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Glycoprotein B

General Information
Protegen ID 1239
Sequence Strain (Species/Organism) Human betaherpesvirus 5
Taxonomy ID 10359
Molecule Role Protective antigen
Related Vaccines(s) Human cytomegalovirus DNA vaccine pcGB , Human cytomegalovirus DNA vaccine VCL-CB01 encoding phosphoprotein 65 and gB
References  
Gene Information
Gene Name Glycoprotein B
NCBI Gene ID 3077424
Genbank Accession AY446894
Locus Tag HHV5wtgp060
Gene Starting Position 82065
Gene Ending Position 84788
DNA Sequence 
>NC_006273.2:82065-84788 Human herpesvirus 5 strain Merlin, complete genome
TTCAGACGTTCTCTTCTTCGTCAGAGTCTTTCAAGTGTCGGTAGCCGTTTTTGCGATGTCGCAGTCGGTC
TAGTAGGTTGGGCTTCTGTCCCTTGTCCTGCGTGCCAGTCCGTCCGTCCAAAGAATCTGTACCGTTCTGC
TGCGCTCGCTGCTCTGCGTCCAGACGGGCCAGGGCCAGAAGCATCTGGTAAGCCTGCTCGTTGGTGTAAG
GCGGAGCCGCCGTGGATGCATCAGACGACGGTGGTCCCGGTCCTTTGCGACCAGAATTATAAACACTTTC
CTCGTAGGAAGGCGGAGCCTGTAACGACGTGTCTTTGGTGCTGCCCGACGTCACGGTGGTCCCGTCGGCG
GACACCAGATAGGGAAAGAGGTTCTGCAGCGGCTGCGTGCACAAACGCCGCTGTCGAGTATAGATCAAAT
AAGTGATAATGACTACAGCTATGGCCACGAGGATGATGGTGAACGCTCCGAAGGGGTTTTTGAGGAAGGT
GGCAACGCCTTCGACCACGGAGGCCACCGCGCCACCCACGGCCCCAATGGCTACGCCAACGGCCTTTCCC
GCGGCGCCCAGGCCGCTCATGAGGTCGTCCAGACCCTTGAGGTAGGGCGGTAGCGGGTCGACTACCTTGT
CCTCCACGTACTTTACCCGCTGCTTGTACGAGTTGAATTCGCGCATGATCTCTTCGAGGTCAAAAACGTT
GCTGGAACGCAGCTCTTTCTGCGAGTAAAGTTCCAGTACCCTGAAGTCGGTATTTTCCAGCGGGTCGATA
TCCAGGGCGATCATGCTGTCGACGGTGGAGATACTGCTGAGGTCAATCATGCGTTTGAAGAGGTAGTCCA
CGTACTCGTAGGCCGAGTTCCCGGCGATGAAGATCTTGAGGCTGGGAAGCTGACATTCCTCAGTGCGGTG
GTTGCCCAACAGGATTTCGTTGTCCTCGCCCAGTTGACCGTACTGCACGTACGAGCTGTTGGCGAAATTA
AAGATGACCACGGGTCGTGAGTAGCAGCGTCCTGGCGACTCCTTCACGTTCATATCACGCAGCACCTTGA
CGCTGGTTTGGTTGATGGTCACGCAGCTGGCCAGGCCCAAGACATCACCCATGAAACGCGCGGCAATCGG
TTTGTTGTAAATGGCCGAGAGAATGGCTGACGGGTTGATCTTGCTGAGTTCCTTGAAGACCTCTAGGGTG
CGCCGTTGATCCACACACCAGGCTTCTGCGATTTGCGCCAGCGCCCGGTTGATGTAACCGCGCAACGTGT
CATAGGTGAACTGCAGCTGGGCGTAGACCAGATTGTGCACCGATTCCATGTTGGATAAATGAGTTGCATT
GTTGCCATCTGTACTTCTTTTGGTTCTATTATGAGTAAGATTCAGACTGGAGCGGTTGGCCAAACGTTCG
AGTTCCACCAGAGATTTTTGCTTGATACCTTGCCAGAACACTACCAAACCACCAGTGGTTTCAAAGACGG
ACACGTTTCCATATTTTTCATATGTTTGATTGTATGAAGTATTGAAAATCTGCTGTAACTTATTTATAGC
CTCATCACGTACGCAGTCCAGCGCAGAGTCGGACATGTTCACCTCTTGCTTCTTAGATAAGAAAGTGGCG
GTCATTTTGGCAGAAGAAAAGTGATACGAGTCCTCGGCTTCGGAACGAATGGTGCGTTCCGAGGCTTCCC
AGAAAGTGAGTTGACAAGTGACATTCTTTTCGTCCTGTATATCCCAGGAGATCACCGAGTCCGCACGTTC
