MSP1 from P. knowlesi |
| General Information |
| Protegen ID |
1746 |
|
Sequence Strain (Species/Organism) |
Plasmodium knowlesi strain H |
|
Taxonomy ID |
5851
|
|
Other Database IDs |
CDD:284802
CDD:289698
CDD:289699
EnsemblGenomes-Gn:PKH_072850
EnsemblGenomes-Tr:PKH_072850
GOA:B3L2X8
InterPro: IPR010901
InterPro: IPR024730
InterPro: IPR024731
UniProtKB/TrEMBL: B3L2X8 |
|
Molecule Role |
Protective antigen |
| Related Vaccines(s) |
P. knowlesi DNA vaccine encoding PkCSP, PkSSP2, PkAMA1, and PkMSP1p42
|
| References |
|
| Gene Information |
|
Gene Name |
MSP1 from P. knowlesi |
|
NCBI Gene ID |
7320035
|
| Protein Information |
|
Protein Name |
merozoite surface protein 1, MSP-1 |
|
NCBI Protein GI |
XP_002258582.2
|
|
Protein pI |
5.06 |
|
Protein Weight |
192886.042 |
|
Protein Length |
1931 |
|
Protein Note |
Merozoite surface protein 1 (MSP1) C-terminus; pfam07462 |
|
Protein Sequence |
>XP_002258582.2 merozoite surface protein 1 [Plasmodium knowlesi strain H]
MKALLFLFSLIFFVTKCQCETEDYKQLLVKLDKLEGLVVDGYELFHKNKISLDNIDAVQNIDGNNVNALA
YKIRDIVGKYLELQIPGHGNLLHMIRELALDANGLKYLVENYEEFNQLMHVINFNYDLLRAKLNDMCAHE
YCKIPEHLKISAKELDMLKKVVLGYRKPLDNIKDDIGKMEAFINKNKETINNINQLITAENAKIVGHPIN
GVNVTGASSDAVANTGTPVAAAAGAAAAAVPGAIASPSPVESSTPENYDQKKVIFQAIYNFIFYTNQLEE
AQKLMQVLEKRVKLLKEHKSIKALLEQIATEKNNLTTNNATTGGATTIPEEVQKKIADLEKQIVAIAKTV
NFDMDGLFTNVEELEYYLREKAKMAGTLIGPESSQSTGTPGKAVPTLKETYPYGITYALPERTIYELIEK
FGSEESFGDLQNPDNGRQPNKGIIINETKRKTLVDKIMSKIKLEEEKLPKLKKEYDEKMEQYKQKVQDFL
PTLKYFYEGKLDNTLVGSKFDEFKNKREAYMKEKEELEKCTYEQSINLINKLKKQLTYLVDYTLKKDVTE
DEINYFSDLEWKLKNEIYELAKEVRKNENKLIMENKFDFSGVLELQIHKVLMIKKIGALKNVQNLLKNAK
LKDKLYIPKVYKTGQKPEPYYLIVLKKEIDKLKDFIPKIETMIATEKAKAPTEPVKVRAQSLRGASETAP
SEPPTATESGSTTSASTAVQQPTQQAAQAAQAASPVTVTQPTETVTQTPAPATETAGEAAQETSPVSPTA
PAVVSEAGTEGGEGTTEVVAQPEAASGETQTPTPGAVDASPAAPVPAGTPGTTDAAPEASVPAPAGSALP
ATTAPAAAAPAAPAMSKLEYLEKLLEFLKSSYACHKHIFLTNSTMNPELLKQYALTTDEEKKIKESACDE
LDLLFNVQNNLPSMYSIYDTMINDLQNLYIELYQKEMVYNIYKNKDTDTKIKAFLETLKSNAASVTPAVV
PAAAPVVTPAPAEPVVTPAPAPGQAAPAAAPTTTNPSTTPSGTTTNAVSPTTAVTPGAQDTTQTTTQDTT
VTEEGGVTVQASSEEEPETNIVNVEKIYEKHLSQMDKYNDYFIKFLESQKEKITSMTEEQANALGAEIEA
LKKKVQVSLDHYGKYKLKLERFLEKKNKISNSKEHIKKLTSLKNKLERKLNFLNNPTSVLKNYIIFFNKK
