VIOLIN Logo
VO Banner
Search: for Help
About
Introduction
Statistics
VIOLIN News
Your VIOLIN
Register or Login
Submission
Tutorial
Vaccine & Components
Vaxquery
Vaxgen
VBLAST
Protegen
VirmugenDB
DNAVaxDB
CanVaxKB
Vaxjo
Vaxvec
Vevax
Huvax
Vaccine Mechanisms
Vaximmutordb
Vaxism
Vaxar
Vaccine Literature
VO-SciMiner
Litesearch
Vaxmesh
Vaxlert
Vaccine Design
Vaxign
Community Efforts
Vaccine Ontology
ICoVax 2012
ICoVax 2013
Advisory Committee
Vaccine Society
Vaxperts
VaxPub
VaxCom
VaxLaw
VaxMedia
VaxMeet
VaxFund
VaxCareer
Data Exchange
V-Utilities
VIOLINML
Help & Documents
Publications
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

Vaccine Detail

Influenza virus HA protein vaccine (Influenza A virus (A/Fukuoka/C29/85(H3N2)))
Vaccine Information
  • Vaccine Name: Influenza virus HA protein vaccine (Influenza A virus (A/Fukuoka/C29/85(H3N2)))
  • Target Pathogen: Influenza virus
  • Target Disease: Influenza (flu)
  • Vaccine Ontology ID: VO_0004018
  • Type: Subunit vaccine
  • Status: Research
  • Antigen: Influenza A virus (A/Fukuoka/C29/85(H3N2)) HA hemagglutinin
  • HA gene engineering:
    • Type: Recombinant protein preparation
    • Description:
    • Detailed Gene Information: Click Here.
  • Adjuvant: cholera toxin B subunit
  • Immunization Route: Intranasal
Host Response

Mouse Response

  • Host Strain: BALB/c
  • Vaccination Protocol: Mice were anaesthetized by an intraperitoneal injection of amobarbital sodium (0.25 ml of a solution of 1 p.g ml-1) and then immunized by an intranasal inoculation of 10lal phosphate-buffered saline (PBS) containing the required dose of HA vaccine and CTB (Tamura et al., 1989).
  • Challenge Protocol: Viral challenge four weeks after intranasal inoculation (Tamura et al., 1989).
  • Efficacy: The inoculation of HA vaccine prepared from influenza viruses A/Yamagata/120/86 (H1N1) or A/Fukuoka/C29/85 (H3N2) together with CTB provided partial protection against PR-8 infection in Balb/c mice (Tamura et al., 1989).
References
Tamura et al., 1989: Tamura SI, Samegai Y, Kurata H, Kikuta K, Nagamine T, Aizawa C, Kurata T. Enhancement of protective antibody responses by cholera toxin B subunit inoculated intranasally with influenza vaccine. Vaccine. 1989; 7(3); 257-262. [PubMed: 2781859].