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MSP-1 from P. falciparum

General Information
Protegen ID 143
Sequence Strain (Species/Organism) Plasmodium falciparum 3D7
VO ID VO_0010958
Taxonomy ID 36329
Other Database IDs CDD:289698
CDD:304395
Molecule Role Protective antigen
Molecule Role Annotation Aotus monkeys were challenged with the virulent Vietnam Oak Knoll (FVO) strain of P. falciparum. Vaccination of A. nancymai with yMSP1(19) induced protective immune responses. Both of the A. nancymai vaccinated with yMSP1(19) self-resolved an otherwise lethal infection (Kumar et al., 1995).
Related Vaccines(s) ChAd63-MVA MSP1 , NYVAC-Pf7 , P. falciparum MSP1 from transgenic mice with Freund's adjuvant , P. falciparum vaccine Combination B
References
Kumar et al., 1995: Kumar S, Yadava A, Keister DB, Tian JH, Ohl M, Perdue-Greenfield KA, Miller LH, Kaslow DC. Immunogenicity and in vivo efficacy of recombinant Plasmodium falciparum merozoite surface protein-1 in Aotus monkeys. Molecular medicine (Cambridge, Mass.). 1995; 1(3); 325-332. [PubMed: 8529111].
Gene Information
Gene Name MSP-1 from P. falciparum
NCBI Gene ID 813575
Genbank Accession AL844508
Chromosome No 9
Locus Tag PF3D7_0930300
Gene Starting Position 1201811
Gene Ending Position 1206973
DNA Sequence 
>NC_004330.2:1201811-1206973 Plasmodium falciparum 3D7 genome assembly, chromosome: 9
AATGAAGATCATATTCTTTTTATGTTCATTTCTTTTTTTTATTATAAATACACAATGTGTAACACATGAA
AGTTATCAAGAACTTGTCAAAAAACTAGAAGCTTTAGAAGATGCAGTATTGACAGGTTATAGTTTATTTC
AAAAGGAAAAAATGGTATTAAATGAAGAAGAAATTACTACAAAAGGTGCAAGTGCTCAAAGTGGTGCAAG
TGCTCAAAGTGGTGCAAGTGCTCAAAGTGGTGCAAGTGCTCAAAGTGGTGCAAGTGCTCAAAGTGGTGCA
AGTGCTCAAAGTGGTACAAGTGGTCCAAGTGGTCCAAGTGGTACAAGTCCATCATCTCGTTCAAACACTT
TACCTCGTTCAAATACTTCATCTGGTGCAAGCCCTCCAGCTGATGCAAGCGATTCAGATGCTAAATCTTA
CGCTGATTTAAAACACAGAGTACGAAATTACTTGTTCACTATTAAAGAACTCAAATATCCCGAACTCTTT
GATTTAACCAATCATATGTTAACTTTGTGTGATAATATTCATGGTTTCAAATATTTAATTGATGGATATG
AAGAAATTAATGAATTATTATATAAATTAAACTTTTATTTTGATTTATTAAGAGCAAAATTAAATGATGT
ATGTGCTAATGATTATTGTCAAATACCTTTCAATCTTAAAATTCGTGCAAATGAATTAGACGTACTTAAA
AAACTTGTGTTCGGATATAGAAAACCATTAGACAATATTAAAGATAATGTAGGAAAAATGGAAGATTACA
