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LmSTI1
Gene Name	LmSTI1
Sequence Strain (Species/Organism)	Leishmania major
VO ID	VO_0011274
NCBI Gene ID	5649395
NCBI Nucleotide GI	1698879
NCBI Protein GI	1698880
Protein Accession	AAB37318.1
Other Database IDs	CDD:290150 CDD:278916 CDD:276809 CDD:290160 CDD:128966
Taxonomy ID	5664
Gene Strand (Orientation)	?
Protein Name	protein antigen LmSTI1
Protein pI	6.04
Protein Weight	60559.91
Protein Length	617
Protein Note	TPR repeat; pfam13414
DNA Sequence	>gi\|1698879\|gb\|U73845.1\|LMU73845 Leishmania major protein antigen LmSTI1 mRNA, partial cds TGGACGCAACTGAGCTGAAGAACAAGGGGAACGAAGAGTTCTCCGCCGGCCGCTATGTGGAGGCGGTGAA CTACTTCTCAAAGGCGATCCAGTTGGATGAGCAGAACAGTGTCCTCTACAGCAACCGCTCCGCCTGTTTT GCAGCCATGCAGAAATACAAGGACGCGCTGGACGACGCCGACAAGTGCATCTCGATCAAGCCGAATTGGG CCAAGGGCTACGTGCGCCGAGGAGCAGCTCTCCATGGCATGCGCCGCTACGACGATGCCATTGCCGCGTA TGAAAAGGGGCTCAAGGTGGACCCTTCCAACAGCGGCTGCGCGCAGGGCGTGAAGGACGTGCAGGTAGCC AAGGCCCGCGAAGCACGTGACCCCATCGCTCGCGTCTTCACCCCGGAGGCGTTCCGCAAGATCCAAGAGA ATCCCAAGCTGTCTCTACTTATGCTGCAGCCGGACTACGTGAAGATGGTAGACACCGTCATCCGCGACCC TTCGCAGGGCCGGCTGTACATGGAAGACCAGCGCTTTGCCCTGACGCTCATGTACCTGAGCGGAATGAAG ATTCCCAACGATGGTGATGGCGAGGAGGAGGAACGTCCGTCTGCGAAGGCGGCAGAGACAGCGAAGCCAA AAGAGGAGAAGCCTCTCACCGACAACGAGAAGGAGGCCCTGGCGCTCAAGGAGGAGGGCAACAAGCTGTA CCTCTCGAAGAAGTTTGAGGAGGCGCTGACCAAGTACCAAGAGGCGCAGGTGAAAGACCCCAACAACACT TTATACATTCTGAACGTGTCGGCCGTGTACTTCGAGCAGGGTGACTACGACAAGTGCATCGCCGAGTGCG AGCACGGTATCGAGCACGGTCGCGAGAACCACTGCGACTACACAATCATTGCGAAGCTCATGACCCGGAA CGCCTTGTGCCTCCAGAGGCAGAGGAAGTACGAGGCTGCTATCGACCTTTACAAGCGCGCCCTTGTCGAG TGGCGTAACCCTGACACCCTCAAGAAGCTGACGGAGTGCGAGAAGGAGCACCAAAAGGCGGTGGAGGAAG CCTACATCGATCCTGAGATCGCGAAGCAGAAGAAAGACGAAGGTAACCAGTACTTCAAGGAGGATAAGTT CCCCGAGGCCGTGGCAGCGTACACGGAGGCCATCAAGCGCAACCCTGCCGAGCACACCTCCTACAGCAAT CGCGCGGCCGCGTACATCAAGCTTGGAGCCTTCAACGACGCCCTCAAGGACGCGGAGAAGTGCATTGAGC TGAAGCCCGACTTTGTTAAGGGCTACGCGCGCAAGGGTCATGCTTACTTTTGGACCAAGCAGTACAACCG CGCGCTGCAGGCGTACGATGAGGGCCTCAAGGTGGACCCGAGCAATGCGGACTGCAAGGATGGGCGGTAT CGCACAATCATGAAGATTCAGGAGATGGCATCTGGCCAATCCGCGGATGGCGACGAGGCGGCGCGCCGGG CCATGGACGATCCTGAAATCGCGGCAATCATGCAAGATAGCTACATGCAACTAGTGTTGAAGGAGATGCA GAACGATCCCACGCGCATTCAGGAGTACATGAAGGACTCCGGGATCTCATCGAAGATCAACAAGCTGATT TCAGCTGGCATCATTCGTTTTGGTCAGTAGACTTCTACGCTGCCTCATCTTTTCCGTGTCTTTGCGTCGG