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GLURP
Gene Name	GLURP
Sequence Strain (Species/Organism)	Plasmodium falciparum 3D7
VO ID	VO_0011343
NCBI Gene ID	810501
NCBI Protein GI	124802897
Locus Tag	PF3D7_1035300
Genbank Accession	LN999944
Protein Accession	XP_001347628
Taxonomy ID	36329
Chromosome No	10
Gene Starting Position	1399194
Gene Ending Position	1402895
Gene Strand (Orientation)	+
Protein Name	glutamate-rich protein
Protein pI	3.98
Protein Weight	130731.93
Protein Length	1233
DNA Sequence	>NC_037281.1:1399194-1402895 Plasmodium falciparum 3D7 chromosome 10, complete sequence AATGAGAAACCTTTTCCATATTACCATTTGTTTAGTTACACTTAATTTATTTATATTGGAAATAAATGCA AAAACCAATACAAGTGAGAATAGAAATAAACGAATCGGGGGTCCTAAATTAAGGGGTAATGTTACAAGTA ATATAAAGTTCCCATCAGATAACAAAGGTAAAATTATAAGAGGTTCGAATGATAAACTTAATAAAAACTC TGAAGATGTTTTAGAACAAAGCGAAAAATCGCTTGTTTCAGAAAATGTTCCTAGTGGATTAGATATAGAT GATATCCCTAAAGAATCTATTTTTATTCAAGAAGATCAAGAAGGTCAAACTCATTCTGAATTAAATCCTG AAACATCAGAACATAGTAAAGATTTAAATAATAATGATTCAAAAAATGAATCTAGTGATATTATTTCAGT AAATAATAAATCAAATAAAGTACAAAATCATTTTGAATCATTATCAGATTTAGAATTACTTGAAAATTCC TCACAAGATAATTTAGACAAAGATACAATTTCAACAGAACCTTTTCCTAATCAAAAACATAAAGACTTAC AACAAGATTTAAATGATGAACCTTTAGAACCCTTTCCTACACAAATACATAAAGATTATAAAGAAAAAAA TTTAATAAATGAAGAAGATTCAGAACCATTTCCCAGACAAAAGCATAAAAAGGTAGACAATCATAATGAA GAAAAAAACGTATTTCATGAAAATGGTTCTGCAAATGGTAATCAAGGAAGTTTGAAACTTAAATCATTCG ATGAACATTTAAAAGATGAAAAAATAGAAAATGAACCACTTGTTCATGAAAATTTATCCATACCAAATGA TCCAATAGAACAAATATTAAATCAACCTGAACAAGAAACAAATATCCAGGAACAATTGTATAATGAAAAA CAAAATGTTGAAGAAAAACAAAATTCTCAAATACCTTCGTTAGATTTAAAAGAACCAACAAATGAAGATA TTTTACCAAATCATAATCCATTAGAAAATATAAAACAAAGTGAATCAGAAATAAATCATGTACAAGATCA TGCGCTACCAAAAGAGAATATAATAGACAAACTTGATAATCAAAAAGAACACATCGATCAATCACAACAT AATATAAATGTATTACAAGAAAATAACATAAACAATCACCAATTAGAACCTCAAGAGAAACCTAATATTG AATCGTTTGAACCTAAAAATATAGATTCAGAAATTATTCTTCCTGAAAATGTTGAAACAGAAGAAATAAT AGATGATGTGCCTTCCCCTAAACATTCTAACCATGAAACATTTGAAGAAGAAACAAGTGAATCTGAACAT GAAGAAGCCGTATCTGAAAAAAATGCCCACGAAACTGTCGAACATGAAGAAACTGTGTCTCAAGAAAGCA ATCCTGAAAAAGCTGATAATGATGGAAATGTATCTCAAAACAGCAACAACGAATTAAATGAAAATGAATT