TTAAAAAAAATAAAACAACCATAGCAAATATAAATGAATTAATTGAAGGAAGTAAGAAAACAATTGATCA
AAATAAGAATGCAGATAATGAAGAAGGGAAAAAAAAATTATACCAAGCTCAATATGATCTTTCTATTTAC
AATAAACAATTAGAAGAAGCACATAATTTAATAAGCGTTTTAGAAAAACGTATTGACACTTTAAAAAAAA
ATGAAAACATAAAGAAATTACTTGATAAGATAAATGAAATTAAAAATCCCCCACCGGCCAATTCTGGAAA
TACACCAAATACTCTCCTTGATAAGAACAAAAAAATCGAGGAACACGAAGAAAAAATAAAAGAAATTGCC
AAAACTATTAAATTTAACATTGATAGTTTATTTACTGATCCACTTGAATTAGAATATTATTTAAGAGAAA
AAAATAAAAAAGTTGATGTAACACCTAAATCACAAGATCCTACGAAATCTGTTCAAATACCAAAAGTTCC
TTATCCAAATGGTATTGTATATCCTTTACCACTCACTGATATTCATAATTCATTAGCTGCAGATAATGAT
AAAAATTCATATGGTGATTTAATGAATCCTCATACTAAAGAAAAAATTAATGAAAAAATTATTACAGATA
ATAAGGAAAGAAAAATATTCATTAATAACATTAAAAAAAAAATTGATTTAGAAGAAAAAAACATTAATCA
CACAAAAGAACAAAATAAAAAATTACTTGAAGATTATGAAAAGTCAAAAAAGGATTATGAAGAATTACTT
GAAAAATTTTATGAAATGAAATTTAATAATAATTTTAACAAAGATGTCGTAGATAAAATATTCAGTGCAA
GATATACATATAATGTTGAAAAACAAAGATATAATAATAAATTTTCATCCTCTAATAATTCTGTATATAA
TGTTCAAAAATTAAAAAAGGCTCTTTCATATCTTGAAGATTATTCTTTAAGAAAAGGAATTTCTGAAAAA
GATTTTAATCATTATTATACTTTGAAAACTGGCCTCGAAGCTGATATAAAAAAATTAACAGAAGAAATAA
AGAGTAGTGAAAACAAAATTCTAGAAAAAAATTTTAAAGGACTAACACATTCAGCAAATGGTTCCTTAGA
AGTATCTGATATTGTAAAATTACAAGTACAAAAAGTTTTATTAATTAAAAAAATAGAAGACTTAAGAAAG
ATAGAATTATTTTTAAAAAATGCACAACTAAAAGATAGTATTCATGTACCAAATATTTATAAACCACAAA
ATAAACCAGAACCATATTATTTAATTGTATTAAAAAAAGAAGTAGATAAATTAAAAGAATTTATACCAAA
AGTAAAAGACATGTTAAAGAAAGAACAAGCTGTCTTATCAAGTATTACACAACCTTTAGTTGCAGCAAGC
GAAACAACTGAAGATGGGGGTCACTCCACACACACATTATCCCAATCAGGAGAAACAGAAGTAACAGAAG
AAACAGAAGAAACAGAAGAAACAGTAGGACACACAACAACGGTAACAATAACATTACCACCAACACAACC
ATCACCACCAAAAGAAGTAAAAGTTGTTGAAAATTCAATAGAACATAAGAGTAATGACAATTCACAAGCC
TTGACAAAAACAGTTTATCTAAAGAAATTAGATGAATTTTTAACTAAATCATATATATGTCATAAATATA
TTTTAGTATCAAACTCTAGTATGGACCAAAAATTATTAGAGGTATATAATCTTACTCCAGAAGAAGAAAA
TGAATTAAAATCATGTGATCCATTAGATTTATTATTTAATATTCAAAATAACATACCTGCTATGTATTCA
TTATATGATAGTATGAACAATGATTTACAACATCTCTTTTTTGAATTATATCAAAAGGAAATGATTTATT
ATTTACATAAACTAAAAGAGGAAAATCACATCAAAAAATTATTAGAGGAGCAAAAACAAATAACTGGAAC
ATCATCTACATCCAGTCCTGGAAATACAACCGTAAATACTGCTCAATCCGCAACTCACAGTAATTCCCAA
AACCAACAATCAAATGCATCCTCTACCAATACCCAAAATGGTGTAGCTGTATCATCTGGTCCTGCTGTAG
TTGAAGAAAGTCATGATCCCTTAACAGTATTGTCTATTAGTAACGATTTGAAAGGTATTGTTAGTCTCTT