CGGGTATCGTAAAGCACAATAAAGCAGCGATTCACATGCACGAGTAAAGTGCTGCGCCTCTCAAACACGA CGTCGAGGCTGTGGTGCAGATGCGCGTCCTGCATGAAGGTAGTGAAGAGGAAAGTAAGGGATGTTGTTTG TGGGCCTTCGTGGCTGCGCACACACCTCTTATCTCCTTCGCTTGGTACCTTCTCCCTTTTTCGTCTTCAC CCCCCTTTCTCTTCTCACGCTCTCCCTGGCGCGGTGGTGCAACGATTTCGTTTTATTTACGTCTGTGTAG CTCCTCTATTCAACGGTGCGATGACGCTAACGAAGCTGGCCTGTATTCGGCTAAGGCGAAGGCAAAAGAC TAGGAGGGGGGGGGGAAGGAGACGGCGTGACCATCACTGCGAAGAAACAAGCCGAAGAAAAGGCCCCGAA CGCCTGCATTTCCGCGCGCCCTCGCCCGCCTTCCTTCCTTCCTTCGCTCTCTCTCTCTCTCTCTCTCGCT ATCTTCTCAACGGAGACATGAAAGGCGTTTGTTAGGAAAAGAGGGGGGGGGGAAGAGTGGGACGACGCGC TGCGTCTTTTGGGCACTGGTCACGTGCGTCACCCTCTTTTTTTATCTCTATTGGCACTGTCTTGTTTCTT TTCCCTTTCCTATCATACGCGTCTCGCAAACGACTCCGCGCTGAGCAGCCATGTGCTGCGGCGTGGAGGA AGTACACAGACATCACGGATGCATATGTGCGCGTCCGTGTACGCGCTTGTATGGGGCTTCTAACAGCGCC TGTGTGTGTTTGTGTGTGTGTGTGTGTGTGTGTCTGTGTATTTCGAGCGTCTGTATGCTATTCTATTAAG CACCGAAGAAGAGACACACACGACAGCGAAGGAGATGGTGTCGGCTTTTCGGCTAATCACTCCCTTCCAT AGCTTCTCTGAAGGAGGCTCTCTTCCAGAGGAATAGACTGCAGATGGGGTCCACGTTTATCTGAGGAGTC AACGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACTCGAG
Protein Sequence	>AAB37318.1 protein antigen LmSTI1, partial [Leishmania major] DATELKNKGNEEFSAGRYVEAVNYFSKAIQLDEQNSVLYSNRSACFAAMQKYKDALDDADKCISIKPNWA KGYVRRGAALHGMRRYDDAIAAYEKGLKVDPSNSGCAQGVKDVQVAKAREARDPIARVFTPEAFRKIQEN PKLSLLMLQPDYVKMVDTVIRDPSQGRLYMEDQRFALTLMYLSGMKIPNDGDGEEEERPSAKAAETAKPK EEKPLTDNEKEALALKEEGNKLYLSKKFEEALTKYQEAQVKDPNNTLYILNVSAVYFEQGDYDKCIAECE HGIEHGRENHCDYTIIAKLMTRNALCLQRQRKYEAAIDLYKRALVEWRNPDTLKKLTECEKEHQKAVEEA YIDPEIAKQKKDEGNQYFKEDKFPEAVAAYTEAIKRNPAEHTSYSNRAAAYIKLGAFNDALKDAEKCIEL KPDFVKGYARKGHAYFWTKQYNRALQAYDEGLKVDPSNADCKDGRYRTIMKIQEMASGQSADGDEAARRA MDDPEIAAIMQDSYMQLVLKEMQNDPTRIQEYMKDSGISSKINKLISAGIIRFGQ
Molecule Role	Protective antigen
Molecule Role Annotation	Researchers evaluated the potency of different DNA vaccine candidates in BALB/c mice using high dose footpad parasite challenge with L. major. Mice inoculated pCMV3ISS-LmSTI1 developed significantly smaller lesions in their footpads after challenge with the parasite. The vaccine was able to induce a partially protective effect (Ahmed et al., 2009).
Related Vaccines(s)	L. major DNA Vaccine encoding LACKp24, TSA, LmSTI1 and CPa , L. major DNA vaccine encoding TSA, LMSTI1, KMP11, and LACK , LEISH-F1+MPL-SE
References

LmSTI1