VIOLIN: Vaccine Investigation and Online Information Network

isdB
Gene Name	isdB
Sequence Strain (Species/Organism)	Staphylococcus aureus subsp. aureus str. Newman
NCBI Gene ID	5330644
NCBI Protein GI	151221252
Locus Tag	NWMN_1040
Genbank Accession	AP009351
Protein Accession	YP_001332074
Other Database IDs	CDD:213844
Taxonomy ID	426430
Gene Starting Position	1142079
Gene Ending Position	1144016
Gene Strand (Orientation)	-
Protein Name	iron-regulated heme-iron binding protein IsdB
Protein pI	9.6
Protein Weight	67826.06
Protein Length	645
Protein Note	heme uptake protein IsdB; TIGR03657
DNA Sequence	>NC_009641.1:1142079-1144016 Staphylococcus aureus subsp. aureus str. Newman DNA, complete genome ATTAGTTTTTACGTTTTCTAGGTAATACGAATGCAACGATGCTACTTAAAGCTAATAATGCCATTAATGG TAATGTCATATCTTTATTTGATTCTTCACCAGTTTGTGGTAATGATTTTGCTTTATTTTCTTGTGTATTT TTATTGTTTTGGCTTTGAGTGTGTCCATCATTTGTGTTTTTAATGTTTGCTTTTTGTAATGGAGCACTAT CTTTTGCTTCGCTAGAACCTGCTGAAGTTTGAACAACATCTTTTGTTGTTTTTGATGAAGCAGTTGTTGG TTTTGCAACATTTTGAGTCGTAGATACTACCTTAGTTGGAGTTGTACTACTTGATTCTACTTCACCTTTA GTTGGTTTTGTAGCAGGCGTTTTGTCTTTACCTGACTCACTAGATGCGTCATTTTCTTTTTCAACACTTG GTAATTGTTTATTGTCATCTTTTTGGCTGTCTTGTTTTTGTGATTCTTTTTCAACAGGTGATGGTGTTGG TTTGCTAGGCGTAGCTGGAGTAGCTTCCTTCTTAGCTGAGTTATCTTGTTGTTCTTTTTTGTTAGATTTA TCGGTATTGGCTTTTGTAAATGCTTCTTTATCAACGATTCTGACATGGTATTGTCCATCATAATCAATCG TTTTTACGTGAACTTTAACGATAGCATCATATAGAGTTTTACCTTCAACATATGGGAAAATAATTGTTCT AGTATTATTTTTAGCATCTTTGCTTATAGTTCTAACACGTTGACCTTCAACCATGAAATCTTTCCAGTAA TCGTCATTAGTAGTTTCCATGACCATATATTTTTTGCCGTTAAGCATACCTGTTTTAATAGGGTGTTTAA CAAAAGTATCCATCATAGATTCGTTATTCTCAACACTTTCATAAACAACATATTTTGTATCTTGTAAATC AGTCATTTTTTCATTTGTTGGTTGTACATTTTGGAATTCAGTAATAGCTGATTTCACTTGCTCATCTAAA GCTTTCTTTGTATCCTCTAATTTCTTCTTGTACTCAGCCTTTAATTTTTCAGGAAGTTTATCTTGAATTT TATTTAATTCATAAACTTGTCTTTCTAGTGTTTTCGCTTTTTTATATGGCGCTAATAATTTTTCAGCTTT ATAATCTTCTTCAGTTTTGAATTTATCTGCACTGTTATAAATTGGTTGTGCGAATTCCATTAATGTGTAA TCGTATTTTTCTTCTTTGTTATTGAAGTGTGTTGAACTAACAATTTTAACAGCTTTTGTTCCGTTTGATA CAGAGAAGCGAATGTAAGCATAATCTTTAACAGTATCGTATGATACTAATTTAATTGGCAACTTTTTGTC ACCTTCATAAACTTCAAATTTTCTCCAAAATTGACCTGATTGTAATCCTAATTCAATTTCTGGTTTTGAA TCAGTGAAAATAACTCTAGCAGGTTTAACAGAACTTGCATAATGATAAAACTGTTGAGTTCCATCTTTCT TTTTCATTTCAAAATCAATTGGACGAGAGTTTGGTGCGCTATGATCTTTGTCTTTTATTGCAGGGTTTTT AATCGCTTCTCTAAGTTCCTGATTCAAAATAGGATATGTATTGTTAGTGGCTTTTGCTGCTGGTTTAACT TCTTTTGTTTCCTTAGGGGCTTTAACTTCTTTAACTTCTTTAGCTTCTTTTGTTTCAGAAGTAGGGGCCT CAACTTCTTTATTAGATACTGAGACAGCATTAGCTACTGGTTTAGTTTCTGGAGCTTTTTCAGATGTTGT TGTTGGACTTGCAACTGCTTCAGTTTTTGGTTGTGCTTCTGTATTTGTACCACCTGTTTCTTCAGCTGCT GCTTGTGCTTCGCCATTTGACATTAATAATAAAAGTGTACTAATTGCTACAGATGCAACGCCTAGTGATG ACTTTCTAATTGAATAAAATGATTTAAATTCTTTTTGCTGTTTGTTCA
Protein Sequence	>YP_001332074.1 iron-regulated heme-iron binding protein IsdB [Staphylococcus aureus subsp. aureus str. Newman] MNKQQKEFKSFYSIRKSSLGVASVAISTLLLLMSNGEAQAAAEETGGTNTEAQPKTEAVASPTTTSEKAP ETKPVANAVSVSNKEVEAPTSETKEAKEVKEVKAPKETKEVKPAAKATNNTYPILNQELREAIKNPAIKD KDHSAPNSRPIDFEMKKKDGTQQFYHYASSVKPARVIFTDSKPEIELGLQSGQFWRKFEVYEGDKKLPIK LVSYDTVKDYAYIRFSVSNGTKAVKIVSSTHFNNKEEKYDYTLMEFAQPIYNSADKFKTEEDYKAEKLLA PYKKAKTLERQVYELNKIQDKLPEKLKAEYKKKLEDTKKALDEQVKSAITEFQNVQPTNEKMTDLQDTKY VVYESVENNESMMDTFVKHPIKTGMLNGKKYMVMETTNDDYWKDFMVEGQRVRTISKDAKNNTRTIIFPY VEGKTLYDAIVKVHVKTIDYDGQYHVRIVDKEAFTKANTDKSNKKEQQDNSAKKEATPATPSKPTPSPVE KESQKQDSQKDDNKQLPSVEKENDASSESGKDKTPATKPTKGEVESSSTTPTKVVSTTQNVAKPTTASSK TTKDVVQTSAGSSEAKDSAPLQKANIKNTNDGHTQSQNNKNTQENKAKSLPQTGEESNKDMTLPLMALLA LSSIVAFVLPRKRKN
Molecule Role	Protective antigen
Molecule Role Annotation	In preclinical studies, a isdB vaccine has shown protection from lethal infection in mice (Harro et al., 2010). Iron-regulated surface determinant B (IsdB) of Staphylococcus aureus (S. aureus) is a highly conserved surface protein that can induce protective CD4(+) T-cell immune response. A pivotal role of CD4(+) T-cells in effective immunity against S. aureus infection has been proved(Yu et al., 2015)
References

isdB