AAGAAAAGCCACCAACCTGTGGGTCTCTAACGCAGAATTCGGTCTTCCAAAGTCGGAGACGATAGTGTAG
TTCGGAAAAATGAAAAACTTGTCGGCGTTTTCTCCAAAGTAGCTGGCATTGCGATTGGTTCCGTTGTAGA
AAGGAGAAATGTCAACCACGTCACCCGTGGAAGTGGCGAAAAAATGATAAGGATATTTGGAGCGCGCAGT
AGTGATGGTCACCATACAATTCAGATTACAGGTCTCACGATAGAGCCAGGTGCTGCCGCGGCTGTGCCAT
TGATCCTTGACCGTCACGTAACGGGTACTGTGGGTGTTGGAATAATCGTCGGGCATTAATTGCATGGTTT
TGTTTTCATAGCTGTCCCTATGATAAGCCACGAAAACCGTGCCTGCTATAACGCGGCTGTAGGAACTGTA
GCACTGACTGTGGCTGTTGATATGATGAATCTCCCACATAGGAGGCGCCACGTATTCCGTGTTGCTGCCC
AGCAGATAAGTGGTGTGGATGTAAGCGTAGCTACGACGAAACGTCAAAACCTTCTGGTAGACTCGTACCT
TAAAGGTGTGCGCGACGATGTTGCGTTTGTAGACCACCATGATGCCCTCGTCCAGGTCTTCATTGATGGG
CTTCATCGAGGTGCAGACGATATTACGTTCAAAGCGAATAAGATCCGTACCCTGGGCCATAGAACACACG
CGATAGGGGTACTTGGTGGTATTGACCCCCACCACATCTCCGTACTTGAGGGTAGTGTTGTAGATGGTCT
CGTTAACACCATGGCTGACCGTTTGGGAAGAAGTTACGCGTTGAGAGACTGAACCGGATCGAGAGTGAGC
AGCAGACGTCGTATGAGAGGAATGGTGACTGTGAGTAGCAGAAGTTCCACGAGTAGAAGATGAGGAAACC
GCAGCACCCAGACAGACGATACACAAGTTAACGCAGACTACCAGGCACCAGATCCTGGATTCCA
Protein Information
Protein Name envelope glycoprotein B
NCBI Protein GI 52139241
Protein Accession YP_081514
Protein pI 7.31
Protein Weight 94542.1
Protein Length 907
Protein Sequence 
>YP_081514.1 envelope glycoprotein B [Human betaherpesvirus 5]
MESRIWCLVVCVNLCIVCLGAAVSSSSTRGTSATHSHHSSHTTSAAHSRSGSVSQRVTSSQTVSHGVNET
IYNTTLKYGDVVGVNTTKYPYRVCSMAQGTDLIRFERNIVCTSMKPINEDLDEGIMVVYKRNIVAHTFKV
RVYQKVLTFRRSYAYIHTTYLLGSNTEYVAPPMWEIHHINSHSQCYSSYSRVIAGTVFVAYHRDSYENKT
MQLMPDDYSNTHSTRYVTVKDQWHSRGSTWLYRETCNLNCMVTITTARSKYPYHFFATSTGDVVDISPFY
NGTNRNASYFGENADKFFIFPNYTIVSDFGRPNSALETHRLVAFLERADSVISWDIQDEKNVTCQLTFWE
ASERTIRSEAEDSYHFSSAKMTATFLSKKQEVNMSDSALDCVRDEAINKLQQIFNTSYNQTYEKYGNVSV
FETTGGLVVFWQGIKQKSLVELERLANRSSLNLTHNRTKRSTDGNNATHLSNMESVHNLVYAQLQFTYDT
LRGYINRALAQIAEAWCVDQRRTLEVFKELSKINPSAILSAIYNKPIAARFMGDVLGLASCVTINQTSVK
VLRDMNVKESPGRCYSRPVVIFNFANSSYVQYGQLGEDNEILLGNHRTEECQLPSLKIFIAGNSAYEYVD
YLFKRMIDLSSISTVDSMIALDIDPLENTDFRVLELYSQKELRSSNVFDLEEIMREFNSYKQRVKYVEDK
VVDPLPPYLKGLDDLMSGLGAAGKAVGVAIGAVGGAVASVVEGVATFLKNPFGAFTIILVAIAVVIITYL
IYTRQRRLCTQPLQNLFPYLVSADGTTVTSGSTKDTSLQAPPSYEESVYNSGRKGPGPPSSDASTAAPPY
TNEQAYQMLLALARLDAEQRAQQNGTDSLDGRTGTQDKGQKPNLLDRLRHRKNGYRHLKDSDEEENV
Vaxign Prediction
Localization(Probability)
(Prob.=0)
Adhesin Probability 0.256
Trans-membrane Helices 3
Detailed Vaxign Results Vaxign Results
Epitope Information
IEDB Linear Epitope