLDGRVMLKVPSETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLSEKQKQLLKDLQES
FGGPTGEKNSPRSKSFFDGVKKFFDDLTR
Molecule Role Protective antigen
Molecule Role Annotation Immunisation of mice with DnaJ derived from Salmonella enterica subsp. enterica serovar Typhi str. CT18 was found to provide 70% protection against lethal challenge by S. Typhimurium indicating the possible use of DnaJ as vaccine candidate against typhoid (Sagi et al., 2006).
Related Vaccines(s) S. typhi DnaJ Protein Vaccine
References