KEAEKKEVENTLKNTEILLKYYKARAKYYIGEPFPLKTLSEESLQKEDNYLNLEKFRVLSRMEGRLGNNI
NLEKENISYLSSGLHHVFTELKEIIKNKKYTGNDHAKNTTAVKEALQAYEELLPKVATQTASLPPVAPPA
VVPPVVPEAEAEAEAEAEAEPATSTQPATADTAAPTQTPAAPTQTPAEPATATATTGETAAAPAAPAPVE
VQNAEVKAQEYGEDYDKVITLPLFGNDEDDVEDQEEKQIITGEAENAQPENIVPEGINEYEVVYIKPLAG
MYKSIKKQLENHVAAFNTNITDMLDSRLKKRNYFLDVLDSELNPFKYSSSGEYIIKDPYKLLDLEQKKKL
LGSYQYIGASVDKDLITAKDGMEYYNKMGELYKQHLEAVNAQIKEIEASVPGEQSQLNAQKEELKKYLPF
LNSIQKEYESLVNMAHTYKENLKKFINNCQIEKKETEIIVKKLEDYTKIDENLEIYKKSKKESDVRSSGL
LEKLKNSKLINEEESKKVLSQLLNVQTQMLNMSSAHKCIDTNVPENAACYRYLDGTEEWRCLLGFKEVGG
KCVPASITCEENNGGCAPEAECTMDDKKEVECKCTKEGSEPLFEGVFCSSSSFLSLSFLLLILIFFLSME
L
|
| Epitope Information |
| IEDB Linear Epitope |
|
| IEDB ID |
Epitope |
MHC restriction |
Starting position |
Ending position |
| 483774 |
RCLLGFKEVGGKCVPASI |
|
1740 |
1758 |
| 487182 |
TAKDGMEYYNKMGELYKQ |
|
1557 |
1575 |
| IEDB ID |
Epitope |
Starting position |
Ending position |
| 35783 |
LEYYLREK |
364 |
372 |
| 122138 |
LKKDV |
554 |
559 |
| 481735 |
LDSRLKKRNYFLDVLDSE |
1494 |
1512 |
| 488816 |
YFLDVLDSELNPFKYSSS |
1503 |
1521 |
| 481923 |
LNPFKYSSSGEYIIKDPY |
1512 |
1530 |
| 480787 |
KLLGSYQYIGASVDKDLI |
1539 |
1557 |
| 482437 |
NCQIEKKETEIIVKKLED |
1638 |
1656 |
| 489046 |
YTKIDENLEIYKKSKKES |
1656 |
1674 |
| 477316 |
EEESKKVLSQLLNVQTQM |
1692 |
1710 |
| 475489 |
AFNTNITDMLDSRLKKRN |
1485 |
1503 |
| 487182 |
TAKDGMEYYNKMGELYKQ |
1557 |
1575 |
| 483774 |
RCLLGFKEVGGKCVPASI |
1740 |
1758 |
| 478551 |
GEYIIKDPYKLLDLEQKK |
1521 |
1539 |
| 480775 |
KLLDLEQKKKLLGSYQYI |
1530 |
1548 |
| 486553 |
SSAHKCIDTNVPENAACY |
1713 |
1731 |
| 482841 |
NVPENAACYRYLDGTEEW |
1722 |
1740 |
| 480644 |
KKQLENHVAAFNTNITDM |
1476 |
1494 |
| 485096 |
RYLDGTEEWRCLLGFKEV |
1731 |
1749 |
| 480077 |
IYKKSKKESDVRSSGLLE |
1665 |
1683 |
| 477123 |
DVRSSGLLEKLKNSKLIN |
1674 |
1692 |
| 480761 |
KLKNSKLINEEESKKVLS |
1683 |
1701 |
| 483417 |
QLLNVQTQMLNMSSAHKC |
1701 |
1719 |
| 482843 |
NVQTQMLNMSSAHKCIDT |
1704 |
1722 |
| 477415 |
EELKKYLPFLNSIQKEYE |
1602 |
1620 |
| 481924 |
LNSIQKEYESLVNMAHTY |
1611 |
1629 |
| 486211 |
SLVNMAHTYKENLKKFIN |
1620 |
1638 |
| 480382 |
KENLKKFINNCQIEKKET |
1629 |
