VIOLIN: Vaccine Investigation and Online Information Network

fliC
Gene Name	fliC
VO ID	VO_0011303
NCBI Protein GI	1929918
Other Database IDs	CDD:236344
Taxonomy ID	884204
Gene Strand (Orientation)	?
Protein Name	flagellin
Protein pI	4.84
Protein Weight	37016.41
Protein Length	451
Protein Note	flagellin; Reviewed
Protein Sequence	>AAB51476.1 flagellin [Burkholderia pseudomallei 1026b] MLGINSNINSLVAQQNLNGSQGALSQAITRLSSGKRINSAADDAAGLAIATRMQTQINGLNQGVSNANDG VSILQTASSGLTSLTNSLQRIRQLAVQASNGPLSASDASALQQEVAQQISEVNRIASQTNYNGKNILDGS AGTLSFQVGANVGQTVSVDLTQSMSAAKIGGGMVQTGQTLGTIKVAIDSSGAAWSSGSTGQETTQINVVS DGKGGFTFTDQNNQALSSTAVTAVFGSSTAGTGTAASPSFQTLALSTSATSALSATDQANATAMVAQINA VNKPQTVSNLDISTQTGAYQAMVSIDNALATVNNLQATLGAAQNRFTAIATTQQAGSNNLAQAQSQIQSA DFAQETANLSRAQVLQQAGISVLAQANSLPQQVLKLLQ
Molecule Role	Protective antigen
Molecule Role Annotation	Flagellin encoding plasmid DNA was injected into Balb/c mice intramuscularly and this elicited both a humoral and a cellular immune response. Subsequent intravenous challenge of the vaccinated Balb/c mice with 10^5CFU of B. pseudomallei resulted in the number of bacterial cells detected in liver and/or spleen being significantly reduced in the flagellin plasmid DNA vaccinated mice. At 7 days subsequent to infection of B. pseudomallei, 5/6 (83%) of flagellin plasmid DNA vaccinated mice had survived (Chen et al., 2006).
Related Vaccines(s)	B. pseudomallei DNA vaccine encoding Flagellin Protein
References