VIOLIN: Vaccine Investigation and Online Information Network

P1

General Information

Protegen ID

1073

Taxonomy ID

5661

Other Database IDs

CDD:100109

Molecule Role

Protective antigen

Molecule Role Annotation

DNA vaccine pVAX-P1 in a prime-boost mode was able to induce protection with reduced mortality, a significant (75.68%) decrease in splenic parasite burden and increased expression of Th1 type cytokines in immunized hamsters (Arora et al., 2011).

Related Vaccines(s)

pVAX-P1 DNA vaccine

References

Arora et al., 2011: Arora SK, Masih S, Vasishta RK. Efficacy of Leishmania donovani ribosomal P1 gene as DNA vaccine in experimental visceral leishmaniasis. Experimental parasitology. 2011; ; . [PubMed: 21640106].

Gene Information

Gene Name

NCBI Nucleotide GI

27465165

DNA Sequence

>gi|27465165|gb|AY161269.1| Leishmania donovani ribosomal protein P1-like protein mRNA, complete cds
AATTCGTGTACTTTATTAGCACGTCATCACAGAGAACACCTTCCTTACGCACTGTCCATCATCGCCATGT
CCGCTGAGACCCTCGCGTGCACGTACGCCGCGCTCATGCTGAGTGACGCCGGCCTGCCCACCTCGGCCGA
GAACATCGCCGCGGCGGTGAAGGCGGCCGGCGTCGAGATGCGCCCCACCCTGCCCATCATCTTTGCCCGC
TTCCTGGAGAAGAAGTCCGTGGAGACGCTGATGGCGGCCGCCGCCGCGCAGGCCCCGACGGCCGCGTNCG
CCCCGTCTCCGGCGGCGGGCGCCGCCTCCGCTGCANCGGNCGGCGGCAAGGTGGAGGACAAGAAGAAGGA
CGAGCCTGAGGAAGAGGGCGACGACGACATGGGTTTTGGTCTGTTCGACTGAGCGCCCCGCATGATGACC
GGCATATGCGAGCACATGGTTGTTTGGCCTCATGTTCTGCAACACCCGAGCATGCCGTGAGCGCTGCCTC
TCTGCGTGCACATATATATATATGTGTGTGTGTGTGTGTGCGTGTGTTTCGCTGCTCTCTTTTTCTTTTC
GATTTTATTTACGTGTGCGTTACTCCTTCCTCCTGCGAAAAAAAAAAAAAAAAAAAA

Protein Information

Protein Name

ribosomal protein P1-like protein

NCBI Protein GI

27465166

Protein Accession

AAN60108.1

Protein pI

4.09

Protein Weight

11317.016

Protein Length

182

Protein Note

Ribosomal protein P1. This subfamily represents the eukaryotic large ribosomal protein P1. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P1 is located in the L12 stalk, with proteins...; cd05831

Protein Sequence

>AAN60108.1 ribosomal protein P1-like protein [Leishmania donovani]
MSAETLACTYAALMLSDAGLPTSAENIAAAVKAAGVEMRPTLPIIFARFLEKKSVETLMAAAAAQAPTAA
XAPSPAAGAASAAXXGGKVEDKKKDEPEEEGDDDMGFGLFD

Epitope Information

IEDB Linear Epitope