AAATCTTGGAAATAAAACTAAAGTACCTAATCCATTAACCATTTCTACAACAGAGATGGAAAAATTTTAT
GAGAATATTTTAAAAAATAATGATACCTATTTTAATGATGATATCAAACAATTCGTAAAATCTAATTCAA
AAGTAATTACAGGTTTGACCGAAACACAAAAAAATGCATTAAATGATGAAATTAAAAAATTAAAAGATAC
TTTACAGTTATCATTTGATTTATATAATAAATATAAATTAAAATTAGATAGATTATTTAATAAGAAAAAA
GAACTTGGCCAAGACAAAATGCAAATTAAAAAACTTACTTTATTAAAAGAACAATTAGAATCAAAATTGA
ATTCACTTAATAACCCACATAATGTATTACAAAACTTTTCTGTTTTCTTTAACAAAAAAAAAGAAGCTGA
AATAGCAGAAACTGAAAACACATTAGAAAACACAAAAATATTATTGAAACATTATAAAGGACTTGTTAAA
TATTATAATGGTGAATCATCTCCATTAAAAACTTTAAGTGAAGTATCAATTCAAACAGAAGATAATTATG
CCAATTTAGAAAAATTTAGAGTATTAAGTAAAATAGATGGAAAACTCAATGATAATTTACATTTAGGAAA
GAAAAAATTATCTTTCTTATCAAGTGGATTACATCATTTAATTACTGAATTAAAAGAAGTAATAAAAAAT
AAAAATTATACAGGTAATTCTCCAAGTGAAAATAATAAGAAAGTTAACGAAGCTTTAAAATCTTACGAAA
ATTTTCTCCCAGAAGCAAAAGTTACAACAGTTGTAACTCCACCTCAACCAGATGTAACTCCATCTCCATT
ATCTGTAAGGGTAAGTGGTAGTTCAGGATCCACAAAAGAAGAAACACAAATACCAACTTCAGGCTCTTTA
TTAACAGAATTACAACAAGTAGTACAATTACAAAATTATGACGAAGAAGATGATTCCTTAGTTGTATTAC
CCATTTTTGGAGAATCCGAAGATAATGACGAATATTTAGATCAAGTAGTAACTGGAGAAGCAATATCTGT
CACAATGGATAATATCCTCTCAGGATTTGAAAATGAATATGATGTTATATATTTAAAACCTTTAGCTGGA
GTATATAGAAGCTTAAAAAAACAAATTGAAAAAAACATTTTTACATTTAATTTAAATTTGAACGATATCT
TAAATTCACGTCTTAAGAAACGAAAATATTTCTTAGATGTATTAGAATCTGATTTAATGCAATTTAAACA
TATATCCTCAAATGAATACATTATTGAAGATTCATTTAAATTATTGAATTCAGAACAAAAAAACACACTT
TTAAAAAGTTACAAATATATAAAAGAATCAGTAGAAAATGATATTAAATTTGCACAGGAAGGTATAAGTT
ATTATGAAAAGGTTTTAGCGAAATATAAGGATGATTTAGAATCAATTAAAAAAGTTATCAAAGAAGAAAA
GGAGAAGTTCCCATCATCACCACCAACAACACCTCCGTCACCAGCAAAAACAGACGAACAAAAGAAGGAA
AGTAAGTTCCTTCCATTTTTAACAAACATTGAGACCTTATACAATAACTTAGTTAATAAAATTGACGATT
ACTTAATTAACTTAAAGGCAAAGATTAACGATTGTAATGTTGAAAAAGATGAAGCACATGTTAAAATAAC
TAAACTTAGTGATTTAAAAGCAATTGATGACAAAATAGATCTTTTTAAAAACCCTTACGACTTCGAAGCA
ATTAAAAAATTGATAAATGATGATACGAAAAAAGATATGCTTGGCAAATTACTTAGTACAGGATTAGTTC
AAAATTTTCCTAATACAATAATATCAAAATTAATTGAAGGAAAATTCCAAGATATGTTAAACATTTCACA
ACACCAATGCGTAAAAAAACAATGTCCAGAAAATTCTGGATGTTTCAGACATTTAGATGAAAGAGAAGAA
TGTAAATGTTTATTAAATTACAAACAAGAAGGTGATAAATGTGTTGAAAATCCAAATCCTACTTGTAACG
AAAATAATGGTGGATGTGATGCAGATGCCACATGTACCGAAGAAGATTCAGGTAGCAGCAGAAAGAAAAT
