GP |
| General Information |
| Protegen ID |
1655 |
|
Sequence Strain (Species/Organism) |
Zaire ebolavirus isolate EBOV/H.sapiens-tc/COD/1995/13625 Kikwit |
|
Taxonomy ID |
186538
|
|
Other Database IDs |
CDD:279888
CDD:333284
CDD:197367 |
|
Molecule Role |
Protective antigen |
| Related Vaccines(s) |
Marburg virus recombinant vector vaccine CAdVax-Panfilo
|
| References |
|
| Gene Information |
|
Gene Name |
GP |
| Protein Information |
|
Protein Name |
virion spike glycoprotein |
|
NCBI Protein GI |
1695253
|
|
Protein pI |
6.69 |
|
Protein Weight |
71315.12 |
|
Protein Length |
744 |
|
Protein Note |
Filovirus glycoprotein; pfam01611 |
|
Protein Sequence |
>AAB37095.1 virion spike glycoprotein [Zaire ebolavirus]
MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQVSDVDKLVCRDKLSSTNQLRSVGLNL
EGNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHK
VSGTGPCAGDFAFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPS
SGYYSTTIRYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYTSGKRSNTTGKLIWKVNPE
IDTTIGEWAFWETKKNLTRKIRSEELSFTAVSNRAKNISGQSPARTSSDPGTNTTTEDHKIMASENSSAM
VQVHSQGREAAVSHLTTLATISTSPQPPTTKPGPDNSTHNTPVYKLDISEATQVEQHHRRTDNDSTASDT
PPATTAAGPLKAENTNTSKGTDLLDPATTTSPQNHSETAGNNNTHHQDTGEESASSGKLGLITNTIAGVA
GLITGGRRARREAIVNAQPKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIYTEGLMHNQDGLICGLRQ
LANETTQALQLFLRATTELRTFSILNRKAIDFLLQRWGGTCHILGPDCCIEPHDWTKNITDKIDQIIHDF
VDKTLPDQGDNDNWWTGWRQWIPAGIGVTGVIIAVIALFCICKFVF
|
| Epitope Information |
| IEDB Linear Epitope |
|
| IEDB ID |
Epitope |
Starting position |
Ending position |
| 233152 |
ATQVEQHHRRTDNDSTA |
401 |
418 |
| 233197 |
HNTPVYKLDISEATQVE |
389 |
406 |
| 76393 |
YVQLESRFTPQFLLQ |
241 |
256 |
| 858614 |
DKIDQIIHDFV |
621 |
632 |
| 65808 |
TPVYKLDISEATQVEQHH |
391 |
409 |
| 68320 |
VEQHHRRTD |
404 |
413 |
| 162327 |
GKLGLITNTIAGVAGLI |
477 |
494 |
| 740516 |
TPVYKLDISEATQVEQHHRRTDNDS |
391 |
416 |
| 738996 |
GEESASSGKLGLITNTIAGVAGLIT |
470 |
495 |
| 739800 |
NNNTHHQDTGEESASSGKLG |
461 |
481 |
| 740342 |
SPQNHSETAG |
451 |
461 |
| 739438 |
LDISEATQVEQHHRRTDNDSTASDT |
396 |
421 |
| 738527 |
ASENSSAMVQVHSQGREAAVSHLTTLA |
343 |
370 |
| 852598 |
GAFFLYDRLAST |
157 |
169 |
| 739075 |
GTNTTTEDHKIM |
331 |
343 |
| 739152 |
IDTTIGEWAFWETKKNLTRKIRSE |
281 |
305 |
| 739279 |
IYTSGKRSNTTGKLIWKVNPE |
260 |
281 |
| 835888 |
VGLNLEGNGVATDVPSATKRW |
66 |
87 |
| 832628 |
ENCYNLEIKKPDGSEC |
106 |
122 |
| 833550 |
KEGAFFLYDRLASTVIYRGTTFA |
155 |
178 |
| 740578 |
VAFLILPQAKKDFFSSHPLREPVNATEDPS |
181 |
211 |
| 8777 |
DISEATQVEQHHRRTDND |
397 |
415 |
| 932264 |
VDKTLPDQGDNDNWWTGWRQWIPAG |
631 |
656 |
| 931784 |
TKNITDKIDQIIHDFVDKTL |
616 |
636 |
| 26510 |
IIHDFVDKTLPDQGD |
626 |
641 |
| 929450 |
NSTHNTPVYKLDISE |
386 |
401 |
| 475611 |
AIGLAWIPYF |
526 |
536 |
| 740442 |
TEGLMHNQDGLICGLRQLANETTQALQLFLRATTELRT |
544 |
582 |
| 738955 |
FSILNRKAIDFLLQRWGGTCHILGPD |
582 |
608 |
| 91431 |
GVIHNSTLQ |
36 |
45 |
| 227409 |
NISGQSPARTSSDPG |
317 |
332 |
| 227269 |
IKKPDGSECLPAAPD |
113 |
128 |
| 187300 |
DNSTHNTPVYKLDIS |
385 |
400 |
| 227099 |
DPGTNTTTEDHKIMA |
329 |
344 |
| 52394 |
QSPARTSSDPGTNTT |
321 |