CGTTGAATCGGAAAAAAGCGAGCATGAACCAGCTGAAAATGAAGAAAGTAGTCTTGAAGAAGGTCATCAT GAAGAAATTGTACCTGAACAAAATAATGAAGAATCAGGTGAAAGTAAATTAGTTGATAATGATGAAGGTG GTTTTGAAGAAGCTCATCATGAAAATTTTTCATCTGAAGTAAGTAACTCTGAATTAAATGAAAATGAATT TGTTGAATCTGACAAAAGTGTAACTGAACCTGCTGAACATGAAGAAGTTGTATCTGAAGAAAGCAACCCT GAACCAGCTGAAAATGAAGAAAGTAGTATAGAAGAAGCTCATCAGGAAGAAATTGTACCTGAACAAAATG ATGAAGAATCAGGTGAAAGTGGATTAGTTGATAATGAAGAAGGTGATTTTGAAGAACCTAATCATGAAGA ATTTGAACCTGATCAAAATGACTCTGAATTAAGTGAAAATGAATTAGTTGAATCAGAAAAAAGTGTATCT GAACCAGCTGAACATGTAGAAATTGTATCAGAAAAAAGTGTATCTGAACCAGCTGAACACGTAGAAATTG TATCTGAAAAAAGTACATCCGAACCAGCTGAACATGTAGAAAGTGTATCTGAACAAAGTAATAACGAACC ATCCGAAAAGAAAGATGGACCAGTTCCTTCAAAACCATTTGAAGAAATTGAAAAAGTGGATGTTCAACCT AAAATTGTAGACCTTCAAATAATTGAACCTAATTTTGTTGACTCACAACCAAATCCACAAGAACCAGTTG AACCATCATTTGTCAAAATTGAAAAAGTTCCTTCTGAAGAAAATAAACATGCAAGTGTTGATCCTGAAGT AAAAGAAAAAGAAAATGTATCTGAAGTTGTTGAAGAAAAACAAAATTCACAAGAATCAGTTGAAGAAATT CCAGTAAATGAGGATGAATTTGAAGATGTTCACACTGAACAATTAGATTTAGATCATAAAACAGTTGATC CAGAAATAGTAGAAGTTGAAGAAATTCCTTCAGAACTACATGAAAATGAAGTGGCTCATCCAGAAATTGT TGAAATTGAGGAAGTTTTTCCTGAACCAAATCAAAATAACGAATTTCAAGAAATTAATGAAGATGATAAA AGTGCACATATTCAGCATGAAATAGTAGAAGTAGAAGAAATACTTCCAGAAGATGATAAAAATGAAAAAG TTGAACATGAAATAGTAGAAGTTGAAGAAATTCTACCAGAAGATAAAAATGAAAAAGTTCAACATGAAAT AGTAGAGGTTGAAGAAATTCTACCAGAAGATAAAAATGAAAAAGTTGAACATGAAATAGTAGAAGTTGAA GAAATTCTACCAGAAGATAAAAATGAAAAAGGTCAACATGAAATAGTAGAGGTTGAAGAAATTCTACCAG AAGATAAAAATGAAAAAGTTCAACATGAAATAGTAGAAGTTGAAGAAATTCTACCAGAAGATAAAAATGA AAAAGGTCAACATGAAATAGTAGAGGTTGAAGAAATTCTACCAGAAGATAAAAATGAAAAAGTTGAACAT GAAATAGTAGAAGTTGAAGAAATTCTACCAGAAGATAAAAATGAAAAAGGTCAACATGAAATAGTAGAGG TTGAAGAAATTCTACCAGAAGATGATAAAAATGAAAAAGGTCAACATGAAATAGTAGAGGTTGAAGAAAT TCTTCCAGAAATTGTTGAAATTGAAGAAGTACCATCACAAACAAATAACAATGAAAATATTGAAACTATA AAACCAGAAGAAAAAAAGAATGAATTTAGTGTTGTTGAAGAAAAAGCAATTCCACAAGAACCCGTGGTAC CTACATTAAATGAAAATGAAAACGTTACTCCCAAACCATCTGAAGGTGAATCCACTAAACCAGATATAGT TCAAATTAAAATAGTACAAGAAAATAAACCAAATAAAAAGGAAACACCAGTAGTAGATGGTCCAAAACAT GTAGAACAAAATATACAAGAAGATGATAATGATGAAGAGGATGATGATGATATAGATTTTGAAGGATTAT CAAGAAAAGATGATGAAAAGGATTCATCAAATAAAAATAAAAAGAAATCATCTTTTATAACATATATATC TACAAAGAAATTTAAAAAAGTATCTCAAACTATTGTAAGTGTTATGATTAATGCATATGATGGTGTTATT CAAGTTGTAAGTACAATTAAAGGAATAGCAAAGGATATAGTAATATTTTTCCAAAACATTTA
