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PRF1

General Information
Protegen ID 1815
Sequence Strain (Species/Organism) Homo sapiens
Taxonomy ID 9606
Molecule Role Protective antigen
Related Vaccines(s) Fluarix , YF-Vax
References  
Gene Information
Gene Name PRF1
NCBI Gene ID 5551
Genbank Accession AL355344
Chromosome No 10
Locus Tag RP11-710A11.3
Gene Starting Position 70597347
Gene Ending Position 70602787
DNA Sequence 
>NC_000010.11:70597347-70602787 Homo sapiens chromosome 10, GRCh38.p12 Primary Assembly
ATCACCATAACATCATATTTATTGGCCCTTTATCAAGCTATGTACATGGTGAGACAGGTCAGGACAGGCC
TCCATTTGTCTCAGGGGCAAAGCATTGTGGGCAAAGAAGACAGAGCAGCTGGAGCTGATGGGGCTCCAGT
TAAGGCAATGAAGGCTTTGCCACACCATAGAGGGCTCAAGGGAAGGGTCCTAAAAGACCAGCCCTGAGCA
GCCTGGTGGGAACAGCCTCTTGGCCTTCTGCCCAGCTCCTGGCTGAAGCTGTGATCTGTGTAGCTGTGAC
TGCAGGGCTTGAGAATGGCGGAGGGCTTAGGCAGTTTGGACAGGGTGAATCGGGATTAGCGTGTAAACCC
AGCCACCTCCCTGAAAAACAGTCTGAATCTCCCTTTTCCATCTGTCTGATGCGTATCCAATCTTTTGGCT
TCTCTGGGCCACGTTGGAAGAAGAATTGTGTTGGGCCACATGTAAAATCCACTAGCACTAACGATAGCCG
ATGAGCTAAAAAAAAAAAAAAAATAGCAAAAAGAAACTCATAATGTTTTAAGAAAGTTTGCGAATTTGCG
TTGGGCCGCATTCAAAGCCATCCTGGGCCGCATGCGGGCCTCGGGTTGGACAAGCTTGGTCTAATGGGAA
TACGAAGACAGCCCTGGCTCCCACTGTGAGAACCCCTTCAGTCCAAGCATACTGGTCCTTTCCAAGCTCA
CTGTTCTCACCACACGGCCCCACTCCGGTTTCCTGGAGGCTCCCCCAGAAGCATTTGGGGGACATAGTCC
AGGCAGGTGCCTCCTCCCAGGTGGGGCAAGCACCTGGCATGATAGCGGAATTTTAGGTGGCCATGATTCA
GGTTGCATCTCACCTCATGGGAACCAGACTTGGGAGCCTGATCACAGGTGCCAAGGAGGTCATCGTCCCT
GCCAGAGTCCTGATCCCAGACCTGCAACCTCAGGGGCCCCCCTGTGGCCAGGAGCACATCCCCAAAATCC
AGCCGCACTGACCAGATGGGGTTGTTATTGTCCCACACGGTGCTCGTCCTCAGCTCCTGGCCACCAAAGA
AGAGCTTCACATAGGCATCCGTGGCAGTGAACCAGTCCCCCCACAGGCCCCATGCTTGGATGAAGGTCAC
CTCCAGCTGGGCCAGGCCCCTCTGCCGAGGGCAGCAGTCCTGGGTGGTGACCGCTGAGCCATGGCACACA
CACTGGCATGGGTCTCGGGGGCTCTTCTGCCGCCCTGGTGGGCACGGCCGGCTGCAGTCCCTCCAGCGAG
CCCTGTCCGTCAGGTACTGACTCAGGGCCCTCCTCAGTGCCTCCCGCCGCGGGTCCTGGCTGTCCAGCAG
CACGTGCAGGGGTTCCAGGGTGTAGTCCACCAGGCCAGGGCTGCCGGGCAGCGAGTTTACCCAGGCTGAG
TACTGCTCGGGCCCGGCCTGGATCCCGAACAGCAGGTCGTTAATGGAGGTGTGATGGCCGCCAACCACTT
CCGAGTGGCGCTCCCGGTAGGTTTGGTGGAAGGAGGCCGTCATCTTGTGCTTCTTCTTCTTCTCCTCACA
GGCCTTGGCTTCGGCAGAGATGCTGCCGTGGATGCCTATGTTGACCTGGGCCTCGACAGTCAGGCAGTCC
TCCACCTCGTTGTCCGTGAGCCCTTCCAGGGCCAGCTCGCAGGTGCGCAGGGCAGTGAGGGCCGATATGC
GGCCACCCAGCTCCACAGCCCGGATGAAGTGGGTGCCGTAGTTGGAGATAAGCCTGAGGTAGGCGGGCTG
