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Vaccine Detail
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VSV-RSV(F/G) |
| Vaccine Information |
- Vaccine Name: VSV-RSV(F/G)
- Target Pathogen: Human Respiratory Syncytial Virus
- Target Disease: Respiratory tract disease
- Type: Recombinant vector vaccine
- Status: Licensed
- Host Species for Licensed Use: Mouse
- G
gene engineering:
- Type: Recombinant protein preparation
- Description: Since Gstem lacks the receptor binding and fusion domains, needs the G protein in trans (Johnson et al., 2013).
- Detailed Gene Information: Click Here.
- Preparation: Recombinant vesicular stomatitis virus (rVSV) replicon in which the attachment and fusion domains of the VSV glycoprotein (G) have been deleted (rVSV-Gstem)(Johnson et al., 2013)
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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| References |
Johnson et al., 2013: Johnson JE, McNeil LK, Megati S, Witko SE, Roopchand VS, Obregon JH, Illenberger DM, Kotash CS, Nowak RM, Braunstein E, Yurgelonis I, Jansen KU, Kalyan NK, Sidhu MK. Non-propagating, recombinant vesicular stomatitis virus vectors encoding respiratory syncytial virus proteins generate potent humoral and cellular immunity against RSV and are protective in mice. Immunology letters. 2013; 150(1-2); 134-144. [PubMed: 23261719].
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