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Mcam

General Information
Protegen ID 1339
Sequence Strain (Species/Organism) Mus musculus
Taxonomy ID 10090
Molecule Role Protective antigen
Related Vaccines(s) Melanoma DNA vaccine SINCp c-muMUC18 encoding MCAM/MUC18
References  
Gene Information
Gene Name Mcam
NCBI Gene ID 84004
Genbank Accession AC148328
Chromosome No 9
Gene Starting Position 44134580
Gene Ending Position 44142726
DNA Sequence 
>NC_000075.6:44134580-44142726 Mus musculus strain C57BL/6J chromosome 9, GRCm38.p4 C57BL/6J
TACGCGGGGCGGGGCCGGGCGGCGCCCGGGGTCCCCTCCCCCGCCCCCCTGACGTCAGCCCCCGACAGCG
GCGAGTTCCTCACTTGGCTCGCGCCCTCCGTCGGGGAAGCATGGGGCTGCCCAAACTGGTGTGCGTCTTC
TTGTTCGCTGCCTGCTGCTGCTGTCGCCGTGCCGCGGGTGAGTTCTTTATGTTGAGGGGGCTGTGGGGGG
CCCGACCCGCGTCCCTCAGAGCCCAGGCGTTGGGAGTTTGGGGATGTCTTCGACGGAGCCGGACTGTGCC
GCCTGAGTGTACCGGAGATCAGAGCTGGTAGCAACGTAGAGTCGGGGCTCTGCACCCCAGTGGGCGCTCC
TTCTTGCCAGAGTCCCCGATTTCCAGGCGCCCCGCGTGCGTGCAACTTCTTTGCGGGTGTGCAGCCTAGG
TTTTAGAGTATTCTGGGAACGGACTAGTCGGGTTGCTGCAGCAGCGAGCGGGAAGGGGTGGGGCCGAGCT
TCTGCAGGACGCTGGGCCCGGCCTCCCGCAGGTGTTCGCTCTGGGTGCTGGATGCTGGGTGCTGGAGTCC
CGGCAGAGAGGCGCAGCCGGGGCGCATCCCCAACCCGTGCATCCCGCGCCCGCCTGTTGCTGGAAAAGGC
AGTTTCCCTAGCTGGAGGGGGCCGCCGACCCCTCCCCCTCCGCCTGGGCCTCACGCCAGTTTGGAGGTGA
GCGAGGGAGGAGGCCGCTCCTGCTGGGGCTGGGCGTTGGCAAGGGCAGCGGGTGGTGTGGGTCTCCTTGC
GCCTCCGGGTTTGACGGGATTACAGGGGAAAGACAACAGATGGAGAAGTTCTACAACAGTAACAGCTTCT
GTGGTCCACTAGAGTCAGGTGGAGAGAGCCTGGCACCTCGGAGCTTTCCTTTAAGCCATCGAGTAGACAT
GCTTTCCTGGGTCCGGGCTTCCCTTGTAGGGCACACGCAGCGGTGTCGTGTGTTATTCTTGGCTCTTTCT
CGCGTCTCAGCCACTGGTCAGGCTGGGGAAGGGGAGGACTGGGCATTACCCACTTCTCTGGCCTCTTGCC
CAGTGCCAGCCACGTCCCTGGGGTACTCCAGTCTAGTGCCTCCCAGACTGACCTTATTTCTGGGGAAAGG
GCTAAACCCAGCTAGGCAATCGCAGCACAGAAAACTCAGTTTCGCTCTGCCCTGCTCTTCTGGCCCTTAG
AAAGCAGGGATTCAAAGTTCCTGCTGTTGGTAGAAGGCTATTCCCACCTTCCCTCCAGTCTGGAAGCCAC
ACAGTCCAGACATCCCAGGGTCCAGGCAGATTGTGCTTAGTGACATCACCTCTTCTAAGAGCTGGCAGCA
TGCTGGCACCACTGACGTCACTCCTGCCCACTCTCTGGTTTTTGACCTAACCCTTGGCGGAGACTGACCC
