• Vaccine Name: CGV2631
• Target Pathogen: Brucella spp.
• Target Disease: Brucellosis
• Product Name: B. melitensis Rev. 1 with bp26 and omp31 deletions
• Vaccine Ontology ID: VO_0001171
• Type: Live, attenuated vaccine
• Status: Research
• Antigen: B. melitensis Rev. 1 with bp26 and omp31 deletions (Jacques et al., 2007).
• Immunization Route: Intramuscular injection (i.m.)

Sheep Response

• Vaccination Protocol: Sheep were conjunctivally or subcutaneously vaccinated at 4 months old (Jacques et al., 2007).
• Challenge Protocol: Sheep were challenged with B. melitensis H38 at the middle of the first pregnancy following vaccination (Jacques et al., 2007).
• Efficacy: eletion of bp26 and omp31 genes did not significantly affect the well recognised capacity of Rev.1 to protect sheep against B. melitensis challenge. However, the protection conferred by the CGV2631 mutant was significantly lower than that conferred by the CGV26 mutant or the Rev.1 strain (Jacques et al., 2007).