• Vaccine Name: C. botulinum DNA vaccine pSCARSA/BHc
• Target Pathogen: Clostridium botulinum
• Target Disease: Botulism
• Vaccine Ontology ID: VO_0004166
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• Antigen: Clostridium botulinum neurotoxin serotypes A (BoNT/A) and B (BoNT/B) (Yu et al., 2009)
• BoNT/B gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• BoNT/A1 from C. botulinum A str. Hall gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000810
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0003057
• Efficacy: Vaccinated mice were challenged with doses of 1000 and 10,000 LD50 of BoNT/A and BoNT/B, and immune protection was observed. 100% of mice (8/8) survived in the group challenged with 1000 LD50, which was significantly higher protection than that of the single pSCARSAHc or pSCARSBHc-vaccinated mice groups, and 87.5% of mice (7/8) survived in the group challenged with 10,000 LD50 (Yu et al., 2009).