CTCTAGACTTGGATGGGGTCTTCAGATTGTATTGCAGCGTTTCTTGACATGCTACTGTGGGAACATAAAT
CATAGCCTCTGGCTAGAGTTGGCTCACTGTGTCTTCCAGAGGATTTGGGGGACAGAGGGTAGAATAGTGA
CGTCTTCGTGGAGGGGGGGCACACAAAGGGGCCTGTGTGCCCCAGCCTGGCACATGCCTTACATTCCCCT
AGTCTGAGCTCACCAGGACTAGGAAGGGGCCCAGGAGCAAAGGGGCCTTCATCTTGGCCCAGAGCCCATG
TTGCTCTTATCTGTCTCTCCACCAGCTTCTTCTAAGATATACCCAGTCACTCTGTCTGTGTTTCACTCCG
TATTACACTGGGAGAGGTCTGACCCAGGTTGGGGGTGTGGGCTTGGTGAAGTTGAGGGTAAGGAGAGGGT
AAGGCCCTCCCCAGACCCTTCAAGTGGGACAGCTGCAGTGAACCAGGAGAGGGGAGGGGACCGGACAGAA
CACCTGGAGCTGACAAAGCTGCCTGGGCATGCCCCTCTCTTTCCCCAGGTGTGCCAGGAGAGGAAAAGCA
GCCAGTACCCACGCCCGACCTGGTGGAGGCAGAAGTGGGCAGCACAGCCCTTCTCAAGTGTGGCCCCTCA
CGGGCCTCAGGCAACTTCAGCCAAGTGGACTGGTTTTTGGTGAGCGCCTGGACTTTGGAGGGCAGTAGTT
GTGTGGGAAGCAACTGTCTCTCTGGCAGGTAGCTCATCTCTCAGCTCCTTTCCCTCAGATTCACAAGGAG
AGGCAGATACTGATTTTCCGTGTGCACCAAGGCAAGGGCCAGCGGGAACCTGGTGAATATGAGCACCGCC
TTAGCCTCCAAGACTCGGTGGCTACTCTGGCCCTGAGTCACGTCACTCCCCATGATGAGCGAATGTTCCT
GTGTAAGAGCAAGCGACCACGGCTCCAGGATCACTACGTTGAGCTTCAGGTCTTCAGTGAGTGCCCCCCT
CGTTTCTGCCTTCAGGGTCGTGTGGACCATGTAGCAAAGATGGGTCTCCATGTCCCTGTTCATTCCCCTT
CCACTGTAGAAGCCCCAGAGGAACCAACTATTCAAGCCAATGTCGTGGGCATCCATGTGGACAGGCAAGA
GCTCAGGGAGGTGAGAGGCACTCGGTCAAATGATGGTGGATAGAGGCTAAGCAGGGACGGGGGTGGGGGG
GGGTGGTATGTGGCAGACGCAAGGAGACTCTCGTCCTGTCCTCCTTAGGTTGCTACCTGTGTGGGGAGAA
ACGGCTACCCCATTCCTCAAGTCCTATGGTACAAGAACAGTCTGCCCTTGCAAGAGGAGGAGAACCGTGA
GTAACCCTTACTGAGAAGGCTCAGGAGGACCATCTAGCATGTCCTTGTAGAGCTTTTACTAAAACAAACA
AGCAAACAAACAAAAACCATACAGGTGATGCTGAGTAAGTCAGACTGTAGGCTGGACAGTTAGCTCCATG
AACATCACTGGTTGCTTTTGCAGAGGACCCAGGTCAGTTCCCAATACCCACTTGGTGGTTCCCAACTCCA
CTTCCAGGGGGATCTGATGCCTTTTCCTGACCTCGACCTCTGAGGACAGAAGGCATGCATGTGGTGCATA
TACACACGAAGGCAAAACATTCCTGCACATTAAACAAACAAACAAACAGCCAGGTGTGGTAGCGCACGCT
TTTAAACCCAGCACTTGGGAGGCAGAGGCAGGTGAGTTTCTGAGTTTGAGGCCAGCCTGGTCTACAAAGT
GAGTTCCAGGACAGCCAGGGCTATATGGAGAAACACTGTCTCAAAAAAAAAAAAAAACAAACAAACAAAC
AAAAAACTGTTATAATTAAATAAAGACCTGGCTACAAAATCTTTTAGAAGAAAAATTTAGACTATAAAAA
AACTTAGGAATTCCTTTCTGACCCAGGCTTCTCCCAGAAGTGACTTCTGCTATCAACTGATATTTTCCTT
