VIOLIN: Vaccine Investigation and Online Information Network

Pal

General Information

Protegen ID

101

Sequence Strain (Species/Organism)

Haemophilus influenzae 86-028NP

VO ID

VO_0010915

Taxonomy ID

281310

Molecule Role

Protective antigen

Molecule Role Annotation

Recombinant P6 (pal) was capable of eliciting a protective antibody response against live H. influenzae type b challenge in a modified infant rat model of bacteremia (Yang et al., 1997).
These data demonstrate that active immunization with P6 results in the production of NTHi-specific bactericidal antibody in the chinchilla and also affords a reduction in the incidence of NTHi-induced OM (DeMaria et al., 1996).

COG

COG2885M, under M: Cell wall/membrane/envelope biogenesis

Related Vaccines(s)

Non-typeable H. influenzae rLP4/rLP6 and Moraxella catarrhalis UspA2 protein vaccine , recombinant nontypeable H. influenzae protein P6 with AdDP

References

DeMaria et al., 1996: DeMaria TF, Murwin DM, Leake ER. Immunization with outer membrane protein P6 from nontypeable Haemophilus influenzae induces bactericidal antibody and affords protection in the chinchilla model of otitis media. Infection and immunity. 1996; 64(12); 5187-5192. [PubMed: 8945564].

Yang et al., 1997: Yang YP, Munson RS Jr, Grass S, Chong P, Harkness RE, Gisonni L, James O, Kwok Y, Klein MH. Effect of lipid modification on the physicochemical, structural, antigenic and immunoprotective properties of Haemophilus influenzae outer membrane protein P6. Vaccine. 1997; 15(9); 976-987. [PubMed: 9261944].

Gene Information

Gene Name

Pal

NCBI Gene ID

3429820

Genbank Accession

CP000057

Locus Tag

NTHI0501

Gene Starting Position

470966

Gene Ending Position

471427

DNA Sequence

>NC_007146.2:470966-471427 Haemophilus influenzae 86-028NP, complete genome
ATTAGTACGCTAACACTGCACGACGGTTTTTAGAATATGCAGCTTCATCATGACCTAATACTGCAGGTTT
TTCTTCACCGTAAGATACTGTGCCTAATTTACCAGCATCAACACCTTTACCAGCTAAATAACCTTTAACT
GCATCTGCACGACGTTGGCCTAATGCGATGTTGTATTCTGGTGTACCACGTTCATCAGTGTTACCTTCTA
CTAATACTTTAGCAGCTGGCGTTGCATTTAAATATGCAGCGTGCGCATCTAAGATTTGAACGTATTCACC
AGTAATGTCATATTTATCAAAACCGAAATAAACGGTATTGTAACGTTGTTGAAGATCAGCAACAGAGTAA
CCGCCAAAAGTTTGAGCAGCACCATTGCCTGCAGCATCGTTGTTAGATGAACTACAAGCTGCTAATGCAG
CTACAGAACCTGCAACTAATAATGATTTAACAAATTTGTTCA

Protein Information

Protein Name

outer membrane protein P6

NCBI Protein GI

68248984

Protein Accession

YP_248096

Protein pI

6.52

Protein Weight

14818.12

Protein Length

153

Protein Note

Similar to: HI0381, PAL_HAEIN

Protein Sequence

>YP_248096.1 outer membrane protein P6 [Haemophilus influenzae 86-028NP]
MNKFVKSLLVAGSVAALAACSSSNNDAAGNGAAQTFGGYSVADLQQRYNTVYFGFDKYDITGEYVQILDA
HAAYLNATPAAKVLVEGNTDERGTPEYNIALGQRRADAVKGYLAGKGVDAGKLGTVSYGEEKPAVLGHDE
AAYSKNRRAVLAY

Epitope Information

IEDB Linear Epitope