VIOLIN: Vaccine Investigation and Online Information Network

NS1
Gene Name	NS1
VO ID	VO_0011312
NCBI Protein GI	288848
Other Database IDs	CDD:213897 CDD:279316 InterPro: IPR001157 UniProtKB/TrEMBL: Q06371
Taxonomy ID	11060
Gene Strand (Orientation)	?
Protein pI	7.2
Protein Weight	41028.15
Protein Length	429
Protein Note	flavivirus envelope glycoprotein E, stem/anchor domain; TIGR04240
Protein Sequence	>CAA78918.1 NS1, partial [Dengue virus 2] MNSRSTSLSVSQVLVGIVTLYLGVMVQADSGCVVSWKNKELKCGSGIFVTDNVHTRTEQYKFQPESPSKL ASAIQKAHEEGICGIRSVTRLENLMWKQITSELNHILSENEVKLTIMTGDIKGIMQVGKRSLRPQPTELR YSWKTWGKAKMLSTELHNQTFLIDGPETAECPNTNRAWNSLEVEDYGFGVFTTNIWLRLREKQDAFCDSK LMSAAIKDNRAVHADMGYWIESALNDTWKIEKASFIEVKSCHWPKSHTLWSNGVLESEMVIPKNFAGPKS QHNNRPGYHTQTAGPWHLGKLEMDFDFCEGTTVVVTEDCGNRGPSLRTTTASGKLITEWCCRSCTLPPLR YRGEDGCWYGMEIRPLKEKEENLVSSLVTA
Molecule Role	Protective antigen
Molecule Role Annotation	The protective efficacy and immune responses of mice intramuscularly injected with plasmid encoding DEN-2 non-structural protein 1 (NS1) was evaluated. Intravenously challenged by lethal DEN-2, mice vaccinated with NS1-DNA exhibited a delay onset of paralysis, a marked decrease of morbidity, and a significant enhancement of survival (Wu et al., 2003).
Related Vaccines(s)	Dengue DNA Vaccine encoding NS1 Protein , Dengue Virus DNA Vaccine encoding NS1 , Dengue virus DNA vaccine pcTPANS1 encoding NS1 fused to the tissue plasminogen activator signal sequence
References