CATTCTTACTTCTGTGTCCATCATGTAAACAAATGCTTGCAGACGTGTAGAGAGGGCTGTCTGCGGTGTT
TTGAGACAGGAAGTCATGCAGCTCGATGACCTAACTGCAGATCCTCTCTGCCTACCCCTCAAAGCGCTGG
GATCCATGCCTGTAACACTGTTCCTGGCTCAAACAAGGCTTGTGTTTTGTTTTTTGTTTTGTTTTTGTTT
TCCTGTCTTTAACCAGGAGTGATTTTTGCATACACACTAGTCTGGGGATACTTGGCAGTGTCTGTGGGCA
TTAGTGGATGTCACAAACAGGGAGGCTGCTGTTGACATCTGATACGTAGAGGTTAGAACTACAGCTCAGC
ATCCTACAGTGCACAGGATGGGCCCCACCACAAAGGTTTAATTCCACCCCAACACATCAATAGTGCTGAG
CCGAGAAGCCCTGACCCCAGTGGCCATGCTGGGCACACATCCCTTTGTGTAACTTTCCCAGGTCAGTCTG
TTCAGATAGACTCACCTTGCTTCCTAGCCTCGTATTGCATATGATGTGGCTGAGTTTCCACTCTTCCTTT
AGCATTTAATGTCTCAGTGTCTCAGCACCTTGGGGCATTTGTTTTGGATTCTGTATTGAACCTAAGGCCA
TGCACATGTTAAGAATTTGCTCTACCACTCAGCCTTTCATTCAACTCCATTTTTCTTTGTCTTTGGGGTG
TTCCTGGCCCCATCCTTGTACATATGCTAAGGTGTAAGTGCTTTCTAGGGTAAATACCAAGCAATAAAAG
TGCTAGGCTGAAGGGTCGTCATTCTGTGTTCGGCTATGGGCCTCTCCTTTAGACATCTCCCTGCTGACCC
CCAGGGGAAGTCTGAGGGGTCCTGAGGCCAGGCCTTGCTTCCTCCTTCTGCCCAGGAGTTCATATCCAGT
CATCACAGATTGTCGAGTCCAGTGGCTTGTACACCTTGAAGAGTGTTCTGAGTGCACGCCTAGTTAAGGA
AGACAAAGATGCCCAGTTTTACTGTGAACTCAGCTACCGGCTACCCAGTGGGAACCACATGAAGGAATCT
AAGGAGGTCACTGTCCCTGTTTTCTGTGAGTGCTGACTTCCTAGCGCCTCTGGATTTTTTTTGAGGGGGG
GAGGATTGGGGTGGGCCTGGTGGGAACTCCTGCTGGTCCCTCTGTGTCAAATTCGGGGCCACCTCTTGGA
CTGAGAGCCTTCTCCTTTGCCCAAACAGACCCTGCAGAAAAAGTGTGGGTGGAGGTAGAGCCTGTGGGGC
TGCTGAAGGAAGGGGATCATGTGACAATCAGGTGTCTGACAGATGGCAACCCTCAACCCCACTTCACTAT
CAACAAGAAGGTACAGAGAGAGCGAGCGCTCCATGCTGGGTGCACGGAGTGGGCGTAAGGGTGTGGGCAG
GAGGTGGGGACAGTAGCTGGAGGGCATCAGCTCACTCTCACCCCTTTGTGCTCCCCCCAGGACCCCAGCA
CTGGGGAGATGGAAGAGGAGAGCACCGATGAAAATGGGCTCCTGTCCTTGGAGCCTGCCGAAAAGCACCA
TAGCGGGCTCTACCAGTGTCAGAGTCTGGACCTGGAAACTACCATCACACTGTCAAGTGACCCCCTGGAG
CTGCTGGTGAACTGTGAGACCCTGGGATGGATGCAGGCTCCATCTGGGCAAAGAGGGAACTGGCTCGTCC
TGTCAGGCTGACATTTTTTTGCTATGCCTCCAGATGTGTCTGATGTTCAAGTGAATCCAACTGCCCCTGA
AGTCCAGGAAGGTGAGAGCCTCACGCTGACCTGCGAGGCAGAAAGTAACCAGGACCTTGAGTTTGAGTGG
CTGAGAGACAAGGTACCCAGACACCTTTGAGACTGGGGGAGAGGGGGGACAATGAGAGCTTGCTCCTTTT