CACATGTGAATGTACTAAACCTGATTCTTATCCACTTTTCGATGGTATTTTCTGCAGTTCCTCTAACTTC
TTAGGAATATCATTCTTATTAATACTCATGTTAATATTATACAGTTTCATTTA
Protein Information
Protein Name merozoite surface protein 1
NCBI Protein GI 124507147
Protein Accession XP_001352170
Protein pI 6.46
Protein Weight 187682.63
Protein Length 1720
Protein Note clinical isolate
Protein Sequence 
>XP_001352170.1 merozoite surface protein 1 [Plasmodium falciparum 3D7]
MKIIFFLCSFLFFIINTQCVTHESYQELVKKLEALEDAVLTGYSLFQKEKMVLNEEEITTKGASAQSGAS
AQSGASAQSGASAQSGASAQSGASAQSGTSGPSGPSGTSPSSRSNTLPRSNTSSGASPPADASDSDAKSY
ADLKHRVRNYLFTIKELKYPELFDLTNHMLTLCDNIHGFKYLIDGYEEINELLYKLNFYFDLLRAKLNDV
CANDYCQIPFNLKIRANELDVLKKLVFGYRKPLDNIKDNVGKMEDYIKKNKTTIANINELIEGSKKTIDQ
NKNADNEEGKKKLYQAQYDLSIYNKQLEEAHNLISVLEKRIDTLKKNENIKKLLDKINEIKNPPPANSGN
TPNTLLDKNKKIEEHEEKIKEIAKTIKFNIDSLFTDPLELEYYLREKNKKVDVTPKSQDPTKSVQIPKVP
YPNGIVYPLPLTDIHNSLAADNDKNSYGDLMNPHTKEKINEKIITDNKERKIFINNIKKKIDLEEKNINH
TKEQNKKLLEDYEKSKKDYEELLEKFYEMKFNNNFNKDVVDKIFSARYTYNVEKQRYNNKFSSSNNSVYN
VQKLKKALSYLEDYSLRKGISEKDFNHYYTLKTGLEADIKKLTEEIKSSENKILEKNFKGLTHSANGSLE
VSDIVKLQVQKVLLIKKIEDLRKIELFLKNAQLKDSIHVPNIYKPQNKPEPYYLIVLKKEVDKLKEFIPK
VKDMLKKEQAVLSSITQPLVAASETTEDGGHSTHTLSQSGETEVTEETEETEETVGHTTTVTITLPPTQP
SPPKEVKVVENSIEHKSNDNSQALTKTVYLKKLDEFLTKSYICHKYILVSNSSMDQKLLEVYNLTPEEEN
ELKSCDPLDLLFNIQNNIPAMYSLYDSMNNDLQHLFFELYQKEMIYYLHKLKEENHIKKLLEEQKQITGT
SSTSSPGNTTVNTAQSATHSNSQNQQSNASSTNTQNGVAVSSGPAVVEESHDPLTVLSISNDLKGIVSLL
NLGNKTKVPNPLTISTTEMEKFYENILKNNDTYFNDDIKQFVKSNSKVITGLTETQKNALNDEIKKLKDT
LQLSFDLYNKYKLKLDRLFNKKKELGQDKMQIKKLTLLKEQLESKLNSLNNPHNVLQNFSVFFNKKKEAE
IAETENTLENTKILLKHYKGLVKYYNGESSPLKTLSEVSIQTEDNYANLEKFRVLSKIDGKLNDNLHLGK
KKLSFLSSGLHHLITELKEVIKNKNYTGNSPSENNKKVNEALKSYENFLPEAKVTTVVTPPQPDVTPSPL
SVRVSGSSGSTKEETQIPTSGSLLTELQQVVQLQNYDEEDDSLVVLPIFGESEDNDEYLDQVVTGEAISV
TMDNILSGFENEYDVIYLKPLAGVYRSLKKQIEKNIFTFNLNLNDILNSRLKKRKYFLDVLESDLMQFKH
ISSNEYIIEDSFKLLNSEQKNTLLKSYKYIKESVENDIKFAQEGISYYEKVLAKYKDDLESIKKVIKEEK
EKFPSSPPTTPPSPAKTDEQKKESKFLPFLTNIETLYNNLVNKIDDYLINLKAKINDCNVEKDEAHVKIT
KLSDLKAIDDKIDLFKNPYDFEAIKKLINDDTKKDMLGKLLSTGLVQNFPNTIISKLIEGKFQDMLNISQ
HQCVKKQCPENSGCFRHLDEREECKCLLNYKQEGDKCVENPNPTCNENNGGCDADATCTEEDSGSSRKKI
TCECTKPDSYPLFDGIFCSSSNFLGISFLLILMLILYSFI
Epitope Information
IEDB Linear Epitope