GGTGGAGGCGTTGAAGTGGTGGGGCAGGTCCCCGAGGGCCCTCTTGAAGTCAGGGTGCAGCGGGGGAGTG
TGTACCACATGGAAACTGCGAGAAGAGAGAGACCTCAGCTGGGCCCAGGGGAGTATTTCCCCCATTCAAT
CAAATAACTCCTTCAGGACTGCTCAAGGTCACATGTAAGTGGGCAGAACTAGGACTGGAACCCAGGGGCC
CGGCTCCAGAGCACAAGCACAGTGGCACGGGGCTGGCAGGAATGCCTCCGCTCTCACCCCTCAGGGACCT
CAGTGCTCTGTATAGGTATTTTCTCTTTTCCTTTTCAAAATAACATTTTTTTCTTTCCTTTTAATTTTCT
TATTATAAAAGCAATGATCCTGGCCGGGAGCAGTGGTTCATGCCTGTAACCCCAGCACTTTGGGAGGCCG
AGGCGGGAGGATCACTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACATAGTGAGACCCCATCTCTAT
TTTTTTTTTAAGAAAAAGTAAAAAAGAACATAAAAGCAATGATCCTGCACTGATGGTATCTGTCGAACTT
TGGAACTAGTCATGTGGCCTTCATCCATCCGTCCCCCTGGATGGGTCCCACATGCCCGGGATCCTGACAG
CTTGGGCCATGCTCGGCCTCTCTGTGGAGGAAACGTGGCCCCCAGGTCTGATGAATCAGACCAGGTGACT
TGGGTCTGGCCTACAAACACTGTGCCTTTCTCAGACGTGGAATATGGGTCCCATACTTCCTACTCCCAGG
GGCTAGGGTAGTGACTGCTGTCGCTCAGCAGTGTGGCCCTGCCACAGGCAGGTGTGAGTATTGGTTGAGT
GGATGATTGAAGCTCAGAGAGAAGTGAGATGCTCAAGGTCACACAGCGATGAGGAAGGATGACCCGGCCA
GGTCTCCTGCCTCTGTCCCTATCCAGGAAGGACTCTGTGGAAGGCTGGCTGTGCCCAGGAAAGGCAGGGT
TCAGTACTCACTAGACCTAAATGGCACCCTGCTGGGACTCTCAGGCATGGTCTCACTCACTTTCTCTCTA
CTTGATGTCTCACTGGGCACTCCCAGATTTGGGACCTCCTGGATGAGAGGAGGCCACAGGGCTGAATCAC
CTGAAGTCTGAGAGCCAGGATTGCAGTTTCTTCCTGGTGGAAGCAGCCTCCAAGTTTGATTGGAGGACTC
TGCCTTTCCAGGGCTCCTAGACCACCCAGAGTTTCCCGCGCCTTTTCCAGCCCCCCACCCCTAGCCCCAG
CTCTCACCTGTAGAAGCGGCACTCCACCGTGTCAGTGCTGAAGCTGTACTGGTCCTGGTGGGTCTTCTGG
GCTGCAAAGTTGGCTGCCTGTGAGTGTGAGCCGGCCACAGACACATGCACATTGCTGGTGGGCTTAGGAG
TCACGTCCAGCCCGACCTTCCAGTCGTTGCGGATGCTACGAGCCGCATCCCGGGCCACAGCTTCAGTGGA
GCTGACTTTGGCCCTGGTTACATGGCGCTGGCAGCCAGAGCCCTGGGCCCGCCAGTTGGTGAGCGCCAGA
GGCAGGCGCTGGAGGGTGCCCTCCTGTAGGGCATTTTCACAGAGGGTGCAGGTGCCGTCGGGCCGCAGGA
ACCTTTGTGTGTCCACTGGGAAGGAGCCCGAGCGGCGGAGGCTGGTCACGTCCACACCCTCCCCGGCCAG
CCATGCACCAGGCACGAACTTGTGGCTGCGCTTGCACTCTGAGCGTGCGGCTGTGTGGCACGGGGCAGGG
ACGGGCAGGGGCAGCAGCAGGAGAAGGATGCCCAGGAGGAGCAGACGGGCTGCCATGGAGCTGCAGAGAC
AGGGGGCACTTGGGCTCTGGGAAGCCATGGGTGGAGGGATGGAGGATGACTGCTCCCTTCCCCCACAGCC
ACAGATTATCAGGGCACATGGAAGGGGAGGGGCTGAGATATCTCTTAAGTCATTATTCAATGAATGTCAG
AGCTGGTATGTCCCTTATAGGCCTGGTTCAGCCCCCACATTGTACAGATGGGCCCAGAGAGGGGAAAAGC
CCAGCCAAGGGGAGCCCCTTTTTAGAATTTCCCTAAGGCCTAATGGGGATCTAGGTGGATGGCTCTGTCC
CCAGGACACAACTGTGGGTGGTGGGGAGGGGGCTGTGGCCACAGAAGAGGGGACAGAGTAGCTGTAGCAG
GTTTAGGGAGGGGTCTGGGGACCTGAGGAAGCCTTCATTCTGAAGAAGTGTCATTTTTGGCCCCAGAACA
AGCCACCCTTTGCCCACCCTGACTCTCACTCTGTTTCTTTGTCTCTGTCACTCTCTCTAACCTCTCTCCC
