VIOLIN: Vaccine Investigation and Online Information Network

AMA1 from P. falciparum 3D7

General Information

Protegen ID

139

Sequence Strain (Species/Organism)

Plasmodium falciparum 3D7

VO ID

VO_0010923

Taxonomy ID

36329

Other Database IDs

UniProt: P22621

Molecule Role

Protective antigen

Related Vaccines(s)

AMA 49-CPE , AMA1-C1Alhydrogel , AMA1-C1Alhydrogel + CPG 7909 , ChAd63-MVA AMA1 , FMP1/AS02A , NYVAC-Pf7 , PfAMA1-FVO/ Alhydrogel

References

Gene Information

Gene Name

AMA1 from P. falciparum 3D7

NCBI Gene ID

810891

Genbank Accession

LN999945

Chromosome No

Locus Tag

PF3D7_1133400

Gene Starting Position

1293855

Gene Ending Position

1295723

DNA Sequence

>NC_037282.1:1293855-1295723 Plasmodium falciparum 3D7 chromosome 11, complete sequence
AATGAGAAAATTATACTGCGTATTATTATTGAGCGCCTTTGAGTTTACATATATGATAAACTTTGGAAGA
GGACAGAATTATTGGGAACATCCATATCAAAATAGTGATGTGTATCGTCCAATCAACGAACATAGGGAAC
ATCCAAAAGAATACGAATATCCATTACACCAGGAACATACATACCAACAAGAAGATTCAGGAGAAGACGA
AAATACATTACAACACGCATATCCAATAGACCACGAAGGTGCCGAACCCGCACCACAAGAACAAAATTTA
TTTTCAAGCATTGAAATAGTAGAAAGAAGTAATTATATGGGTAATCCATGGACGGAATATATGGCAAAAT
ATGATATTGAAGAAGTTCATGGTTCAGGTATAAGAGTAGATTTAGGAGAAGATGCTGAAGTAGCTGGAAC
TCAATATAGACTTCCATCAGGGAAATGTCCAGTATTTGGTAAAGGTATAATTATTGAGAATTCAAATACT
ACTTTTTTAACACCGGTAGCTACGGGAAATCAATATTTAAAAGATGGAGGTTTTGCTTTTCCTCCAACAG
AACCTCTTATGTCACCAATGACATTAGATGAAATGAGACATTTTTATAAAGATAATAAATATGTAAAAAA
TTTAGATGAATTGACTTTATGTTCAAGACATGCAGGAAATATGATTCCAGATAATGATAAAAATTCAAAT
TATAAATATCCAGCTGTTTATGATGACAAAGATAAAAAGTGTCATATATTATATATTGCAGCTCAAGAAA
ATAATGGTCCTAGATATTGTAATAAAGACGAAAGTAAAAGAAACAGCATGTTTTGTTTTAGACCAGCAAA
AGATATATCATTTCAAAACTATACATATTTAAGTAAGAATGTAGTTGATAACTGGGAAAAAGTTTGCCCT
AGAAAGAATTTACAGAATGCAAAATTCGGATTATGGGTCGATGGAAATTGTGAAGATATACCACATGTAA
ATGAATTTCCAGCAATTGATCTTTTTGAATGTAATAAATTAGTTTTTGAATTGAGTGCTTCGGATCAACC
TAAACAATATGAACAACATTTAACAGATTATGAAAAAATTAAAGAAGGTTTCAAAAATAAGAACGCTAGT
ATGATCAAAAGTGCTTTTCTTCCCACTGGTGCTTTTAAAGCAGATAGATATAAAAGTCATGGTAAGGGTT
ATAATTGGGGAAATTATAACACAGAAACACAAAAATGTGAAATTTTTAATGTCAAACCAACATGTTTAAT
TAACAATTCATCATACATTGCTACTACTGCTTTGTCCCATCCCATCGAAGTTGAAAACAATTTTCCATGT
TCATTATATAAAGATGAAATAATGAAAGAAATCGAAAGAGAATCAAAACGAATTAAATTAAATGATAATG
ATGATGAAGGGAATAAAAAAATTATAGCTCCAAGAATTTTTATTTCAGATGATAAAGACAGTTTAAAATG
CCCATGTGACCCTGAAATGGTAAGTAATAGTACATGTCGTTTCTTTGTATGTAAATGTGTAGAAAGAAGG
GCAGAAGTAACATCAAATAATGAAGTTGTAGTTAAAGAAGAATATAAAGATGAATATGCAGATATTCCTG
AACATAAACCAACTTATGATAAAATGAAAATTATAATTGCATCATCAGCTGCTGTCGCTGTATTAGCAAC
TATTTTAATGGTTTATCTTTATAAAAGAAAAGGAAATGCTGAAAAATATGATAAAATGGATGAACCACAA
GATTATGGGAAATCAAATTCAAGAAATGATGAAATGTTAGATCCTGAGGCATCTTTTTGGGGGGAAGAAA
AAAGAGCATCACATACAACACCAGTTCTGATGGAAAAACCATACTATTA

Protein Information

Protein Name

Apical membrane antigen 1 (AMA1); PF11_0344; AMA-1, Pf83, RMA1, RMA 1, rhoptry membrane antigen

NCBI Protein GI

124804478

Protein Accession

XP_001348015

3D structure: PDB ID

1Z40

Protein pI

5.23

Protein Weight

69161.85

Protein Length

622

Protein Note

This is apical membrane antigen 1 (AMA1), or designated at PF11_0344 (PF11_0344 in GeneDB).

Protein Sequence

>XP_001348015.1 apical membrane antigen 1 [Plasmodium falciparum 3D7]
MRKLYCVLLLSAFEFTYMINFGRGQNYWEHPYQNSDVYRPINEHREHPKEYEYPLHQEHTYQQEDSGEDE
NTLQHAYPIDHEGAEPAPQEQNLFSSIEIVERSNYMGNPWTEYMAKYDIEEVHGSGIRVDLGEDAEVAGT
QYRLPSGKCPVFGKGIIIENSNTTFLTPVATGNQYLKDGGFAFPPTEPLMSPMTLDEMRHFYKDNKYVKN
LDELTLCSRHAGNMIPDNDKNSNYKYPAVYDDKDKKCHILYIAAQENNGPRYCNKDESKRNSMFCFRPAK
DISFQNYTYLSKNVVDNWEKVCPRKNLQNAKFGLWVDGNCEDIPHVNEFPAIDLFECNKLVFELSASDQP
KQYEQHLTDYEKIKEGFKNKNASMIKSAFLPTGAFKADRYKSHGKGYNWGNYNTETQKCEIFNVKPTCLI
NNSSYIATTALSHPIEVENNFPCSLYKDEIMKEIERESKRIKLNDNDDEGNKKIIAPRIFISDDKDSLKC
PCDPEMVSNSTCRFFVCKCVERRAEVTSNNEVVVKEEYKDEYADIPEHKPTYDKMKIIIASSAAVAVLAT
ILMVYLYKRKGNAEKYDKMDEPQDYGKSNSRNDEMLDPEASFWGEEKRASHTTPVLMEKPYY

Epitope Information

IEDB Linear Epitope