VIOLIN: Vaccine Investigation and Online Information Network

H1
Gene Name	H1
Sequence Strain (Species/Organism)	Leishmania infantum
VO ID	VO_0011285
NCBI Gene ID	5070063
NCBI Nucleotide GI	78146499
NCBI Protein GI	78146500
Protein Accession	ABB22792.1
Taxonomy ID	5671
Gene Strand (Orientation)	?
Protein Name	histone H1
Protein pI	12.41
Protein Weight	10687.41
Protein Length	155
Protein Note	L.infH1
DNA Sequence	>gi\|78146499\|gb\|DQ232891.1\| Leishmania infantum histone H1 gene, complete cds ATGTCCTCTGATTCCGCCGTTGCTGCCCTTTCCGCTGCCATGACCTCGCCGCAGAAGTCTCCTCGCTCGT CGCCGAAGAAGACGGCTGCGAAGAAGGCCGCGGCGAAGAAGGCCGCGGCGAAGAAGGCCGGGGCGAAGAA GGCCGGGGCGAAGAAGGCGGTGAGGAAGGTGGCTACGCCGAAGAAGCCGGCGAAGAAGGCTGCGAAGAAG GCCGCGAAGAAGCCGGCGAAGAAGGTCGCGAAGAAGCCGGCGAAGAAGGCTGCGAAGAAGCCGGCGAAGA AGCCGGCGAAGAAGGCTGCGAAGAAGGCCGCGGCGAAGAAGTAA
Protein Sequence	>ABB22792.1 histone H1 [Leishmania infantum] MSSDSAVAALSAAMTSPQKSPRSSPKKTAAKKAAAKKAAAKKAGAKKAGAKKAVRKVATPKKPAKKAAKK AAKKPAKKVAKKPAKKAAKKPAKKPAKKAAKKAAAKK
Molecule Role	Protective antigen
Molecule Role Annotation	Following infection with L. infantum promastigotes, five out of eight beagle dogs immunized with H1 Montanide remained free of clinical signs, compared to two out of eight dogs in the control group. The results demonstrate that H1 antigens with Montanide were able to induce partial protection against canine leishmaniasis, even under extreme experimental challenge conditions (Moreno et al., 2007).
Related Vaccines(s)	L. infantum H1 protein vaccine
References