CAGACCCCCTGACCCACCTCTCACCCCTAGACAGGCCAGCTGCTGGGAAAGGGTCCCGTCCTCCAGCTAA
ACAACGTGAGACGGGAAGCAGGGGGACGGTATCTCTGCATGGCATCTGTCCCCAGAGTTCCTGGCTTGAA
TCGTACCCAGCTGGTCAGCGTGGGCATTTTTGGTGAGGCCCTTTGTACAGTGACCAGGTCACCCTGAGTT
GTGTGGTTTTGAGCTGTTGGCCAGCTTGTACTGTGGGAGCTGAGCGGGGAGCAGGCTATTTGGTATTTGG
GGGGTCTAACCCTTCCCTGCCCCCAAGGGTCCCCATGGATGGCATTAAAGGAGAGGAAGGTGTGGGTGCA
AGAGAATGCAGTGCTGAATCTGTCTTGTGAGGCTTCAGGACATCCTCAGCCCACCATCTCCTGGAATGTC
AATGGTTCGGTGAGCCGGCTTGCTTCATCTCCCCATTCTCTTAATCCCTGCCTAGGCCTTGAGGCCATGG
CCAGAGATGCTTCCGCCCTCTGAGAGGCCCATTTACTTCTAGGCAACTGAATGGAACCCAGATCCACAGA
CAGTAGTGAGCACCTTGAATGTCCTTGTGACGCCAGAGCTTCTGGAGACAGGTGCAGAGTGTACAGCCTC
CAACTCCCTGGGCTCAAACACCACCACCATTGTTCTGAAGCTGGGTGAGAGCGGACTCCCTGCAGAGGCT
GGCAGGGGCATGCCCAGGCACAGGCATTAACTTGTGCTACTAACCCCCCAACTCCTTCTGCCTCCTAGTC
ACTTTAACCACCCTCATACCTGACTCCAGCCAAACCACTGGCCTCAGCACCCTCACAGTCAGTCCTCACA
CCAGAGCCAACAGCACCTCCACAGGTAAGCCGGGCCTGCGCAGTGGTACCCAGTCAGTCTCCCCTTTTGA
GAAAGTTAACGGCCCATCTGTCCCCCTGGGCTGGAGAGGGTGGGGCAGCAACAGCAATTTGGCAGCCAGG
AGCAGGGAATGACTACAAGTGTCTTTGTTTGACAGAGAAAAAGCTGCCACAGCCAGAGAGCAAAGGTGTG
GTCATCGTGGCTGTGATAGTGTGTACCTTGGTGCTTGCTGTGCTGGGTGCTGCTCTCTATTTCTTCTACA
AGAAGGGCAAGCTGCCATGTGGACGCTCGGGAAAACAGGAGATGTAAGCCAGGCTTATGCCCTCCTCCCA
CCCCACCCCCATTTTTGGCTGCCCAGCTTGCTGTCTTATAAGGGCCCTGCCTACCCAGTGCCCATTACCC
TGGAGAGCAGAAACTGGACCTGTTTTTATTGTCCACTACCAAACTGCCACCAACCACACCATCTTCCCCA
ATTCTCCCTTCCTGAGCCGGCCCCAAAGCACCAGAGTATCCATTCCTAAAAGGTCCCCCCCTCCCCAGCC
TCCCCCAGCCCCCGAGTTGCCAACCTCTCACCTCCCTTCTCCCAGCACGCTGCCCCCGACTCGTAAGAGT
GAATTTGTAGTTGAAGTTAAGTCAGATAAGCTCCCAGAAGAGATGGCTCTCCTTCAGGGCAGCAACGGTG
ACAAGAGGGCTCCAGGAGACCAGGTAGGAGGCAGTTCCTGAGGCCAGGGCTCTATTTTCAGGAATTGGGG
GTAGTGGGGTAATGCTACTTGTTCCTGAACACTAACTCTTTCTGTCCTTCATCCTTGGTTAGAGATGGGG
AGCAGACCTCTCTTGCCTTAACATTACTACAGGTGGCAGGATGAGGGAAACGGTGGAGGGACCCTAGAGA
AAGACAACGCCCCAGCCACCTTCTGTTAAACGTAGAGACTTAGCTGGGGGACTTCTGTCTTTTCCTCCCC
CACCCCATTCCTGCTGCTTGCTTTAAGGATGTTGCAGCCCATCAGCTTTTGCTTCGGCCTTTTCTGTCTG
GTGGTCACGCTGTAAACCTTGCTGGCTCTCCATGTTCTGGTGACTTCTCTGTATCCATTTTCAGGGAGAG
