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Protegen: Protective Antigens

     Protective antigens are specifically targeted by the acquired immune response of the host and are able to induce protection in the host against infectious and non-infectious diseases. Protective antigens play important roles in development of vaccines and biological markers for disease diagnosis and analysis of fundamental host immunity against diseases. Protegen is a web-based central database and analysis system that curates, stores, and analyzes protective antigens.

Protegen Search
Search Field	Search Parameter
Pathogen or Disease	Any pathogen Actinobacillus pleuropneumoniae Aeromonas salmonicida Allergy Babesia bovis Bacillus anthracis Bordetella pertussis Borrelia burgdorferi Bovine herpesvirus 1 Bovine Leukemia virus Brucella spp. Burkholderia pseudomallei Campylobacter jejuni Cancer Canine distemper virus Canine parvovirus Chlamydia muridarum Chlamydophila abortus Chlamydophila pneumoniae Chlamydophila psittaci Classical swine fever virus Clostridium botulinum Clostridium tetani Coccidioides spp. Corynebacterium diphtheriae Coxiella burnetii Cryptosporidium parvum Dengue Virus Ebola virus Eimeria maxima Eimeria tenella Entamoeba histolytica Escherichia coli Feline leukemia virus Francisella tularensis Giardia duodenalis Haemophilus influenzae Hantavirus Helicobacter pylori Hendra virus Hepatitis A virus Hepatitis B virus Herpes simplex virus type 1 and 2 Human Immunodeficiency Virus Human Papillomavirus Infectious Hematopoietic Necrosis Virus Influenza virus Japanese encephalitis virus Lassa Fever Virus Leishmania amazonensis Leishmania donovani Leishmania infantum Leishmania major Listeria monocytogenes Marburg Virus Marek's disease virus Measles virus Mumps virus Mycobacterium tuberculosis Mycoplasma gallisepticum Mycoplasma hyopneumoniae Neisseria meningitidis Neospora caninum Newcastle disease virus Nipah virus Pasteurella multocida Plasmodium spp. Poliovirus Porcine circovirus 2 Pseudomonas aeruginosa Pseudorabies virus Rabies virus Ricin toxin of Ricinus communis Rickettsia spp Rift Valley Fever virus Rotavirus Salmonella spp. Sarcocystis neurona SARS-CoV Shigella Staphylococcus aureus Streptococcus agalactiae Streptococcus equi Streptococcus pneumoniae Streptococcus pyogenes Theileria annulata Theileria parva Tick-borne Encephalitis Virus (TBEV) Toxoplasma gondii Treponema pallidum Trypanosoma brucei Trypanosoma cruzi Varicella-zoster virus Variola virus VEE Virus Vibrio anguillarum (Listonella anguillarum) Vibrio cholerae West Nile virus Western equine encephalomyelitis virus Yellow fever virus Yersinia enterocolitica Yersinia pestis Yersinia pseudotuberculosis
Gene Name	(e.g., sodC)
Locus Tag	(e.g., BAB2_0535)
Database ID	NCBI Gene GI NCBI Nucleotide GI NCBI Protein Accesion No NCBI Protein GI Protegen ID VO ID Other Database ID
COG category	Any Amino acid transport and metabolism Carbohydrate transport and metabolism Cell cycle control, cell division, chromosome partitioning Cell motility Cell wall/membrane/envelope biogenesis Chromatin structure and dynamics Coenzyme transport and metabolism Cytoskeleton Defense mechanisms Energy production and conversion Extracellular structures Function unknown General function prediction only Inorganic ion transport and metabolism Intracellular trafficking, secretion, and vesicular transport Lipid transport and metabolism Nuclear structure Nucleotide transport and metabolism Posttranslational modification, protein turnover, chaperones Replication, recombination and repair RNA processing and modification Secondary metabolites biosynthesis, transport and catabolism Signal transduction mechanisms Transcription Translation, ribosomal structure and biogenesis
Subcellular Localization	Any Localization Cellwall Cytoplasmic Cytoplasmic Membrane Extracellular Outer Membrane Periplasmic Unknown
Maximum Number of Transmembrane Helices	(Note: check box to include)
Minimum Adhesin Probability (0-1.0)
No Similarity to Human Proteins
No Similarity to Mouse Proteins
Description	(e.g., superoxide dismutase)

Statistics: Protegen includes 607 protective antigens for now.

Provenance: The data in Progeten originates from our literature curation and boinformatics analyses.

Publication: Yang B, Sayers S, Xiang Z, He Y. Protegen: a web-based protective antigen database and analysis system. Nucleic Acids Research. 2010. 2010 Oct 19. [Epub ahead of print]. [PMID: 20959289] [NAR] [PDF].