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Vaccine Detail

N. meningitidis TbpA Protein Vaccine
Vaccine Information
  • Vaccine Name: N. meningitidis TbpA Protein Vaccine
  • Target Pathogen: Neisseria meningitidis
  • Target Disease: Meningitis
  • Vaccine Ontology ID: VO_0004064
  • Type: Subunit vaccine
  • Status: Research
  • Antigen: rTbpA
  • tbpA gene engineering:
    • Type: Recombinant protein preparation
    • Description:
    • Detailed Gene Information: Click Here.
  • Adjuvant: complete Freunds adjuvant
    • Adjuvant name: complete Freunds adjuvant
    • VO adjuvant ID: VO_0000139
    • Description: Vaccines were prepared with an equal volume of either Freund's complete adjuvant (first immunization) or Freund's incomplete adjuvant (subsequent immunizations) (West et al., 2001).
  • Adjuvant: incomplete Freunds adjuvant
    • Adjuvant name: incomplete Freunds adjuvant
    • VO adjuvant ID: VO_0000142
    • Description: Vaccines were prepared with an equal volume of either Freund's complete adjuvant (first immunization) or Freund's incomplete adjuvant (subsequent immunizations) (West et al., 2001).
  • Immunization Route: subcutaneous injection
Host Response

Mouse Response

  • Host Strain: NIH
  • Vaccination Protocol: Each mouse received 0.2 ml, containing 10 μg of rTbpA protein and Freund's complete adjuvant, by subcutaneous injection. All animals were immunized on days 1, 21, and 28 (West et al., 2001).
  • Challenge Protocol: Mice were infected by intraperitoneal injection of N. meningitidis at several challenge doses (West et al., 2001).
  • Efficacy: 100% protection was afforded by vaccination with rTbpA at the 2 × 107 CFU challenge dose andat the 2 × 108 CFU challenge dose, the rTbpA-vaccinated group had an 85% survival rate (West et al., 2001).
References
West et al., 2001: West D, Reddin K, Matheson M, Heath R, Funnell S, Hudson M, Robinson A, Gorringe A. Recombinant Neisseria meningitidis transferrin binding protein A protects against experimental meningococcal infection. Infection and immunity. 2001; 69(3); 1561-1567. [PubMed: 11179327].