AAATACATCGATCTGAGGCATTAGATGGCTCCCATTGCACTGCTCGCAGCTCCCTGCTCAGACTTCACCC
CAAGCTGAAGCCTCCAGAGGGACAGCAGGGACGAGCCACACTCAACCCCCCCCCTGCACATCAGGTCTGA
GAGCTAGGAGCTGGGACAGGAGTCGTCTGCAGGAGCTCAGTTGGCTACAGAGGCCTGGTTTTAGAGACCA
AGCCCTCCTCTGTGTCCAGTAAATAATGCTTATCCCAAGGGGCCCGTCTCCCAGGGCATTTCCCCCTCCC
GTGCACAGCCATTGGTGGCAAATCCTTCTGCCATCAGCTGTGTGGGCTTGCCTCTTTGAGCTCATCTCCC
CTCACAGGCTGTCTTCATGATGCAGGACCTGGGCACATGGTCACATTATTCCGTTCACATTGGTCCTTGT
GAGAACCTCACAGTCTGGAGGCGGCTGCTTTTGTACCTTCCTGCCTGCTACTAATTCAGGGTCTCATTTG
GAACATTTTTCCTTTGGGTAGTGGTCAGGAACTGGTGTAAGTCCTCCAGACACATCCCTGTGTAAGGAAG
CCAGGCACTGTTTCTCTGAGTTTTGTTGTTTTGTTTTCTTTGAAGGCTACTGAGCCCAAGCTTCCCGCAT
TCCCTTAGTAACAAGAGACAGGACAGAGAGAAGGTCTACTGTTCATGGGGATTAGGCTTATAGGAATGTT
AGTACCAAATTTCTACATGTGAGCTTTGGGGGCCAGGTCCTAGAGAGCCCAAGTGGGAGAATGGTATTTA
GGAGATGAAAAACCTGGCCTAGCAAGAGCTTTTGAGGTGTGTGTGTGTGTGTGTGTATACATATATGTGT
GTATATATATATATATATATATGGTTTTGTCTGTAAATTTGCAAATTTTTCCTTTTATATGTGTGTTAGA
AAAATAAAGTGTTATTGTTCCAAAAGC
Protein Information
Protein Name transcript variant X2
NCBI Protein GI 1327848422
Protein Accession NP_001346459
Protein pI 5.64
Protein Weight 61047.95
Protein Length 606
Protein Note Also known as CD146; CD149; Muc18; s-endo; AV025631; 1-gicerin; s-gicerin
Protein Sequence 
>NP_001346459.1 cell surface glycoprotein MUC18 isoform 2 precursor [Mus musculus]
MGLPKLVCVFLFAACCCCRRAAGVPGEEKQPVPTPDLVEAEVGSTALLKCGPSRASGNFSQVDWFLIHKE
RQILIFRVHQGKGQREPGEYEHRLSLQDSVATLALSHVTPHDERMFLCKSKRPRLQDHYVELQVFKAPEE
PTIQANVVGIHVDRQELREVATCVGRNGYPIPQVLWYKNSLPLQEEENRVHIQSSQIVESSGLYTLKSVL
SARLVKEDKDAQFYCELSYRLPSGNHMKESKEVTVPVFYPAEKVWVEVEPVGLLKEGDHVTIRCLTDGNP
QPHFTINKKDPSTGEMEEESTDENGLLSLEPAEKHHSGLYQCQSLDLETTITLSSDPLELLVNYVSDVQV
NPTAPEVQEGESLTLTCEAESNQDLEFEWLRDKTGQLLGKGPVLQLNNVRREAGGRYLCMASVPRVPGLN
RTQLVSVGIFGSPWMALKERKVWVQENAVLNLSCEASGHPQPTISWNVNGSATEWNPDPQTVVSTLNVLV
TPELLETGAECTASNSLGSNTTTIVLKLVTLTTLIPDSSQTTGLSTLTVSPHTRANSTSTEKKLPQPESK
GVVIVAVIVCTLVLAVLGAALYFFYKKGKLPCGRSGKQEMERNTSI
Epitope Information
IEDB Linear Epitope