1647 |
| 477691 |
EIIVKKLEDYTKIDENLE |
1647 |
1665 |
| 477855 |
EQSQLNAQKEELKKYLPF |
1593 |
1611 |
| 478326 |
GASVDKDLITAKDGMEYY |
1548 |
1566 |
| 482668 |
NKMGELYKQHLEAVNAQI |
1566 |
1584 |
| 479348 |
HLEAVNAQIKEIEASVPG |
1575 |
1593 |
| 480296 |
KEIEASVPGEQSQLNAQK |
1584 |
1602 |
|
|
|
MKALLFLFSLIFFVTKCQCETEDYKQLLVKLDKLEGLVVDGYELFHKNKISLDNIDAVQNIDGNNVNALAYKIRDIVGKYLELQIPGHGNLLHMIRELALDANGLKYLVENYEEFNQLMHVINFNYDLLRAKLNDMCAHEYCKIPEHLKISAKELDMLKKVVLGYRKPLDNIKDDIGKMEAFINKNKETINNINQLITAENAKIVGHPINGVNVTGASSDAVANTGTPVAAAAGAAAAAVPGAIASPSPVESSTPENYDQKKVIFQAIYNFIFYTNQLEEAQKLMQVLEKRVKLLKEHKSIKALLEQIATEKNNLTTNNATTGGATTIPEEVQKKIADLEKQIVAIAKTVNFDMDGLFTNVEELEYYLREKAKMAGTLIGPESSQSTGTPGKAVPTLKETYPYGITYALPERTIYELIEKFGSEESFGDLQNPDNGRQPNKGIIINETKRKTLVDKIMSKIKLEEEKLPKLKKEYDEKMEQYKQKVQDFLPTLKYFYEGKLDNTLVGSKFDEFKNKREAYMKEKEELEKCTYEQSINLINKLKKQLTYLVDYTLKKDVTEDEINYFSDLEWKLKNEIYELAKEVRKNENKLIMENKFDFSGVLELQIHKVLMIKKIGALKNVQNLLKNAKLKDKLYIPKVYKTGQKPEPYYLIVLKKEIDKLKDFIPKIETMIATEKAKAPTEPVKVRAQSLRGASETAPSEPPTATESGSTTSASTAVQQPTQQAAQAAQAASPVTVTQPTETVTQTPAPATETAGEAAQETSPVSPTAPAVVSEAGTEGGEGTTEVVAQPEAASGETQTPTPGAVDASPAAPVPAGTPGTTDAAPEASVPAPAGSALPATTAPAAAAPAAPAMSKLEYLEKLLEFLKSSYACHKHIFLTNSTMNPELLKQYALTTDEEKKIKESACDELDLLFNVQNNLPSMYSIYDTMINDLQNLYIELYQKEMVYNIYKNKDTDTKIKAFLETLKSNAASVTPAVVPAAAPVVTPAPAEPVVTPAPAPGQAAPAAAPTTTNPSTTPSGTTTNAVSPTTAVTPGAQDTTQTTTQDTTVTEEGGVTVQASSEEEPETNIVNVEKIYEKHLSQMDKYNDYFIKFLESQKEKITSMTEEQANALGAEIEALKKKVQVSLDHYGKYKLKLERFLEKKNKISNSKEHIKKLTSLKNKLERKLNFLNNPTSVLKNYIIFFNKKKEAEKKEVENTLKNTEILLKYYKARAKYYIGEPFPLKTLSEESLQKEDNYLNLEKFRVLSRMEGRLGNNINLEKENISYLSSGLHHVFTELKEIIKNKKYTGNDHAKNTTAVKEALQAYEELLPKVATQTASLPPVAPPAVVPPVVPEAEAEAEAEAEAEPATSTQPATADTAAPTQTPAAPTQTPAEPATATATTGETAAAPAAPAPVEVQNAEVKAQEYGEDYDKVITLPLFGNDEDDVEDQEEKQIITGEAENAQPENIVPEGINEYEVVYIKPLAGMYKSIKKQLENHVAAFNTNITDMLDSRLKKRNYFLDVLDSELNPFKYSSSGEYIIKDPYKLLDLEQKKKLLGSYQYIGASVDKDLITAKDGMEYYNKMGELYKQHLEAVNAQIKEIEASVPGEQSQLNAQKEELKKYLPFLNSIQKEYESLVNMAHTYKENLKKFINNCQIEKKETEIIVKKLEDYTKIDENLEIYKKSKKESDVRSSGLLEKLKNSKLINEEESKKVLSQLLNVQTQMLNMSSAHKCIDTNVPENAACYRYLDGTEEWRCLLGFKEVGGKCVPASITCEENNGGCAPEAECTMDDKKEVECKCTKEGSEPLFEGVFCSSSSFLSLSFLLLILIFFLSMEL
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