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Vaccine Detail
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Monoclonal Antibody 105AD7 Anti-idiotype Vaccine |
| Vaccine Information |
- Vaccine Name: Monoclonal Antibody 105AD7 Anti-idiotype Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007432
- Type: Subunit vaccine
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- CD55
gene engineering:
- Description: A cancer vaccine consisting of a humanized monoclonal antibody that mimics a tumor-associated antigen 791Tgp72 (also known as CD55). Vaccination with this agent may stimulate a host cytotoxic T-cell response against tumor cells expressing CD55, resulting in tumor cell lysis. (NCI04) (NCIT_C2648).
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| Host Response |
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| References |
NCIT_C2648: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2648]
Ullenhag et al., 2008: Ullenhag GJ, Spendlove I, Watson NF, Kallmeyer C, Pritchard-Jones K, Durrant LG. T-cell responses in osteosarcoma patients vaccinated with an anti-idiotypic antibody, 105AD7, mimicking CD55. Clinical immunology (Orlando, Fla.). 2008; 128(2); 148-154. [PubMed: 18508409].
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