Protein Sequence	>XP_001347628.1 glutamate-rich protein [Plasmodium falciparum 3D7] MRNLFHITICLVTLNLFILEINAKTNTSENRNKRIGGPKLRGNVTSNIKFPSDNKGKIIRGSNDKLNKNS EDVLEQSEKSLVSENVPSGLDIDDIPKESIFIQEDQEGQTHSELNPETSEHSKDLNNNDSKNESSDIISV NNKSNKVQNHFESLSDLELLENSSQDNLDKDTISTEPFPNQKHKDLQQDLNDEPLEPFPTQIHKDYKEKN LINEEDSEPFPRQKHKKVDNHNEEKNVFHENGSANGNQGSLKLKSFDEHLKDEKIENEPLVHENLSIPND PIEQILNQPEQETNIQEQLYNEKQNVEEKQNSQIPSLDLKEPTNEDILPNHNPLENIKQSESEINHVQDH ALPKENIIDKLDNQKEHIDQSQHNINVLQENNINNHQLEPQEKPNIESFEPKNIDSEIILPENVETEEII DDVPSPKHSNHETFEEETSESEHEEAVSEKNAHETVEHEETVSQESNPEKADNDGNVSQNSNNELNENEF VESEKSEHEPAENEESSLEEGHHEEIVPEQNNEESGESKLVDNDEGGFEEAHHENFSSEVSNSELNENEF VESDKSVTEPAEHEEVVSEESNPEPAENEESSIEEAHQEEIVPEQNDEESGESGLVDNEEGDFEEPNHEE FEPDQNDSELSENELVESEKSVSEPAEHVEIVSEKSVSEPAEHVEIVSEKSTSEPAEHVESVSEQSNNEP SEKKDGPVPSKPFEEIEKVDVQPKIVDLQIIEPNFVDSQPNPQEPVEPSFVKIEKVPSEENKHASVDPEV KEKENVSEVVEEKQNSQESVEEIPVNEDEFEDVHTEQLDLDHKTVDPEIVEVEEIPSELHENEVAHPEIV EIEEVFPEPNQNNEFQEINEDDKSAHIQHEIVEVEEILPEDDKNEKVEHEIVEVEEILPEDKNEKVQHEI VEVEEILPEDKNEKVEHEIVEVEEILPEDKNEKGQHEIVEVEEILPEDKNEKVQHEIVEVEEILPEDKNE KGQHEIVEVEEILPEDKNEKVEHEIVEVEEILPEDKNEKGQHEIVEVEEILPEDDKNEKGQHEIVEVEEI LPEIVEIEEVPSQTNNNENIETIKPEEKKNEFSVVEEKAIPQEPVVPTLNENENVTPKPSEGESTKPDIV QIKIVQENKPNKKETPVVDGPKHVEQNIQEDDNDEEDDDDIDFEGLSRKDDEKDSSNKNKKKSSFITYIS TKKFKKVSQTIVSVMINAYDGVIQVVSTIKGIAKDIVIFFQNI
Molecule Role	Protective antigen
Molecule Role Annotation	Some of the S. sciureus monkeys immunized with MSP-3(212-380)-AS02 or GLURP(27-500)-alum were able to fully or partially control parasitaemia upon an experimental P. falciparum [Falciparum Uganda Palo Alto (FUP-SP) strain] blood-stage infection, and this protection was related to the prechallenge antibody titres induced. The data are indicative that MSP-3 and GLURP can induce protective immunity against an experimental P. falciparum infection using adjuvants that are acceptable for human use and this should trigger further studies with those new antigens (Carvalho et al., 2004).
References

GLURP