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Vaccine Detail

S. typimurium Vi4072
Vaccine Information
  • Vaccine Name: S. typimurium Vi4072
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Vaccine Ontology ID: VO_0004186
  • Type: Recombinant vector vaccine
  • Status: Research
  • TviB gene engineering:
    • Type: Recombinant vector construction
    • Description:
    • Detailed Gene Information: Click Here.
  • Immunization Route: Orally
Host Response

Mouse Response

  • Host Strain: BALB/c
  • Vaccination Protocol: Mice were immunized orally with 5 x 107 recombinant Salmonella Vi4072. As controls, groups of mice were inoculated orally with 5 x 107 χ4072(pYA248) or BSG (Cao et al., 1992).
  • Challenge Protocol: At 60 days postimmunization, mice were challenged with virulent S. typhi Ty2 (Cao et al., 1992).
  • Efficacy: Immunization of mice with Vi4072 afforded complete protection against fatal infection with virulent S. typhi Ty2 (Cao et al., 1992).
  • Description: The viaB (tviB) gene coding for the Vi antigen of Salmonella typhi Ty2 was subcloned into expression vector pYA248. The recombinant plasmid was termed SMM202 and transformed into Salmonella typhimurium Vi4072, an attenuated ΔcyaΔcrp mutant (Cao et al., 1992).
References
Cao et al., 1992: Cao Y, Wen Z, Lu D. Construction of a recombinant oral vaccine against Salmonella typhi and Salmonella typhimurium. Infection and immunity. 1992; 60(7); 2823-2827. [PubMed: 1612747].