TCCCACTGAGCCCTTAACAGAATTGGAAGAGAAATGAGGTCCTATATTGCACCTATTCTTCTCATTTTCC
CTTTGGGGCTCTCCCTCTGAGCTTTATGGAATAACATCAGCCCGAATTCTAGAATAAAATCTGCCGACCT
GGCCAGGTGTGGTGGCTCACACCTGTAAACCGAACACTGTGGGAGGCAGAGGCAGGTGGATCACTGGAGG
TCAGAAGTTCGAGACCAGCCTGGCCAACGTGGTGAAACCCCCTCTTTACTAAAAATACAAAAATTAGCTG
GGCATGGTGGCGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCCAGG
AGGCGGAGGTTGCAGTGAGCCAAGATCGTACCACTGCACTCCCGCCTGGGTGATAGAGTAAGACTCTGCC
TCAAAAAAAAAAAAAAAAAGGGGCAGACCTGACCACACCCTTGGATTTTGTGTGGGGAGAGGCCTCGATG
GTTGCTCTTCAGATCCTTTCTTGCTGCCCCTCCCCTCTTTGCCACTCCCTGCCAAGCTCTGTGGCCTTCG
GCAGTGACAGGGGCCCCCCTATTGCCTACTATGGACAATGATTGTCTGGAAGGTTCTTCCTAATTTTAAG
GTGTTTCTGGGGCCTTGCCTGGGCCTGTTTATGATCTGGAACCTCCTTTCTCTAACCTTACCCAAGCCTA
ACCTTATCCAAGCTGAGCTCTTCAAAGGCCTTTGCCCTTGGGTACCACAGGTTCTGAGACAAGAGGGCTA
TGGAGAGCCCCCATTATAGCTGGAGCCTCCTGCCCTGCCCAAAGGTGTGACTTGAAGGGTGGAATTTCAG
GCAGCGTGGCTCGCCCCAGGGAGGCAAAGAGGCCAGGGGAATCTTCAAAGGCCCTGGGCTCATCCCAGCT
AGGAGGCGGGCACAGTCATAACCCTAATCCAGTGAACTCAGCCCTCATCCTGACTCTCATGGTATTCTGT
CCCAGGGAGCCTCTTTCCAGCTTTCTTAGAAGCTTTAATGTCAGCACTTGCAGGGCCTTAGAAACTGCAC
GCTACCTCTTCATTTCATACATGAGGAAACTGAGGCCCAGGGTGGACACAGGGCTGCCCAGCGAGTTAGT
GATGGGCACCGTCTGTGACCCAGGTGTCTTGTCTTATAGGTCACAGCACTTCCTGCTCCATCAGCCTCTT
CCCCTCCACCCAGGGCCCCAGGCCCCCCAATCCCTGCTCTCTCCTTACCTGGAATCCCGTATAGAGAAGC
GGCTACACAGATGGATATCCTCTCTTCACCGAGGCTCCTGGAATGGTGGCATCAGCCCCCCAGGCAGCCC
ACTGTGGCTCCTTGCACCAGCCACCACTCACATCACTTCTACTTCCTGCCC
Protein Information
Protein Name transcript variant 1
NCBI Protein GI 133908621
Protein Accession NP_001076585
Protein pI 7.87
Protein Weight 57804.35
Protein Length 555
Protein Note Also known as P1; PFP; FLH2; PFN1; HPLH2
Protein Sequence 
>NP_001076585.1 perforin-1 precursor [Homo sapiens]
MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFPVDTQRFLRPD
GTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARDAARSIRNDWKVGLDVTPKPT
SNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYSFHVVHTPPLHPDFKRALGDLPHHFNASTQP
AYLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACE
EKKKKHKMTASFHQTYRERHSEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLL
DSQDPRREALRRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVT
FIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRLQVWDQDSGRD
DDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQMLLGEPPGNRSGAVW
Epitope Information
IEDB Linear Epitope