336 |
| 187296 |
DISEATQVEQHHRRT |
397 |
412 |
| 227097 |
DNLTYVQLESRFTPQ |
237 |
252 |
| 13781 |
EPVNATEDPSSGYYS |
201 |
216 |
| 187541 |
TGEESASSGKLGLIT |
469 |
484 |
| 227307 |
KPGPDNSTHNTPVYK |
381 |
396 |
| 227141 |
ENSSAMVQVHSQGRE |
345 |
360 |
| 227248 |
HNTPVYKLDISEATQ |
389 |
404 |
| 227687 |
VYKLDISEATQVEQH |
393 |
408 |
| 50368 |
QATGFGTNETEYLFE |
221 |
236 |
| 187314 |
EDHKIMASENSSAMV |
337 |
352 |
| 227064 |
CRDKLSSTNQLRSVG |
53 |
68 |
| 61752 |
STLQVSDVDKLVCRD |
41 |
56 |
| 227450 |
PPKVVNYEAGEWAEN |
93 |
108 |
| 187509 |
RTSSDPGTNTTTEDH |
325 |
340 |
| 227422 |
NTTTEDHKIMASENS |
333 |
348 |
| 227170 |
FGTNETEYLFEVDNL |
225 |
240 |
| 27448 |
IMASENSSAMVQVHS |
341 |
356 |
| 187549 |
TIRYQATGFGTNETE |
217 |
232 |
| 478550 |
GEWAF |
286 |
291 |
| 740269 |
SGYYSTTIRYQATGFGTNETEYLFEVDNLT |
211 |
241 |
| 740397 |
STLQVSDVDKLVCRDKLSSTNQLRS |
41 |
66 |
| 739466 |
LFLRATTELRT |
571 |
582 |
| 739164 |
IEPHDWTKNITDKIDQIIHDFVDKTLPDQGDNDNWWTGWRQWI |
610 |
653 |
| 739659 |
MHNQDGLICGLRQLANETTQALQ |
548 |
571 |
| 858307 |
DNDSTASDTPPATTAAGPLK |
412 |
432 |
| 13837 |
EQHHRRTDN |
405 |
414 |
| 57019 |
SATKRWGFRSGVPPK |
81 |
96 |
| 739719 |
NAQPKCNPN |
506 |
515 |
| 738477 |
AKKDFFSSHPLREPVNATEDPS |
189 |
211 |
| 739533 |
LNETIYTSGKRSNTTGKLIWKVN |
256 |
279 |
| 739153 |
IDTTIGEWAFWETKKNLTRKIRSEELSF |
281 |
309 |
| 739163 |
IEPHDWTKNITDKIDQIIHDFVDKTLPDQGDND |
610 |
643 |
| 769762 |
TDKIDQIIHDFVDKTL |
620 |
636 |
| 91945 |
SETAGNNNT |
456 |
465 |
| 833870 |
LMHNQDGLICGLRQLA |
547 |
563 |
| 832979 |
GEESASSGKLGLITNTIAGVAGL |
470 |
493 |
| 72065 |
VYKLDISEA |
393 |
402 |
| 832618 |
EDHKIMASENSSAMVQ |
337 |
353 |
| 833006 |
GPLKAENTN |
428 |
437 |
| 832524 |
ATTELRTFSILNRKAI |
575 |
591 |
| 833625 |
KNISGQSPAR |
316 |
326 |
| 835856 |
VDKTLPDQGDNDNWWT |
631 |
647 |
| 833196 |
IDFLLQRWGGTCHILGPDCCIE |
590 |
612 |
| 834427 |
RSEELSFTAV |
302 |
312 |
| 834038 |
NATEDPSSGYYSTTIR |
204 |
220 |
| 836134 |
VQVHSQGREAAVSHLT |
351 |
367 |
| 91451 |
HHRRTDNDS |
407 |
416 |
| 833465 |
IWKVNPEIDTTIGEWA |
274 |
290 |
| 858649 |
LEIKKPDGSE |
111 |
121 |
| 6391 |
CHILGPDCCIEPHDW |
601 |
616 |
| 47064 |
PDCCIEPHDWTKNIT |
606 |
621 |
| 13658 |
EPHDWTKNITDKIDQ |
611 |
626 |
| 64624 |
TKNITDKIDQIIHDF |
616 |
631 |
| 8885 |
DKIDQIIHDFVDKTL |
621 |
636 |
| 68003 |
VDKTLPDQGDNDNWW |
631 |
646 |
| 47167 |
PDQGDNDNWWTGWRQ |
636 |
651 |
| 43502 |
NDNWWTGWRQWIPAG |
641 |
656 |
| 72638 |
WIPAGIGVTGVIIAV |
651 |
666 |
| 26343 |
IGVTGVIIAVIALFC |
656 |
671 |
|
|
|
MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQVSDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTIRYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYTSGKRSNTTGKLIWKVNPEIDTTIGEWAFWETKKNLTRKIRSEELSFTAVSNRAKNISGQSPARTSSDPGTNTTTEDHKIMASENSSAMVQVHSQGREAAVSHLTTLATISTSPQPPTTKPGPDNSTHNTPVYKLDISEATQVEQHHRRTDNDSTASDTPPATTAAGPLKAENTNTSKGTDLLDPATTTSPQNHSETAGNNNTHHQDTGEESASSGKLGLITNTIAGVAGLITGGRRARREAIVNAQPKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIYTEGLMHNQDGLICGLRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQRWGGTCHILGPDCCIEPHDWTKNITDKIDQIIHDFVDKTLPDQGDNDNWWTGWRQWIPAGIGVTGVIIAVIALFCICKFVF
|
