VIOLIN: Vaccine Investigation and Online Information Network

gag

General Information

Protegen ID

1268

Sequence Strain (Species/Organism)

Human immunodeficiency virus 1

Taxonomy ID

11676

Other Database IDs

CDD:249943
CDD:279002
CDD:197667
CDD:285867

Molecule Role

Protective antigen

References

Gene Information

Gene Name

gag

Protein Information

Protein Name

gag

NCBI Protein GI

5081475

Protein pI

9.19

Protein Weight

54682.29

Protein Length

566

Protein Note

isolated from patient SC49 PBMC; infection was aquired in Sydney, Australia 1998; this patient registered low levels of viral RNA in plasma by RT-PCR (Amplicor 1.0) and low levels of P24 (gag) antigen by monoclonal ELISA despite symptomatic seroconversion; HIV RNA quantitation by an alternative method (bDNA, Chiron 3.0) on the same sample yielded a level of >500,000 copies/ml; subtyping in envelope and P17 gag by sequencing and phylogenetic analysis revealed subtype B; the entire gag gene was then sequenced to search for mutations to account for the failure of detection methods directed to this genomic area;
subtype: B

Protein Sequence

>AAD39400.1 gag [Human immunodeficiency virus 1]
MGARASVLSGGKLDKWEKIRLRPGGKKTYQLKHIVWASRELERFAVNPGLLETGGGCKQILVQLQPSLQT
GSEELKSLYNAVATLYCVHQGIEVRDTKEALDKIEEEQNKSKKKAQQAAADTGNSSQVSQNYPIVQNLQG
QMVHQAISPRTLNAWVKVIEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAA
EWDRLHPAHAGPNAPGQMREPRGSDIAGTTSTLQEQIGWMTSNPPVPVGEIYKRWIILGLNKIVRMYSPV
SILDIRQGPKEPFRDYVDRFYKTLRAEQASQDVKNWMTETLLVQNANPDCKTILKALGPAATLEEMMTAC
QGVGGPSHKARILAEAMSQVTSPANIMMQRGNFRNQRKTIKCFNCGKEGHLARHCRAPRKKGCWKCGREG
HQMKDCTERQANFLGKIWPSHKGRPGNFLQSRPEPTAPPEESFRFGEETTTPPQKQEPLPSQKQETIDKD
LYPLASLKSLFGNDPSLQ

Epitope Information

IEDB Linear Epitope